1. Shih-Chieh Lin*, Ya-Chuan Tsai, Jui-Lin Wang, Hsian-Jean Chin, Shin-Chih Lin, Yi-Syuan Lin, Bo-Wen Lin, Shaw-Jenq Tsai*. Targeting NUDT21-mediated alternative polyadenylation of oncogenes ameliorates colorectal cancer malignancy and metastasis. British Journal of Cancer 2025 (major revision). *: indicates co-corresponding author
2. Yu-Sheng Cheng, Hsing-Yi Chen, Chia-Min Liu, Hsiu-Chiung Hou, Yu-Chiao Lin, Tsung-Yen Lin, Shih-Chieh Lin Attributes of a large cohort of human seminal extracellular vesicles with varied sperm features. Reproductive BioMedicine Online 2025 Aug (Accepted)
3. Shin-Chih Lin#, Yu-Sheng Cheng#, Yi-Syuan Lin, Hui-Kuan Lin, Thi My Hang Nguyen, Wen-Tai Chiu, Ya-Chuan Tsai, Hsing-Yi Chen, Tsung-Yen Lin, Shih-Chieh Lin. Long noncoding RNA lncZBTB10 facilitates AR function by S-palmitoylation to promote prostate cancer progression and abiraterone resistance. British Journal of Cancer 2025 Apr;132(7):587-598. #: indicates co-first author. 5 year-IF=8.6 (Ranking: 47/326, ONCOLOGY) (Citation times=6)
4. Yi-Syuan Lin, Ya-Chuan Tsai, Chia-Jung Li, Tzu-Tang Wei, Bo-Wen Lin, Ya-Na Wu, Shang-Rung Wu, Shin-Chih Lin, Shih-Chieh Lin. Overexpression of NUDT16L1 sustains proper function of mitochondria and leads to ferroptosis insensitivity in colorectal cancer. Redox Biology 2024 Nov;77:103358. 5 year-IF=11.7 (Ranking: 17/313, BIOCHEMISTRY & MOLECULAR BIOLOGY) (Citation times=10)
5. Shin-Chih Lin, Ya-Chuan Tsai, Ying-Lan Chen, Yun-Chen Huang, Hui-Kuan Lin, Yi-Syuan Lin, Yu-Sheng Cheng, Hsing-Yi Chen, Chia-Jung Li, Tsung-Yen Lin, Shih-Chieh Lin. Un-methylation of NUDT21 represses docosahexaenoic acid biosynthesis contributing to enzalutamide resistance in prostate cancer. Drug Resist Updat. 2024 Nov;77:101144. 5 year-IF=18 (Ranking: 3/354, PHARMACOLOGY & PHARMACY) (Citation times=10)
6. Shih-Chieh Lin, Wan-Ning Li, Shin-Chih Lin, Haun-Tzu Hou, Ya-Chuan Tsai, Tin-Chien Lin, Meng-Hsing Wu, Shaw-Jenq Tsai. Targeting YAP1 ameliorates progesterone resistance in endometriosis. Human Reproduction, 2023 Jun, 38(6):1124-1134. 5 year-IF=6.4 (Ranking: 6/136, OBSTETRICS & GYNECOLOGY) (Citation times=16)
7. Pei-Ling Hsu, Chun-Wei Chien, Yen-An Tang, Bo-Wen Lin, Shih-Chieh Lin, Yi-Syuan Lin, Sih-Yu Chen, H Sunny Sun, Shaw-Jenq Tsai. Targeting BRD3 eradicates nuclear TYRO3-induced colorectal cancer metastasis. Sci Adv. 2023 Apr 14;9(15):eade3422. 5 year-IF=13.7 (Ranking: 11/134, MULTIDISCIPLINARY SCIENCES)
8. Yu-Sheng Cheng, Hsing-Yi Chen, Yu-Chiao Lin, Yi-Syuan Lin, Yi-Chun Yeh, Yi-Hsuan Yeh, Yung-Hsuan Cheng, Yung-Ming Lin, Han-Yu Weng, Tsung-Yen Lin, Shih-Chieh Lin. The MAEL expression in mitochondria of human spermatozoa and the association with asthenozoospermia. Andrology, 2023 Oct;11(7):1286-1294. (Citation times=2)
9. Kai-Che Wei, Shih-Fan Lai, Wei-Lun Huang, Kuo-Chung Yang, Ping-Chin Lai, Wan-Ju Wei, Tsung-Hsien Chang, Yun-Chen Huang, Ya-Chuan Tsai, Shin-Chih Lin, Sun-Jang Lin, Shih-Chieh Lin. An innovative targeted therapy for fluoroscopy-induced chronic radiation dermatitis. J Mol Med (Berl). 2022 Jan;100(1):135-146 (Citation times=4)
10. An-Lun Li, Che-Yi Chou, Chien-Lung Chen, Kun-Lin Wu, Shih-Chieh Lin, Hung-Chun Chen, Ming-Cheng Wang, Chia-Chu Chang, Bang-Gee Hsu, Mai-Szu Wu, Nianhan Ma, Chiu-Ching Huang 12The MicroRNA Prediction Models as Ancillary Diagnosis Biomarkers for Urothelial Carcinoma in Patients With Chronic Kidney Disease. Front Med (Lausanne). 2021 Oct 1;8:726214. doi: 10.3389/fmed.2021.726214. eCollection 2021.
