Publications

Selected publication (* correspondence) Citation index

1. Tseng YC, Liu PF, Chen YR, Yang WH, Chang CC, Chang HW, Lee CH, Goan YG, Shu CW*. Elevated neuregulin‑1 expression modulates tumor malignancy and autophagy in esophageal squamous cell carci-noma. Int J Mol Med. 2025 Apr;55(4):62. (IF: 5.8, 39/195, MEDICINE, RESEARCH & EXPERI-MENTAL).

2. Weng JR, Shu CW(co-first), Chang CC, Wu YC, Yang HC, Lee CH, Dahms HU, Lin WY, Chen CL, Liu PF. Aglaia elliptifolia Leaf Extract Inhibits Autophagy-Related 4B Protease and Suppresses Malignancies of Colorectal Cancer Cells. Environ Toxicol. 2024 Nov 22. doi: 10.1002/tox.24439. (IF: 4.119, 21/98, WATER RESOURCES)

3. Hu WH, Liu TT, Liu PF, Morgan P, Lin IL, Tsai WL, Cheng YY, Hsieh AT, Hu TH, Shu CW*. ATG4B and pS383/392-ATG4B serve as potential biomarkers and therapeutic targets of colorectal cancer. Cancer Cell Int. 2023 Apr 10;23(1):63. (IF:6.435, 59/241, Oncology)

4. Liu PF, Chen CF, Ger LP, Tsai WL, Tseng HH, Lee CH, Yang WH, Shu CW*. MAP3K11 facilitates autophagy activity and is correlated with malignancy of oral squamous cell carcinoma. J Cell Physiol. 2022 Nov;237(11):4275-4291. (IF:6.513, 10/81, PHYSIOLOGY)

5. WL Tsai*, JS Cheng, PF Liu, TH Chang, WC Sun, WC Chen, CW Shu*. Sofosbuvir induces gene expression for promoting cell proliferation and migration of hepatocellular carcinoma cells. Aging 2022 Jul 12;14(14):5710-5726. (IF: 5.955, 15/54, GERIATRICS & GERONTOLOGY) 

6. Yu TJ, Shiau JP, Tang JY, Yen CH, Hou MF, Cheng YB, Shu CW*, Chang HW*. Physapruin A Induces Reactive Oxygen Species to Trigger Cytoprotective Autophagy of Breast Cancer Cells. Antioxidants. 2022 Jul 11;11(7):1352. (IF: 7.675, 4/63, CHEMISTRY, MEDICINAL)

7. Liu PF, Farooqi AA, Peng SY, Yu TJ, Dahms HU, Lee CH, Tang JY, Wang SC, Shu CW*, Chang HW*. Regulatory effects of noncoding RNAs on the interplay of oxidative stress and autophagy in cancer malignancy and therapy. Semin Cancer Biol. 2022 Aug;83:269-282. (IF: 17.012, 15/245, in ONCOLOGY)

8. Chang KC, Liu PF, Chang CH, Lin YC, Chen YJ, Shu CW*. The interplay of autophagy and oxidative stress in the pathogenesis and therapy of retinal degenerative diseases. Cell Biosci. 2022 Jan 3;12(1):1. (IF: 9.606, 31/296, BIOCHEMISTRY & MOLECULAR BIOLOGY)

9. Tseng YC, Shu CW*, Chang HM, Lin YH, Tseng YH, Hsu HS, Goan YG, Tseng CJ*. Next Generation Sequencing for Potential Regulated Genes and Micro-RNAs of Early Growth Response-1 in the Esophageal Squamous Cell Carcinoma. Protein J. 2022 Dec 7. 41(6):563-571 (IF: 4.0, 162/297, BIOCHEMISTRY & MOLECULAR BIOLOGY

10. Tseng YC, Shu CW*, Chang HM, Lin YH, Tseng YH, Hsu HS, Goan YG, Tseng CJ*. Assessment of Early Growth Response 1 in Tumor Suppression of Esophageal Squamous Cell Carcinoma. J Clin Med. 2022 Sep 29;11(19):5792. (IF: 4.964, 54/172, MEDICINE, GENERAL & INTERNAL)

