From walking across uneven ground to reaching for a cup of coffee, everyday behaviour depends on precise communication between the brain and spinal cord. Most behaviours are remarkably reliable, yet they must remain flexible enough to respond to an ever-changing world - whether walking across ice instead of pavement, navigating a crowded vs an empty room, or choosing one action over an another. Yet we still understand remarkably little about how distributed neural circuits integrate these diverse influences to generate adaptive behaviour. Our laboratory combines systems neuroscience, quantitative behavioural phenotyping, neural circuit analysis and molecular approaches to understand the neural circuit mechanisms underlying adaptive behaviour and how they are disrupted in neurological disease.