Publications 論文

• NKT cell deficiency exacerbates adenine-induced renal fibrosis through enhanced Treg infiltration and TGF-β expression.

Kuno Y, Ishikawa H, Nagashima R, Matsuzaka Y, Kohda C, Isozaki T, Kuwata H, Iyoda M. 

Am J Physiol Cell Physiol. Aug 1;329(2):C471-C479. 2025

• Pathogenic effects of Streptococcus oralis intestinal colonization on bladder health in mice.

Nakamura N*, Iioka K*, Morisaki H, Okahashi N, Kurosawa M, Fukamachi H, Matsui S, Funatsu T, Kuwata H, Itsumi M. (* equal contribution)

Curr Res Microb Sci. Mar:100375. 2025

• Inflammasome regulation by the cell surface ecto-5'-nucleotidase of the oral commensal, Streptococcus oralis.

Nakamura N, Morisaki H, Itsumi M, Okahashi N, Fukamachi H, Sato A, Kadena M, Kikuchi M, Matsui S, Funatsu T, Kuwata H.

Biochem Biophys Res Commun. Jan;744:151206. 2025 

• Experimental murine periodontitis increases salivary gland IgA-Producing B cells following oral dysbiosis.

Nara M, Kurosawa M, Itsumi M, Morisaki H, Fukamachi H, Okahashi N, Suzuki N, Kuwata H.

Microbiol Immunol. Feb 69(2):114-127. 2025

• Metagenomic analysis of bacterial microflora in dental and atherosclerotic plaques of patients with internal carotid artery stenosis. 

Sato A, Arai S, Sumi K, Fukamachi H, Miyake S, Ozawa M, Myers M, Maruoka Y, Shimizu K, Mizutani T, Kuwata H.

Clin Med Insights Cardiol. 6;18:11795468231225852. 2024

• The Klebsiella mannose phosphotransferase system promotes proliferation and the production of extracellular polymeric substances from mannose, facilitating adaptation to the host environment.

Miki S, Fukamachi H, Itsumi M, Fujiwara N, Takaki T, Kurosawa M, Morisaki H, Suzuki N, Kuwata H. 

J Oral Biosci. 19:S1349-0079(24)00003-3. 2024

• Severity of acute lung injury in aspiration pneumonia model mice transplanted with human oral microflora.

Hayashi M*, Mori M*,  Itsumi M, Nakamura N, Takaki T, Onoyama K, Fukamachi H, Kurosawa M, Morisaki H, Funatsu T, Myers M, Iijima T, Kuwata H.

Oral Science International. 21:121-130. 2024. (* equal contribution)

• Oral commensal bacterial flora is responsible for peripheral differentiation of neutrophils in the oral mucosa in the steady state.

Trtić N*, Mori M*, Matsui S, Nakamura N, Fukamachi H, Kurosawa M, Morisaki H, Maruoka Y, Mayers M, Okahashi N, Kuwata H, Itsumi M.

J Oral Biosci. 65(1):119-125. 2023. (* equal contribution)

• Metagenomic analysis of oral plaques and aortic valve tissues reveals oral bacteria associated with aortic stenosis.

Yoshiba S, Nakagawa H, Kuwata H, Nabuchi A, Yaso A, Shirota T.

Clin Oral Investig. 27(8):4335-4344. 2023.

• Melatonin suppresses the antiviral immune response to EMCV infection through intracellular ATP deprivation caused by mitochondrial fragmentation.

Kikuchi M, Kadena M, Fukamachi H, Takaki T, Matsui S, Hoashi-Takiguchi S, Morisaki H, Trtić N, Mori M, Kurosawa M, Itsumi M, Funatsu T, Sakurai A, Shintani S, Kato H, Fujita T, Maruoka Y, Kuwata H. 

Heliyon. 8(10):e11149. 2022.

• Oral mitis group streptococci: a silent majority in our oral cavity.

Okahashi N, Nakata M, Kuwata H, Kawabata S.

Microbiol Immunol. 66(12):539-551. 2022.

• Novel antibody assessment method for microbial compositional alteration in the oral cavity.

Hoashi-Takiguchi S, Morisaki H, Itsumi M, Kikuchi M, Fukamachi H, Kurosawa M, Yamada M, Suzuki N, Kuwata H.

Biochem Biophys Rep. 30:101269. 2022.

• Particle size analysis in aerosol-generating dental procedures using laser diffraction technique.

Onoyama K*, Matsui S*, Kikuchi M, Sato D, Fukamachi H, Kadena M, Funatsu T, Maruoka Y, Baba K, Maki K, Kuwata H. (* equal contribution)

Front Oral Health. 3:804314. 2022.

• Dysregulation of Intestinal Microbiota Elicited by Food Allergy Induces IgA-Mediated Oral Dysbiosis.