11. Morgan P, Arnold SJ, Hsiao NW, Shu CW*. A Closer Look at Dexamethasone and the SARS-CoV-2-Induced Cytokine Storm: In Silico Insights of the First Life-Saving COVID-19 Drug. Antibiotics 2021, 10(12), 1507. (IF: 5.22, 76/276, PHARMACOLOGY & PHARMACY)

12. Chang CC, Chiu CC, Liu PF, Wu CH, Tseng YC, Lee CH, Shu CW*. Kinome-Wide siRNA Screening Identifies DYRK1B as a Potential Therapeutic Target for Triple-Negative Breast Cancer Cells. Cancers. 2021 Nov 18;13(22):5779. SCI, IF: 6.639, 51/242 in ONCOLOGY

13. Hu WH, Yang WC, Liu PF, Liu TT, Morgan P, Tsai WL, Pan HW, Lee CH, Shu CW*. Clinicopathological Association of Autophagy Related 5 Protein with Prognosis of Colorectal Cancer. Diagnostics. 2021 Apr 26;11(5):782.(SCI, IF: 3.706, 45/169, in MEDICINE, GENERAL & INTERNAL)

14. Shu CW, Weng JR, Chang HW, Liu PF, Chen JJ, Peng CC, Huang JW, Lin WY, Yen CY. Tribulus terrestris fruit extract inhibits autophagic flux to diminish cell proliferation and metastatic characteristics of oral cancer cells. Environ Toxicol. 2021 Mar 10. (SCI, IF: 4.119, 21/98, in Water Resources)

15. Shu CW*, Bee YS, Chen JL, Tsen CL, Tsai WL, Sheu SJ. Detection of Autophagy-Related Gene Expression by Conjunctival Impression Cytology in Age-Related Macular Degeneration. Diagnostics. 2021 Feb 12;11(2):296. doi: 10.3390/diagnostics11020296. (SCI, IF: 3.706, 45/169, in MEDICINE, GENERAL & INTERNAL)

16. Klionsky DJ, Abdel-Aziz AK, Abdelfatah S,….Shu CW….et al. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition), Autophagy. 2021 Feb 8;1-382. (SCI, IF: 16.016, 14/195, in CELL BIOLOGY)

17. Lin CJ, Tsao YN, Shu CW*. Autophagy modulation as a potential targeted cancer therapy: From drug repurposing to new drug development. Kaohsiung J Med Sci. 2021 Jan 26. doi: 10.1002/kjm2.12361, (SCI, IF: 2.744, 93/140 in MEDICINE, Research & Experimental) 

18. Cheng JT, Liu PF, Yang HC, Huang SJ, Griffith M, Morgan P, Shu CW*. Tumor Susceptibility Gene 101 facilitates rapamycin-induced autophagic flux in neuron cells. Biomedicine & Pharmacotherapy 2021 Feb. 10.1016/j.biopha.2020.111106. (SCI, IF: 7.419, 25/275, in Pharmacology& pharmacy)

19.  Shu CW, Tsen CL, Li MS, Bee YS, Lin SH, Sheu SJ, Metformin and rapamycin protect cells from vital dye-induced damage in retinal pigment epithelial cells and in vivo, Graefes Arch Clin Exp Ophthalmol, vol. 14, 2020.Mar (SCI, IF: 2.25, 24/60 in OPHTHALMOLOGY)

20.  Liu PF, Chen HC, Cheng JS, Tsai WL, Lee HP, Wang SC, Peng WH, Lee CH, Ger LP, Shu CW*. Association of ATG4B and Phosphorylated ATG4B Proteins with Tumorigenesis and Prognosis in Oral Squamous Cell Carcinoma. Cancers, 2019, 11(12). pii: E1854 (SCI, IF: 6.162, 31/229 in ONCOLOGY)

21.  Goan YG, Liu PF, Chang HW, Chen HC, Chen WC, Kuo SM, Lee CH, Shu CW*. Kinome-Wide Screening with Small Interfering RNA Identified Polo-like Kinase 1 as a Key Regulator of Proliferation in Oral Cancer Cells, Cancers, vol. 11(8)., pp. E1117, 2019.08 (SCI, IF: 6.162, 31/229 in ONCOLOGY)

