Members

Career

• Apr 2024 – present   Associate Professor, Dept. of Biomedical Science, Chubu University

• Jun 2022 – present   Visiting Researcher, Institute of Advanced Research, Nagoya University

• Dec 2021 – present   Concurrent Faculty, Center for AI, Mathematical and Data Sciences, Chubu University

• Apr 2022 – Mar 2024   Senior Assistant Professor, Dept. of Biomedical Science, Chubu University

• Nov 2017 – Mar 2022   Assistant Professor, Dept. of Biomedical Science, Chubu University

• Apr 2015 – Oct 2017   JSPS Research Fellow (PD), Dept. of Physics, Graduate School of Science, The University of Tokyo

• Nov 2012 – Mar 2015   Research Assistant, Faculty of Science and Engineering, Waseda University

Education

• Apr 2012 – Mar 2015   Graduate School of Advanced Science and Engineering, Waseda University — Physics & Applied Physics (Doctoral)   Ph.D. (Science)

• Apr 2010 – Mar 2012   Graduate School of Advanced Science and Engineering, Waseda University — Physics & Applied Physics (Master’s)   M.Sc. (Science)

• Apr 2006 – Mar 2010   School of Science and Engineering, Waseda University — Dept. of Applied Physics   B.Eng.

Research Focus

How do living systems reconcile “order” with “chaos,” and how can these principles inspire next‑generation bio‑medical technologies?

• Physics of Sarcomere Chaos (Chaordic Homeodynamics)
  Using high‑precision tools such as our proprietary SL‑nanometry, we dissect high‑speed autonomous oscillations (HSOs) of cardiac sarcomeres and the concept of periodic chaotic homeostasis. We propose that a delicate cooperation between periodicity and chaos underlies heartbeat robustness and unveils new mechanisms of arrhythmia.

• Visualization of Muscle‑Wave Dynamics & Engineering Applications
  By revealing Z‑line oscillations and “hole” dynamics (muscle‑wave propagation with phase jumps) as novel topological/wave indicators, we guide the design of bio‑motors and biomaterials and develop diagnostics for muscle‑function deterioration.

• Fusion of AI with Ultra‑High‑Speed Imaging
  Through “AI nanometry”—deep learning integrated with physical modeling—and the construction of self‑driving laboratories, we perform real‑time molecular‑level analysis from >1,000 fps movies. Emphasizing transparency and explainability, we practice and expand the AI2L (AI to Learn) guideline.

• Multiscale Muscle Biomechanics & Device Development
  Combining real‑time electron microscopy, advanced optical microscopy, and opto‑thermal manipulation, we build a seamless mechanics platform spanning molecules → cells → tissues → whole‑heart beating. While grounded in fundamental science, we also target applications in regenerative medicine, materials science, and sports science.

• researchmap (English) : https://researchmap.jp/Seine_A_Shintani?lang=en

• University profile English : https://research-db.chubu.ac.jp/chbhp/KgApp/k03/resid/S002311?lang=en

Message
“We explore the ‘life‑likeness’ that lies between order and chaos through the crossover of physics, engineering, and AI. If our work interests you, feel free to contact us!”

• E‑mail: s‑shintani[at]fsc.chubu.ac.jp (replace [at] with @)

Graduate Students

S. T. "Probing homeochaos in cardiac sarcomeres: Development of a high‑resolution real‑time controlled microscopy system"

Senior Undergraduates (B4, Graduation Research 2025)

N. I. "Sarcomere dynamics in flash‑frozen cardiomyocytes analyzed by cryo‑electron microscopy"

A. Y. "Building a local SLM environment for learning support"

Alumni

March 2025

S. T. "Probing homeochaos in cardiac sarcomeres: Development of a high‑resolution real‑time controlled microscopy system (Master’s interim presentation)"

March 2024

M. K. "Mechanical and chemical properties of polyimide films for live‑electron‑microscopy applications"

K. M. "Glass‑formation reaction of TEOS studied by real‑time Raman spectroscopic microscopy"

O. N. "Utilization and effects of large language AI models in learning support for biomedical science"

March 2023

S. T. "Homology analysis of sarcomere dynamics in cardiac muscle"

Y. T. "Development of real‑time Raman spectroscopic microscopy"

March 2022

Y. Y. "Preclinical diagnostics for chronic diseases: Non‑invasive measurement of heart rate and respiration"

Y. M. "Preclinical diagnostics for chronic diseases: Resonance Raman scattering analysis of blood"

K. H. "Locally‑globally coupled autonomous oscillator model reproducing mechanical properties of striated muscle"

March 2021

I. C. "Development of in‑liquid electron‑microscopy for pre‑disease diagnosis"

March 2020

Y. Y. "Live‑imaging methods to clarify hierarchical structure–function relationships in cardiac muscle"

March 2019

H. M. "Relationship between sarcomere structure and oscillatory ability revealed by contraction‑vibration analysis of pressurized myofibrils"