Publications

• Wen, Z.-H., Chang, L., Yang, S.-N., Yu, C,-L., Tung, F.-Y., Kuo, H.-M., Lu, I.-C,. Wu, C.-Y., Shih, P.-C., Chen, W.-F, Chen, N.-F. The anti-angiogenic and anti-vasculogenic mimicry effects of GN25 in endothelial and glioma cells. Biochimica et Biophysica Acta (BBA)-Molecular Cell Research. 2024. https://doi.org/10.1016/j.bbamcr.2024.119799 (IF: 4.6, 74/313= 23.6% in Biochemistry & Molecular Biology)

• Chiang, Y.-C., Selvam P, Liu, Y.-X., Shih, P.-C., Chen, N.-F., Kuo, H.-M., Lin, H.-Y., Wen, Z.-H., Chen, W.-F. STAT3 phosphorylation inhibitor Bt354 exhibits anti-neoplastic activity in glioblastoma multiforme cells. Environmental Toxicology. 2024. https://doi.org/10.1002/tox.24178  (IF: 4.5, 16/94= 17.0% in Toxicology)

• Shih, P.-C., Naganuma, M., Tsuji G., Demizu, Y., Naito, M. Development of decoy oligonucleotide-warheaded chimeric molecules targeting STAT3. Bioorganic and Medicinal Chemistry. 2023. https://doi.org/10.1016/j.bmc.2023.117507 (IF: 3.5, 12/52 = 23.1% in Organic Chemistry)

• Shih, P.-C., Naganuma, M., Demizu, Y., Naito, M. Current status of oligonucleotide-based protein degraders. Pharmaceutics. 2023. https://doi.org/10.3390/pharmaceutics15030765 (IF: 5.4, 51/277= 18.2% in Pharmacology & Pharmacy)

• Wen, Z.-H.*, Kuo, H.-M.*, Shih, P.-C.*, Hsu, L.-C., Chuang, J. M.-J., Chen, N.-F., Sun, H.-W., Liu, H.-T., Sung, C.-S., Chen, W.-F. Isoaaptamine increases ROS levels causing autophagy and mitochondria-mediated apoptosis in glioblastoma multiforme cells. Biomedicine & Pharmacotherapy. 2023 https://doi.org/10.1016/j.biopha.2023.114359 (IF: 7.5, 23/277= 8.1% in Pharmacology & Pharmacy)

*The authors contributed equally.

• Mao, Y.-W., Lu, L.-P., Shih, P.-C., Hsiao, J.-F., Wu, V., Tsai, G. E. Ultrapure and potent tannic acid (UPPTA) is a novel inhibitor of D-amino acid oxidase to improve the N-methyl-D-aspartate function of CNS disorders. Phytomedicine Plus. 2023. https://doi.org/10.1016/j.phyplu.2022.100399 

• Hsu S.-Y., Wen, Z.-H., Shih, P.-C., Kuo, H.-M., Lin, S.-C., Liu, H.-T., Lee, Y.-H., Wang, Y.-J., Chen, W.-F., Chen, N.-F. Sinularin Induces Oxidative Stress-Mediated Apoptosis and Mitochondrial Dysfunction, and Inhibits Angiogenesis in Glioblastoma Cells. Antioxidants. 2022; https://doi.org/10.3390/antiox11081433  (IF: 7.0, 6/60 = 10% in Chemistry, Medicinal)

• Kuo, T.-J., Jean, Y.-H., Shih, P.-C., Cheng, S.-Y., Kuo, H.-M., Lee, Y.-T., Lai, Y.-C., Tseng, C.-C., Chen, W.-F., and Wen, Z.-H. Stellettin B Induces Autophagic Cell Death and Apoptosis through Endoplasmic Reticulum in Human Oral Cancer. International Journal of Molecular Sciences. 2022; https://doi.org/10.3390/ijms23158813 (IF: 5.6, 66/285 = 23% in Biochemistry & Molecular Biology)

• Shih, P.-C.*, Mao, Y.-W.*, Hu, J.-W.*, Hsieh, H.-Y.*, Shih, T.-M.*, Lu, L.-P.*, Chang, W.-H.*, Huang, C.-H.*, Lin, C.-H.*, Lin, C.-H., Tan, P., Yang, Y.-C., Chien, M.-H., Su, C.-C., Ye, C.-H., Chuang, P.-Y., Hsieh, T.-L., Wang, C.-C., Hsieh, P.-S., Chou, T.-Y., Tsai, G. E. Development of the ultrapure and potent tannic acid as an orally bioavailable, pancoronal antiviral therapeutic. ACS Pharmacology & Translational Science. 2022; https://doi.org/10.1021/acsptsci.1c00264 (IF: 6.0, 25/366=6.8% in Pharmacology & Pharmacy) (被選為期刊封面、臨床試驗NCT04911777的臨床前數據發表)

*The authors contributed equally.