Matsui S, Kataoka H, Tanaka JI, Kikuchi M, Fukamachi H, Morisaki H, Matsushima H, Mishima K, Hironaka S,  Takaki T, Okahashi N, Maruoka Y, Kuwata H.

Infect Immun. 88(1). e00741-19. 2019.

• Streptococcus sanguinis noncoding cia-dependent small RNAs negatively regulate expression of type IV pilus retraction ATPase PilT and biofilm formation.

Ota C, Morisaki H, Nakata M, Arimoto T, Fukamachi H, Kataoka H, Masuda Y, Suzuki N, Miyazaki T, Okahashi N, Kuwata H.

Infect Immun. 20;86(3). 2018.

• Influence of excess branched-chain amino acid uptake by Streptococcus mutans in human host cells.

Arimoto T, Yambe R, Morisaki H, Umezawa H, Kataoka H, Matsui S, Kuwata H.

FEMS Microbiol Lett. 1;365(3). 2018.

• Caveolin-1, a binding protein of CD26, is essential for the anti-inflammatory effects of dipeptidyl peptidase-4 inhibitors on human and mouse macrophages.

Hiromura M, Nohtomi K, Mori Y, Kataoka H, Sugano M, Ohnuma K, Kuwata H, Hirano T.

Biochem Biophys Res Commun. 1;495(1):223-229. 2018.

• Microarray and gene co-expression analysis reveal that melatonin attenuates immune responses and modulates actin rearrangement in macrophages.

Kadena M, Kumagai Y, Vandenbon A, Matsushima H, Fukamachi H, Maruta N, Kataoka H, Arimoto T, Morisaki H, Funatsu T, Kuwata H.

Biochem Biophys Res Commun. 1;485(2):414-420. 2017.

• Microarray analysis of macrophage response to infection with Streptococcus oralis reveals the immunosuppressive effect of hydrogen peroxide.

Matsushima H, Kumagai Y, Vandenbon A, Kataoka H, Kadena M, Fukamachi H, Arimoto T, Morisaki H, Fujiwara N, Okahashi N, Kuwata H.

Biochem Biophys Res Commun. 1;485(2):461-467. 2017.

• Nucleases from Prevotella intermedia can degrade neutrophil extracellular traps.

Doke M, Fukamachi H, Morisaki H, Arimoto T, Kataoka H, Kuwata H.

Mol Oral Microbiol. 32(4):288-300. 2017.

• Streptococcus oralis induces lysosomal impairment of macrophages via bacterial hydrogen peroxide.

Okahashi N, Nakata M, Kuwata H, Kawabata S.

Infect Immun. 23;84(7):2042-50. 2016.

• Effects of hangeshashinto on growth of oral microorganisms.

Fukamachi H, Matsumoto C, Omiya Y, Arimoto T, Morisaki H, Kataoka H, Kadena M, Funatsu T, Fukutake M, Kase Y, Kuwata H.

Evid Based Complement Alternat Med. 2015-ID512947:1-6 2015.

• Role of protease maturation lipoprotein in osmoadaptation of Streptococcus mutans.

Kunii M, Arimoto T, Hasegawa T, Kuwata H, Igarashi T.

FEMS Microbiol Lett. 356(1):45-52. 2014.

• Hydrogen peroxide contributes to the epithelial cell death induced by the oral mitis group of streptococci.

Okahashi N, Sumitomo T, Nakata M, Sakurai A, Kuwata H, Kawabata S.

PLoS One. 31;9(1):e88136. 2014.

• Rothia dentocariosa induces TNF-alpha production in a TLR2-dependent manner.

Kataoka H, Taniguchi M, Fukamachi H, Arimoto T, Morisaki H, Kuwata H.

Pathog Dis. 71(1):65-8. 2014.

• Bacterial sphingophospholipids containing non-hydroxy fatty acid activate murine macrophages via Toll-like receptor 4 and stimulate bacterial clearance.

Fujiwara N, Porcelli SA, Naka T, Yano I, Maeda S, Kuwata H, Akira S, Uematsu S, Takii T, Ogura H, Kobayashi K.

Biochim Biophys Acta. 1831(6):1177-84. 2013.

Conference presentations 学会報告

• 第６５回歯科基礎医学会 (東京)  2023年9月16-18日 

三木 優「Klebsiellaのマンノースホスホトランスフェラーゼシステムは腸管定着関連因子である」ポスター、モリタ優秀発表賞 (微生物部門) 

• 第５９回歯科基礎医学会 (松本)  2017年9月17日 

大田 千明「Streptococcus sanguinisのノンコーディングcsRNAはIV型線毛pilT遺伝子の発現を負に制御し、バイオフィルム形成を抑制する」ポスター、モリタ優秀発表賞 (微生物部門) 

Previous publications (Kuwata)

• "Cytoskeletal control of CD36 diffusion promotes its receptor and signaling function."