11. Jin-Wei Jhu, Jia-Bao Yan, Zou-Han Lin, Shih-Chieh Lin, I-Chen Peng. SREBP1-Induced Glutamine Synthetase Triggers a Feedforward Loop to Upregulate SREBP1 through Sp1 O-GlcNAcylation and Augments Lipid Droplet Formation in Cancer Cells. Int J Mol Sci. 2021 Sep 10;22(18):9814. doi: 10.3390/ijms22189814.
12. HC Lee, CH Ou, YC Huang, PC Hou, CJ Creighton, YS Lin, CY Hu, SC Lin. YAP1 overexpression contributes to the development of enzalutamide resistance by induction of cancer stemness and lipid metabolism in prostate cancer. Oncogene 2021 Apr;40 (13):2407-2421 (Citation times=64)
13. HC Lee, SC Lin, MH Wu, SJ Tsai. Inhibiting NTRK2 signaling causes endometriotic lesion regression. Reproduction 2021 Jan;161(1):11-19. doi: 10.1530/REP-20-0163.
14. CY Kao, M Xu ,L Wang ,SC Lin, HJ Lee, L Duraine, HJ Bellen, DS Goldstein, SY Tsai, MJ Tsai. Elevated COUP-TFII expression in dopaminergic neurons accelerates the progression of Parkinson's disease through mitochondrial dysfunction. PLoS Genet. 2020 Jun 24;16(6):e1008868. doi: 10.1371/journal.pgen.1008868. eCollection 2020 Jun.
15. JB Yan, CC Lai, JW Jhu, B Gongol, TL Marin, SC Lin, HY Chiu, CJ Yen, LY Wang, IC Peng. Insulin and Metformin Control Cell Proliferation by Regulating TDG-Mediated DNA Demethylation in Liver and Breast Cancer Cells. Mol Ther Oncolytics 2020 Jun 24;18:282-294. doi: 10.1016/j.omto.2020.06.010.
16. PS Chen, WT Chiu, PL Hsu, SC Lin, IC Peng, CY Wang, SJ Tsai. Pathophysiological implications of hypoxia in human diseases. J Biomed Sci. 2020 May 11;27(1):63. doi: 10.1186/s12929-020-00658-7.
17. SC Lin, HC Lee, CT Hsu, YH Huang, WN Li, PL Hsu, MH Wu, and SJ Tsai. Targeting anthrax toxin receptor 2 ameliorates endometriosis progression. Theranostics. 2019 Jan 21;9(3):620-632 (Citation times=31)
18. AL Li, TS Chung, YN Chan, CL Chen, SC Lin, YR Chiang, CH Lin, CC Chen , N Ma. microRNA expression pattern as an ancillary prognostic signature for radiotherapy. J Transl Med. 2018 Dec 5;16(1):341
19. HC Lee, SC Lin, MH Wu, SJ Tsai Induction of Pyruvate Dehydrogenase Kinase 1 by Hypoxia Alters Cellular Metabolism and Inhibits Apoptosis in Endometriotic Stromal Cells. Reprod Sci. 2018 Aug 9:1933719118789513.
