Hiroshi Nohara (野原ひろし) (35 years old), Harry Nohara  is the father of the Nohara family, and its sole source of income as he works at as kakarichô (a low-level manager) at Futaba Shoji where he does overtime to earn a little more money and because of the 32-year mortgage he still has to pay. Quite surprisingly he still manages to have time to spend with his family. He is a loving father to his two children, and ultimately a devoted husband. While he is the family breadwinner, he hands the reins of finance over to his wife, who maintains a totalitarian level of control on family spending. He is a stereotypical Japanese salaryman, working eight-hour days, enduring overstuffed trains, enjoying the occasional nightlife, and giving every bit of his take-home pay to his wife every month. He is a quiet, reasonable person .

Misae Nohara (née Koyama) (野原みさえ), Mitsy Nohara , is the mother of the Nohara family, and its caretaker. She is 29 years old but she always tells people that she is 24 or 25. She is the classical housewife of post-war Japan - she cleans, launders, cooks, sews, mothers, and lazes all to varying degrees of success. A paragon of hypocrisy, after handing out irrevocable edicts to her husband and children (mainly Shinnosuke), she will not hesitate to immediately break them once they are out of sight and has even been known to display double standards while in their company. Her famous and symbolic moves includes "drilling" others' head with her fists  and one or more punches to the head creating comically large lumps.While she spends as little as possible on the less-essential needs of her husband and son, she loves to splurge on Himawari and herself. She always changes her hair style, as seen it is sometimes curly and sometimes long and shattered hair.

She is Shin-chan's sister and the youngest child of the Nohara family, born. She is an energetic, precocious and vibrant infant. While technically newborn, her character has matured and grown more intelligent during her stay in the series, being able to discern a real jewel from a simple piece of imitation (and throwing away the latter). Like Misae, she also possesses a palpable lust for shiny objects (jewels and precious metals) and brand-name goods. She emulates her mother in her utterly stubborn pursuit of handsome young men who catch her eye, not unlike her brother, who soon discovered that a way to pacify her was to put on a cutout mask of a known handsome actor. In her family, she is an icon of adoration and annoyance, causing trouble she cannot be blamed for given her infantile innocence. She is an extremely fast crawler, tiring out even Shin-chan, and often uses Shiro as a toy. She looks up to her brother a lot and is very close to him, although they occasionally fight. Her name, which is Japanese for "sunflower". 

Shiro (シロ, Shiro) is a white, fluffy pup Shin-chan found in a cardboard box early in the series. While a beloved member of the family, he is the subject of neglect thanks to his owner's mental condition. He is a very intelligent dog, often presenting logic and intellect that surpasses his human owners. As his meals from the Nohara's are at best inconsistent, he has developed a talent for foraging, though other times he has to eat Misae's failed culinary experiments. An oddly human-like dog, he is very responsible and painstakingly careful. He takes care of his owners diligently, though often they do not realize his help or understand what he is trying to show them. His doghouse also often ends up becoming a place for Shin-chan to hide himself or something he doesn't want his family to find. He often plays protector to Himawari, more often than not sacrificing his well being in the process.