* Co-first authors / # Co-corresponding authors

2024

1. S Son*, K Nagahama*, J Lee*, K Jung*, C Kwak, J Kim, YW Noh, E Kim, S Lee#, H-B Kwon#, WD Heo#.
   Real-time visualization of structural dynamics of synapses in live cells in vivo.
   Nature Methods (2024).

2. DY Kang*, Y Jang*, H Lee*, J Lee, M Kang, DW Kim, S Lee#, S Lee#.
   Optogenetic STING clustering system through nanobody-fused photoreceptor for innate immune regulation.
   Sensors and Actuators: B. Chemical 399:134822 (2024)

2023

1. YH Kook*, H Lee*, J Lee*, Y Jeong, J Rho, WD Heo#, S Lee#.
   AAV-compatible optogenetic tools for activating endogenous calcium channels in vivo.
   Molecular Brain 16:73 (2023). 

2022

1. J Won, Y Pankratov, MW Jang, S Kim, YH Ju, S Lee, SE Lee, A Kim, S Park, CJ Lee#, WD Heo#.
   Opto-vTrap, an optogenetic trap for reversible inhibition of vesicular release, synaptic transmission, and behavior.
   Neuron 110, 1-13 (2022). 

2021

1. G Jo, J Bae, HJ Hong, A Han, DK Kim, SP Hong, JA Kim, S Lee, GY Koh, HM Kim.
   Structural insights into the clustering and activation of Tie2 receptor mediated by Tie2 agonistic antibody.
   Nature Communications 12:6287 (2021). 

2020

1. NY Kim*, S Lee*#, N Kim, H Park, WD Heo#.
   Optogenetic control of mRNA localization and translation in live cells.
   Nature Cell Biology 22, 341 (2020). 

2. S Kim, T Kyung, J-H Chung, N Kim, S Keum, J Lee, H Park, HM Kim, S Lee #, H-S Shin#, WD Heo#.
   Non-invasive optical control of endogenous Ca2+ channels in awake mice.
   Nature Communications 11:210 (2020).

2019

1. SW Park, P Jeon, YW Jun, JH Park, SH Lee, S Lee, JA Lee, DJ Jang.
   Monitoring LC3-or GABARAP-positive autophagic membranes using modified RavZ-based probes.
   Scientific Reports 9:1 (2019). 

2. D Woo, Y Seo, H Jung, S Kim, N Kim, S-M Park, H Lee, S Lee, K-H Cho, WD Heo.
   Locally activating TrkB receptor generates actin waves and specifies axonal fate.
   Cell Chemical Biology 26:1652 (2019). 

3. J Kim*, S Lee*, K Jung, WC Oh, N Kim, S Son, Y Jo, H-B Kwon#, WD Heo#.
   Intensiometric biosensors visualize the activity of multiple small GTPases in vivo.
   Nature Communications 10:211 (2019).
   Video: Multiplexed visualization of activity of HRas and Rac1 small GTPases in a single cell
   R-HRas (Red fluorescent sensor) and G-Rac1 (Green fluorescent sensor) were co-expressed in MDA-MB-231 cells and the activity of both proteins was monitored during random cell migration.

~2017

1. H Park*, NY Kim*, S Lee, N Kim, WD Heo.
   Optogenetic protein clustering through fluorescent protein tagging and extension of CRY2.
   Nature Communications 8:30 (2017).

2. MK Nguyen, CY Kim, JM Kim, BO Park, S Lee, H Park, WD Heo.
   Optogenetic oligomerization of Rab GTPases regulates intracellular membrane trafficking.
   Nature Chemical Biology 12, 431 (2016).

3. T Kyung*, S Lee*, JE Kim, T Cho, H Park, Y-M Jeong, D Kim, A Shin, S Kim, J Baek, J Kim, NY Kim, D Woo, S Chae, C-H Kim, H-S Shin, Y-M Han#, D Kim#, WD Heo#.
   Optogenetic control of endogenous Ca2+ channels in vivo. 
   Nature Biotechnology 33, 1092 (2015). (*Co-first author) Cover Article. This article was recommended by the faculty of 1000.

4. K-Y Chang*, D Woo*, H Jung, S Lee, S Kim, J Won, T Kyung, H Park, N Kim, HW Yang, J-Y Park, EM Hwang, WD Heo.
   Light-inducible receptor tyrosine kinases that regulate neurotrophin signaling.
   Nature Communications 5:4057 (2014).

5. S Lee*, H Park*, T Kyung, NY Kim, S Kim, J Kim, WD Heo.
   Reversible protein inactivation by optogenetic trapping in cells.
   Nature Methods 11, 633 (2014). (*Co-first author) This article was highlighted by Nature Methods.

6. H-W Lee, T Kyung, J Yoo, T Kim, C Chung, JY Ryu, H Lee, K Park, S Lee, WD Jones, D-S Lim, C Hyeon, WD Heo, T-Y Yoon.
   Real-time single-molecule co-immunoprecipitation analyses reveal cancer-specific Ras signalling dynamics.
   Nature Communications 4:1505 (2013).

7. S Lee*, JS Ha*, SG Lee, TK Kim.
   Inducible biosynthetic nanoscaffolds as recruitment platforms for detecting molecular target interactions inside living cells.
   J. Am. Chem. Soc. 134, 11346 (2012). (*Co-first author)

8. HW Yang, MK Shin, S Lee, WS Park, J-R Kim, K-H Cho, T Meyer, WD Heo.
   Cooperative activation of PI3K by Ras and Rho family small GTPases.
   Molecular Cell 47, 281 (2012).

9. S Lee, KH Lee, JS Ha, SG Lee, TK Kim.
   Small-molecule-based nanoassemblies as inducible nanoprobes for monitoring dynamic molecular interactions inside live cells.
   Angew. Chem. Int. Ed. Engl. 50, 8709-8713 (2011).

10.  KH Lee, S Lee, WY Lee, HW Yang, WD Heo.
    Visualizing dynamic interaction between calmodulin and calmodulin-related kinases via a monitoring method in live mammalian cells.
    Proc. Natl. Acad. Sci. USA 107, 3412-3417 (2010). 

BOOK CHAPTERS

1. H Park, S Lee, WD Heo.
   Protein inactivation by optogenetic trapping in living cells.
   Methods Mol. Biol. 1408, 363-376 (2016).