• Shih, P.-C.# The role of the STAT3 signaling transduction pathways in radioresistance. Pharmacology & Therapeutics. 2022; https://doi.org/10.1016/j.pharmthera.2022.108118 (IF: 13.5, 7/277=2.3% in Pharmacology & Pharmacy)

#First author and corresponding author.

• Chen, Y.-P.*, Shih, P.-C.*, Feng, C.-W., Wu, C.-C., Tsui, K.-H., Lin, Y.-H., Kuo, H.-M., and Wen, Z.-H. Pardaxin activates excessive mitophagy and mitochondria-mediated apoptosis in human ovarian cancer by inducing reactive oxygen species. Antioxidants. 2021; https://doi.org/10.3390/antiox10121883 (IF: 7.0, 6/60 = 10% in Chemistry, Medicinal) 

*The authors contributed equally.

• Lin, C.-H., Shih, P.-C., Tsai, G. E. Perspective Chapter: NMDA Treatments for CNS Disorders under the book title Ketamine Revisited - New Insights into NMDA Inhibitors. IntechOpen. 2021

• Ko, C.-Y.*, Shih, P.-C.*, Huang, P.-W., Lee, Y.-H., Chen, Y.-F., Tai M.-H., Liu, C.-H., Wen, Z.-H., Kuo, H.-M. Sinularin, an anti-cancer agent causing mitochondria-modulated apoptosis and cytoskeleton disruption in human hepatocellular carcinoma. International Journal of Molecular Sciences. 2021; https://doi.org/10.3390/ijms22083946 (IF: 5.6, 66/285 = 23% in Biochemistry & Molecular Biology) 

*The authors contributed equally.

• Shih, P.-C.#, Mei, K.-C. Role of STAT3 signaling transduction pathways in cancer stem cell-associated chemoresistance. Drug Discovery Today. 2021; https://doi.org/10.1016/j.drudis.2020.11.032   (IF: 7.4, 24/277= 8.5 % in Pharmacology & Pharmacy)  

#First author and corresponding author.

• Yuan, C.-H.*, Ma, Y.-L.*, Shih, P.-C.*, Chen, C.-T., Cheng, S.-Y., Pan, C.-Y., Jean, Y.-H., Chu, Y.-M., Lin, S.-C, Lai, Y,-C., Kuo, H,-M. The antimicrobial peptide tilapia piscidin 3 induces mitochondria-modulated intrinsic apoptosis of osteosarcoma cells. Biochemical Pharmacology. 2020;. doi: 10.1016/j.bcp.2020.114064 (IF: 5.8, 40/277 = 14.3% in Pharmacology & Pharmacy)  

*The authors contributed equally.

• Chen, Y.-F.*, Shih, P.-C.*, Kuo, H.-M.*, Yang, S.-N., Lin, Y.-Y., Chen, W.-F., Tzou, S.-J., Liu, H.-T., Chen, N.-F. TP3, an antimicrobial peptide, inhibits infiltration and motility of glioblastoma cells via modulating the tumor microenvironment. Cancer Medicine. 2020;. doi: 10.1002/cam4.3005 (IF: 4.0, 96/241 = 39.6% in Oncology)

*The authors contributed equally.

• Shih, P.-C.# Revisiting the development of small molecular inhibitors that directly target the signal transducer and activator of transcription 3 (STAT3) domains. Life Sciences. 2019; doi: 10.1016/j.lfs.2019.117241 (IF: 6.1, 35/277 = 12.5% in Pharmacology & Pharmacy) 

#First author and corresponding author.

• Shih, P.-C., Yang, Y., Parkinson, G. N., Wilderspin, A. & Wells, G. A high-throughput fluorescence polarization assay for discovering inhibitors targeting the DNA-binding domain of signal transducer and activator of transcription 3 (STAT3). Oncotarget. 2018; doi: 10.18632/oncotarget.26013