Chromatin and Disease Biology Lab

Publications

1. Bhagat PN, Jadhav SH, Chattopadhyay S, Paknikar KM. (2018) Carbon nanospheres mediated nuclear delivery of SMAR1 protein (DNA binding domain) controls breast tumor in mice model Nanomedicine.
2. Mirlekar B, Gautam D, Chattopadhyay S. (2017) Chromatin Remodeling Protein SMAR1 Is a Critical Regulator of T Helper Cell Differentiation and Inflammatory Diseases. Frontiers in Immunology.
3. Patel S, Choksi A, Pant R, Alam A and Chattopadhyay S. (2017) Nutritional programming of metabolic syndrome: Role of nutrients in shaping the epigenetics. A Handbook of nutrition, diet and epigenetics. Springer International Publishing AG 2017. DOI 10.1007/978-3-319-31143-2_42-1
4. Paul D, Ghorai S., Chattopadhyay S., Dinesh US, Shetty P and Santra MK (2017) Cdc20 directs proteasome-mediated degradation of the tumor suppressor SMAR1 in higher grades of cancer through the anaphase promoting complex. Cell Death and Disease.
5. Sengupta P, Chattopadhyay S, Chatterjee S., (2017) G-Quadruplex surveillance in BCL-2 gene: a promising therapeutic intervention in cancer treatment. Drug Discovery.
6. Ramu V, Aute S, Taye N, Guha R, Walker MG, Mogare D, Parulekar A, Thomas JA, Chattopadhyay S and Das A. (2017) Photo-induced cytotoxicity and anti-metastaticactivity of ruthenium(II)–polypyridyl complexesQ1 functionalized with tyrosine or tryptophan. Dalton Transaction.
7. Chatterjee B, Banoth B, Mukherjee T, Taye N, Vijayaragavan B, Chattopadhyay S, Gomes J, Basak S. (2016) Late-phase synthesis of IκBα insulates the TLR4-activated canonical NF-κB pathway from noncanonical NF-κB signaling in macrophages. Science Signaling.
8. Agarwalla H, Mahajan PS, Sahu D, Taye N, Bishwajit Ganguly B, Mhaske SB, Chattopadhyay S, Das A. (2016) A Switch-On NIR Probe for Specific Detection of Hg2+ Ion in Aqueous Medium and in Mitochondria. Inorganic Chemistry.
9. Anila HA, Ali F, Kushwaha SA, Taye N, Chattopadhyay S, Das A. (2016) A Cysteine Specific Fluorescent Switch for Monitoring Oxidative Stress and Quantification of Aminoacylase-1 in Blood Serum. Analytical Chemistry.
10. Mathai J, Mittal SP, Alam A, Ranade P, Mogare D, Patel S, Saxena S, Ghorai S, Kulkarni AP, and Chattopadhyay S. (2016) SMAR1 binds to T(C/G) repeat and inhibits tumor progression by regulating miR-371-373 cluster. Scientific Reports.
11. Pal S, Vadde R, Taye N , Mogare DG, Yeware AM, Sarkar D, Reddy DS, Chattopadhyay S, Das A.(2016) GSH Induced Controlled Release of Levofloxacin form a Purpose-built Prodrug: Luminescence Response for Probing the Drug Release in E-coli and Staphylococcus aureus. Bioconjugate Chemistry.
12. Chemmannur SV, Bhagat P, Mirlekar B, Paknikar KM and Chattopadhyay S. (2016) Carbon Nanosphere mediated delivery of nuclear matrix protein SMAR1 to direct experimental autoimmune encephalomyelitis in mice. International Journal of Nanomedicine.
13. Ali F, A AH, Taye N, Mogare DG, Chattopadhyay S and Das A. (2016) Specific receptor for hydrazine: mapping the in situ release of hydrazine in live cells and in an in vitro enzymatic assay. Chemical Communications.
14. Nakka KK, Chaudhary N, Joshi S, Bhat J, Singh K, Chatterjee S, Malhotra R, De A, Santra MK, Dilworth J and Chattopadhyay S. (2015) Nuclear matrix-associated protein SMAR1 regulates alternative splicing via HDAC6-mediated deacetylation of Sam68. Proceedings of National Academy of Sciences, USA.