20. P Li, S You, C Nguyen, Y Wang , J Kim, D Sirohi, A Ziembiec, D Luthringer, SC Lin, T Daskivich , J Wu, MR Freeman, R Saouaf, D Li, HL Kim. Genes involved in prostate cancer progression determine MRI visibility. Theranostics. 2018 Feb 12;8(7):1752-1765
21. PC Hou, YH Li, SC Lin SC Lin, JC Lee, PW Lin, JP Liou, JY Chang, C-C Kuo, YM Liu, HS Sun and SJ Tsai*. (2017, Aug) Hypoxia-Induced Downregulation of DUSP-2 Phosphatase Drives Colon Cancer Stemness. Cancer Res. 15;77(16):4305-4316
22. SC Lin, HC Lee, PC Hou, JL Fu, MH Wu and SJ Tsai*. (2017, Aug) Targeting hypoxia-mediated YAP1 nuclear translocation ameliorates pathogenesis of endometriosis without compromising material fertility J Pathol. (Cover page) 242(4):476-487. (Citation times=32)
23. HJ Lee, CY Kao, SC Lin, M Xu, X Xie , S Y Tsai, MJ Tsai. Dysregulation of nuclear receptor COUP-TFII impairs skeletal muscle development. 2017 Sci Rep. 2017 Jun 9;7(1):3136. doi: 10.1038/s41598-017-03475-5.
24. SC Lin *, KY Hsiao*, N Chang, PC Hou, and SJ Tsai. Loss of dual specificity phosphatase-2 promotes angiogenesis and metastasis via upregulation of interleukin-8 in colon cancer. J Pathol. 2017 Apr;241(5):638-648 *: SC Lin and KY Hsiao contributed equally to this study. (Citation times=32)
25. SC Lin, CY Kao, HJ Lee, CJ Creighton, MM Ittmann, SJ Tsai, SY Tsai, MJ Tsai. Dysregulation of miRNAs-COUP-TFII-FOXM1-CENPF axis contributes to the metastasis of prostate cancer Nat Commun. 2016 Apr 25;7:11418. doi: 10.1038/ncomms11418. (Citation times=116)
26. YH Liu, YS Tsai, SC Lin, NS Liao, MS Jan, CT Liang, SW Hsu, WC Chen, JM Sung, N Maeda, PJ Tsai. Quantitative PPARγ expression affects the balance between tolerance and immunity. Sci Rep. 2016 May 25;6:26646. doi: 10.1038/srep26646.
27. HC Tai, PJ Tsai, JY Chen, CH Lai, KC Wang, SH Teng, SC Lin, A Chang, MJ Jiang, YH Li, HL Wu, N Maeda, YS Tsai. PPARγ level contributes to structural integrity and component production of elastic fibers in the aorta Hypertension 2016 Apr 4. 67(6):1298-308.
28. CW Chien, PC Hou, HC Wu, YL Chang, SC Lin, SC Lin, BW Lin, JC Lee, YJ Chang, HS Sun, SJ Tsai. Targeting TYRO3 inhibits epithelial-mesenchymal transition and increases drug sensitivity in colon cancer. Oncogene 2016 Nov 10;35(45):5872-5881
29. L Wang, M Xu, J Qin, SC Lin, HJ Lee, SY Tsai, MJ Tsai. MPC1, a key gene in cancer metabolism, is regulated by COUP-TFII in human prostate cancer. Oncotarget 2016 Mar 22;7(12):14673-83
30. KY Hsiao, SC Lin, MH Wu, SJ Tsai. Pathological functions of hypoxia in endometriosis. Front Biosci (Elite Ed). 2015 Jan 1;7:309-21.
31. KY Hsiao, N Chang, SC Lin, YH Li and MH Wu. Inhibition of dual specificity phosphatase-2 by hypoxia promotes interleukin-8-mediated angiogenesis in endometriosis. Hum Reprod. 2014 Dec;29(12):2747-55.
