Aptamer Pattern Recognition in using SELEX data

SELEX Data Generation

Systematic Evolution of Ligands by EXponential Enrichment (SELEX) is a common method currently used for isolating high-affinity single-stranded (ss) DNAs or RNAs from a large library with random sequences

Aptamers

Aptamers are single-stranded oligonucleotides that fold into defined architectures and bind to targets such as proteins

Project TimeLine

  • Found the human embryonic stem cells whole-cell SELEX-Seq data

  • Download Data and import it in python

  • Generate Sequence Profiles based on the counts

  • Compare the Control and Original data

  • Find Aptamer candidates

  • Find the Aptamer pattern based on the candidates

  • compare with the paper results