Senescence, a gradual age-specific decline in contribution to fitness, has been observed across taxa. However, the onset and rates of senescence differ among species, populations and individuals. Variation in senescence patterns can arise due to different life-history strategies or differing resource allocation trade-offs, and currently, one key challenge is to quantify and explain such differences. Moreover, the mechanisms that underlie senescence patterns still remain understudied, yet they are crucial to increase our understanding of how differences in senescence patterns arise. Examples of underlying mechanisms are oxidative stress or telomere dynamics, which have been successfully related to key life-history traits such as reproduction and lifespan. Both telomere shortening –the progressive attrition of the protective ends of eukaryotic chromosomes with successive cellular division– and oxidative stress –the unbalance between antioxidants and pro-oxidants resulting from cellular metabolism– are highly conserved processes, thus highlighting their relevance and contribution to long-standing questions in ageing biology and evolutionary ecology. The study of other mechanisms as potential mediators of senescence, such as mitochondrial function or epigenetic processes (i.e. DNA methylation and epigenetic clock) is in its infant stage, but on the rise as a promising avenue for senescence research. There is a distinct lack of experimental studies exploring the link between these established and candidate mechanisms but scientific meetings such as the proposed one provide the ideal scenario to (i) share the most recent advances on the above-mentioned fields, (ii) enhance fruitful interdisciplinary collaborations that will result in relevant scientific publications and (iii) create an environment for the interaction between senior and early career researchers from different nationalities and institutions, leading to future collaborations.