SIM.bio.Sys
Simulating biological systems, one at a time...
Simulating biological systems, one at a time...
Biological systems are highly complex. In our team, we use mathematical models to sift through the complexities in cellular metabolism in order to try and understand why different biological systems do what they do.
Velayudhan, V., and Sanu, S. 2025. "Modelling leaf metabolism using a charge- and proton-balanced diel flux balance analysis model" In Silico Plants, 7(2). https://doi.org/10.1093/insilicoplants/diaf008
Sprent, N, Cheung CYM, Shameer S, Ratcliffe RG, Sweetlove LJ and Töpfer N. 2024. “Metabolic modelling reveals distinct roles of sugars and carboxylic acids in stomatal opening and uncovers unexpected carbon fluxes” The Plant Cell. https://doi.org/10.1093/plcell/koae252
Daems S, Shameer S, Ceusters N, Sweetlove LJ., and Ceusters J. 2024. “Metabolic Modelling Identifies Mitochondrial Pi Uptake and Pyruvate Efflux as Key Aspects of Daytime Metabolism and Proton Homeostasis in Crassulacean Acid Metabolism Leaves.” New Phytologist 244 (1): 159–75. https://doi.org/10.1111/nph.20032
José G. Vallarino, Sanu Shameer, Youjun Zhang, R George Ratcliffe, J Sweetlove, and Alisdair R Fernie. 2022. “Leaf Specific Overexpression of a Mitochondrially-Targeted Glutamine Synthetase in Tomato Increased Assimilate Export Resulting in Earlier Fruiting and Elevated Yield.” BioRxiv. https://doi.org/10.1101/2022.06.28.497938.
Sanu Shameer, Yu Wang, Pedro Bota, R. George Ratcliffe, Stephen P. Long, and Lee J. Sweetlove. 2022. “A Hybrid Kinetic and Constraint‐based Model of Leaf Metabolism Allows Predictions of Metabolic Fluxes in Different Environments.” The Plant Journal 109 (1): 295–313. https://doi.org/10.1111/tpj.15551.
Sanu Shameer, José G. Vallarino, Alisdair R. Fernie, R. George Ratcliffe, and Lee J. Sweetlove. 2020. “Flux Balance Analysis of Metabolism during Growth by Osmotic Cell Expansion and Its Application to Tomato Fruits.” The Plant Journal 103 (1): 68–82. https://doi.org/10.1111/tpj.14707.
Töpfer, Nadine, Thomas Braam, Sanu Shameer, R. George Ratcliffe, and Lee J. Sweetlove. 2020. “Alternative Crassulacean Acid Metabolism Modes Provide Environment-Specific Water-Saving Benefits in a Leaf Metabolic Model.” The Plant Cell 32 (12): 3689–3705. https://doi.org/10.1105/tpc.20.00132.
Sanu Shameer, R. George Ratcliffe, and Lee J. Sweetlove. 2019. “Leaf Energy Balance Requires Mitochondrial Respiration and Export of Chloroplast NADPH in the Light.” Plant Physiology 180 (4): 1947–61. https://doi.org/10.1104/pp.19.00624.
Sanu Shameer, Kambiz Baghalian, C. Y.Maurice Cheung, R. George Ratcliffe, and Lee J. Sweetlove. 2018. “Computational Analysis of the Productivity Potential of CAM.” Nature Plants 4 (3): 165–71. https://doi.org/10.1038/s41477-018-0112-2.
Totanes, Francis Isidore, Sanu Shameer, David R. Westhead, Fabien Jourdan, and Glenn A. McConkey. 2016. “Understanding Protozoan Parasite Metabolism and Identifying Drug Targets through Constraint-Based Modeling.” In Comprehensive Analysis of Parasite Biology: From Metabolism to Drug Discovery, 487–512. Weinheim, Germany: Wiley-VCH Verlag GmbH & Co. KGaA. https://doi.org/10.1002/9783527694082.ch21.
Buckley, Mike, Muxin Gu, Sanu Shameer, Soyab Patel, and Andrew T. Chamberlain. 2016. “High-Throughput Collagen Fingerprinting of Intact Microfaunal Remains; a Low-Cost Method for Distinguishing between Murine Rodent Bones.” Rapid Communications in Mass Spectrometry : RCM 30 (7): 805–12. https://doi.org/10.1002/rcm.7483.
Sanu Shameer, Flora J. Logan-Klumpler, Florence Vinson, Ludovic Cottret, Benjamin Merlet, Fiona Achcar, Michael Boshart, et al. 2015. “TrypanoCyc: A Community-Led Biochemical Pathways Database for Trypanosoma Brucei.” Nucleic Acids Research 43 (Database issue): D637-44. https://doi.org/10.1093/nar/gku944.
"Study of Crassulacean Acid Metabolism using multiphase flux balance analysis", at the 23rd International Conference on Systems Biology (ICSB2024) organized by IIT Bombay, India and the International Society of Systems Biology.
Cochaired the Day 1 discussion of Workshop Metabolism and mathematical models: Two for a tango - 2nd Edition, organized by University of São Paulo (Brazil), INRIA (France), CNRS (France), University of Lyon 1(France), Instituto Superior Técnico (Portugal) and INESC-ID (Portugal).
"Modelling growth by osmotic expansion using FBA", at the 5th annual Crops in silico Symposium and Hackathon 2021 organized by University of Illinois at Urbana-Champaign, USA and National Center for Supercomputing Applications (NCSA), USA
"Modelling Growth by osmotic expansion using FBA", at FluxMAPS2021 organized by IIT-Mandi and the University of Oxford
"Prospects for constraint-based modelling in whole plant models", at 3rd annual Crops in silico Symposium and Hackathon 2018 held at the University of Illinois Urbana-Champaign, Illinois, USA
"Computational analysis of the productivity potential of CAM", at Oxford Congress on Plant Sciences 2018 held at the Department of Plant Sciences, University of Oxford, Oxford, UK
"A diel constraint-based modelling approach to study photosynthesis", at Gordon Research Seminar (GRS) on CO2 Assimilation in Plants from Genome to Biome 2017 held in Lucca, Italy
"Analyzing the T.brucei metabolism from a Systems Biology perspective", at the 47th microsymposium on Parasite/Trypanosomatid Metabolism, Drug Design and Glycosomes 2015 held at the University of Glasgow, Glasgow, UK
"Flux Balance Analysis of the Trypanosoma metabolis", at the 5th AcetoTryp meeting (2015) held in Toulouse, France
"Genome-scale reconstruction of Trypanosoma brucei", at Journee SEVAB 2013 held at University Paul Sabatier, Toulouse, France