Main results of the laboratory over the past 5 years:

• In order to develop sorbents for medical purposes, systematic comprehensive studies of the sorption capacity and biological activity of aluminosilicates of various structures, chemical composition and particle morphology were carried out. The nature of the influence of the morphology of aluminosilicate particles on their cytotoxicity and hemolytic activity has been established, and ways to regulate the biological activity, in particular toxicity, of aluminosilicate particles by varying their composition and morphology have been determined. The results obtained open up the possibility of widespread use of synthetic aluminosilicates to solve medical problems, where they have not been used until now due to the toxicity of natural aluminosilicates. (Golubeva O.Yu., Alikina Yu.A., Brazovskaya E.Yu., Vasilenko, N.M. Hemolytic Activity and Cytotoxicity of Synthetic Nanoclays with Montmorillonite Structure for Medical Applications. Nanomaterials. 2023, 13, 1470/ https://doi.org/10.3390/nano13091470; Alikina Yu.A., Kalashnikova T.A., Golubeva O.Yu. Sorption capacity of aluminosilicates of the kaolinite group of various morphologies. Glass Physics and Chemistry. 2021. V. 47. No. 1. P. 54-64.  https://doi.org/10.1134/S1087659621010028)

• A study was conducted of the potential use of synthetic aluminosilicates as selective and non-toxic hemosorbents. The potential possibility of using aluminosilicates as sorbents for extracorporeal blood purification using model experiments on the adsorption of proteins of various molecular weights and degrees of ionogenicity in a medium simulating the blood plasma environment was assessed. Results were obtained indicating the prospects of developing aluminosilicate selective sorbents for the selective adsorption of toxic substances of protein origin that accumulate in the body during oncological, immune, infectious and other diseases, in particular in sepsis (O.Yu. Golubeva, Y.A. Alikina, E.Y. Brazovskaya, N.M. Vasilenko. Adsorption properties and hemolytic activity of porous aluminosilicates in a simulated body fluids // Chemengeneering. ChemEngineering. 2022, 6(5), 78); Olga Yu. Golubeva, Yulia A. Alikina, The peculiarities of oxytocin, albumin and immunoglobulin adsorption by synthetic montmorillonites in a simulated body fluid, Colloids and Surfaces A: Physicochemical and Engineering Aspects, Volume 682, 2024, 132949, ISSN 0927-7757, https://doi.org/10.1016/j.colsurfa.2023.132949) 

• Approaches have been developed to obtain magnetically susceptible nanocomposites based on Beta zeolites and magnetite nanoparticles of the “magnetic core-zeolite shell” type. Zeolites with a hierarchical pore system were obtained. The possibility of using synthetic aluminosilicates as a basis for creating systems for targeted delivery of drugs has been studied (Golubeva O.Yu. et al. Synthesis and study of nanocomposites based on Beta zeolite and magnetite for targeted delivery of drugs // Glass Physics and Chemistry. 2019. T. 45. No. 1. P. 74-87. https://doi.org/10.1134/S1087659619010036; E. Yu. Brazovskaya, O. Yu. Golubeva. Development of Magnetic Nanocomposites Based on Beta Zeolites and Study of Their Sorption Properties // Petroleum Chemistry. 2020. V. 60. N 8. P. 857-963. Olga Yu. Golubeva, Yulia A. Alikina, Elena Yu. Brazovskaya, Valery L. Ugolkov. Peculiarities of the 5-fluorouracil adsorption on porous aluminosilicates with different morphologies // Applied Clay Science. 2020. V.184. 105401. https://doi.org/10.1016/j.clay.2019.105401; Brazovskaya E.Yu., Golubeva O.Yu. Synthesis and study of Beta zeolites with a hierarchical pore structure // Glass Physics and Chemistry. 2020. Vol. 46. No. 1. pp. 74-81 ). 

• Various approaches to the synthesis of layered aluminosilicates and their post-synthetic processing have been studied. A comparative study of the properties of synthetic montmorillonites and natural bentonites of the Dash-Salakhlinsky deposit was carried out. Studies have been carried out on the catalytic activity of synthetic aluminosilicates of various morphologies and compositions in isoprene synthesis reactions. Promising areas for the use of synthetic aluminosilicates have been identified and the foundations of the industrial technology for their production have been laid (Alikina Yu.A., Brazovskaya E.Yu., Vasilenko N.M., Golubeva O.Yu. Acid-base properties of the surface of porous silicate sorbents of various morphologies and compositions // Glass Physics and Chemistry. 2022. T. 48. No. 4. P. 458-464; Golubeva, O. Y.; Brazovskaya, E. Y.; Alikina, Y. A. Influence of the Preparation Method on the Physico-Chemical and Sorption Properties of Montmorillonite // Ceramics 2023 ,6, 922-934.  https://doi.org/10.3390/ceramics6020054; Alikina Yu.A., Spetsov E.A., Ulyanova N.Yu., Golubeva O.Yu. Study of the catalytic properties of synthetic aluminosilicates of various morphologies in cracking reactions of by-products of isoprene synthesis // 2021. Glass Physics and Chemistry. T. 47. No. 5. P. 545-560.)

• The antimicrobial activity of silver in ionic form, in the form of nanoparticles and bioconjugates with lysozyme, stabilized in zeolite matrices, was studied. It has been shown that the zeolite matrix allows the stabilization of nanoparticles and bioconjugates, which will allow the development of sorbents with antimicrobial properties. It has been established that bioconjugates of silver nanoparticles and antimicrobial peptides have high antimicrobial activity (at the level of ionic silver) and low (compared to ionic silver and silver nanoparticles) toxicity (Olga Yu. Golubeva, Natalia Yu. Ulyanova, Elizaveta V. Vladimirova, Olga V Shamova, Comparison of the antimicrobial and hemolytic activities of various forms of silver (ions, nanoparticles, bioconjugates) stabilized in a zeolite matrix // Langmuir, 2021, V. 37, N 42, pp. 12356-12364. https://doi.org/10.1021/acs.langmuir.1c01899). The promise of using bioconjugates of silver nanoparticles and antimicrobial peptides to obtain new effective antibiotic materials has been shown.