MCF-7/AdrVp is a multidrug-resistant human breast cancer subline that displays an ATP-dependent reduction in the intracellular accumulation of anthracycline anticancer drugs in the absence of overexpression of known multidrug resistance transporters such as P glycoprotein or the multidrug resistance protein. RNA fingerprinting led to the identification of a 2.4-kb mRNA that is overexpressed in MCF-7/AdrVp cells relative to parental MCF-7 cells. The mRNA encodes a 655-aa [corrected] member of the ATP-binding cassette superfamily of transporters that we term breast cancer resistance protein (BCRP). Enforced expression of the full-length BCRP cDNA in MCF-7 breast cancer cells confers resistance to mitoxantrone, doxorubicin, and daunorubicin, reduces daunorubicin accumulation and retention, and causes an ATP-dependent enhancement of the efflux of rhodamine 123 in the cloned transfected cells. BCRP is a xenobiotic transporter that appears to play a major role in the multidrug resistance phenotype of MCF-7/AdrVp human breast cancer cells.

Stem cells from bone marrow, skeletal muscle and possibly other tissues can be identified by the 'side-population' (SP) phenotype. Although it has been assumed that expression of ABC transporters is responsible for this phenotype, the specific molecules involved have not been defined. Here we show that expression of the Bcrp1 (also known as Abcg2 murine/ABCG2 human) gene is a conserved feature of stem cells from a wide variety of sources. Bcrp1 mRNA was expressed at high levels in primitive murine hematopoietic stem cells, and was sharply downregulated with differentiation. Enforced expression of the ABCG2 cDNA directly conferred the SP phenotype to bone-marrow cells and caused a reduction in maturing progeny both in vitro and in transplantation-based assays. These results show that expression of the Bcrp1/ABCG2 gene is an important determinant of the SP phenotype, and that it might serve as a marker for stem cells from various sources.

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A transporter that engages in transportation of hazardous waste must apply for a transporter license to cover all locations of the business, all conveyances owned, leased or otherwise controlled by the business and used for transportation of hazardous waste which are located or used in Maine and all operators of such conveyances employed by the business which operates in Maine. Any person who transports hazardous waste in the State of Maine in any quantity is considered a transporter. The term includes, without limitation, individuals who own, lease or otherwise control conveyances, and businesses regardless of the size and form of business organization, which engage in transportation of hazardous waste.

Hazardous wastes are subject to regulation according to the provisions of 38 M.R.S., Chapter 13, Maine Hazardous Waste, Septage and Solid Waste Management Act and Department Rule, Chapter 853, Licensing of Transporters of Hazardous Waste. The rule requires transporters of hazardous waste be licensed and to comply with standards intended to protect the health, safety and welfare of the public and the environment.

The supplemental hazardous waste transporter forms (drivers and conveyances) are for use by licensed transporters to add drivers and conveyances to existing licenses. There is a fee of fifty ($50.00) dollars per additional conveyance or driver added to a license. In order to obtain a complete application for a new or renewal license please call the Hazardous Waste Licensing Unit (207) 287-7688.

In California, unless specifically exempted, it is unlawful for any person to transport hazardous wastes unless the person holds a valid registration issued by DTSC. A hazardous waste transporter registration is valid for one year and is assigned a unique registration number. The following reports provide information about registered hazardous waste transporters. DTSC does not endorse or recommend any particular company.

The following is a list of registered biomedical waste transporters registered with the Florida Department of Health. The list is organized by county of registration; however, some companies often service multiple counties. This list also contains trauma scene clean-up providers. If you are in need of a registered biomedical waste transporter and there is not one listed in your county, contact the transporters in the surrounding areas.

Should you wish to validate the registration of a transporter not contained on this list or request to place your company on this list, please contact the Florida Department of Health Biomedical Waste Program.

Under the E-Cycle Washington program, transporters are entities that transport covered electronic products from collection sites to processors for recycling. To receive compensation, you are required to register with us, meet performance standards, and be listed as "in compliance" on the transporter registration list.

Transporters must register with us in order to be eligible to receive compensation from a covered electronic product recycling plan for transporting covered electronic products (televisions, computers, laptops, and monitors). To be approved to transport covered electronic products for a plan, a transporter must:

Generators of greater than 50 pounds of untreated medical waste who intend to self-transport and transporters of other generators' untreated medical waste must obtain a registration. Click on the sections below for more information about each topic.

