Circadian rhythms and interorgan crosstalk

Department of Cell Biology, Physiology and Immunology

University of Barcelona

The Liver Clock Tunes Transcriptional Rhythms in Skeletal Muscle to Regulate Mitochondrial Function - PubMedCircadian clocks present throughout the brain and body coordinate diverse physiological processes to support daily homeostasis, yet the specific interorgan signaling axes involved are not well defined. We previously demonstrated that the skeletal muscle clock controls transcript oscillations of gene …

Circadian clock communication during homeostasis and ageing - Nature Reviews Molecular Cell BiologyCommunication between the circadian clocks of different cell and tissue types supports the daily rhythms of homeostatic processes that maintain bodily health. Ageing leads to a decline in this complex communication network to the detriment of these daily homeostatic rhythms. This Review discusses clock communication pathways in the healthy versus aged state and explores the potential of modulating these communication pathways to slow circadian rhythm decline with ageing.

Emerging interactions between circadian rhythms and extracellular vesiclesCircadian rhythms are present across species, tuning internal processes to daily changes in the environment. Driven by genetically encoded circadian c…

Impact of Bmal1 Rescue and Time-Restricted Feeding on Liver and Muscle Proteomes During the Active Phase in MiceIn BriefCircadian clock genes and feeding cycles regulate the transcriptome of metabolic tissues. Here, we used tandem mass tag labeling combined with LC–MS/MS to interrogate regulation of the proteome and show that, at nighttime, the effect of knocking out the molecular clock component Bmal1 is substantially greater than the effect of time-restricted feeding. In addition, we show that Bmal1-dependent proteins are enriched for secreted proteins, such as fibroblast growth factor 1, which modulates mitochondrial respiration in hepatocytes.

Liver and muscle circadian clocks cooperate to support glucose tolerance in miceSmith et al. rescued circadian clock function in liver and muscle in otherwise clock-less mice, finding that glucose tolerance is achieved only when feeding rhythms and Bmal1 function in liver and muscle are engaged simultaneously. The authors posit that disruption of this spatiotemporal mechanism contributes to circadian-disruption-induced metabolic disease.

Integration of feeding behavior by the liver circadian clock reveals network dependency of metabolic rhythmsThe inner workings of the clock system rely on communicating signals between distal tissues to maintain daily metabolism.

Defining the Independence of the Liver Circadian ClockA autonomous branch of the liver circadian clock is independent from all other clocks yet still dependent on the light-dark cycle.

Antibiotic-induced microbiome depletion remodels daily metabolic cycles in the brainThe gut microbiome influences cognition and behavior in mammals, yet its metabolic impact on the brain is only starting to be defined. Using metabolit…

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