Fujii R, Melotti R, Gögele M, Barin L, Ghasemi-Semeskandeh D, Barbieri G, Pramstaller PP, Pattaro C. Structural equation modeling (SEM) of kidney function markers and longitudinal CVD risk assessment. PLoS One. 2023 Apr 20;18(4):e0280600. doi: 10.1371/journal.pone.0280600. PMID: 37079513; PMCID: PMC10118200.

Fujii R, Pattaro C, Tsuboi Y, Ishihara Y, Melotti R, Yamada H, Ando Y, Ishikawa H, Ohashi K, Hashimoto S, Hamajima N, Barbieri G, Ghasemi-Semeskandeh D, Suzuki K. Comparison of glomerular filtration rate estimating formulas among Japanese adults without kidney disease. Clin Biochem. 2023 Jan;111:54-59. doi: 10.1016/j.clinbiochem.2022.10.011. Epub 2022 Nov 2. PMID: 36334798.

Ando Y, Ohta Y, Munetsuna E, Yamada H, Nouchi Y, Kageyama I, Mizuno G, Yamazaki M, Fujii R, Ishikawa H, Suzuki K, Hashimoto S, Ohashi K. Laboratory analysis of glucose, fructose, and sucrose contents in Japanese common beverages for the exact assessment of beverage-derived sugar intake. Fujita Med J. 2023 May;9(2):126-133. doi: 10.20407/fmj.2022-009. Epub 2022 Oct 28. PMID: 37234384; PMCID: PMC10206900.

Fujii R†, Sato S†, Tsuboi Y, Cardenas A, Suzuki K. DNA methylation as a mediator of associations between the environment and chronic diseases: A scoping review on application of mediation analysis. Epigenetics. 2022 Jun-Jul;17(7):759-785. doi: 10.1080/15592294.2021.1959736. Epub 2021 Aug 12. PMID: 34384035; PMCID: PMC9336467.

Ando Y, Yamada H, Munetsuna E, Yamazaki M, Kageyama I, Teshigawara A, Nouchi Y, Fujii R, Mizuno G, Sadamoto N, Ishikawa H, Suzuki K, Hashimoto S, Ohashi K. Maternal high-fructose corn syrup consumption causes insulin resistance and hyperlipidemia in offspring via DNA methylation of the Pparα promoter region. J Nutr Biochem. 2022 May;103:108951. doi: 10.1016/j.jnutbio.2022.108951. Epub 2022 Feb 2. PMID: 35123000.

Kageyama I, Yamada H, Munetsuna E, Yamazaki M, Ando Y, Mizuno G, Fujii R, Nouchi Y, Wakasugi T, Sakakibara T, Teshigawara A, Ishikawa H, Shimono Y, Suzuki K, Hashimoto S, Ohashi K. Differential effects of excess high-fructose corn syrup on the DNA methylation of hippocampal neurotrophic factor in childhood and adolescence. PLoS One. 2022 Jun 17;17(6):e0270144. doi: 10.1371/journal.pone.0270144. PMID: 35714129; PMCID: PMC9205497.

Yamazaki M, Yamada H, Munetsuna E, Maeda K, Ando Y, Mizuno G, Fujii R, Tsuboi Y, Ohashi K, Ishikawa H, Hashimoto S, Hamajima N, Suzuki K. DNA methylation level of the gene encoding thioredoxin-interacting protein in peripheral blood cells is associated with metabolic syndrome in the Japanese general population. Endocr J. 2022 Mar 28;69(3):319-326. doi: 10.1507/endocrj.EJ21-0339. Epub 2021 Oct 14. PMID: 34645728.

Fujii R, Hishida A, Nakatochi M, Tsuboi Y, Suzuki K, Kondo T, Ikezaki H, Hara M, Okada R, Tamura T, Shimoshikiryo I, Suzuki S, Koyama T, Kuriki K, Takashima N, Arisawa K, Momozawa Y, Kubo M, Takeuchi K, Wakai K; J-MICC Study Group. Associations of Genome-Wide Polygenic Risk Score and Risk Factors With Hypertension in a Japanese Population. Circ Genom Precis Med. 2022 Aug;15(4):e003612. doi: 10.1161/CIRCGEN.121.003612. Epub 2022 Jun 6. PMID: 35666837.

