Publications

Guanyu Chen, LeDarius Whitley, Xiaogang Tong, Min-Ho Kim, Woo Shik Shin*, Songping D. Huang* "Repurposing the Anticancer Drug KP46 to Beat the CRAB Out of Resistance: Towards an Orally Active Ga-based Antiplantonic and Antibiofilm Agent." submitted to Antibiotics August 2025

Alhussain Ojaym, Trae Hiller, Guanyu Chen, Songping D. Huang, Woo Shik Shin*, Min-Ho Kim* “Harnessing the synergy of copper nanoparticles and vitamin C towards the resolution of wound infection.” submitted to Biomaterials Science July 2025 

Man Hwan Oh, Md Minarul Islam, Nayeong Kim, Chul Hee Choi, Minsang Shin, Woo Shik Shin, and Je Chul Lee* "AbOmpA in Acinetobacter baumannii: Exploring Virulence Mechanisms of Outer Membrane Vesicle-Associated AbOmpA and Developing Anti-Infective Agents Targeting AbOmpA." Journal of Biomedical Science 2025, 32(53) 10.1186 

Md Minarul Islam, Je Chul Lee, Woo Shik Shin*, Man Hwan Oh* "In silico screening of epitopes as potential vaccine candidates against pathogenic Acinetobacter baumannii." Genes Genomics. 2025 Aug;47(8):899-909  

Trae Hillyer, Bogdan M. Benin, Bovinari A. Csubak, Noah Aguirre, Chounghun Kang, Christine M. Dengler-Crish, Woo Shik Shin* "Discovery of Three Flavonoids as Potent Tau Aggregation Inhibitors and In vivo Demonstration of Myricetin." Pharmacological Research - Natural Products  Revision submitted Feb 2025 

Bogdan M. Benin, Rupak Kharel, Trae Hillyer, Chuanqi Sun,  Anna Cmolik, Taylor Kuebler, Yuk Yin Sham, Robert A. Bonomo, Jeffrey D. Mighion, Woo Shik Shin* "Development of non-β-Lactam covalent allosteric inhibitors targeting PBP2a in Methicillin-Resistant Staphylococcus aureus" PNAS  Revision submitted Jan 2025  

Md Minarul Islam, Ye-Ji Bang, Kyudong Han, Woo Shik Shin*, Man Hwan Oh* "Gut microbiota as a modulator of aging: exploring the links." submitted to Journal of Biomedical Science Nov 2024

Bogdan M. Benin, Trae Hillyer, Noah Aguirre, Yuk Yin Sham, Belinda Willard, Woo Shik Shin*, "Carbapenem-induced β-lactamase-isoform expression trends in Acinetobacter baumannii" Scientific Reports  2024 Dec 28;14(1):30841.  

Md Minarul Islam, Da Eun Jung, Woo Shik Shin*, Man Hwan Oh* "Colistin Resistance Mechanism and Management Strategies of Colistin-Resistant Acinetobacter baumannii Infections" Pathogens 2024, 13(12), 1049   

Md Minarul Islam, Nasir Uddin Mahbub, Woo Shik Shin*, Man Hwan Oh*, "Phage-encoded depolymerases as a strategy for combating multidrug-resistant Acinetobacter baumannii" Frontiers in Cellular and Infection Microbiology  volume 14 - 2024 | doi: 10.3389 

Bogdan M. Benin, Rupak Kharel, Trae Hillyer, Chuanqi Sun,  Anna Cmolik, Taylor Kuebler, Yuk Yin Sham, Robert A. Bonomo, Jeffrey D. Mighion, Woo Shik Shin* "Development of non-β-Lactam covalent allosteric inhibitors targeting PBP2a in Methicillin-Resistant Staphylococcus aureus" BioRxiv.2024.596450 

Trae Hillyer, Woo Shik Shin*, "Meropenem/Vaborbactam - A Mechanistic Review for Insight on Future Development of Combinational Therapies " Antibiotics 2024, 13, 472. 10.3390

Bryan Shin, Trae Hillyer, Woo Shik Shin*, "Rational Design and Testing of Antibacterial Aloe Vera Hemostatic Hydrogel" Gels 2024, 10 (6), 409  

Saba Imdad, Jin-Hee Kim, Byunghun So, Junho Jang , Jinhan Park, Wonchung Lim,  Yoon-Kwang Lee, Woo Shik Shin, Trae Hillyer, Chounghun Kang* “Effect of aerobic exercise and particulate matter exposure duration on the diversity of gut microbiota” Animal Cells and Systems 2024 28:1, 137-151

Jinhan Park, Junho Jang, Byunghun So, Kanggyu Lee, Dongjin Yeom, Ziyi Zhang, Woo Shik Shin, Chounghun Kang* “Effects of particulate matter (PM) inhalation during exercise on oxidative stress and mitochondrial function in mouse skeletal muscle” Antioxidants 2024, 13, 113.

