DSC Lab @ CAU - Research

◆ How can we design a synthetic yet life-like system?

Living systems operate in non-equilibrium states, maintaining their structures and functions through the perpetual formation and breakdown of transient chemical species. Inspired by these natural processes, synthetic chemists have been working to create artificial systems that also function out-of-equilibrium in controlled environments. However, despite considerable progress, synthetic dissipative systems remain far less complex than those observed in living organisms. Our research group focuses on developing simple yet innovative synthetic systems that replicate key non-equilibrium behaviors found in cells. Through this work, we aim to better understand the fundamental principles governing life-like chemical networks and explore potential applications in dynamic material.

Schematic energy diagram of a system operating out-of-equilibrium

Illustration of a chemically driven dynamic oligoester library

◆ Developing molecular machines with controlled motion

Controlling the movement of molecular systems is a critical challenge in modern supramolecular chemistry and nanoscience. While synthetic molecular machines capable of performing specific mechanical motions in response to external stimuli have been successfully created, designing nanoscale machines that can carry out practical tasks—such as selective catalysis, cargo transport, drug delivery, or molecular assembly—remains difficult. Our research group focuses on developing next-generation molecular machines by leveraging organic synthesis and spectroscopic techniques. We aim to create systems capable of complex, coordinated movements driven by multiple energy inputs. We envision a future where nanoscale robots navigate the bloodstream to seek out and eliminate pathogens—turning what once seemed like science fiction into reality.

Directional motion of kinesin on the microtubule railwayImage credit ©Hadrien Ledieu

◆ Development of peptide-based drugs

Peptides have become an exciting class of therapeutic agents, attracting significant attention in pharmaceutical research. Over the past decade, chemical synthesis and modification techniques, combined with innovative design and delivery approaches, have helped overcome key challenges such as poor stability and bioavailability. These advancements have enabled the discovery and development of both natural and engineered peptides for a wide range of therapeutic applications. Our lab is dedicated to fundamental research on bioactive peptides with therapeutic potential, with the goal of advancing the development of next-generation peptide-based drugs.