Mizuno G, Yamada H, Munetsuna E, Ando Y, Teshigawara A, Ito M, Kageyama I, Nouchi Y, Wakasugi T, Sakakibara T, Yamazaki M, Fujii R, Ishikawa H, Suzuki K, Hashimoto S, Ohashi K. High-fructose corn syrup intake has stronger effects on the transcription level of hepatic lipid metabolism-related genes, via DNA methylation modification, in childhood and adolescence than in other generations. Life Sci. 2022 Jul 15;301:120638. doi: 10.1016/j.lfs.2022.120638. Epub 2022 May 16. PMID: 35588866.

Nouchi Y, Munetsuna E, Yamada H, Yamazaki M, Ando Y, Mizuno G, Fujii R, Kageyama I, Wakasugi T, Sakakibara T, Teshigawara A, Ishikawa H, Shimono Y, Suzuki K, Hashimoto S, Ohashi K. Effects of High-Fructose Corn Syrup Intake on Glucocorticoid Metabolism in Rats During Childhood, Adolescence and Adulthood. Exp Clin Endocrinol Diabetes. 2022 Dec;130(12):814-820. doi: 10.1055/a-1936-3310. Epub 2022 Nov 11. PMID: 36368682.

Maeda K, Yamada H, Munetsuna E, Fujii R, Yamazaki M, Ando Y, Mizuno G, Ishikawa H, Ohashi K, Tsuboi Y, Hattori Y, Ishihara Y, Hashimoto S, Hamajima N, Suzuki K. Association of drinking behaviors with TXNIP DNA methylation levels in leukocytes among the general Japanese population. Am J Drug Alcohol Abuse. 2022 May 4;48(3):302-310. doi: 10.1080/00952990.2022.2037137. Epub 2022 Apr 13. PMID: 35416731.

Hattori Y, Yamada H, Munetsuna E, Ando Y, Mizuno G, Fujii R, Tsuboi Y, Ichino N, Osakabe K, Sugimoto K, Ishikawa H, Ohashi K, Suzuki K. Increased brain-derived neurotrophic factor in the serum of persons with nonalcoholic fatty liver disease. Endocr J. 2022 Aug 29;69(8):999-1006. doi: 10.1507/endocrj.EJ21-0584. Epub 2022 Mar 31. PMID: 35354697.

Tsuboi Y, Yamada H, Munetsuna E, Fujii R, Yamazaki M, Ando Y, Mizuno G, Hattori Y, Ishikawa H, Ohashi K, Hashimoto S, Hamajima N, Suzuki K. Intake of vegetables and fruits rich in provitamin A is positively associated with aryl hydrocarbon receptor repressor DNA methylation in a Japanese population. Nutr Res. 2022 Nov;107:206-217. doi: 10.1016/j.nutres.2022.10.006. Epub 2022 Oct 15. PMID: 36334347.

Mizuno G, Yamada H, Munetsuna E, Yamazaki M, Ando Y, Fujii R, Tsuboi Y, Teshigawara A, Kageyama I, Osakabe K, Sugimoto K, Ishikawa H, Ichino N, Ohta Y, Ohashi K, Hashimoto S, Suzuki K. Association between the Extent of Peripheral Blood DNA Methylation of HIF3A and Accumulation of Adiposity in community-dwelling Women: The Yakumo Study. Endocr Res. 2022 Aug-Nov;47(3-4):130-137. doi: 10.1080/07435800.2022.2121967. Epub 2022 Sep 14. PMID: 36104828.

Takegami Y, Seki T, Osawa Y, Makida K, Ochiai S, Nakashima H, Fujii R, Yamada H, Suzuki K, Hasegawa Y, Imagama S. A preliminary examination of the association between locomotive syndrome and circulating miRNA-199 in community-dwelling people: The Yakumo study. J Orthop Sci. 2022 May;27(3):696-700. doi: 10.1016/j.jos.2021.02.003. Epub 2021 Mar 31. PMID: 33810936.

Fujii R, Suzuki K, Yamada H, Kawado M, Hashimoto S, Tsuboi Y, Wakai K, Iso H, Watanabe Y, Fujino Y, Tamakoshi A; JACC Study Group. Association between serum carotenoids and premature mortality in a population-based case-control study. Nagoya J Med Sci. 2022 Aug;84(3):607-620. doi: 10.18999/nagjms.84.3.607. PMID: 36237882; PMCID: PMC9529633.