15. Mirlekar B., Ghorai S., Khetmalas M., Bopanna R and Chattopadhyay S. (2015) Nuclear Matrix Protein SMAR1 control regulatory T cell fate during Inflammatory Bowel Disease (IBD). Mucosal Immunology (NPG).
16. Chemmannur SV, Badhwar AJ, Mirlekar B, Malonia SK., Gupta M, Wadhwa N, Bopanna R, Mabalirajan U, Majumdar S, Ghosh B and Chattopadhyay S (2015) Nuclear matrix binding protein SMAR1 regulates T cell differentiation and allergic airway disease. Mucosal Imunology.
17. Khan D, Katoch A, Das A, Sharathchandra A, Lal R, Roy P, Das S, Chattopadhyay S and Das S (2015) Reversible induction of translational isoforms of p53 in glucose-deprivation. Cell Death and Differentiation.
18. Mirlekar B, Patil S, Bopanna R and Chattopadhyay S. (2015) MAR binding protein SMAR1 favors IL-10 mediated regulatory T cell function in acute colitis. Biochemical and Biophysical Research Communication.
19. Khan D., Chattopadhyay S. and Das S. (2015) Influence of metabolic stress on translation of p53 isoforms. Molecular and Cellular Oncology.
20. Yadav B, Malonia SK, Majumdar SS, Gupta P, Wadhwa N, Badhwar A, Gupta UD, Katoch VM and Chattopadhyay S (2015) Constitutive expression of SMAR1 confers susceptibility to Mycobacterium tuberculosis infection in a transgenic mice model. Indian Journal of Medical Research.
21. Reddy U G, Firoj Ali, Taye N, Chattopadhyay S and Das A (2015). A new turn on Pd2+-specific fluorescence probe and its use as an Imaging reagent for cellular uptake in Hct116 cells. Chemical Communications.
22. Chaudhary N, Nakka K K, Pavithra L, Bhat J, Chatterjee S and Chattopadhyay S (2014) SMAR1 coordinates HDAC6-induced deacetylation of Ku70 and dictates cell fate upon irradiation. Cell Death and Disease.
23. Malonia SK., Yadav B, Sinha S, Lazennec G and Chattopadhyay S (2014) Chromatin remodeling protein SMAR1 regulates NF-kB dependent Interleukin-8 (IL-8) transcription in breast cancer. The International Journal of Biochemistry & Cell Biology.
24. Mirlekar B, Majumdar S, Khetmalas M and Chattopadhyay S (2014) Regulation of T cell lineage commitment by SMAR1 during Inflammatory and Autoimmune Diseases. Indian Journal of Medical Research.
25. Reddy G U. , Ramu V., Roy S., Taye N., Chattopadhyay S. and Das A. (2014) Specific probe for Hg2+ to delineate even H+ in pure aqueous buffer / Hct116 colon cancer cells: Hg(II)-?2-arene p-interaction and a TBET-based fluorescence response. Chemical Communications.
26. Chemmannur S and Chattopadhyay S (2014) Role of nuclear matrix associated region (MAR) binding proteins in the regulation of T helper cell differentiation. Proceedings of Indian National Science Academy, June 2 issue, 2014.
27. G UR, Agarwalla H, Taye N, Ghorai S, Chattopadhyay S, Das A. (2014) A novel fluorescence probe for estimation of Cysteine/ Histidine in human blood plasma and recognition of endogenous Cysteine in live Hct116 cells. Chemical Communications Cambridge.
28. Patel S, Choksi A and Chattopadhyay S (2014) Understanding Inter-individual Epigenetic Variations in Obesity and its Management. Personalized Epigenetics , Book chapter, Elsevier publication.
