# indicates equal contribution. 

The entries appear in reverse chronological order.

Bold names denote our lab teammates.

A complete list of publications is available here.

Li, H., Sajbel, K.C. and Xia, S., 2026. Protein circuits as programmable biomaterials. Cell Biomaterials. (Link)

Lu, A., Moeller, L.#, Moore, S.#, Xia, S., Ho, K., Zhang, E., Budde, M.W., Larson, H., Diaz, A.A., Linton, J.M., Klock, L., Flynn, M.J., Gao, X., Siegwart, D.J., Zhu, H. and Elowtiz, M.B., 2026. Engineered protein circuits for cancer therapy. bioRxiv. (Link)

Parikh, K.S.#, Yang, J.#, Ding, Z., Shi, R., Poudel, S., Oh, Y., Luo, L., Xia, S., Duncan, G., Eberhar, C., Ensign, L.M., Hanes, J. and Xu, Q., 2025. Sunitinib-eluting thin films for inhibition of corneal neovascularization. Drug Delivery and Translational Research. (Link)

Chen, Z., Linton, J.M., Xia, S., Fan, X., Yu, D., Wang, J., Zhu, R. and Elowitz, M.B., 2024. A synthetic protein-level neural network in mammalian cells. Science. (Link)

Fontana, P.#, Du, G.#, Zhang, Y.#, Zhang, H.#, Vora, S.M., Hu, J.J., Shi, M., Tufan, A.B., Healy, L.B., Xia, S., Lee, D.-J., Li, Z., Flores, P.B., Ru, H., Luo, H.R., Agudo, J., Lieberman, J. and Wu, H., 2024. Small molecule GSDMD agonism in tumors stimulates antitumor immunity without toxicity. Cell. (Link) 

Xia, S., Lu, A.C.#, Tobin, V.#, Luo, K.#, Moeller, L., Shon, D.J., Du, R., Linton, J.M., Sui, M., Horns, F. and Elowitz, M.B., 2024. Synthetic protein circuits for programmable control of mammalian cell death. Cell. (Link) 

Li, J.#, Cheng, R.#, Wang, Z.#, Yuan, W., Xiao, J., Zhao, X., Du, X., Xia, S., Wang, L., Zhu, B. and Wang, L., 2024. Structures and activation mechanism of the Gabija anti-phage system. Nature. (Link) 

Miao, R.#, Jiang, C.#, Chang, W.#, Chen, P., Zhang, H., Junqueira, C., Amgalan, D., Liang, F.G., Zhang, J., Evavold, C.L., Hafner-Bratkovic, I., Zhang, Z., Xia, S., Waldeck-Weiermair, M., Michel, T., Bar-Peled, L., Wu, H., Kagan, J.C., Kitsis, R.N., Zhang, P., Liu, X. and Lieberman, J., Gasdermin D permeabilization of mitochondrial inner and outer membranes accelerates and enhances pyroptosis. Immunity. (Link) 

Shen, Z.#, Yang, X.Y.#, Xia, S., Huang, W., Taylor, D.J., Nakanishi, K. and Fu, T.-M., 2023. Oligomerization-mediated activation of a short prokaryotic Argonaute. Nature. (Link) 

Kong, Q.#, Xia, S.#, Pan X., Ye, K., Li, Z., Li, H., Tang, X., Sahni, N., Yi, S.S., Liu, X., Wu, H., Elowitz, M.B., Lieberman, J., and Zhang, Z., 2023. Alternative splicing of GSDMB modulates killer lymphocyte-triggered pyroptosis. Science Immunology. (Link) 

Meng, T.#, Zheng, J.#, Chen, M.#, Zhao, Y., Sudarjat, H., MR, A.A., Kulkarni, V., Oh, Y., Xia, S., Ding, Z. and Han, H., Anders, N., Rudek, M.A., Chow, W., Stark, W., Ensign, L.M., Hanes, J., and Xu, Q., 2023. Six-month effective treatment of corneal graft rejection. Science Advances. (Link) 

Zheng, W.#, Shen, C.#, Wang, L.#, Rawson, S.#, Xie, W.J., Nist-Lund, C., Wu, J., Shen, Z., Xia, S., Holt, J.R., Wu, H. and Fu, T.-M., 2022. pH regulates potassium conductance and drives a constitutive proton current in human TMEM175. Science Advances. (Link) 

Xie, W.J.#, Xia, S.#, Warshel, A. and Wu, H., 2022. Electrostatic influence on IL-1 transport through the GSDMD pore. Proceedings of the National Academy of Sciences, 119(6), p.e2120287119. (Link) 

Xia, S., Zhang, Z., Magupalli, V.G., Pablo, J.L., Dong, Y., Vora, S.M., Wang, L., Fu, T.-M., Jacobson, M.P., Greka, A., Lieberman, J., Ruan, J. and Wu, H., 2021. Gasdermin D pore structure reveals preferential release of mature interleukin-1. Nature. (Link) 

Liu, X.#, Xia, S.#, Zhang, Z.#, Wu, H. and Lieberman, J., 2021. Channelling inflammation: gasdermins in physiology and disease. Nature Reviews Drug Discovery. (Link) 