32. J Qin, HJ Lee, SP Wu, SC Lin, RB Lanz, CJ Creighton, FJ DeMayo, SY Tsai, MJ Tsai. Androgen deprivation-induced NCoA2 promotes metastatic and castration resistant prostate cancer. J Clin Invest. 2014 Nov;124(11):5013-26
33. SC Lin *, YH Li *, MH Wu, YF Chang, DK Lee, SY Tsai, MJ Tsai, SJ Tsai. Suppression of COUP-TFII by proinflammatory cytokines contributes to the pathogenesis of endometriosis. *: SC Lin, YH Li contributed equally to this study. J Clin Endocrinol Metab. 2014 Mar; 99(3):E427-37. doi: 10.1210/jc.2013-3717. Epub 2014 Jan 1 (Citation times=54)
34. HC Wang, TK Kooi, HY Kao, SC Lin, SJ Tsai. Using positive and negative patterns to extract information from journal articles regarding the regulation of a target gene by a transcription factor. Comput Biol Med. 2013 Dec;43(12):2214-21.
35. SC Lin*, CC Wang *, MH Wu, SH Yang, YH Li, and SJ Tsai. Hypoxia-induced microRNA-20a expression increases ERK phosphorylation and angiogenic gene expression in endometriotic stromal cells. J Clin Endocrinol Metab. 2012. Aug; 97(8):E1515-23. *: SC Lin, CC Wang contributed equally to this study. (Citation times=135)
36. MH Wu *, SC Lin*, KY Hsiao, and SJ Tsai. Hypoxia-inhibited dual specificity phosphatase-2 expression in endometriotic cells regulates cyclooxygenase-2 expression. J Pathol. 2011 Nov; 225(3):390-400. doi: 10.1002/path.2963. Epub 2011 Aug 24. *: MH Wu, SC Lin contributed equally to this study. (Citation times=63)
37. CW Lu, SC Lin, CW Chien, SC Lin, CT Lee, BW Lin, JC Lee, and SJ Tsai* 2011 Overexpression of pyruvate dehydrogenase kinase-3 increases drug resistance and predicts poor prognosis of colon cancer. Am J Pathol. 2011 Sep;179(3):1405-14. Epub 2011 Jul 18.
38. SC Lin, CW Chien, JC Lee, YC Yeh, KF Hsu, YY Lai, SC Lin, SJ Tsai. Suppression of dual-specificity phosphatase-2 by hypoxia increases chemoresistance and malignancy in human cancer cells. J Clin Invest. 2011;121(5):1905–1916 (Citation times=95)
39. YC Yeh, WC Wei, YK Wang, SC Lin, JM Sung, MJ Tang. Transforming growth factor-{beta}1 induces Smad3-dependent {beta}1 integrin gene expression in epithelial-to-mesenchymal transition during chronic tubulointerstitial fibrosis. Am J Pathol. 2010 Oct;177(4):1743-54. Epub 2010 Aug 13.
40. CW Chien, SC Lin, YY Lai, BW Lin, SC Lin, JC Lee, SJ Tsai. Regulation of CD151 by hypoxia controls cell adhesion and metastasis in colorectal cancer. Clin Cancer Res. 2008 Dec 15;14 (24):8043-51. Epub 2008 Dec 10
41. CW Lu, SC Lin, KF Chen, YY Lai, SJ Tsai. Induction of pyruvate dehydrogenase kinase-3 by hypoxia-inducible factor-1 promotes metabolic switch and drug resistance. J Biol Chem. 2008 Oct 17;283(42):28106-14. (Name changed from SJ Lin to SC Lin)
42. MH Wu, KF Chen, SC Lin, CW Lgu, SJ Tsai. Aberrant Expression of Leptin in Human Endometriotic Stromal Cells Is Induced by Elevated Levels of Hypoxia Inducible Factor-1. Am. J. Pathol. 2007 Feb; 170 (2): 590-8 Name changed from SJ Lin to SC Lin
43. SJ Tsai *,SJ Lin *, YM Cheng, HM Chen, and LYC Wing. Expression and functional analysis of pituitary tumor transforming gene-1 in uterine leiomyomas. J Clin Endocrinol Metab. 2005 Jun; 90(6):3715-23. *:Tsai SJ and SJ Lin contributed equally to this study.