Jaqaman K*, Kuwata H*, Touret N, Collins R, Trimble WS, Danuser G, Grinstein S. (* equal contribution)

Cell. 19;146(4):593-606. 2011

• "Uptake of oxidized low density lipoprotein by CD36 occurs by an actin-dependent pathway distinct from macropinocytosis."

Collins RF, Touret N, Kuwata H, Tandon NN, Grinstein S, Trimble WS.

 J Biol Chem. 30;284(44):30288-97. 2009

• "Fra-1 negatively regulates lipopolysaccharide-mediated inflammatory responses."

Morishita H, Saito F, Kayama H, Atarashi K, Kuwata H, Yamamoto M, Takeda K. 

Int Immunol. 21(4):457-65. 2009

• "Lipocalin 2-dependent inhibition of mycobacterial growth in alveolar epithelium."

Saiga H, Nishimura J, Kuwata H, Okuyama M, Matsumoto S, Sato S, Matsumoto M, Akira S, Yoshikai Y, Honda K, Yamamoto M, Takeda K.

J Immunol. 15;181(12):8521-7. 2008

• "Inefficient phagosome maturation in infant macrophages."

Saito F, Kuwata H, Oiki E, Koike M, Uchiyama Y, Honda K, Takeda K.

Biochem Biophys Res Commun. 10;375(1):113-8. 2008

• "Robust single-particle tracking in live-cell time-lapse sequences."

 Jaqaman K, Loerke D, Mettlen M, Kuwata H, Grinstein S, Schmid SL, Danuser G.

Nat Methods. 5(8):695-702. 2008

• "Potent antimycobacterial activity of mouse secretory leukocyte protease inhibitor."

Nishimura J, Saiga H, Sato S, Okuyama M, Kayama H, Kuwata H, Matsumoto S, Nishida T, Sawa Y, Akira S, Yoshikai Y, Yamamoto M, Takeda K.

J Immunol. 15;180(6):4032-9. 2008

• "TLR-dependent induction of IFN-beta mediates host defense against Trypanosoma cruzi."

Koga R, Hamano S, Kuwata H, Atarashi K, Ogawa M, Hisaeda H, Yamamoto M, Akira S, Himeno K, Matsumoto M, Takeda K.

J Immunol. 15;177(10):7059-66. 2006

• "Detection of pathogenic intestinal bacteria by Toll-like receptor 5 on intestinal CD11c+ lamina propria cells."

Uematsu S, Jang MH, Chevrier N, Guo Z, Kumagai Y, Yamamoto M, Kato H, Sougawa N, Matsui H, Kuwata H, Hemmi H, Coban C, Kawai T, Ishii KJ, Takeuchi O, Miyasaka M, Takeda K, Akira S.

Nat Immunol. 7(8):868-74. 2006

• "IkappaBNS inhibits induction of a subset of Toll-like receptor-dependent genes and limits inflammation."

Kuwata H, Matsumoto M, Atarashi K, Morishita H, Hirotani T, Koga R, Takeda K.

Immunity. 24(1):41-51. 2006

• "The nuclear IkappaB protein IkappaBNS selectively inhibits lipopolysaccharide-induced IL-6 production in macrophages of the colonic lamina propria."

Hirotani T, Lee PY, Kuwata H, Yamamoto M, Matsumoto M, Kawase I, Akira S, Takeda K.

J Immunol. 15;174(6):3650-7. 2005

• "Regulation of Toll/IL-1-receptor-mediated gene expression by the inducible nuclear protein IkappaBzeta."

Yamamoto M, Yamazaki S, Uematsu S, Sato S, Hemmi H, Hoshino K, Kaisho T, Kuwata H, Takeuchi O, Takeshige K, Saitoh T, Yamaoka S, Yamamoto N, Yamamoto S, Muta T, Takeda K, Akira S.

Nature. 8;430(6996):218-22. 2004

• "IL-10-inducible Bcl-3 negatively regulates LPS-induced TNF-alpha production in macrophages."

Kuwata H, Watanabe Y, Miyoshi H, Yamamoto M, Kaisho T, Takeda K, Akira S.

Blood.  1;102(12):4123-9. 2003

• "Capsular hyaluronic acid of group A streptococci hampers their invasion into human pharyngeal epithelial cells."

Kawabata S, Kuwata H, Nakagawa I, Morimatsu S, Sano K, Hamada S.

Microb Pathog. 27(2):71-80. 1999 

日本語総説

• 「細胞骨格によるスカベンジャー受容体CD36重合体形成とシグナル制御機構」

桑田啓貴  生化学 84(12):1012-6. 2013