22.  Chang HW, Liu PF, Tsai WL, Hu WH, Hu YC, Yang HC, Lin WY, Weng JR, Shu CW*, Xanthium strumarium Fruit Extract Inhibits ATG4B and Diminishes the Proliferation and Metastatic Characteristics of Colorectal Cancer Cells, Toxins, vol. 11, no. 6, pp. E313, 2019.06, (SCI, IF: 5.07, 19/135 in Food Science & Technology)

23.  Cheng JS, Tsai WL, Liu PF, Goan YG, Lin CW, Tseng HH, Lee CH, Shu CW*., The MAP3K7-mTOR Axis Promotes the Proliferation and Malignancy of Hepatocellular Carcinoma Cells, Front Oncol, vol. 9, pp. 474, 2019.06 (SCI, IF: 4.8, 70/229 in ONCOLOGY) 

24.  Sheu SJ, Chen JL, Bee YS, Lin SH, Shu CW*, ERBB2-modulated ATG4B and autophagic cell death in human ARPE19 during oxidative stress, PLoS One, vol. 14, no. 3, pp. e0213932, 2019.03 (SCI, IF: 2.776, 24/69 in MULTIDISCIPLINARY SCIENCES)

25.  PF Liu, HW Chang, JS Cheng, HP Lee, CY Yen, WL Tsai, JT Cheng, YJ Li, WC Huang, CH Lee, LP Ger, Shu CW*. MAPLC3B and SQSTM1 modulated autophagy for tumorigenesis and prognosis in certain subsites of oral squamous cell carcinoma. Journal of Clinical Medicine 2018, 7(12), pii: E478. (SCI, IF: 5.583, 15/155, MEDICINE, GENERAL & INTERNAL) 

26.  Tang JY, Farooqi AA, Fu QY, Hou MF, Huang HW, Wang HR, Li KT, Fayyaz S, Shu CW*, Chang HW*, Oxidative stress-modulating drugs have preferential anticancer effects - involving the regulation of apoptosis, DNA damage, endoplasmic reticulum stress, autophagy, metabolism, and migration, Seminars in Cancer Biology, 2018, S1044-579X(18)30084-1. (SCI, IF: 11.09, 14/244 in ONCOLOGY)

27.  Tzeng YD; Li JY; Chang HW; Liu LF; Kuo SY; Hsieh CW; Lee CS; Liu PF; Wu CH; Chang HT; Shu CW*.  Kinome-wide siRNA screening identifies Src-enhanced resistance of chemotherapeutic drugs in triple-negative breast cancer cells. Frontiers in Pharmacology 2018; 9:1285 (SCI, IF:4.225, 48/261, PHARMACOLOGY & PHARMACY)

28.  Liu PF; Tsai KL; Hsu CJ; Tsai WL; Cheng JS; Chang HW; Shiau CW; Goan YG; Tseng HH; Wu CH; Reed JC; Yang LW; Shu CW*. Drug Repurposing Screening Identifies Tioconazole as an ATG4 Inhibitor that Suppresses Autophagy and Sensitizes Cancer Cells to Chemotherapy. Theranostics. 2018 8(3): 830-845 (SCI, IF: 8.537, 8/133, MEDICINE, RESEARCH & EXPERIMENTAL) 

29.  Liu PF; Hsu CJ; Tsai WL; Cheng JS; Chen JJ; Huang IF; Tseng HH; Chang HW; Shu CW*. Ablation of ATG4B suppressed autophagy and activated AMPK for cell cycle arrest in cancer cells. Cell Physiol Biochem. 2017 Nov 23;44(2):728-740. (SCI, IF: 5.500, 8/83, PHYSIOLOGY). 

30.  Liu PF, Hu YC, Kang BH, Tseng YK, Wu PC, Liang CC, Hou YY, Fu TY, Liou HH, Hsieh IC, Ger LP, Shu CW*. Expression levels of cleaved caspase-3 and caspase-3 in tumorigenesis and prognosis of oral tongue squamous cell carcinoma. PLoS One. 2017 Jul 10;12(7):e0180620. (IF: 2.806, SCI, 11/63, MULTIDISCIPLINARY SCIENCES).