Fujii R, Hishida A, Nishiyama T, Nakatochi M, Matsuo K, Ito H, Nishida Y, Shimanoe C, Nakamura Y, Turin TC, Suzuki S, Watanabe M, Ibusuki R, Takezaki T, Mikami H, Nakamura Y, Ikezaki H, Murata M, Kuriki K, Kuriyama N, Matsui D, Arisawa K, Katsuura-Kamano S, Tsukamoto M, Tamura T, Kubo Y, Kondo T, Momozawa Y, Kubo M, Takeuchi K, Wakai K. Assessing the Relationship Between High-sensitivity C-reactive Protein and Kidney Function Employing Mendelian Randomization in the Japanese Community-based J-MICC Study. J Epidemiol. 2022 Nov 5;32(11):483-488. doi: 10.2188/jea.JE20200540. Epub 2021 Jul 10. PMID: 33612706; PMCID: PMC9551292.

Fujii R, Suzuki K, Niimi J. Public perceptions, individual characteristics, and preventive behaviors for COVID-19 in six countries: a cross-sectional study. Environ Health Prev Med. 2021;26(1):29. Published 2021 Mar 3. doi:10.1186/s12199-021-00952-2.

Yamada H, Suzuki K, Fujii R, Kawado M, Hashimoto S, Watanabe Y, Iso H, Fujino Y, Wakai K, Tamakoshi A. Circulating miR-21, miR-29a, and miR-126 are associated with premature death risk due to cancer and cardiovascular disease: the JACC Study. Sci Rep. 2021 Mar 5;11(1):5298. doi: 10.1038/s41598-021-84707-7. PMID: 33674633; PMCID: PMC7935984.

Fujii R, Yamada H, Munetsuna E, Yamazaki M, Mizuno G, Ando Y, Maeda K, Tsuboi Y, Ohashi K, Ishikawa H, Hagiwara C, Wakai K, Hashimoto S, Hamajima N, Suzuki K. Dietary fish and ω-3 polyunsaturated fatty acids are associated with leukocyte ABCA1 DNA methylation levels. Nutrition. 2021 Jan;81:110951. doi: 10.1016/j.nut.2020.110951. Epub 2020 Jul 21. PMID: 33045487.

Mizuno G, Munetsuna E, Yamada H, Yamazaki M, Ando Y, Hattori Y, Kageyama I, Teshigawara A, Nouchi Y, Fujii R, Ishikawa H, Suzuki K, Hashimoto S, Ohashi K, Shimono Y. Maternal fructose consumption downregulates hippocampal catalase expression via DNA methylation in rat offspring. Nutr Res. 2021 Aug;92:40-48. doi: 10.1016/j.nutres.2021.06.002. Epub 2021 Jun 12. PMID: 34274553.

Ito S, Nakashima H, Ando K, Kobayashi K, Machino M, Seki T, Ishizuka S, Fujii R, Takegami Y, Yamada H, Ando Y, Suzuki K, Hasegawa Y, Imagama S. Association between Low Muscle Mass and Inflammatory Cytokines. Biomed Res Int. 2021 Apr 27;2021:5572742. doi: 10.1155/2021/5572742. PMID: 33997015; PMCID: PMC8099521.

Fujii R, Tsuboi Y, Maeda K, Ishihara Y, Suzuki K. Analysis of Repeated Measurements of Serum Carotenoid Levels and All-Cause and Cause-Specific Mortality in Japan. JAMA Netw Open. 2021 Jun 1;4(6):e2113369. doi: 10.1001/jamanetworkopen.2021.13369. PMID: 34115126; PMCID: PMC8196342.

Suzuki K, Yamada H, Fujii R, Munetsuna E, Ando Y, Ohashi K, Ishikawa H, Yamazaki M, Maeda K, Hashimoto S, Hamajima N. Association between circulating vascular-related microRNAs and an increase in blood pressure: a 5-year longitudinal population-based study. J Hypertens. 2021 Jan;39(1):84-89. doi: 10.1097/HJH.0000000000002606. PMID: 32740403.

Munetsuna E, Yamada H, Yamazaki M, Ando Y, Mizuno G, Hattori Y, Kageyama I, Teshigawara A, Nouchi Y, Ishikawa H, Fujii R, Ohta Y, Suzuki K, Shimono Y, Ohashi K, Hashimoto S. Maternal fructose intake predisposes rat offspring to metabolic disorders via abnormal hepatic programming. FASEB J. 2021 Dec;35(12):e22030. doi: 10.1096/fj.202101276R. PMID: 34748238.

