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Language
Language
Psycholinguistics
Psycholinguistics
Brain
Brain
Cognitive Neuroimaging
Cognitive Neuroimaging
Behavior
Behavior
Affective Neuroscience
Affective Neuroscience
Two lines of research:
[1] language system, and [2] language & behavior/cognition
Two lines of research:
[1] language system, and [2] language & behavior/cognition
Language System and Language impairments [1]
Language System and Language impairments [1]
Current work is organized into three key research teams:
(1) The first line of research focuses on the development of a sensitive and clinically relevant metrics system of natural language production by integrating MRI and AI technology to support clinical decision-making, monitoring, and treatment-response in aphasia.
Connected Speech Samples (CSS) across etiologies
Sentential and lexical predictors of aphasia subtypes
Minimalist Grammars (MGs) and expectation-based (e-MGs) approaches to syntax (in collaboration with Dr. Chesi): predicting case checking, thematic role assignment, and memory tenure during syntax processing in PPA.
Smartphone Action Rapid Naming Test (in collaboration with UCSF: The ALLFTD study)
Screening for early cognitive decline by examining verb motility and fronto-striatal network using Item Response Theory approaches
Categorical Ambiguity in PPA
The mechanisms underlying categorical ambiguity (i.e., disambiguation) by contrasting models (lexical vs. perceptual-embodiment) and taking advantage of unique neurodegenerative syndromes.
Neurocognitive patterns of verb production therapy
a single case with logopenic variant PPA and VNeST effects across contexts
(2) The second line of research focuses on using implementation science to involve speech-language pathologists and other healthcare professionals in regularly assessing conversational linguistic abilities, alongside traditional structured language tests, in both clinical and home settings. The goal is to detect and improve real-life language use for individuals with aphasia.
(3) The third line of research explores the role of language in emotions and other cognitive systems in the context of aging and how dysfunction in one system might impact the other.
In progress:
Lukic, S. (In prep). Neurocognitive patterns of verb production deficit therapy: a single case with logopenic variant Primary Progressive Aphasia. (Presented at the Academy of Aphasia, Oct 18-20, 2024 and the Society for Neurobiology of Language, Oct 23-25, 2024).
Vukovic, M., & Lukic, S. (In prep). The production of clitics in Serbian speakers with acquired aphasia. (Presented at the Academy of Aphasia, Oct 18-20, 2024)
Lukic, S., Barbieri, E., Rogalski, E. J., Weintraub, S., Marsel-Mesulam, M., & Thompson, K. C (In prep). Neural correlates of transitive and finite verb production deficits in Primary Progressive Aphasia: the role of inferior parietal and frontal regions. (Presented at the Society for Neurobiology of Language, Oct 7, 2022).
Key outputs:
Lukic, S., Fan, Z., García, A. M., Welch, A. E., Ratnasiri, B. M., Wilson, S. M., ... & Gorno-Tempini, M. L. (2024). Discriminating nonfluent/agrammatic and logopenic PPA variants with automatically extracted morphosyntactic measures from connected speech. Cortex, 173, 34-48. https://doi.org/10.1016/j.cortex.2023.12.013
Barbieri, E., Lukic, S., Rogalski, E., Weintraub, S., Mesulam, M. M., & Thompson, C. K. (2023). Neural mechanisms of sentence production: a volumetric study of primary progressive aphasia. Cerebral Cortex, bhad470. https://doi.org/10.1093/cercor/bhad470
Lukic*, S., Krauska*, A., Yoshida, M., & Thompson, C. K. (2023). The role of category ambiguity in normal and impaired lexical processing: can you paint without the paint?. Frontiers in Human Neuroscience, 17, 188. https://doi.org/10.3389/fnhum.2023.1028378
Lukic*, S., Licata, A. E., Weis, E., Bogley, R., Ratnasiri, B., Welch, A. E., ... & Borghesani, V. (2022). Auditory verb generation performance patterns dissociate variants of Primary Progressive Aphasia. Frontiers in Psychology, 13, 887591. https://doi.org/10.3389/fpsyg.2022.887591.
Lukic, S., Borghesani, V., Weis, E., Welch, A., Bogley, R., Neuhaus, J., ... & Gorno-Tempini, M. L. (2021). Dissociating nouns and verbs in temporal and perisylvian networks: Evidence from neurodegenerative diseases. Cortex, 142, 47-61. https://doi.org/10.1016/j.cortex.2021.05.006
Lukic, S., Thompson, C. K., Barbieri, E., Chiappetta, B., Bonakdarpour, B., Kiran, S., ... & Caplan, D. (2021). Common and distinct neural substrates of sentence production and comprehension. NeuroImage, 224, 117374. https://doi.org/10.1016/j.neuroimage.2020.117374
Lukic, S., Meltzer-Asscher, A., Higgins, J., Parrish, T. B., & Thompson, C. K. (2019). Neurocognitive correlates of category ambiguous verb processing: The single versus dual lexical entry hypotheses. Brain and language, 194, 65-76. https://doi.org/10.1016/j.bandl.2019.04.005
Lukic, S., Barbieri, E., Wang, X., Caplan, D., Kiran, S., Rapp, B., ... & Thompson, C. K. (2017). Right hemisphere grey matter volume and language functions in stroke aphasia. Neural plasticity. https://doi.org/10.1155/2017/5601509; PMCID: PMC5441122.