Xia, S., Ding, Z., Luo, L., Chen, B., Schneider, J., Yang, J., Eberhart, C.G., Stark, W.J. and Xu, Q., 2021. Shear-Thinning Viscous Materials for Subconjunctival Injection of Microparticles. AAPS PharmSciTech. (Link) 

Xia, S., Chen, Z., Shen, C. and Fu, T.-M., 2021. Higher-order assemblies in immune signaling: Supramolecular complexes and phase separation. Protein & Cell. (Link) 

Yang, J., Luo, L., Oh, Y., Meng, T., Chai, G., Xia, S., Emmert, D., Wang, B., Eberhart, C.G., Lee, S., Stark, W.J., Ensign, L.M., Hanes, J. and Xu, Q., 2020. Sunitinib malate-loaded biodegradable microspheres for the prevention of corneal neovascularization in rats. Journal of Controlled Release. (Link) 

Hu, J.J.#, Liu, X.#, Xia, S., Zhang, Z., Zhang, Y., Zhao, J., Ruan, J., Luo, X., Lou, X., Bai, Y., Wang, J., Hollingsworth, L.R., Magupalli, V.G., Zhao, L., Luo, H.R., Kim, J., Lieberman, J. and Wu, H., 2020. FDA-approved disulfiram inhibits pyroptosis by blocking gasdermin D pore formation. Nature Immunology. (Link) 

Zhang, Z.#, Zhang, Y.#, Xia, S., Kong, Q., Li, S., Liu, X., Junqueira, C., Meza-Sosa, K.F., Mok, T.M.Y., Ansara, J., Sengupta, S., Yao, Y., Wu, H. and Lieberman, J., 2020. Gasdermin E suppresses tumour growth by activating anti-tumour immunity. Nature. (Link) 

Xia, S.#, Hollingsworth, L.R.# and Wu, H., 2020. Mechanism and regulation of gasdermin-mediated cell death. Cell Survival and Cell Death. (Link) 

Xia, S., 2020. Biological mechanisms and therapeutic relevance of the gasdermin family. Molecular Aspects of Medicine. (Link) 

Wang, B.#, Tang, Y.#, Oh, Y., Lamb, N.W., Xia, S., Ding, Z., Chen, B., Suarez, M.J., Meng, T., Kulkarni, V., Eberhart, C.G., Ensign, L.M., Stark, W.J., Hanes, J. and Xu, Q., 2019. Controlled release of dexamethasone sodium phosphate with biodegradable nanoparticles for preventing experimental corneal neovascularization. Nanomedicine: Nanotechnology, Biology and Medicine. (Link) 

Luo, L., Yang, J., Oh, Y., Hartsock, M.J., Xia, S., Kim, Y.C., Ding, Z., Meng, T., Eberhart, C.G., Ensign, L.M., Thorne, J.E., Stark, W.J., Duh, E.J., Xu, Q. and Hanes, J., 2019. Controlled release of corticosteroid with biodegradable nanoparticles for treating experimental autoimmune uveitis. Journal of Controlled Release. (Link) 

Xia, S.#, Wang, L.#, Fu, T.-M. and Wu, H., 2019. Mechanism of TRPM 2 channel gating revealed by cryo‐EM. The FEBS journal. (Link) 

Shen, C., Sharif, H., Xia, S. and Wu, H., 2019. Structural and mechanistic elucidation of inflammasome signaling by cryo-EM. Current Opinion in Structural Biology. (Link) 

Xia, S., Ruan, J. and Wu, H., 2019. Monitoring gasdermin pore formation in vitro. Methods in Enzymology. (Link) 

Wang, L.#, Fu, T.M.#, Zhou, Y., Xia, S., Greka, A. and Wu, H., 2018. Structures and gating mechanism of human TRPM2. Science. (Link) 

Orning, P., Weng, D.#, Starheim, K.#, Ratner, D.#, Best, Z., Lee, B., Brooks, A., Xia, S., Wu, H., Kelliher, M.A., Berger, S.B., Gough, P.J., Bertin, J., Proulx, M.M., Goguen, J., Kayagaki, N., Fitzgerald, K.A. and Lien, E., 2018. Pathogen blockade of TAK1 triggers caspase-8–dependent cleavage of gasdermin D and cell death. Science. (Link) 

Ruan, J., Xia, S., Liu, X., Lieberman, J. and Wu, H., 2018. Cryo-EM structure of the gasdermin A3 membrane pore. Nature. (Link) 

Evavold, C.L., Ruan, J., Tan, Y., Xia, S., Wu, H. and Kagan, J.C., 2018. The pore-forming protein gasdermin D regulates interleukin-1 secretion from living macrophages. Immunity. (Link) 

Xia, S., Fu, T.M. and Wu, H., 2018. Inflammation NODs to antagonists of RIP2-XIAP interaction. Molecular Cell. (Link) 

Elgogary, A.#, Xu, Q.#, Poore, B., Alt, J., Zimmermann, S.C., Zhao, L., Fu, J., Chen, B., Xia, S., Liu, Y., Neisser, M., Nguyen, C., Lee, R., Park, J.K., Reyes, J., Hartung, T., Rojas, C., Rais, R., Tsukamoto, T., Semenza, G.L., Hanes, J., Slusher, B.S. and Le, A., 2016. Combination therapy with BPTES nanoparticles and metformin targets the metabolic heterogeneity of pancreatic cancer. Proceedings of the National Academy of Sciences. (Link)