29. Adhikary A, Chakraborty S, Mazumdar M, Ghosh S, Mukherjee S, Manna A, Mohanty S, Nakka KK, Joshi S, De A, Chattopadhyay S, Sa G, Das T. (2014) Inhibition of Epithelial to Mesenchymal transition by E-cadherin up-regulation via repression of Slug transcription and inhibition of E-cadherin degradation: Dual role of SMAR1 in breast cancer cells. Journal of Biological Chemistry.
30. Chakraborty S, Das K, Saha S, Mazumdar M, Manna A, Chakraborty S, Mukherjee S, Khan P, Adhikary A, Mohanty S, Chattopadhyay S, Biswas S, Sa G,Das T. (2014) Nuclear matrix protein SMAR1 represses c-Fos-mediated HPV18 E6 transcription through alteration of chromatin histone de-acetylation. Journal of Biological Chemistry.
31. Dhar A., Mallick S., Maiti A., Ghosh P.; Ahmed, I., Bhattacharyya S., Mandal T., Manna A., Singh S., Nayak D., Wilder, P., Markowitz, J., Weber D., Ghosh M., Chattopadhyay S., Guha, R., Konar A., Bandyopadhyay S. and Roy S. (2014) Simultaneous inhibition of key growth pathways in melanoma cells and tumor regression by a designed bidentate constrained helical peptide. Biopolymers.
32. Chakraborty S, Adhikary A, Mazumdar M, Mukherjee S, Bhattacharjee P, Guha D. Choudhuri T, Chattopadhyay S, Sa G, Sen A and Das T, (2014) Capsaicin-induced activation of p53-SMAR1 auto-regulatory loop down-regulates VEGF in non-small cell lung cancer to restrain angiogenesis. PLoS ONE, 13; 9 (6), 1-11.
33. Mittal S P., Kulkarni A. P., Mathai J., Chattopadhyay S. and Pal J. K. (2014) Dose-dependent differential response of mammalian cells to cytoplasmic stress is mediated through the heme-regulated eIF2a kinase. International Journal of Biochemistry and Cell Biology.
34. Mittal S. P, Mathai J, Kulkarni A P, Pal J. K. and Chattopadhyay S. (2013) miR-320a regulates erythroid differentiation through MAR binding protein SMAR1. International Journal of Biochemistry and Cell Biology.
35. Singh S, Raina V, Chavali P L, Dubash T, Kadreppa S, Parab P, Chattopadhyay S. (2012) Regulation of GAD65 expression by SMAR1 and p53 upon Streptozotocin treatment. BMC Molecular Biology
36. Chaudhary N., Nakka K K., Maulik N. and Chattopadhyay S., (2012) Epigenetic manifestation of metabolic syndrome and dietary management. Antioxidants & Redox Signaling
37. Sinha S, Malonia SK, Mittal P K S, Pal J K and Chattopadhyay S. (2012) Chromatin remodelling protein SMAR1 inhibits p53 dependent transactivation by regulating acetyl transferase p300. International Journal of Biochemistry and Cell Biology
38. Sen GS, Mohanty S, Hossain DM, Bhattacharyya S, Banerjee S, Chakraborty J, Saha S, Ray P, Bhattacharjee P, Mandal D, Bhattacharya A, Chattopadhyay S, Das T and Sa G. (2011) Curcumin enhances the efficacy of chemotherapy by tailoring p65 NFkB-p300 cross-talk in favor of p53-p300 in breast cancer. Journal of Biological Chemistry.
39. Malonia SK., SinhaS., Pavithra L., Singh K., Jalota-Badhwar A., Rampalli S.,Kaul-Ghanekar R. and Chattopadhyay S.,(2011) Gene regulation by SMAR1: Role in cellular homeostasis and cancer. BBA Reviews on Cancer.
40. Pavithra L, Chavali S. and Chattopadhyay S. (2010) Nutritional epigenetics- impact on metabolic syndrome. Review in book chapter on Molecular Mechanisms of Epigenetics. CRC Press.
41. Chattopadhay, S. Protein decides arrest or death. Nature News , doi:10.1038/ nindia.(2010).65; Published online, May 2010
42. Kopikar S., Choudhari A S., Kumari A., Chattopadhyay S. and Kaul-Ghanekar R. (2010), Aqueous cinnamon extract (ACE-c) from the bark of Cinnamomum cassia causes apoptosis in human cervical cancer cell line (SiHa) through loss of mitochondrial membrane potential. BMC Cancer.