Bogdan M. Benin, Trae Hillyer, Aylin S. Crugnale, Andrew Fulk, Caitlyn A. Thomas, Michael W. Crowder, Matthew A. Smith and Woo Shik Shin* "Taxifolin as a 

Metallo-β-Lactamase Inhibitor in Combination with Augmentin against VIM-2 Expressing Pseudomonas aeruginosa" Microorganisms 2023, 11, 2653.

James B. Thoden, Bogdan M. Benin, Adam Priebe, Woo Shik Shin, Ramaiah Muthyala, Yuk Yin Sham* and Hazel M. Holden* “Characterization of a new inhibitor

for the New Delhi metallo-β-lactamase-4: implications for drug design and combating bacterial resistance” J Biol Chem July 2023 105135 doi: 10.1016. 

Nalin Abeydeera, Bogdan M. Benin, Khalil Mudarmah, Bishnu D. Pant, Guanyu Chen, Min-Ho Kim, Woo Shik Shin* and Songping D. Huang* “Harnessing a Dual Antimicrobial Mechanism of Action with Fe(8-hydroxyquinoline)3 to Develop a Topical Ointment for Mupirocin-Resistant MRSA Infections” Antibiotics 2023, May 10;12(5):886. doi: 10.3390/antibiotics12050886. 

Trae Hillyer, Bogdan M. Benin, Chuanqi Sun, Noah Aguirre, Belinda Willard, Yuk Yin Sham, Woo Shik Shin* “A novel strategy to characterize the pattern of beta-lactam antibiotic-induced multi-drug resistance in Acinetobacter baumannii” Scientific Reports 2023 DOI:10.1038/s41598-023-36475-9 

Chuanqi Sun, Kang Zhou, Peter DePaola IV, Woo Shik Shin, Trae Hillyer, Michael R. Sawaya,  Z. Hong Zhou, Lin Jiang “Cryo-EM structure of amyloid fibril formed by α-synuclein hereditary A53E mutation reveals a distinct protofilament interface” Journal of Biological Chemistry 2023.104566 

Chuanqi Sun, Kang Zhou, Peter DePaola IV, Woo Shik Shin, Trae Hillyer, Michael R. Sawaya,  Z. Hong Zhou, Lin Jiang “Cryo-EM structure of amyloid fibril formed by α-synuclein familial A53E mutation” bioRxiv  March 2022 10.1101/483992

Bogdan M. Benin, Trae Hillyer, Woo Shik Shin “Quercetin, a potential Metallo-β-lactamase inhibitor for use in combination therapy against β-lactam antibiotic-resistant bacteria.” OJPTR. 2021.MS.ID.000503 

Shin WS, Nguyen ME, Bergstrom A, Jennings IR, Crowder MW, Muthyala R, Sham YY. Fragment based screening and hit-based substructure search: Rapid discovery of 8-hydroxyquinoline-7-carboxylic acid as a low-cytotoxic, nanomolar metallo β-lactamase inhibitor. Chem Biol Drug Des. 2021 Jun 20. doi: 10.1111/cbdd.13912. 

Xiaojuan Ma, Yi Zhu, Jinxia Lu, Jingfei Xie, Chong Li, Woo Shik Shin, Jiali Qiang, Jiaqi Liu, Shuai Dou, Yi Xiao, Chuchu Wang, Chunyu Jia, Houfang Long, Juntao Yang, Yanshan Fang, Lin Jiang, Yaoyang Zhang, Shengnan Zhang, Rong Grace Zhai, Cong Liu, and Dan L “Nicotinamide mononucleotide adenylyltransferase uses its NAD+ substrate-binding site to chaperone phosphorylated Tau” eLife. 2020; 9: e51859. 

