Publications

Generation of an inducible dCas9-SAM human PSC line for endogenous gene activation. Petazzi P, Gutierrez-Agüera F, Roca-Ho H, Castaño J, Bueno C, Alvarez N, Forrester LM, Sevilla A, Fidanza A, Menendez P. Front Cell Dev Biol. 2024 Nov 29;12:1484955. doi: 10.3389/fcell.2024.1484955. eCollection 2024. PMID: 39676795; Free PMC article.

Current Advances in Photodynamic Therapy (PDT) and the Future Potential of PDT-Combinatorial Cancer Therapies. Alvarez N, Sevilla A. Molecular Sciences. 2024 Jan 13;25(2), 1023. doi: 10.3390/ijms25021023. PMID: 37190034; Free PMC article.

Preclinical Studies with Glioblastoma Brain Organoid Co-Cultures Show Efficient 5-ALA Photodynamic Therapy. Pedrosa L, Bedia C, Diao D, Mosteiro A, Ferrés A, Stanzani E, Martínez-Soler F, Tortosa A, Pineda E, Aldecoa I, Centellas M, Muñoz-Tudurí M, Sevilla A, Sierra À, González Sánchez JJ. Cells. 2023 Apr 10;12(8):1125. doi: 10.3390/cells12081125. PMID: 37190034; Free PMC article.

ABO gene editing for the conversion of blood type A to universal type O in Rhnull donor-derived human-induced pluripotent stem cells. Petazzi P, Miquel-Serra L, Huertas S, González C, Boto N, Muñiz-Diaz E, Menéndez P, Sevilla A, Nogués N. Clin Transl Med. 2022 Oct;12(10):e1063. doi: 10.1002/ctm2.1063. PMID: 36281739; Free PMC article. 

Esrrb Regulates Specific Feed-Forward Loops to Transit From Pluripotency Into Early Stages of Differentiation. Mazloom AR, Xu H, Reig-Palou J, Vasileva A, Román AC, Mulero-Navarro S, Lemischka IR, Sevilla A. Front Cell Dev Biol. 2022 May 16;10:820255. doi: 10.3389/fcell.2022.820255. eCollection 2022. Free PMC article.

An Esrrb and Nanog Cell Fate Regulatory Module Controlled by Feed Forward Loop Interactions. Sevilla A, Papatsenko D, Mazloom AR, Xu H, Vasileva A, Unwin RD, LeRoy G, Chen EY, Garrett-Bakelman FE, Lee DF, Trinite B, Webb RL, Wang Z, Su J, Gingold J, Melnick A, Garcia BA, Whetton AD, MacArthur BD, Ma'ayan A, Lemischka IR. Front Cell Dev Biol. 2021 Mar 19;9:630067. doi: 10.3389/fcell.2021.630067. eCollection 2021. Free PMC article.

CRISPR/Cas9-Mediated Gene Knockout and Knockin Human iPSCs. Petazzi P, Menéndez P, Sevilla A. Methods Mol Biol. 2020 Nov 15. doi: 10.1007/7651_2020_337. Online ahead of print. PMID: 33190185

Glia Crosstalk in Neuroinflammatory Diseases. Bernaus A, Blanco S, Sevilla A.Front Cell Neurosci. 2020 Jul 29;14:209. doi: 10.3389/fncel.2020.00209. eCollection 2020.PMID: 32848613 Free PMC article.

 Pre- and peri-implantation Zika virus infection impairs fetal development by targeting trophectoderm cells.Tan L, Lacko LA, Zhou T, Tomoiaga D, Hurtado R, Zhang T, Sevilla A, Zhong A, Mason CE, Noggle S, Evans T, Stuhlmann H, Schwartz RE, Chen S. Nat Commun. 2019 Sep 13;10(1):4155. doi: 10.1038/s41467-019-12063-2.PMID: 31519912 Free PMC article.

 Post-transcriptional regulation by cytosine-5 methylation of RNA. García-Vílchez R, Sevilla A, Blanco S. Biochim Biophys Acta Gene Regul Mech. 2019 Mar;1862(3):240-252. doi: 10.1016/j.bbagrm.2018.12.003. Epub 2018 Dec 27.PMID: 30593929 Review.

 Derivation and characterization of the NIH registry human stem cell line NYSCF101 under defined feeder-free conditions. Sevilla A, Forero E, Zimmer M, Martinez H, Reggio K, Paull D, Egli D, Noggle S.Stem Cell Res. 2018 May;29:197-201. doi: 10.1016/j.scr.2018.04.017. Epub 2018 Apr 30.PMID: 29730569 Free article.

 Derivation and characterization of the NIH registry human stem cell line NYSCF100 line under defined feeder-free conditions. Sevilla A, Forero E, Zimmer M, Martinez H, Reggio K, Paull D, Egli D, Noggle S.Stem Cell Res. 2018 May;29:99-102. doi: 10.1016/j.scr.2018.03.017. Epub 2018 Mar 31.PMID: 29631040 Free article.