43. Sreenath K., Pavithra L., Singh S, Sinha S, Raut S, Dash PK., Siddappa NB., Mangaiarkarasi A, Ranga UK, Mitra D. and Chattopadhyay S. (2010) Nuclear Matrix Protein SMAR1 Represses HIV-1 LTR Mediated Transcription through Chromatin Remodeling. Virology.
44. Sinha S, Malonia SK, Mittal SPK, Singh K, Kadreppa S, Kamat R., Mukhopadhyaya R., Pal JK and Chattopadhyay S. (2010) Coordinated regulation of p53 apoptotic targets BAX and PUMA by SMAR1 through an identical MAR element. EMBO Journal.
45. Pavithra L., Sreenath K., Singh S. and Chattopadhyay S,. (2010) Heat shock protein 70 binds to a novel sequence in 5\92 UTR of tumor suppressor SMAR1 and regulates its mRNA stability upon PGA2 treatment. FEBS Letters.
46. Singh S, Sreenath K, Pavithra L, Roy S, Chattopadhyay S. (2010), SMAR1 regulates free radical stress through modulation of AKR1a4 enzyme activity. International Journal of Biochemistry and Cell Biology.
47. Singh K., Sinha S, Malonia SK and Chattopadhyay S., (2010) Tumor Necrosis Factor alpha (TNFalpha) regulates CD40 expression through SMAR1 phosphorylation. Biochemical and Biophysical Research Communication.
48. Nakka K. and Chattopadhyay, S. (2009) Modulation of chromatin by MARs and MAR binding oncogenic transcription factor SMAR1. Molecular and Cellular Biochemistry.
49. Kaul-Ghanekar R., Singh S., Mamgain H., Jalota-Badhwar A., Paknikar K. M. and Chattopadhyay S. (2009) SMAR1, a phenotypic diagnostic marker for differentiation between cancerous and non-cancerous cells: combined AFM and SEM study. BMC Cancer.
50. Pavithra L., Mukherjee S. Kadreppa S., Kar S., Sakaguchi K., Roy S. and Chattopadhyay S., (2009) SMAR1 forms ternary complex with p53-MDM2 and negatively regulates p53 mediated transcription. Journal of Molecular Biology.
51. Singh V B, Pavithra L, Chattopadhyay S, Pal JK., (2009) Stress-induced overexpression of the heme-regulated eIF-2alpha kinase is regulated by Elk-1 activated through ERK pathway. Biochemical and Biophysical Research Communication.
52. Singh K, Sinha S, Malonia SK, Bist P, Tergaonkar V, Chattopadhyay S.(2009)Tumor suppressor SMAR1 represses IkBa expression and inhibits p65 transactivation through MARs. Journal of Biological Chemistry, 9; 284 (2):1267-78.
53. Pavithra L, Singh S, Sreenath K, Chattopadhyay S. (2009) Tumor suppressor SMAR1 downregulates Cytokeratin 8 expression by displacing p53 from its cognate site. International Journal of Biochemistry and Cell Biology. 41(4):862-71.
54. Bavikar SN, Salunke DB,Hazra BG, Pore VS, Dodd RH, Thierry J, Shirazi F, Deshpande MV, Kadreppa S, Chattopadhyay S. (2008), Synthesis of chimeric tetrapeptide-linked cholic acid derivatives: impending synergistic agents. Bioorganic & Medicinal Chemistry Letters, 18 (20):5512-7.
55. Vatmurge NS, Hazra BG, Pore VS, Shirazi F, Deshpande MV, Kadreppa S, Chattopadhyay S, Gonnade RG. Synthesis and biological evaluation of bile acid dimers linked with 1, 2, 3-triazole and bis-beta-lactam. Organic and Biomolecular Chemistry. 2008, Oct 21; 6(20):3823-30.