Shin WS, Di J, Murray K, Sun C, Li B, Bitan G, Jiang L “Different amyloid-β self-assemblies have distinct effects on intracellular tau aggregation” Front. Mol. Neurosci. 12:268. doi: 10.3389/fnmol.2019.00268 

Shin WS, Di J, Cao Q, Li B, Seidler PM, Murray KA, Bitan G, Jiang L “Amyloid β-protein oligomers promote the uptake of tau fibril seeds potentiating intracellular tau aggregation” Alzheimers Res Ther. 2019 Oct 18;11(1):86   

Jennifer Putman, Eric Y. Hayden, Woo Shik Shin, Stefanie Nunez, Mandavi Oberoi, Malena Charreton, Suman Dutta, Zizheng Li, Yutaro Komuro, Mary Teena Joy, Gal Bitan, Allan MacKenzie-Graham, Lin Jiang, Jason D. Hinman “Ischemic axonal injury up-regulates MARK4 in cortical neurons and primes tau phosphorylation and aggregation” Acta Neuropathol Commun. 2019 Aug 20;7(1):135. 

Qin Cao, Woo Shik Shin, Henry Chan, Bethany Dubois, Binsen Li, Michael Sawaya, Juli Feigon, Lin Jiang “Inhibiting Amyloid-ß cytotoxicity through its interaction with the cell surface receptor LilrB2 by structure-based design” Nature Chemistry Oct 2018 10.1038 

Xinrui Gui , Feng Luo, Yichen Li, Heng Zhou, Zhenheng Qin, Zhenying Liu, Jinge Gu, Bin Dai, Woo Shik Shin, Liqiong Xu , Jianhua He, Lin Jiang , Minglei Zhao, Bo Sun, Xueming Li, Dan Li “Structural basis for reversible amyloids of hnRNPA1 elucidates their role in stress granule assembly”  Nature Communications, 2019 May 1;10(1):2006. DOI: 10.1038 

Binsen Li, Peng Ge, Kevin A. Murray, Phorum Sheth, Meng Zhang, Gayatri Nair, Michael R. Sawaya, Woo Shik Shin, David R. Boyer, Shulin Ye, David S. Eisenberg, Z. Hong Zhou and Lin Jiang “Cryo-EM structures of α-synuclein fibril polymorphs with a common structural kernel” Nature Communications 2018 Sep 3609 | DOI: 10.1038 

Kang CH, Shin WS, Lim W, Ji LL “Data on the mode of binding between Avenanthramides and IKKβ domains in a docking model.” Data in Brief 2018 Feb 1 S2352-3409 (18) 30117-3S0891-5849 (18) 30030-3 

Kang CH, Shin WS, Yeo D, Lim W, Ji LL “Anti-inflammatory Effect Of Avenanthramides Via Nf-κB Pathways In C2c12 Skeletal Muscle Cells” Free Radic. Biol. Med. 2018 Jan 22. pii: S0891-5849(18)30030-3. doi: 10.1016 

Shin WS, Bergstrom A, Xie J, Bonomo RA, Crowder MW, Muthyala R, Sham YY, “Discovery of 1-hydroxypyridine-2(1H)-thiones-6-carboxylic acid as a first-in-class low-cytotoxic nanomolar metallo β-lactamase inhibitor” ChemMedChem. 2017 Jun 7;12(11):845-849 

Muthyala R, Shin WS, Xie J, Sham YY “Discovery of 1-hydroxypyridine-2-thiones as selective histone deacetylase inhibitors and their potential application for treating leukemia” Bioorganic & Medicinal Chemistry Letters, 25: 4320–4324 (2015). PMID: 26264503 

Muthyala R, Rastogi N, Shin WS, Peterson ML, Sham YY “Cell permeable vanX inhibitors as vancomycin re-sensitizing agents” Bioorganic & Medicinal Chemistry Letters, 24: 2535-2538 (2014). PMID: 24751446

Zhuang C, Sheng C, Shin WS, Wu Y, Li J, Yao J, Dong G, Zhang W, Sham YY, Miao Z, Zhang W “A novel drug discovery strategy: Mechanistic investigation of an enantiomeric antitumor agent targeting dual p53 and NF-κB pathways” Oncotarget, 5: 10830-10839 (2014). PMID: 25350970 

Cui Q, Shin WS, Luo Y, Tian J, Cui H, Yin D, Thymidylate kinase: an old topic brings new perspectives. Current Medicinal Chemistry. 2013; 20(10):1286-305

Soomi Yang, Yoon Gi Yang and Woo Shik Shin, A Network Reliability Model for a Privilege Description and Management, International Conference on Convergence Technology and Information, Vol.12, No.4, July 2009 

Shin WS “Interdisciplinary Challenges in Modern Drug Discovery”, University of the Pacific, College of Pharmacy (Invited Talk, July 2025)

Shin WS “The Role of Computational Approaches in Advancing Modern Drug Development”, University of Ulsan, School of Medicine, S. Korea (Invited Talk, July 2025)

