1-People

Former Lab Members

Postdoctoral Fellow

Liping Bai, PhD (2012-2014): Professor @Chinese Academy of Medical Sciences & Peking Union Medical College, China

Yunfeng Lin, PhD

Graduate Students

(8) Md. Akram Hossain (2016-2021): PhD. Graduate School Summer Fellowship (2019 & 2020)

Publications:

(a) Hossain MA¶, Lin Y#, Yan S*. 2018. SSB end resection in genome stability: mechanism and regulation by APE2. International Journal of Molecular Sciences. 19 (8): 2389.  (PMCID: PMC6122073; PMID:30110897) DOI: https://doi.org/10.3390/ijms19082389

(b) Lin Y§,#, Raj J§,‡, Li J#, Ha A¶, Hossain MA¶, Richardson C, Mukherjee P, Yan S*. 2020. APE1 senses DNA single-strand breaks for repair and signaling. Nucleic Acids Research. 48(4):1925-1940 (PMCID: PMC7038996; PMID: 31828326; Epub ahead of print) DOI: https://doi.org/10.1093/nar/gkz1175

(c) Lin Y§,#, Bai L§,#, Cupello S¶, Hossain MA¶, Deem B¶, McLeod M¶, Raj J‡, Yan S*. 2018. APE2 promotes DNA damage response pathway from a single-strand break. Nucleic Acids Research. 46 (5): 2479-2494. (PMCID: PMC5861430; PMID: 29361157) DOI: https://doi.org/10.1093/nar/gky020

(7) Anh Ha (2018-2020): M.S.,

Publications:

(a) Ha A¶, Lin Y#, and Yan S*. 2020. A non-canonical role for the DNA glycosylase NEIL3 in suppressing APE1 endonuclease-mediated ssDNA damage. Journal of Biological Chemistry (online ahead of print August 14, 2020). 295 (41): 14222-14235. (PMCID: PMC7549043; PMID: 32817342) DOI: https://doi.org/10.1074/jbc.RA120.014228

(b) Lin Y§,#, Raj J§,‡, Li J#, Ha A¶, Hossain MA¶, Richardson C, Mukherjee P, Yan S*. 2020. APE1 senses DNA single-strand breaks for repair and signaling. Nucleic Acids Research. 48(4):1925-1940 (PMCID: PMC7038996; PMID: 31828326; Epub ahead of print) DOI: https://doi.org/10.1093/nar/gkz1175

(c)  Lin Y#, Ha Anh¶‡, Yan S*. 2019. Methods for studying DNA single-strand break repair and signaling in Xenopus egg extracts. Methods in Molecular Biology: DNA Repair Methods and Protocols.  1999: 161-172. (PMCID: PMC6550457; PMID: 31127575) (Balakrishnan and Stewart eds). DOI: https://doi.org/10.1007/978-1-4939-9500-4_9

(6) Steven Cupello (2014-2019): PhD. Graduate School Summer Fellowship

Publications:

(a) Cupello S¶, Lin Y#, Yan S*. 2019. Distinct roles of XRCC1 in genome integrity in Xenopus egg extracts. Biochemical Journal. (PMID: 31808793; Epub ahead of print) DOI: https://doi.org/10.1042/BCJ20190798

(b) Lin Y§,#, Bai L§,#, Cupello S¶, Hossain MA¶, Deem B¶, McLeod M¶, Raj J‡, Yan S*. 2018. APE2 promotes DNA damage response pathway from a single-strand break. Nucleic Acids Research. 46 (5): 2479-2494. (PMCID: PMC5861430; PMID: 29361157) DOI: https://doi.org/10.1093/nar/gky020

(c) Cupello S¶, Richardson C, and Yan S*. 2016. Cell-free Xenopus egg extracts for studying DNA damage response pathways. International Journal of Developmental Biology. 60 (7-8-9): 229-236. (PMCID: PMC5071109; PMID: 27160070) DOI: http://dx.doi.org/10.1387/ijdb.160113sy

(5) Melissa McLeod (2014-2016): M.S.. The 2018 Graduate School Outstanding M.S. Thesis Award

Publications:

(a) DeStephanis D§,¶, McLeod M§,¶, Yan S*. 2015. REV1 is important for the ATR-Chk1 DNA damage response pathway in Xenopus egg extracts. Biochemical and Biophysical Research Communications. 460 (3): 609-615.(PMCID: PMC4426025; PMID: 25800873) DOI: http://dx.doi.org/10.1016/j.bbrc.2015.03.077

(b) Lin Y§,#, Bai L§,#, Cupello S¶, Hossain MA¶, Deem B¶, McLeod M¶, Raj J‡, Yan S*. 2018. APE2 promotes DNA damage response pathway from a single-strand break. Nucleic Acids Research. 46 (5): 2479-2494. (PMCID: PMC5861430; PMID: 29361157) DOI: https://doi.org/10.1093/nar/gky020

(4) Bradley Deem (2014-2015): M.S. transfer to non-thesis track

Publications:

(a) Lin Y§,#, Bai L§,#, Cupello S¶, Hossain MA¶, Deem B¶, McLeod M¶, Raj J‡, Yan S*. 2018. APE2 promotes DNA damage response pathway from a single-strand break. Nucleic Acids Research. 46 (5): 2479-2494. (PMCID: PMC5861430; PMID: 29361157) DOI: https://doi.org/10.1093/nar/gky020

(3) Zachary Berman  (2013-2015): M.S. student.