56. Pavithra L, Rampalli S, Sinha S., Sreenath K., Pestell R. G. and Chattopadhyay S. (2007) Stabilization of SMAR1 mRNA by PGA2 involves a stem loop structure in the 5 UTR. Nucleic Acids Research, 35:6004-6016.
57. Singh, K. Mogare, D. Ramprasad O. G., Rajinikanth G., Pande, G. and Chattopadhyay, S. (2007) p53 Target Gene SMAR1 is dysregulated in Breast Cancer: Its Role in Cancer Cell Migration and Invasion.PLoS-ONE, 2(8): e660.
58. Pavithra,L and Chattopadhyay, S. (2007) Chromatin and cancer: Reprogramming chaos in the cell. Natl. Acad. Sci. 30 (3&4), 71-82.
59. Jalota-Badhwar,A., Kaul-Ghanekar, R., Mogare, D., Boppana, R., Packnikar, K. M. and Chattopadhyay, S.(2007) SMAR1-derived P44 peptide retains its tumor suppressor function through modulation of p53. Journal of Biological Chemistry, 282(13): 9902-13.
60. Chattopadhyay S and Pavithra L. MARs and MARBPs: key modulators of gene regulation and disease manifestation. Chromatin and Disease: Book, Vol 41, Series: Subcellular Biochemistry,Edited by Kundu and Dasgupta, Springer, 2006.
61. Sarkar A, Kulkarni A, Chattopadhyay S, Mogare D, Sharma KK, Singh K, Pal JK. Lead-induced upregulation of the heme-regulated eukaryotic initiation factor 2alpha kinase is compromised by hemin in human K562 cells.Biochim Biophys Acta. 2005Dec 30; 1732(1-3):15-22. Epub 2005.
62. Rampalli,S., Pavithra, L., Bhatt A., Tapas K. Kundu and Chattopadhyay, S. Tumor suppressor SMAR1 mediates Cyclin D1 repression by recruitment of SIN3/HDAC1 complex. Molecular and Cellular Biology,2005. Vol. 25 October
63. Jalota A, Singh K, Pavithra L, Kaul R, Jameel S, Chattopadhyay S. (2005) Tumor suppressor SMAR1 activates and stabilizes p53 through its arginine-serine (RS) rich motif. Journal of Biological Chemistry, 280 (16), 16019-16029.
64. Kaul-Ghanekar,R., Majumdar, S., Jalota, A., Gulati, N., Dubey, N., Saha, B., Chattopadhyay, S. (2005) Abnormal V(D)J Recombination of T Cell Receptor {beta} Locus in SMAR1 Transgenic Mice. Journal of Biological Chemistry, 280 (10): 9450-9459.
65. Kulkarni, A, Ravi, D. S., Singh, K., Rampalli, S., Parekh, V., Mitra, D., Chattopadhyay, S. (2005) HIV-1 Tat modulates T-bet expression and induces Th1 type of immune response Biochemical and Biophysical Research Communication. 329 (2): 706-712.
66. Kaul-Ghanekar, R., Jalota, A., L. Pavithra, Tucker, P. and Chattopadhyay, S. (2004) SMAR1 and Cux/CDP modulate chromatin and act as negative regulators of the TCRb enhancer (Eb). Nucleic Acids Research, 32; 16: 4862-4875.
67. Kulkarni, A., Pavithra L, Rampalli, S., Mogare, D., Babu, K. Shiekh, G., Ghosh, S. and Chattopadhyay, S. (2004) HIV-1 integration sites are flanked by potential MARs that alone can act as promoters. Biochemical and Biophysical Research Communication, 322; 7672-77.
68. Rampalli, S., Kulkarni, A., Kumar, P., Mogare D., Galande, S., Mitra, D and Chattopadhyay, S. (2003) Stimulation of Tat independent transcriptional processivity from the HIV-1 LTR promoter by Matrix Attachment Regions. Nucleic Acids Research, 31, 3248-3256.
