Since Sept. 2018 : Assistant Professor (permanent position) at 'Université de Lorraine", Metz, FRANCE - "Laboratoire Interdisciplinaire des Environnements Continentaux" (LIEC) (UMR 7360).
Research theme:
① Impact of phthalates compounds on the zebrafish Danio rerio and the crustacean Daphnia magna.
2017-2018 : Post-doctoral researcher at 'Université Reims Champagne-Ardenne", Reims, FRANCE - ''Unité Stress Environnementaux et BIOsurveillance des milieux aquatiques" (UMR-I 02 INERIS-URCA-ULH SEBIO)
Research theme:
① Development of a comparative metabolomic approach in the zebra mussel Dreissena polymorpha
NMR based metabolomic analysis - metabolites extraction , data acquisition, bioinformatical processing and analysis
Multivariate statistical analysis of comparative metabolomic data
- 2 published article
2016-2017 : Research and teaching assistant (ATER) at ‘Université Picardie Jules Verne’, Amiens, FRANCE – ‘Unité de recherche Ecologie et Dynamique des Systèmes Anthropisés’ (FRE 3498 EDYSAN CNRS-Université de Picardie Jules Verne)
Research themes:
① Assessment of multigenerational impact of fungicide treatments (azoxystrobine and tebuconazole) on tritrophic interactions between soft wheat, the grain aphid Sitobion avenae and the parasitoid wasp Aphidius colemani.
Life-history and developmental traits assessment
② Influence of invasive history of Drosophila suzukii strains on glycoalkaloids toxicity.
Comparative bioassays
2011-2015 : Researcher (PhD student) in the ‘Laboratoire d’Ecologie Alpine’ (LECA, UMR5553, Université Grenoble Alpes), Grenoble, FRANCE. Led by Dr S. Reynaud and J-P David.
Research themes:
① Trans- and multigenerational impacts of micropollutants on life-history traits and population dynamics of the mosquito Aedes aegypti.
- 2 published article
Life-history and developmental traits assessment
Rearing and reproduction of mosquito populations (Aedes aegypti)
Rearing of pollution-exposed populations over multiple generations
② Deciphering of the molecular mechanisms involved in intergenerational effects of ibuprofen on the mosquito Aedes aegypti through multiscale approach.
mRNA extraction and processing for transcriptomic approaches (mRNAseq)
Differential gene expression analysis (mRNAseq)
Bioinformatical processing of mRNAseq raw data (Galaxy plateform)
Analysis of metabolomic data (NMR-HRMAS & GC-MS)
Hormonal follow-up by enzymatic-immuno-assay
③ Impact of combined exposure to UV light and polycyclic aromatic hydrocarbons (PAH) on insecticide sensitivity of the mosquito Aedes aegypti.
- 2 published articles
Comparative bioassays
2011 : Research assistant (internship – 4 months) in the Laboratoire d’Ecologie Alpine (LECA, UMR5553, Université Grenoble Alpes), Grenoble, FRANCE. Led by Dr P. Taberlet.
Research theme:
① Assessment of environmental metabarcoding potential for plant biodiversity assessment.
- 1 published article.
Biodiversity indexes
Development of sequencing data filtering approach to improve biodiversity assessment reliability
2010 : Research assistant (internship – 4 months) in the ‘Institut de Génomique Fonctionnelle’ (UMR 5242, CNRS/ENS Lyon/UCBL/INRA) Lyon, FRANCE. Led by Prof. V. Laudet.
Research theme:
① Assessment of the implication of Estrogen Related Receptor γ (ERR γ) in Zebrafish embryo otic vesicle defects induced by Bisphenol A.
- 1 published article.
Rearing and reproduction of zebrafish populations
Morpholino injections
2010 : Research assistant (internship) in the Laboratoire de Développement des Gonades (CEA/INSERM U566/Universités Paris 7 et Paris 11), Fontenay-aux-Roses, FRANCE. Led by Prof. R. Habert.
Research theme:
① Endocrine disruption activity of bisphenol A on the developing fetal testis.
- 1 published article.
Hormonal follow-up by radio-immuno-assay
Differential gene expression analysis (RT-qPCR)
2013-2014 : Occasional contributor on "Echosciences Grenoble" - participatory platform for scientific news communication.
– 4 published articles.
2013 : Scientific communication officer (200h) for the "Université Joseph Fourier" communication service, Grenoble, FRANCE. Led by Muriel Jakobiak.
Contact : prudhomme.sophie at gmail.com