Is Cardarine is Miracle Drug with A Catch?

Cardarine, otherwise known as GW-501516, is a research chemical called a PPAR receptor agonist. Often mistakenly lumped to the SARMs class, cardarine has been considered greatly as an alternative for treating disorders such as high cholesterol and other metabolic-related problems like obesity and diabetes.

But despite being an apparent "miracle drug," cardarine has since become a topic of controversy due to findings of a potential link to the development and progression of cancer and liver damage, casting doubt on its therapeutic advantages.

What Is Cardarine?

To know what cardarine is, you need to understand what it isn't. While most people lump cardarine to the course of SARMs, this chemical compound isn't a SARM but instead a PPARδ (delta) receptor agonist (1).

It is important to differentiate this reality because cardarine's primary influence on the entire body is in opposition to a lot of SARMs. Cardarine's influence is often catabolic in that it stimulates fat oxidation although many SARMs are used exclusively for anabolic purposes, such as building muscle and strength.

PPAR Receptor Agonists

Peroxisome Proliferator-Activator Receptor agonists (PPAR) influence cells in an identical manner as SARMs. PPAR receptors are deemed nuclear receptors because they're within cells and influence what happens within the nucleus, triggering certain changes inside the cell and throughout the entire body as a whole.

When a PPAR receptor agonist such as cardarine is used, this chemical diffuses into the cytoplasm, or interstitial fluid of different cells depending upon the particular tissue that the agonist targets. Upon entering the cytoplasm, cardarine docks onto PPARδ receptors. When it does, this receptor starts specific gene transcription within the nucleus. This gene transcription then accomplishes some events in the body (5).

Possible Benefits Of Cardarine

Depending on the current research available, it's clear that cardarine is a compound that provides benefits linked to enhancing body composition. By specifically targeting and binding with the PPARδ receptor, cardarine includes a significant influence on the cells utilize and metabolize energy, specifically from fat sources.

As a result of having this degree of influence over metabolism, you will find many specific benefits that cardarine affords, worth mentioning.

• Insulin Sensitivity & Glucose Tolerance

Among the more attractive characteristics of cardarine is that it is a potent PPAR receptor agonist, so it favorably influences how our bodies metabolize and use glucose as well as other energy resources such as fat. But what’s most important here is the ability of this chemical to improve glucose tolerance and insulin sensitivity.

You have probably heard of insulin sensitivity before because it is a favorite subject. And fairly so, since insulin sensitivity plays a role in metabolic health and also influences the growth of disease such as diabetes.

In ordinary, insulin-sensitive individuals, insulin acts, as it should. When you eat carbohydrates (and also a protein), these carbohydrates are metabolized into glucose, a simple sugar. This sugar passes the blood, and insulin aids shuttle this sugar from the blood and into tissues and organs that can use it as muscle and the liver, which holds onto sugar for times of low food consumption (7).

Summary: Cardarine enhances glucose disposal and insulin sensitivity, which might prove useful for preventing the growth of obesity and diabetes.

• Complete & LDL Cholesterol

High cholesterol, although often overstated, is an issue that plagues many. The CDC reports that nearly 29 million Americans have cholesterol levels that would be considered high and at risk for the development of the cardiovascular-related disorder (12).

In the world of cholesterol, there are two chief categories to worry about.

-- LDL (low-density lipoprotein) and in particular, VLDL (very Low-density lipoprotein) is traditionally thought to be "bad cholesterol," because these molecules often collect in blood vessels, causing a blockage which may lead to a heart attack or stroke.

-- HDL (high-density lipoprotein), on the other hand, does the reverse. HDL particles help to transport the low-density particles for removal and recycling. Together, it's apparent that maintaining a greater level of HDL cholesterol particles is optimal.

Research about cardarine and cholesterol treatment does show a guarantee.

• Endurance Exercise Performance

Among the more fascinating advantages of cardarine is its influence on athletic performance and its ability to alter how your muscles function.

