* Co-first authors / # Co-corresponding authors
HJ Jang*, J Shin*, S Lee, B Lee#, DW Kim
Deciphering distinct spatial alterations in N-glycan expression profiles in the spinal cord and brain of male rats in a neuropathic pain model.
Cellular & Molecular Biology Letters 30:31 (2025).
J Shin, J Wu, H Park, SI Kim, N Shin, HJ Shin, G Ren, J-a Kim, PTJ Hwang, HW Jun, SY Lee, S Lee, H-G Kim, DW Kim#
Microglial pyroptosis drives neuropathic pain and targeting NLRP3 alleviates pain and neuroinflammation.
BBA - Molecular Basis of Disease 1871:167737 (2025).
J Cho*, S Lee*, YH Kook, J Park, WD Heo#, CJ Lee#, H-I Kim#
Optogenetic calcium modulation in astrocytes enhances post-stroke recovery in chronic capsular infarct.
Science Advances 11:eadn7577 (2025).
B Timalsina*, S Lee, B-K Kaang#
Advances in the labelling and selective manipulation of synapses.
Nature Reviews Neuroscience 25, 668-687 (2024).
S Son*, K Nagahama*, J Lee*, K Jung*, C Kwak, J Kim, YW Noh, E Kim, S Lee#, H-B Kwon#, WD Heo#
Real-time visualization of structural dynamics of synapses in live cells in vivo.
Nature Methods 21, 353-360 (2024).
DY Kang*, Y Jang*, H Lee*, J Lee, M Kang, DW Kim, S Lee#, S Lee#
Optogenetic STING clustering system through nanobody-fused photoreceptor for innate immune regulation.
Sensors and Actuators: B. Chemical 399:134822 (2024).
YH Kook*, H Lee*, J Lee*, Y Jeong, J Rho, WD Heo#, S Lee#
AAV-compatible optogenetic tools for activating endogenous calcium channels in vivo.
Molecular Brain 16:73 (2023).
J Won, Y Pankratov, MW Jang, S Kim, YH Ju, S Lee, SE Lee, A Kim, S Park, CJ Lee#, WD Heo#
Opto-vTrap, an optogenetic trap for reversible inhibition of vesicular release, synaptic transmission, and behavior.
Neuron 110, 1-13 (2022).
G Jo, J Bae, HJ Hong, A Han, DK Kim, SP Hong, JA Kim, S Lee, GY Koh, HM Kim
Structural insights into the clustering and activation of Tie2 receptor mediated by Tie2 agonistic antibody.
Nature Communications 12:6287 (2021).
NY Kim*, S Lee*#, N Kim, H Park, WD Heo#
Optogenetic control of mRNA localization and translation in live cells.
Nature Cell Biology 22, 341 (2020).
S Kim, T Kyung, J-H Chung, N Kim, S Keum, J Lee, H Park, HM Kim, S Lee#, H-S Shin#, WD Heo#
Non-invasive optical control of endogenous Ca2+ channels in awake mice.
Nature Communications 11:210 (2020).
SW Park, P Jeon, YW Jun, JH Park, SH Lee, S Lee, JA Lee, DJ Jang
Monitoring LC3-or GABARAP-positive autophagic membranes using modified RavZ-based probes
Scientific Reports 9:1 (2019).
D Woo, Y Seo, H Jung, S Kim, N Kim, S-M Park, H Lee, S Lee, K-H Cho, WD Heo
Locally activating TrkB receptor generates actin waves and specifies axonal fate.
Cell Chemical Biology 26:1652 (2019).
J Kim*, S Lee*, K Jung, WC Oh, N Kim, S Son, Y Jo, H-B Kwon#, WD Heo#
Intensiometric biosensors visualize the activity of multiple small GTPases in vivo.
Nature Communications 10:211 (2019).
Video: Multiplexed visualization of activity of HRas and Rac1 small GTPases in a single cell
R-HRas (Red fluorescent sensor) and G-Rac1 (Green fluorescent sensor) were co-expressed in MDA-MB-231 cells and the activity of both proteins was monitored during random cell migration.
H Park*, NY Kim*, S Lee, N Kim, WD Heo
Optogenetic protein clustering through fluorescent protein tagging and extension of CRY2.
Nature Communications 8:30 (2017).
MK Nguyen, CY Kim, JM Kim, BO Park, S Lee, H Park, WD Heo
Optogenetic oligomerization of Rab GTPases regulates intracellular membrane trafficking.
Nature Chemical Biology 12, 431 (2016).
T Kyung*, S Lee*, JE Kim, T Cho, H Park, Y-M Jeong, D Kim, A Shin, S Kim, J Baek, J Kim, NY Kim, D Woo, S Chae, C-H Kim, H-S Shin, Y-M Han#, D Kim#, WD Heo#
Optogenetic control of endogenous Ca2+ channels in vivo.
Nature Biotechnology 33, 1092 (2015). (*Co-first author)
Cover Article. This article was recommended by the faculty of 1000.
K-Y Chang*, D Woo*, H Jung, S Lee, S Kim, J Won, T Kyung, H Park, N Kim, HW Yang, J-Y Park, EM Hwang, WD Heo
Light-inducible receptor tyrosine kinases that regulate neurotrophin signaling.
Nature Communications 5:4057 (2014).
S Lee*, H Park*, T Kyung, NY Kim, S Kim, J Kim, WD Heo
Reversible protein inactivation by optogenetic trapping in cells.
Nature Methods 11, 633 (2014). (*Co-first author)
This article was highlighted by Nature Methods.
H-W Lee, T Kyung, J Yoo, T Kim, C Chung, JY Ryu, H Lee, K Park, S Lee, WD Jones, D-S Lim, C Hyeon, WD Heo, T-Y Yoon
Real-time single-molecule co-immunoprecipitation analyses reveal cancer-specific Ras signalling dynamics.
Nature Communications 4:1505 (2013).
S Lee*, JS Ha*, SG Lee, TK Kim
Inducible biosynthetic nanoscaffolds as recruitment platforms for detecting molecular target interactions inside living cells.
J. Am. Chem. Soc. 134, 11346 (2012). (*Co-first author)
HW Yang, MK Shin, S Lee, WS Park, J-R Kim, K-H Cho, T Meyer, WD Heo
Cooperative activation of PI3K by Ras and Rho family small GTPases.
Molecular Cell 47, 281 (2012).
S Lee, KH Lee, JS Ha, SG Lee, TK Kim
Small-molecule-based nanoassemblies as inducible nanoprobes for monitoring dynamic molecular interactions inside live cells.
Angew. Chem. Int. Ed. Engl. 50, 8709-8713 (2011).
KH Lee, S Lee, WY Lee, HW Yang, WD Heo
Visualizing dynamic interaction between calmodulin and calmodulin-related kinases via a monitoring method in live mammalian cells.
Proc. Natl. Acad. Sci. USA 107, 3412-3417 (2010).
H Park, S Lee, WD Heo
Protein inactivation by optogenetic trapping in living cells.
Methods Mol. Biol. 1408, 363-376 (2016).