 Derivation and characterization of the NYSCFe003-A human embryonic stem cell line. Sevilla A, Forero E, Zimmer M, Martinez H, Reggio K, Paull D, Egli D, Noggle S.Stem Cell Res. 2017 Dec;25:217-220. doi: 10.1016/j.scr.2017.10.017. Epub 2017 Nov 21.PMID: 29161648 Free article.

 The silver lining of induced pluripotent stem cell variation.Fossati V, Jain T, Sevilla A.Stem Cell Investig. 2016 Dec 6;3:86. doi: 10.21037/sci.2016.11.16. eCollection 2016.PMID: 28066788 Free PMC article.

 Myeloid Dysregulation in a Human Induced Pluripotent Stem Cell Model of PTPN11-Associated Juvenile Myelomonocytic Leukemia. Mulero-Navarro S, Sevilla A, Roman AC, Lee DF, D'Souza SL, Pardo S, Riess I, Su J, Cohen N, Schaniel C, Rodriguez NA, Baccarini A, Brown BD, Cavé H, Caye A, Strullu M, Yalcin S, Park CY, Dhandapany PS, Yongchao G, Edelmann L, Bahieg S, Raynal P, Flex E, Tartaglia M, Moore KA, Lemischka IR, Gelb BD.Cell Rep. 2015 Oct 20;13(3):504-515. doi: 10.1016/j.celrep.2015.09.019. Epub 2015 Oct 8.PMID: 26456833 Free PMC article.

 Automated, high-throughput derivation, characterization and differentiation of induced pluripotent stem cells. Paull D, Sevilla A, Zhou H, Hahn AK, Kim H, Napolitano C, Tsankov A, Shang L, Krumholz K, Jagadeesan P, Woodard CM, Sun B, Vilboux T, Zimmer M, Forero E, Moroziewicz DN, Martinez H, Malicdan MC, Weiss KA, Vensand LB, Dusenberry CR, Polus H, Sy KT, Kahler DJ, Gahl WA, Solomon SL, Chang S, Meissner A, Eggan K, Noggle SA.Nat Methods. 2015 Sep;12(9):885-92. doi: 10.1038/nmeth.3507. Epub 2015 Aug 3.PMID: 26237226

 Construction and validation of a regulatory network for pluripotency and self-renewal of mouse embryonic stem cells. Xu H, Ang YS, Sevilla A, Lemischka IR, Ma'ayan A.PLoS Comput Biol. 2014 Aug 14;10(8):e1003777. doi: 10.1371/journal.pcbi.1003777. eCollection 2014 Aug.PMID: 25122140 Free PMC article.

 Post-translational modifications of the histone variant H2AZ.Sevilla A, Binda O.Stem Cell Res. 2014 Jan;12(1):289-95. doi: 10.1016/j.scr.2013.11.004. Epub 2013 Nov 15.PMID: 24316985 Free PMC article. Review. No abstract available.

 Patterning pluripotency in embryonic stem cells.Zhang YS, Sevilla A, Wan LQ, Lemischka IR, Vunjak-Novakovic G.Stem Cells. 2013 Sep;31(9):1806-15. doi: 10.1002/stem.1468.PMID: 23843329 Free PMC article.

 SETD6 monomethylates H2AZ on lysine 7 and is required for the maintenance of embryonic stem cell self-renewal. Binda O, Sevilla A, LeRoy G, Lemischka IR, Garcia BA, Richard S.Epigenetics. 2013 Feb;8(2):177-83. doi: 10.4161/epi.23416. Epub 2013 Jan 16.PMID: 23324626 Free PMC article.

 Nanog-dependent feedback loops regulate murine embryonic stem cell heterogeneity. MacArthur BD, Sevilla A, Lenz M, Müller FJ, Schuldt BM, Schuppert AA, Ridden SJ, Stumpf PS, Fidalgo M, Ma'ayan A, Wang J, Lemischka IR.Nat Cell Biol. 2012 Nov;14(11):1139-47. doi: 10.1038/ncb2603. Epub 2012 Oct 28.PMID: 23103910 Free PMC article.

 Regulation of embryonic and induced pluripotency by aurora kinase-p53 signaling.Lee DF, Su J, Ang YS, Carvajal-Vergara X, Mulero-Navarro S, Pereira CF, Gingold J, Wang HL, Zhao R, Sevilla A, Darr H, Williamson AJ, Chang B, Niu X, Aguilo F, Flores ER, Sher YP, Hung MC, Whetton AD, Gelb BD, Moore KA, Snoeck HW, Ma'ayan A, Schaniel C, Lemischka IR.Cell Stem Cell. 2012 Aug 3;11(2):179-94. doi: 10.1016/j.stem.2012.05.020.PMID: 22862944 Free PMC article.