Publications:

(a) Wallace BD§, Berman Z§, ¶,, Mueller GA, Lin Y#, Chang T, Andres SN, Wojtaszek JL, DeRose EF, Appel CD, London RE, Yan S*, Williams RS*. 2017.  APE2 Zf-GRF facilitates 3′-5′ resection of DNA damage following oxidative stress. Proceedings of the National Academy of Sciences of the United States of America. 114 (2): 304-309. (PMCID: PMC5240719; PMID: 28028224) DOI: 10.1073/pnas.1610011114

(b) Yan S*, Sorrell M, Berman Z¶. 2014. Functional interplay between ATM/ATR-mediated DNA damage response and DNA repair pathways in oxidative stress. Cellular and Molecular Life Sciences. 71 (20): 3951-3967. (PMCID: PMC4176976; PMID: 24947324) DOI: http://dx.doi.org/10.1007/s00018-014-1666-4

(2) Jeremy Willis (2011-2013): M.S.

Publications:

(a) Willis J§,¶, Patel Y§,‡, Lentz B ‡,  Yan S*. 2013. APE2 is required for ATR-Chk1 checkpoint activation in response to oxidative stress. Proceedings of the National Academy of Sciences of the United States of America. 110 (26): 10592-10597. (PMCID: PMC3696815; PMID: 23754435).  DOI: http://dx.doi.org/10.1073/pnas.1301445110

(b) Yan S*, Willis J¶. 2013. WD40-repeat protein WDR18 collaborates with TopBP1 to facilitate DNA damage checkpoint signaling. Biochemical and Biophysical Research Communications. 431 (2): 466-471. (PMCID: PMC3577970; PMID: 23333389). DOI: http://dx.doi.org/10.1016/j.bbrc.2012.12.144

(c) Willis J§,¶, DeStephanis D§,¶, Patel Y‡, Gowda V‡, Yan S*.2012. Study of the DNA damage checkpoint using Xenopus egg extracts. Journal of Visualized Experiments. (69): e4449. (PMCID: PMC3514051; PMID: 23149695). DOI: http://dx.doi.org/10.3791/4449

(1) Darla DeStephanis (2010-2013): M.S.

Publications:

(a) DeStephanis D§,¶, McLeod M§,¶, Yan S*. 2015. REV1 is important for the ATR-Chk1 DNA damage response pathway in Xenopus egg extracts. Biochemical and Biophysical Research Communications. 460 (3): 609-615.(PMCID: PMC4426025; PMID: 25800873) DOI: http://dx.doi.org/10.1016/j.bbrc.2015.03.077

(b) Willis J§,¶, DeStephanis D§,¶, Patel Y‡, Gowda V‡, Yan S*.2012. Study of the DNA damage checkpoint using Xenopus egg extracts. Journal of Visualized Experiments. (69): e4449. (PMCID: PMC3514051; PMID: 23149695). DOI: http://dx.doi.org/10.3791/4449

Undergraduate Students

(24) Amogh Bandekar: Levine Scholar

(23) Brianna Bush: Charlotte Research Scholar

(22) Kyleigh Payne: OUR Scholar

(21) Naya Kayali (2020-2021):

(20) Amit Thota (2020): Charlotte Research Scholar

(19) Adam Dignan (2019): Charlotte Research Scholar

(18) Emily Floyd (2018-2019):

(17) Katherine Jensen (2017-2018): Charlotte Research Scholar, ANSWER Scholar

(16) Anh Ha (2016-2018): NSF REU Fellow

(15) Mary Tess Overton (2015-2018): Barry Goldwater Scholar, NSF REU Fellow

(14) Victoria Fitts (2016): NSF REU Fellow, undergraduate student from Santa Fe College

(13) Jude Raj (2013-2016): NSF REU Fellow, Honors student

(12) Dafe Omerhi (2015-2016):

(11) Krystal Carmichael (2014-2015): Charlotte Research Scholar, Honors student

(10) Harleen Kaur (2013-2014): 

(9)  Peyman “Alex” Gharavizadeh (2014):

(8)  Jagat Patel (2013):

(7)  Alexa R. Campbell (2013): undergraduate student from UNC-Chapel Hill

(6)  James Hooper (2012):

(5)  Mallorie Hartmann (2012-2013):

(4)  Mohammad Ahmad (2012): 

(3)  Yogin Patel (2011-2012): Honors student

(2)  Barry Lentz (2011): Honors student

(1)  Vrushab Gowda (2010-2012): Levine Scholar

Post-Bac student

(1) John Curtis Dukes (2011):

High School Students

Vijay Rachakonda