Sateesh Dubbu
About me
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Education and Professional Experience
Education and Professional Experience
Postdoctoral Researcher, University of Illinois Urbana-Champaign, USA (Oct 2023 - Present). LINK
Senior Scientist-I, Sygnature Discovery, United Kingdom. (Jan 2023 – Sept 2023). LINK
Research Associate, Institut National de la Recherche Scientifique (INRS), Canada. (Oct 2022 – Dec 2022). LINK
Postdoctoral Researcher, Universität Basel, Switzerland. (April 2021 – Sept 2022). LINK
Research Associate: Pohang University of Science and Technology, South Korea (Mar 2019 - Nov 2020). LINK
Ph.D. in Organic/Medicinal Chemistry, Indian Institute of Technology Kanpur, India (Jan 2014 - Jun 2019). LINK
Master of Science, in Chemistry, Andhra University, India (Jun 2010 - May 2012).
Bachelor in Chemistry, Sri Krishnadevaraya University, India (Jun 2007 – May 2010).
List of Publications
List of Publications
Diversity-Oriented Synthesis of Carbohydrate Scaffolds through the Prins Cyclization of Differently Protected D-Mannitol-Derived Homoallylic Alcohols Dubbu, S., D. Vankar. Y. D*
Eur. J. Org. Chem. 2017, 5986–6002. LINK
A Cascade of Prins Reaction and Pinacol-Type Rearangement: Access to 2,3-Dideoxy-3C-Formyl β-C-Aryl/Alkyl Furanosides and 2-Deoxy-2C-Branched β-C-Aryl Furanoside” Dubbu. S., Bardhan. A., C. Ande, Vankar. Y. D*
Eur. J. Org. Chem. 2018, 6800–6808. LINK
Silica Jar-with-Lid as Chemo-Enzymatic Nano-Compartment for Enantioselective Synthesis inside Living Cells Kim. S., Kumari. N., Lim. J., Dubbu. S., Kumar. A., Lee I. S.*
Angew. Chem. Int. Ed. 2021, 60, 16337−16342. LINK
Nanocatalosomes as Plasmonic Bilayer Shells with Interlayer Catalytic Nanospaces for Solar-Light-Induced Reactions Kumar. A., Kumari. N., Dubbu. S., Kumar. S., Kwon. T., Koo. J. H., J. Lim, Kim. I. Cho. Y.-K., Rho. J., Lee I. S.*
Angew. Chem. Int. Ed. 2020, 132, 9547–9556. LINK
Reaction of 1,2-Anhydrosugars with Arynes: An Approach to 1,2-Dihydrobenzofuran-Fused-C-Aryl Glycosides and C2-O-Phenolic Glycals Dubbu. S., Vankar. Y. D*
Eur. J. Org. Chem. 2018, 5060–5064. LINK
Atomically Conformal Metal Laminations on Plasmonic Nanocrystals for Efficient Catalysis Acharya. A., Dubbu. S., Kumar. S., Kumari. N, Kim. Y., So. S., Kwon T., Wang. Z., Park. J., Cho. Y.-K., Rho. J., Oh. S. H., Kumar. A., Lee I. S.*
J. Am. Chem. Soc. 2021, 143, 10582−10589. LINK
Highly Mesoporous Metal-Organic Frameworks as Synergistic Multimodal Catalytic Platforms for Divergent Cascade Reactions Dutta. S., Kumari. N., Dubbu. S., Kumar. A., Ohtsu. H., Kim, J. Cho. S. H., Kawano. M., Lee. I. S.*
Angew. Chem. Int. Ed. 2020, 132, 3444 –3450. LINK
Stereoselective Synthesis of Sugar-Fused 1,2-Annulated Isochromans and Isochromanones by Using the Oxa-Pictet-Spengler Reaction” Verma, A. K., C. Ande, Dubbu. S., Vankar. Y. D*
Org. Biomol. Chem. 2018, 16, 6880–6884. LINK
AuCl3-AgOTf promoted -O-Glycosylation using Anomeric Sulfoxides as Glycosyl Donors at Room Temperature Palanivel A., C. Ande, Dubbu. S., Mallick. A., Vankar. Y. D*
Carbohydr. Res. 2017, 437, 43–49. LINK
Stereoselective Synthesis of 1,2-Annulated Sugars Having Substituted Tetrahydropyran/(-furan) Scaffolds Using Prins Reaction C. Ande., Dubbu. S., Parasuraman. K., Vankar. Y. D*
Eur. J. Org. Chem. 2018, 6706–6713. LINK
A Stereoselective Synthesis of an Imino Glycal: Application in the Synthesis of (-)-1-epi-Adenophorine and a Homoiminosugar C. Ande., Dahiya. A., Dubbu. S., Vankar. Y. D*
Eur. J. Org. Chem. 2018, 6574–6581. LINK
Stereoselective Synthesis of 2-Deoxy- β-C-Aryl/Alkyl Glycosides by Using Prins Cyclization: Application towards Synthesis of Differently Protected 2-Deoxy-β-C-Aryl Glycosides Dubbu. S., C. Ande., Verma, A. K., Vankar. Y. D*
Carbohydr. Res. 2018, 468, 64–68. LINK
Stereoselective Synthesis of 1,2-Annulated-C-Aryl Glycosides from Carbohydrate-Derived Terminally Unsubstituted Dienes and Arynes: Application towards Synthesis of Sugar-Fused- or Branched- Naphthalenes, and C-Aryl Glycosides Dubbu. S., Verma, A. K., Vankar. Y. D*
Carbohydr. Res. 2018, 465, 29–34. LINK