Shin WS “The Role of Computational Approaches in Advancing Modern Drug Development”, Cleveland Clinic Lerner Research Institute (Invited Talk, June 2025)

Shin WS “An Interdisciplinary Approach to the Challenge of Antibiotic Resistance”, Bioinformatics and Computational Biology (BICB) Symposium, University of Minnesota / Mayo Clinic (Invited Talk, Dec 2024)

Shin WS “An Interdisciplinary Approach to the Challenge of Antibiotic Resistance”, School of Medicine, Kyungbuk National University, Korea (Invited Talk, 2024)  

Shin WS “The Role of Computer-Aided Drug Design in Advancing Modern Drug Development”, School of Pharmacy, Seoul National University, Korea (Invited Talk, 2024)

Shin WS “The Role of Computer-Aided Drug Design in Advancing Modern Drug Development”, School of Medicine, Korea University, Korea (Invited Talk, 2024)

Shin WS “Pharmaceutical Drugs, Sports Doping, And Associated Adverse Effects”, Department of Experimental Physiology, Inha University, Korea (Invited Talk, 2024)

Shin WS “The Role of Computer-Aided Drug Design in Advancing Modern Drug Development”, School of Medicine, Inha University, Korea (Invited Talk, 2024)

Shin WS “Using Computer-aided Drug Design in the Current Drug Discovery Pipeline”, International Workshop on Intelligent Software Engineering (ISE) part of 29th Asia-Pacific Software Engineering Conference (APSEC), Gyeongsang National University, Korea (Invited Talk, 2022)

Shin WS “Computer-aided drug design approaches in current drug resistance research”, Department of Biomedical Sciences, Kent State University, Kent, OH (Invited Talk, 2022)

Noah Aguirre, Bogdan M. Benin, Andrew Fulk, Woo Shik Shin “Mechanistic Studies of Amyloid-Beta induced agglutination of Escherichia Coli”, Sep 2022, NEOMED Student Research Symposium

Woo Shik Shin, James Thoden, Trae Hillyer, Taylor Kueblerd, Alexander Bergstrom, Robert A. Bonomo, Michael W. Crowder, Hazel Holden, Ramaiah Muthyala, Yuk Yin Sham, “Discovery of 1-hydroxypyridine-2(1H)-thione-6-carboxylic acid as a first-in-class nanomolar metallo-β-lactamase inhibitor”, June 2022, Golden Research Conference

Trae Hillyer, Woo Shik Shin “Structure-based discovery of potent NDM-1 Metallo beta-lactamase inhibitors for the design of novel combinational antibiotic therapy”, 2021, NEOMED Research Symposium

Noah Aguirre, Trae Hillyer, Woo Shik Shin, “A Rational Strategy for characterizing the beta-lactam antibiotic-induced multidrug resistance patterns”, 2021, NEOMED Research Symposium

Rachida Bouhenni, Theresa Rowe, Imaan Benmerzouga, Jeffrey Dunmire, Woo Shik Shin, Deepak P Edward, “Cytochrome P450 1B1 binds to all-trans-retinal and affects p53 Expression and Growth Arrest in Human Trabecular Meshwork Cells”, 2021, ARVO Annual Meeting

Shin WS “Multiple Approaches to Alzheimer’s Disease” Invited Talk, Department of Integrative Medical Sciences, Northeast Ohio Medical University, Rootstown, OH (Invited Talk, 2020)

Shin WS “An Interdisciplinary Approach to the Challenge of Antibiotic Resistance” Invited Talk, Department of Pharmaceutical Sciences, University of Texas Tyler, TX (Invited Talk, 2020)

Shin WS “An Interdisciplinary Approach to the Challenge of Antibiotic Resistance” Invited Talk, Department of Biological and Chemical Sciences, NYIT, Old Westbury, NY (Invited Talk, 2020)  

Shin WS “Amyloid β-protein oligomers promote the uptake of tau fibril seeds potentiating intracellular tau aggregation”, Alzheimer Association International Conference (AAIC), July, 2019, Los Angeles, CA, USA (Session Talk)

MIDDLE-CARRER RESEARCHER PROGRAM GRANT (NATIONAL RESEARCH FOUNDATION OF S. KOREA)

NIH/NIAID/1R03 NS135326-01  

NIH/NIAID 1R03AI175990-01

NIH/NIA 1R01AG076699

BRAIN HEALTH RESEARCH INSTITUTE RESEARCH GRANT 

TRANSLATIONAL RESEARCH GRANT 

NEOMED START-UP SEED GRANT