69. S. Chattopadhyay (2003) Anticancer protein identified, September issue 2003, Nature News, London,
70. Kaul, R., Mukherjee, S., Ahmed, F., Bhat, M. K., Chhipa, R., Galande, S. and Chattopadhyay, S. (2003) Direct interaction and activation of p53 by SMAR1 causes cell cycle arrest at G2/M phase and delays tumor growth in mice. International Journal of Cancer, 103 (5), 606-615 (Cover page picture from our lab).
71. Prasad, D. V., Parekh, V. V., Banerjee, P. P., Chattopadhyay, S., Kumar, A. and Mishra, G. C. (2002) the Th1-specific costimulatory molecule, m150, is a post-translational isoform of lysozyme-associated membrane protein-1. Journal of Immunology, 169 (4); 1801-9.
72. Sarkar, A., Chattopadhyay, S., Kaul, R. and Pal, J. K. (2002) Lead exposure and heat shock inhibit cell proliferation in human HeLa and K562 cells by inducing expression and activity of the heme-regulated eIF-2-aKinase. Journal of Biochemistry, Molecular Biology & Biophysics, 6, 391-396.
73. Chattopadhyay S., Kaul R., Charest A., Houseman, D. and Chen, J. SMAR1, a novel alternatively spliced gene product, binds to scaffold/ matrix associated region at TCRb locus. Genomics, 68, 93. 2000.
74. Whitehurst, C., Chattopadhyay, S. and Chen, J.(1999) Control of V(D)J recombinational accessibility of the Db1 gene segment at the TCRb locus by a germline promoter. Immunity, 10, 1-20.
75. Chattopadhyay, S., Whitehurst, C., E. and Chen, J. (1998)A nuclear matrix attachment region (MAR) upstream of the T cell receptor gene enhancer binds Cux/ CDP and SATB1 and functions to repress transcription. Journal of Biological Chemistry, 45, 29838-29846.
76. Chattopadhyay, S., Whitehurst, C., E., Schwenk, F. and Chen, J. (1998) Biochemical and functional analysis of chromatin changes of the T cell receptor ?gene locus during CD4-CD8- to CD4+CD8+ thymocyte differentiation. Journal of Immunology, 160, 1256-1267.
77. Das, A., Pal, M., Garcia, M. J., Crossley, R., Whalen, W., Wolska, K., Byrd, R. A., Court, D., Costantino, N., Mazzula, M., Rees, W., von Hippel, P., Chattopadhyay, S., DeVito, J. and Ghosh, B., (1996) Components of a multiprotein-RNA complex that controls transcription elongation in E. coli phage lambda. Methods in Enzymology, 274: pp 374-402.
78. Chattopadhyay, S., Hung, S. C., Das, A and Gottesman. M. E. (1995) Interaction between the phage HK022 Nun protein and the nut RNA of phage lambda. PNAS, USA, 92: pp12131-12135.
79. Chattopadhyay,S., Garcia, M.J. and Das, A. (1995) Bipartite function of a small RNA hairpin in transcription antitermination in bacteriophage lambda. PNAS, USA, 92: 4061-4065.
80. Chattopadhyay, S.,Garcia, J., Lazinski, D. and Das, A.(1991) Molecular basis of nut site recognition. Journal of Cellular Biochemistry, 15: 246.
81. Nair,B., Oku,Y., Takeda,Y., Ghosh, A., Ghosh, R.K., Chattopadhyay, S., Pal, S. C., Kaper, B.J., Takeda, T. (1988) Toxin profiles of vibrio cholerae Non-01 from environmental sources in Calcutta, India. Applied and Environmental Microbiology, 54: 3180.
82. Chattopadhyay, S. and Ghosh, R.K. (1988) Characterization of the transfer RNA coded by Vibrio eltor phage e4. Virology, 165: 606.
83. Chattopadhyay, S. and Ghosh, R.K. (1988) Localization of the transfer RNA gene on the physical map of Vibrio eltor phage e4. Virology,162: 337.
84. Chattopadhyay, S., Kinchington, D. and Ghosh, R.K. (1987) Characterization of Vibrio eltor typing phages: Properties of the eltor phage e4. J. Gen.Virology, 68: 1411-1416.