Synthesis of 1,2-Annulated Aryl Glycosides Highlighted in
Synfacts 2018, 14, 1130. LINK
Synthesis of Di- and Tri hydroxy Proline Derivatives from D-Glycals: Application in the Synthesis of Polysubstituted Pyrrolizidines and Bioactive 1C-Aryl/Alkyl Pyrrolidines Verma, A. K., Dubbu. S., C. Ande., Vankar. Y. D*
Carbohydr. Res. 2019, 475, 48–52. LINK
Palladium Catalyzed Synthesis of Sugar-Fused Indolines via C(sp2)–H/N–H Activation Verma, A. K., C. Ande., Dubbu. S., Vankar. Y. D*
Carbohydr. Res. 2019, 473, 57–65. LINK
Stereoselective Synthesis of Substituted 1,2-Annulated Sugars by Domino Double-Michael Addition Reaction Parasuraman. K., C. Ande., Dubbu. S., Vankar. Y. D*
Carbohydr. Res. 2019, 477, 26–31. LINK
Magnetothermia-Induced Catalytic Hollow Nanoreactor for Bioorthogonal Organic Synthesis in Living Cells Jihwan Lee,† Dubbu. S., Kumari. N., Kumar. A., Lee I. S.*
Nano Lett. 2020, 20, 6981–6988. († equally contributed). LINK
Surface-Textured Mixed-Metal-Oxide Nanocrystals as Efficient Catalysts for ROS Production and Biofilm Eradication Kumari.N, Kumar. S., Karmacharya. M., Dubbu. S., Kwon T., Singh. V., Chae K. H., Kumar. A., Cho Y.-K.,* Lee I. S.* Nano Lett. 2021, 21, 279−287. LINK
Carbohydrate-Derived Dienes as Building Blocks for Pharmaceutically Relevant Molecules Dubbu. S.,* Santhi J., Hevey. R.*
Helv. Chim. Acta 2022, 105, e202200135. LINK
Versatile Applications of 3-OxoGlycals: A review Dubbu. S.*
Carbohydr. Res. 2024, 536, 109016. LINK
Advancing Carbohydrate Functionality: The role of Hypervalent Iodine Upadhyaya. K.,* Dubbu. S.* Carbohydr. Res. 2024, 542, 109175. LINK
Advancements in Carbohydrate Scaffold Synthesis: Exploring Prins Cyclization Methodology Dubbu. S.,* Santhi J. Reactions 2025, 6, 3. LINK
SKILLS & ABILITIES
My research interests lie at the interface of synthetic organic chemistry, medicinal chemistry, process development, and chemical biology, with a strong focus on the design and synthesis of bioactive molecules, complex glycoconjugates, and novel catalytic methodologies.
Synthetic Organic Chemistry: Design, synthesis and efficient reaction setup, purification, complete characterization and structural elucidation and crystallization techniques.
Organometallics: Glove box, air and moisture sensitive Schlenk line techniques on milligram scale with highly reactive organometallics. Experienced in multi-step synthesis and preparation of intermediates on milligram to multigram (1 KG scale).Improved the overall product yield and purity of intermediates and drugs through reaction optimization.Developed hands-on experience in microwave-assisted reactions.
Biology/Bioconjugation: ELISA, SPR, BCA assay for protein concentration determination. Plate Reader, Antibody internalization assay. Conjugation of various chelators to proteins (BSA, HSA), monoclonal antibodies and their purification, analysis by Nanodrop.
Spectroscopy: Hands on experience with Biotage, HRMS, GC, GC-MS, LC-MS, MALDI-TOF, UV/VIS, FTICR, ¹H NMR, ¹³C NMR, ¹⁹F NMR, ³¹P NMR, 2D NMR Mass, Fluorescence, Phosphorescence, cyclic voltammetry, elemental analysis and TEM studies. Analysis and purification of bioconjugates using Size Exclusion Chromatography.
Software: MS Word, Excel, PowerPoint, MestReNova, ChemDraw, Chem3D, EndNote, Varian NMR, Scifinder, Reaxys, Topspin, ACD Labs, StatDOE (STATS Edge), Photoshop, MS-office, Adobe illustrator, Discovery studio, Molegro Virtual Docker, Origin, Topspin.
Miscellaneous: Meticulous and detailed Electronic lab notebook (ELN) documentation. Communication: English and Telugu.
LEADERSHIP & OUTREACH
Led CRO projects at Sygnature Discovery, optimizing methods and mentoring team members.
Mentored students in lab techniques and research, guiding them through thesis completion.
Reviewed over 130 publications for top-tier journals.
Contributed as editorial board member (American Journal of Heterocyclic Chemistry). LINK
Working an ACS-Young Chemist Committee (YCC) Illinois social media coordinator. LINK
Working as a ACS-East Central Illinois webmaster. LINK
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