 Vaccinia-related kinase 1 (VRK1) is an upstream nucleosomal kinase required for the assembly of 53BP1 foci in response to ionizing radiation-induced DNA damage. Sanz-García M, Monsalve DM, Sevilla A, Lazo PA.J Biol Chem. 2012 Jul 6;287(28):23757-68. doi: 10.1074/jbc.M112.353102. Epub 2012 May 22.PMID: 22621922 Free PMC article.

 Combining competition assays with genetic complementation strategies to dissect mouse embryonic stem cell self-renewal and pluripotency. Lee DF, Su J, Sevilla A, Gingold J, Schaniel C, Lemischka IR.Nat Protoc. 2012 Mar 22;7(4):729-48. doi: 10.1038/nprot.2012.018.PMID: 22441292

 Prdm16 is a physiologic regulator of hematopoietic stem cells. Aguilo F, Avagyan S, Labar A, Sevilla A, Lee DF, Kumar P, Lemischka IR, Zhou BY, Snoeck HW.Blood. 2011 May 12;117(19):5057-66. doi: 10.1182/blood-2010-08-300145. Epub 2011 Feb 22.PMID: 21343612 Free PMC article.

 Patient-specific induced pluripotent stem-cell-derived models of LEOPARD syndrome.Carvajal-Vergara X, Sevilla A, D'Souza SL, Ang YS, Schaniel C, Lee DF, Yang L, Kaplan AD, Adler ED, Rozov R, Ge Y, Cohen N, Edelmann LJ, Chang B, Waghray A, Su J, Pardo S, Lichtenbelt KD, Tartaglia M, Gelb BD, Lemischka IR.Nature. 2010 Jun 10;465(7299):808-12. doi: 10.1038/nature09005.PMID: 20535210 Free PMC article.

 Comprehensive analysis of lymph node stroma-expressed Ig superfamily members reveals redundant and nonredundant roles for ICAM-1, ICAM-2, and VCAM-1 in lymphocyte homing. Boscacci RT, Pfeiffer F, Gollmer K, Sevilla AI, Martin AM, Soriano SF, Natale D, Henrickson S, von Andrian UH, Fukui Y, Mellado M, Deutsch U, Engelhardt B, Stein JV.Blood. 2010 Aug 12;116(6):915-25. doi: 10.1182/blood-2009-11-254334. Epub 2010 Apr 15.PMID: 20395417 Free PMC article.

 Identification of a dominant epitope in human vaccinia-related kinase 1 (VRK1) and detection of different intracellular subpopulations. Valbuena A, López-Sánchez I, Vega FM, Sevilla A, Sanz-García M, Blanco S, Lazo PA.Arch Biochem Biophys. 2007 Sep 1;465(1):219-26. doi: 10.1016/j.abb.2007.06.005. Epub 2007 Jun 14.PMID: 17617371

Vaccinia virus B1R kinase interacts with JIP1 and modulates c-Jun-dependent signaling. Santos CR, Blanco S, Sevilla A, Lazo PA.J Virol. 2006 Aug;80(15):7667-75. doi: 10.1128/JVI.00967-06.PMID: 16840345 Free PMC article.

 VRK1 signaling pathway in the context of the proliferation phenotype in head and neck squamous cell carcinoma. Santos CR, Rodríguez-Pinilla M, Vega FM, Rodríguez-Peralto JL, Blanco S, Sevilla A, Valbuena A, Hernández T, van Wijnen AJ, Li F, de Alava E, Sánchez-Céspedes M, Lazo PA.Mol Cancer Res. 2006 Mar;4(3):177-85. doi: 10.1158/1541-7786.MCR-05-0212.PMID: 16547155 Free article.

 p53 Stabilization and accumulation induced by human vaccinia-related kinase 1. Vega FM, Sevilla A, Lazo PA.Mol Cell Biol. 2004 Dec;24(23):10366-80. doi: 10.1128/MCB.24.23.10366-10380.2004.PMID: 15542844 Free PMC article.

 c-Jun phosphorylation by the human vaccinia-related kinase 1 (VRK1) and its cooperation with the N-terminal kinase of c-Jun (JNK). Sevilla A, Santos CR, Barcia R, Vega FM, Lazo PA.Oncogene. 2004 Nov 25;23(55):8950-8. doi: 10.1038/sj.onc.1208015.PMID: 15378002 Free article.

 Microbial contamination of carcasses, meat, and equipment from an Iberian pork cutting plant. Palá TR, Sevilla A.J Food Prot. 2004 Aug;67(8):1624-9. doi: 10.4315/0362-028x-67.8.1624.PMID: 15330525

 Human vaccinia-related kinase 1 (VRK1) activates the ATF2 transcriptional activity by novel phosphorylation on Thr-73 and Ser-62 and cooperates with JNK. Sevilla A, Santos CR, Vega FM, Lazo PA.J Biol Chem. 2004 Jun 25;279(26):27458-65. doi: 10.1074/jbc.M401009200. Epub 2004 Apr 21.PMID: 15105425 Free article.