31.  Sheu SJ, Chen JL, Bee YS, Chen YA, Lin SH, Shu CW*. Differential autophagic effects of vital dyes in retinal pigment epithelial ARPE-19 and photoreceptor 661W cells. PLoS One. 2017 Mar 30;12(3):e0174736. (IF:2.806, SCI, 11/63, MULTIDISCIPLINARY SCIENCES).

32.  Shu CW, Chang HT, Wu CS, Chen CH, Wu S, Chang HW, Kuo SY, Fu E, Liu PF, Hsieh YD. RelA-Mediated BECN1 Expression Is Required for Reactive Oxygen Species-Induced Autophagy in Oral Cancer Cells Exposed to Low-Power Laser Irradiation. PLoS One. 2016 11(9):e0160586. (IF:2.806, SCI, 11/63, MULTIDISCIPLINARY SCIENCES) 

33.  Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ...Shu CW..et al., Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016 Jan 2;12(1):1-222. (SCI, SCI, IF: 11.3, 13/190 in CELL BIOLOGY) 

34.  Huang IF, Lin IC, Liu PF, Cheng MF, Liu YC, Hsieh YD, Chen JJ, Chen CL, Chang HW, Shu CW*. Lactobacillus acidophilus attenuates Salmonella-induced intestinal inflammation via TGF-β signaling. BMC Microbiol. 2015 Oct 7;15(1):203. (IF: 2.64, 60/125, MICROBIOLOGY) 

35.  Liang WZ, Liu PF, Fu E, Chung HS, Jan CR, Wu CH, Shu CW*, Hsieh YD. Selective cytotoxic effects of low-power laser irradiation on human oral cancer cells. Lasers Surg Med. 2015 Nov;47(9):756-64. doi: 10.1002/lsm.22419. (IF: 2.3, 66/197, SURGERY) 

36.  Liu PF, Hsieh YD, Lin YC, Two A, Shu CW*, Huang CM. Propionibacterium acnes in the Pathogenesis and Immunotherapy of Acne Vulgaris. Curr Drug Metab. 2015;16(4):245-54. (IF: 2.6, 116/257, PHARMACOLOGY & PHARMACY) 

37.  Liu PF, Cheng JS, Sy CL, Huang WC, Yang HC, Gallo RL, Huang CM, Shu CW*. IsaB Inhibits Autophagic Flux to Promote Host Transmission of Methicillin-Resistant Staphylococcus Aureus. J Invest Dermatol. 2015 Nov;135(11):2714-22. (SCI, IF: 6.448, 3/63, DERMATOLOGY). 

38.  Liu PF, Leung CM, Chang YS,Cheng JS, Chen JJ, Weng CJ, Tsai KW, Hsu CJ, Liu YC, Hsu PC, Pan HW, Shu CW*. ATG4B promotes colorectal cancer growth independent of autophagic flux. Autophagy. 2014 Aug;10(8):1454-65. doi: 10.4161/auto.29556. (SCI, IF: 11.3, 13/190 in CELL BIOLOGY) 

39.  Liu PF, Huang IF, Shu CW*, Huang CM. Halitosis vaccines targeting FomA, a biofilm-bridging protein of fusobacteria nucleatum. Curr Mol Med. 2013 Sep;13(8):1358-67. Review. PubMed PMID: 23865430. (IF: 4.197, 27/121, MEDICINE, RESEARCH & EXPERIMENTAL). 

40.  Sano R, Hou YC, Hedvat M, Correa RG, Shu CW, Krajewska M, Diaz PW, Tamble CM, Quarato G, Gottlieb RA, Yamaguchi M, Nizet V, Dahl R, Thomas DD, Tait SW, Green DR, Fisher PB, Matsuzawa S, Reed JC. Endoplasmic reticulum protein BI-1 regulates Ca²⁺-mediated bioenergetics to promote autophagy. Genes Dev. 2012 May 15;26(10):1041-54. (IF: 9.41, 7/167, GENETICS & HEREDITY).  

