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2026
LncRNA-Splicing Factor Condensates Regulate Hypoxia-Responsive Pre-mRNA Processing near Nuclear Speckles
Song YJ, Shinn M*, Bangru S*, Wang Y, Sun Q, Hao Q, Chaturvedi P, Freier S, Perez-Pinera P, Nelson ER, Belmont AS, Guttman M, Prasanth SG, Kalsotra A, Pappu RV, Prasanth KV
Molecular Cell 86(6): 1061-1080
*Equal contributions
Featured in Preview: (Lnc)ing MALAT1-SRSF1 condensates to hypoxia-induced RNA alternative splicing and cancer
Bubenik JL and Swanson MS
Molecular Cell 86(6): 993-995
Nuclear Speckle Proteins Form Intrinsic and MALAT1-dependent Microphases
Shinn M, Tomares DT*, Liu V*, Pant A, Qiu Y, Ruff KM, Song YJ, Ayala Y, Lew MD, Prasanth KV, Pappu RV
Cell 189: 832-852
*Equal contributions
Molecular Grammars of Predicted Intrinsically Disordered Regions that Span the Human Proteome
Ruff KM*, King MR*, Ying AW, Liu V, Pant A, Lieberman WE, Shinn M, Su X, Kadoch C, Pappu RV
Cell 189: 323-342
*Equal contributions
2025
Matrin-3 Forms Spherical and Wormlike Assemblies that are Modulated by RNA Binding and ALS/FTD-associated Mutations
Sprunger ML*, Shinn M*, Talir S, Lee K, Pappu RV, Jackrel M
Molecular Cell 85(19): 3640-3660
*Equal contributions
Featured in Preview: Spheres, Worms, and Packing Problems in the Nanoscale Assembly of ALS-Linked Protein Matrin-3
Deniz AA
Molecular Cell 85(19): 3549-3550
Synapsin Condensation is Governed by Sequence-encoded Molecular Grammars
Hoffman C, Ruff KM, Edu IA, Shinn M, Tromm JV, King MR, Pant A, Ausserwöger H, Morgan JR, Knowles TPJ, Pappu RV, Milovanovic D
Journal of Molecular Biology 437: 168987
2023
A Single Disordered Region Controls cBAF Chromatin Remodelling through Condensation and Partner Recruitment
Patil A*, Strom AR*, Paulo J, Collings CK, Ruff KM, Shinn M, Sankar A, Cervantes KS, Wauer T, St. Laurent J, Xu G, Becker LA, Gygi SP, Pappu RV, Brangwynne CP, Kadoch C
Cell 186: 1-20
*Equal contributions
Featured in Spotlight: Disordered Protein Regions Partner up the cBAF Remodeler for a Chromatin Dance
Heimhalt M and Ladurner AG
Molecular Cell 83(21): 3763-3765
Allosteric Effects of E. coli SSB and RecR Proteins on RecO Protein Binding to DNA
Shinn M, Chaturvedi SK, Kozlov AG, Lohman TM
Nucleic Acids Research 51(5): 2284-2297
2022
Connecting Sequence Features within the Disordered C-terminal Linker of B. subtilis FtsZ to Functions and Bacterial Cell Division
Shinn M, Cohan MC, Bullock JL, Ruff KM, Levin PA, Pappu RV
Proceedings of the National Academy of Sciences 119(42) e2211178119
How Glutamate Promotes Liquid-liquid Phase Separation and DNA Binding Cooperativity of E. coli SSB Protein
Kozlov AG, Cheng X, Zhang H, Shinn M, Weiland E, Nguyen B, Shkel IA, Zytkiewicz E, Finkelstein IJ, Record MT, Lohman TM
Journal of Molecular Biology 434(9), 167562
Uncovering Non-random Sequence Patterns within Intrinsically Disordered Proteins
Cohan MC*, Shinn M*, Lalmansingh JM, Pappu RV
Journal of Molecular Biology 434(2): 167373
*Equal contributions
2021
Regulation of E. coli Rep Helicase Activity by PriC
Nguyen B, Shinn M, Weiland E, Lohman TM
Journal of Molecular Biology 433(15): 167072
Allosteric effects of SSB C-terminal tail on assembly of E. coli RecOR proteins
Shinn M, Kozlov AG, Lohman TM
Nucleic Acids Research 49(4): 1987-2004
2019
Regulation of Nearest-Neighbor Cooperative Binding of E. coli SSB Protein to DNA
Kozlov AG, Shinn M, Lohman TM
Biophysical Journal 117: 1-21
Are the Intrinsically Disordered Involved in SSB Binding to Accessory Proteins?
Shinn M, Kozlov AG, Nguyen B, Bujalowski WM, Lohman TM
Nucleic Acids Research 47(16): 8581-8594
A Novel Chlorophyll Protein Complex in the Repair Cycle of Photosystem II
Weisz DA, Johnson VM, Niedzwiedzki DM, Shinn M, Liu H, Klitzke CF, Gross ML, Blankenship RE, Lohman TM, Pakrasi HB
Proceedings of the National Academy of Sciences 116 (43): 21907-21913
2018
Glutamate Promotes SSB Protein-Protein Interactions via Intrinsically Disordered Regions
Kozlov AG*, Shinn M*, Weiland E, Lohman TM
Journal of Molecular Biology 2017. 429(18):2790- 2801
*Equal contributions