Thompson, C. K., Lukic, S., King, M. C., Mesulam, M. M., & Weintraub, S. (2012). Verb and noun deficits in stroke-induced and primary progressive aphasia: The Northwestern Naming Battery. Aphasiology, 26(5), 632-655. Aphasiology, 26: 632-655. https://doi.org/10.1080/02687038.2012.676852; PMCID: PMC3505449.
Categorical Ambiguity
Categorical Ambiguity
“Can you paint without a paint?”
Single vs Dual Lexical Entry
Lexical retrieval
Lexical retrieval
“I can’t think of the word?”
Nouns vs Verbs
Syntax
Syntax
“Who did what to whom?”
Canonical vs Non-canonical
Language and Behavior/Cognition [2]
Language and Behavior/Cognition [2]
Language and Emotion
Language and Emotion
Project #1
How do words and concepts influence emotional regulation in normal aging?
The findings from this study suggest a powerful relationship between language and emotional experience and indicate that, consistent with prior studies, using precise emotion words to label feelings is adaptive and may help to manage strong feelings, which we found to be related to the inferior frontal cortex.
Key outputs:
Lukic, S., Kosik, E. L., Roy, A. R., Morris, N., Sible, I. J., Datta, S., ... & Sturm, V. E. (2023). Higher emotional granularity relates to greater inferior frontal cortex cortical thickness in healthy, older adults. Cognitive, Affective, & Behavioral Neuroscience, 1-13. https://doi.org/10.3758/s13415-023-01119-y
Project #2
How does patients' ability to use cognitive and linguistic knowledge relate to their capacity for emotional regulation?
Neurodegenerative-associated syndromes can be categorized by various combinations of cognitive, language and behavior symptoms (see Geraudie et al., 2021 for a review), which pose a demand on the national health system. This study examines behavioral alterations in patients with behavioral variant Frontotemporal dementia (bvFTD) and language variants (PPA) patients, and characterizes neuropsychological and language patterns along the FTD spectrum.
Specifically, we administered a comprehensive assessment across FTD syndromes to investigate different cognitive and language components. Principal component analysis was used to evaluate the main components of cognition and language across FTD syndromes, and explore the existence of data-driven clinical clusters.
Key outputs:
Lukic, S., Manoochehri, M., Vysotskiy, M., & Huey, E. The frontal FTD syndromes: intersections between cognition, language and behavior. (Presented at the AAP, 2024)
"Verbal Memory" in the context of neurodegenerative disorders
"Verbal Memory" in the context of neurodegenerative disorders
In the first study in PPA, we provided support for the auditory verbal short-term memory (vSTM) account of repetition deficits, found to be located in left temporo-parietal junction (TPJ) regions, and provided an important tool for diagnosing neurodegenerative diseases and for following their progression.
Interestingly, the same logopenic PPA group which exhibited a hallmark pattern of vSTM deficit, has an increased FRQ of learning disabilities, suggesting a link between av-STM & childhood learning.
Key outputs:
Lukic, S., Mandelli, M. L., Welch, A., Jordan, K., Shwe, W., Neuhaus, J., ... & Gorno-Tempini, M. L. (2019). Neurocognitive basis of repetition deficits in primary progressive aphasia. Brain and language, 194, 35-45. https://doi.org/10.1016/j.bandl.2019.04.003
"Verbal Memory" in the context of neurodevelopmental disorders
"Verbal Memory" in the context of neurodevelopmental disorders
The findings from the second study suggest differences in vSTM capacity and TPJ structural changes in neurodevelopmental disorders (i.e., developmental dyslexia), which may leave developmental “footprints” in the adult phonological store and TPJ. Schwab Dyslexia and Cognitive Diversity Center Innovation Grant Award ($98,328; PI: Dr. Sladjana Lukic).
Key outputs:
Lukic, S., Qi, T.*, Pereira, C., Mandelli, M.L., Bogley R., Shabash M., Caverzasi, E., Borghesani, V., Dronkers, N., & Gorno-Tempini, M.L. (Under review, August 2023). Verbal short-term memory in Developmental Dyslexia: the role of the temporo-parietal area. Preprint DOI: 10.31234/osf.io/8hnfq
"Semantic Strengths" in the context of neurodevelopmental disorders
"Semantic Strengths" in the context of neurodevelopmental disorders
The findings from this study suggest differences in semantic strengths in neurodevelopmental disorders (i.e., developmental dyslexia). The data demonstrate that semantic fluency performance is strongly linked to specific executive function subdomains and a semantic resting-state dynamic brain network and that inter-individual differences should be taken into account in dyslexia.
Key outputs:
Lukic, S., Bunge, S., Gorno-Tempini, M. L. & Watson, C. (Under review, August 2023). Semantic Strength in Developmental Dyslexia: the word clustering and switching in verbal fluency. Preprint DOI: 10.31234/osf.io/g46ne
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