41.  Shu CW, Madiraju C, Zhai D, Welsh K, Diaz P, Sergienko E, Sano R, Reed JC. High-throughput fluorescence assay for small-molecule inhibitors of autophagins/Atg4. J Biomol Screen. 2011 Feb;16(2):174-82. doi: 10.1177/1087057110392996. (IF: 2.423, 37/76, CHEMISTRY, ANALYTICAL). 

42.  Shu CW, Drag M, Bekes M, Zhai D, Salvesen GS, Reed JC. Synthetic substrates for measuring activity of autophagy proteases: autophagins (Atg4). Autophagy. 2010 Oct;6(7):936-47. 2010 Oct 19. (SCI, IF: 11.3, 13/190 in CELL BIOLOGY)  

43.  Kim I, Shu CW, Xu W, Shiau CW, Grant D, Vasile S, Cosford ND, Reed JC. Chemical biology investigation of cell death pathways activated by endoplasmic reticulum stress reveals cytoprotective modulators of ASK1. J Biol Chem. 2009 Jan 16;284(3):1593-603. Epub 2008 Nov 12. (IF: 4.651, 62/290, BIOCHEMISTRY & MOLECULAR BIOLOGY). 

44.  Shu CW, Sun FC, Cho JH, Lin CC, Liu PF, Chen PY, Chang MD, Fu HW, Lai YK. GRP78 and Raf-1 cooperatively confer resistance to endoplasmic reticulum stress-induced apoptosis. J Cell Physiol. 2008 Jun;215(3):627-35. J. Cell. Physiol., 215(3):627-35. (IF: 4.08, 16/84，PHYSIOLOGY). 

45.  Kim U, Shu CW, Dane KY, Daugherty PS, Wang JY, Soh HT. Selection of mammalian cells based on their cell-cycle phase using dielectrophoresis. Proc Natl Acad Sci U S A. 2007 Dec 26;104(52):20708-12. Epub 2007 Dec 19(IF: 9.66, 4/64，MULTIDISCIPLINARY SCIENCES). 

46.  Preyer M, Shu CW, Wang JY. Delayed activation of Bax by DNA damage in embryonic stem cells with knock-in mutations of the Abl nuclear localization signals. Cell Death Differ. 2007 Jun;14(6):1139-48. Epub 2007 Mar 16. (IF: 8.34, 24/290，BIOCHEMISTRY & MOLECULAR BIOLOGY). 

47.  Shu CW, Cheng NL, Chang WM, Tseng TL, Lai YK. Transactivation of hsp70-1/2 in geldanamycin-treated human non-small cell lung cancer H460 cells: involvement of intracellular calcium and protein kinase C. J Cell Biochem. 2005 Apr 15;94(6):1199-209. (IF: 3.09, 130/290，BIOCHEMISTRY & MOLECULAR BIOLOGY).

The other SCI publications >50 papers

Patent

1. C.W. Shu. ISOLATED PEPTIDE, ANTI-CANCER MEDICINAL COMPOSITION INCLUDING THE SAME AND METHOD OF SPECIFICALLY REDUCING OR INHIBITING ACTIVITIES OF CANCER CELLS USING THE SAME. (US 11,866,516 B2), Period 2024/01~2040/11

2. C.W. Shu.  Isolated peptide, anti-cancer medicinal composition including the same and method of specifically reducing or inhibiting activities of cancer cells using the same (US11396529B2), Period 2020/11/12~2040/11/12

3. 徐志文. 單離胜肽、含彼之醫藥組成物及其用於專一性減少或抑制癌細胞活性的方法 (I 783378) 2022/11~2041/02

4. LW Yang, C.W Shu, PF Liu and KL Tsai. METHOD FOR THE TREATMENT OF ATG4-RELATED DISORDERS (US 10583123 B2), Period 2017/12/15~2037/12/15

5.  張學偉、張夢揚、湯人仰、吳長益、徐志文、王聖傑. 含新穎化合物之選擇性殺死口腔癌細胞之醫藥組合物及此化合物之用途-中華民國發明第I694990. 專利期間2020/06/01~2039/03/28