Amazingly, animal research on cardarine shows that using regular management, this chemical can modify the makeup of current muscle fibers and possibly even induce hyperplasia; the generation of entirely new muscle fibers.

This is meaningful because hardly any evidence exists about hyperplasia, especially in humans, and could have serious consequences for muscle wasting diseases as well as other muscle-related ailments (16).

This research tells us is that triggering the PPARδ Receptor initiates a change within cells. Multiple studies have revealed that when cardarine is administered, fibers that traditionally display glycolytic properties begin to act similar to that of oxidative fibers (16, 17, 18).

Summary: Research indicates that cardarine management initiates a shift in glycolytic muscle fibers to display features associated with oxidative fibers. This may be significant for people seeking to increase performance during endurance-related activities.

Adverse Side Effects Of Cardarine

Among the more attractive characteristics of SARMs and PPAR receptor agonists are that they are typically non-androgenic and also target particular tissues. This means that side effects are usually restricted rather than acute, and in the case of cardarine, this is typically correct. Largely, users of cardarine do not report any acute, undesirable side effects.

However, cardarine does come with two glaring issues, which many are quick to dismiss: the potential for cancer and liver damage.

• Possible For Cancer Development & Progression

Current evidence concerning cardarine and cancer development is conflicting. On the flip side, some studies indicate that cardarine administration might help treat cancer. For instance, one study revealed that cardarine administration reduced markers of inflammation in pancreatic cancer cells, which might prove useful for restricting tumor cell growth (20).

Additionally, other research suggests that cardarine may be useful for stimulating endothelial cell proliferation and angiogenesis, which is the generation of new blood vessels. On the flip side, this can prove useful for the treatment and prevention of coronary disease but on the other, this could be further signs of cancer possible.

• Liver Damage

Research on cardarine concerning liver health is also damaging. Studies on this chemical have shown a rise in profibrogenic (harmful) growth factors, which causes higher liver damage (24).

Summary: Clinical trials testing cardarine were left as a result of the development of cancer in animal issues. The possibility for these findings to translate to humans is unknown. Further, other research indicates that cardarine could exacerbate liver damage due to the unchecked proliferation of satellite cells and an elevation of pro-inflammatory signaling.

Overview Of Factors For Cardarine

• Might Be Useful For Avoiding Obesity and Metabolic Disease

Research on cardarine has always confirmed that this Chemical sets the stage for optimum metabolic health. Increased insulin sensitivity, enhanced glucose tolerance, and improved fat oxidation is normal findings of these studies alluding to the reality that cardarine might be useful for treating metabolic-related ailments.

• Might Help Improve Cholesterol Profiles

Studies on cardarine consistently reveal an elevation of HDL or “good” cholesterol particles though simultaneously reducing the amount of LDL or “bad” cholesterol present, making cardarine a good option for regulating cholesterol.

• Strong

Arguably the most important piece of information here is that cardarine was associated with cancer growth and progression. So much so that additional study on the drug was abandoned. It's strongly advised you contemplate this before using this chemical.

• Dosing

Human trials examining cardarine used dosages ranging from 2.5 mg to 10 mg. The influence of dosing concerning cancer and liver damage is presently unknown in human inhabitants (4).

Verdict

Cardarine does indeed show promise for several ailments, specifically, those related to metabolic health. It's apparent that cardarine preferentially stimulates a shift in the body to metabolize fat, which might prove useful in the treatment of obesity and the prevention of metabolic-related disease.

Research on cardarine does suggest other positive influences like an improvement in total and HDL cholesterol as well as improved aerobic athletic performance.

However, the potential for cancer growth and progression is extremely serious and should be the first consideration. While cardarine does indeed offer many positive advantages, the capacity for cancer growth appears to overshadow any possible advantage. We at SARMs Pharm, provide the best quality SARMs at the best price. We also recommend that you should consult a doctor before using any SARMs.