Hazardous waste transporters are individuals or entities that move hazardous waste from one site to another by highway, rail, water, or air. This includes transporting hazardous waste from a generator's site to a facility that can recycle, treat, store, or dispose of the waste. It can also include transporting treated hazardous waste to a site for further treatment or disposal.

North Carolina hazardous waste transporter and transfer facility requirements can be found at 40 CFR 263, adopted by reference at 15A NCAC 13A .0108. The requirements include (but are not limited to): notifying the Hazardous Waste Section and obtaining a EPA identification number (electronically using RCRAInfo); accepting only hazardous waste that are listed on a manifest; compliance with the hazardous waste manifest procedures; delivering the hazardous waste to the facility (or alternate) designated on the manifest or the next designated transporter; and, keeping a copy of the signed manifest for three years after the date of acceptance by the transporter. In the event of a spill hazardous waste during transportation a transporter must take immediate actions necessary to protect human health and the environment.

Additional state requirements for North Carolina hazardous waste transfer facilities can be found at NCGS 130A-295.05. In North Carolina, a hazardous waste transfer facility is a facility or location where a hazardous waste transporter stores hazardous waste for a period of more than 24 hours but less than 10 days (NCGS 130A-290(13a)). A North Carolina hazardous waste transfer facility must submit specific registration forms. Find additional information and forms associated with North Carolina hazardous waste transfer facilities.

Riboflavin transporter deficiency (RTD), comprising RTD2 and RTD3 (caused by biallelic pathogenic variants in SLC52A2 and SLC52A3, respectively) is a rare neurologic condition characterized by progressive peripheral and cranial neuronopathy that causes muscle weakness (and consequent respiratory compromise), vision loss, deafness, and sensory ataxia. Onset is usually in infancy or in childhood; however, on occasion individuals with genetically confirmed RTD present as adults and even as late as the fifth decade. When untreated, most infants with riboflavin transporter deficiency rapidly become ventilator dependent and die in the first decade of life.

Because oral riboflavin supplementation is effective (and possibly lifesaving), it should begin as soon as a riboflavin transporter deficiency is suspected and continued lifelong unless molecular genetic testing fails to identify biallelic pathogenic variants in either SLC52A2 or SLC52A3.

Riboflavin transporter deficiency (RTD), comprising RTD2 and RTD3 (caused by biallelic pathogenic variants in SLC52A2 and SLC52A3, respectively) is a well-defined phenotypic continuum of motor, sensory, and cranial nerve neuronopathy that encompasses the previously recognized phenotypes Brown-Vialetto-Van Laere (BVVL) syndrome and Fazio-Londe syndrome [Green et al 2010, Johnson et al 2010, Johnson et al 2012, Foley et al 2014].

Riboflavin transporter deficiency 2 (RTD2) and riboflavin transporter deficiency 3 (RTD3)should be suspected in individuals with the following clinical, neurophysiologic, brain MRI, and laboratory findings.

As soon as riboflavin transporter deficiency is suspected, begin oral riboflavin supplementation, an effective (and possibly lifesaving) treatment, and continue it lifelong unless molecular genetic testing fails to identify biallelic pathogenic variants in either SLC52A2 or SLC52A3.

The diagnosis of riboflavin transporter deficiency (RTD) is established in a proband with suggestive clinical, neurophysiologic, neuroimaging, and laboratory findings and biallelic pathogenic (or likely pathogenic) variants in either SLC52A2 (RTD2) or SLC52A3 (RTD3) on molecular genetic testing (Table 1).

Riboflavin transporter deficiency 2 (caused by biallelic SLC52A2 pathogenic variants) and riboflavin transporter deficiency 3 (caused by biallelic SLC52A3 pathogenic variants) are clinically characterized by motor neuropathy, sensory neuropathy, and cranial neuronopathy [Bandettini Di Poggio et al 2014, Foley et al 2014, Manole et al 2014]. Motor neuropathy manifests as proximal and distal limb weakness (often with severe distal wasting and breathing problems due to paralysis of the diaphragm), sensory neuropathy as gait ataxia, and cranial neuronopathy as optic atrophy, sensorineural hearing loss, and bulbar palsy. be457b7860

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