The initial premise of the series was to examine what superheroes would be like "in a credible, real world". As the story became more complex, Moore said Watchmen became about "power and about the idea of the superman manifest within society."[67] The title of the series refers to the question "Who will watch the watchmen themselves?", famously posed by the Roman satirist Juvenal (as "Quis custodiet ipsos custodes?"), although Moore was not aware of the phrase's classical origins until Harlan Ellison informed him.[68] Moore commented in 1987, "In the context of Watchmen, that fits. 'They're watching out for us, who's watching out for them?'"[30] The writer stated in the introduction to the Graffiti hardcover of Watchmen that while writing the series he was able to purge himself of his nostalgia for superheroes, and instead he found an interest in real human beings.[28]
Roadway workers in a roadway work group who foul any track outside of working limits shall be given warning of approaching trains by one or more watchmen/lookouts in accordance with the following provisions:
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Three human figures wearing high hats are often carved at the very top of Haida poles. In the past, Haida watchmen were posted at strategic positions around a village to raise the alarm in advance of an approaching enemy.
From May to October the program has provided seasonal employment for Haida men and women as young as 16 and as old as 78. For many visitors, meeting the watchmen is their favourite part of a memorable trip to Haida village sites.
Sirtuins (SIRT1-7) are a family of nicotine adenine dinucleotide (NAD+)-dependent enzymes that catalyze post-translational modifications of proteins. Together, they regulate crucial cellular functions and are traditionally associated with aging and longevity. Dysregulation of sirtuins plays an important role in major diseases, including cancer and metabolic, cardiac, and neurodegerative diseases. They are extensively regulated in response to a wide range of stimuli, including nutritional and metabolic challenges, inflammatory signals or hypoxic and oxidative stress. Each sirtuin is regulated individually in a tissue- and cell-specific manner. The control of sirtuin expression involves all the major points of regulation, including transcriptional and post-translational mechanisms and microRNAs. Collectively, these mechanisms control the protein levels, localization, and enzymatic activity of sirtuins. In many cases, the regulators of sirtuin expression are also their substrates, which lead to formation of intricate regulatory networks and extensive feedback loops. In this review, we highlight the mechanisms mediating the physiologic and pathologic regulation of sirtuin expression and activity. We also discuss the consequences of this regulation on sirtuin function and cellular physiology.-Buler, M., Andersson, U., Hakkola, J. Who watches the watchmen? Regulation of the expression and activity of sirtuins. be457b7860
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