Tsuboi Y, Yamada H, Munetsuna E, Fujii R, Yamazaki M, Ando Y, Mizuno G, Ishikawa H, Ohashi K, Hashimoto S, Hamajima N, Suzuki K. Global DNA hypermethylation in peripheral blood mononuclear cells and cardiovascular disease risk: a population-based propensity score-matched cohort study. J Epidemiol Community Health. 2021 Sep;75(9):890-895. doi: 10.1136/jech-2020-215382. Epub 2021 Mar 25. PMID: 33766847.

Fujii R, Kondo T, Tsukamoto M, Kawai S, Sasakabe T, Naito M, Kubo Y, Okada R, Tamura T, Hishida A, Ueyama J, Hayashi Y, Ohnishi J, Hamajima N, Takeuchi K, Wakai K. Association of self-reported moderate vegetable juice intake with small decline in kidney function in a five-year prospective study. Nutrition. 2021 Apr;84:111114. doi: 10.1016/j.nut.2020.111114. Epub 2020 Dec 10. PMID: 33454529.

Fujii R, Yamada H, Tsuboi Y, Ando Y, Munetsuna E, Yamazaki M, Ohashi K, Ishikawa H, Ishihara Y, Hashimoto S, Hamajima N, Suzuki K. Association between circulating microRNAs and changes in kidney function: A five-year prospective study among Japanese adults without CKD. Clin Chim Acta. 2021 Oct;521:97-103. doi: 10.1016/j.cca.2021.07.002. Epub 2021 Jul 6. PMID: 34242639.

Ito S, Nakashima H, Ando K, Kobayashi K, Machino M, Seki T, Ishizuka S, Kanbara S, Inoue T, Koshimizu H, Fujii R, Yamada H, Ando Y, Ueyama J, Kondo T, Suzuki K, Hasegawa Y, Imagama S. Human Nonmercaptalbumin Is a New Biomarker of Motor Function. J Clin Med. 2021 Jun 2;10(11):2464. doi: 10.3390/jcm10112464. PMID: 34199414; PMCID: PMC8199584.

Suzuki K, Shivappa N, Kawado M, Yamada H, Hashimoto S, Wakai K, Iso H, Okada E, Fujii R, Hébert JR, Tamakoshi A. Association between dietary inflammatory index and serum C-reactive protein concentrations in the Japan Collaborative Cohort Study. Nagoya J Med Sci. 2020 May;82(2):237-249. doi: 10.18999/nagjms.82.2.237. PMID: 32581404; PMCID: PMC7276400.

Fujii R, Yamada H, Munetsuna E, Yamazaki M, Ohashi K, Ishikawa H, Maeda K, Hagiwara C, Ando Y, Hashimoto S, Hamajima N, Suzuki K. Associations of Circulating MicroRNAs (miR-17, miR-21, and miR-150) and Chronic Kidney Disease in a Japanese Population. J Epidemiol. 2020 Apr 5;30(4):177-182. doi: 10.2188/jea.JE20180233. Epub 2019 Mar 23. PMID: 30905898; PMCID: PMC7064557.

Maeda K, Yamada H, Munetsuna E, Fujii R, Yamazaki M, Ando Y, Mizuno G, Ishikawa H, Ohashi K, Tsuboi Y, Hashimoto S, Hamajima N, Suzuki K. Association of smoking habits with TXNIP DNA methylation levels in leukocytes among general Japanese population. PLoS One. 2020 Jul 1;15(7):e0235486. doi: 10.1371/journal.pone.0235486. PMID: 32609762; PMCID: PMC7329107.

Nakashima H, Ando K, Kobayashi K, Seki T, Ishizuka S, Fujii R, Takegami Y, Yamada H, Ando Y, Suzuki K, Hasegawa Y, Imagama S. Associations of Serum MicroRNA with Bone Mineral Density in Community-Dwelling Subjects: The Yakumo Study. Biomed Res Int. 2020 Jul 30;2020:5047243. doi: 10.1155/2020/5047243. PMID: 32802851; PMCID: PMC7414326.

Tsuboi Y, Yamada H, Munetsuna E, Fujii R, Yamazaki M, Ando Y, Mizuno G, Hattori Y, Ishikawa H, Ohashi K, Hashimoto S, Hamajima N, Suzuki K. Increased risk of cancer mortality by smoking-induced aryl hydrocarbon receptor repressor DNA hypomethylation in Japanese population: A long-term cohort study. Cancer Epidemiol. 2022 Jun;78:102162. doi: 10.1016/j.canep.2022.102162. Epub 2022 Apr 20. PMID: 35461154.

Fujii R, Yamada H, Munetsuna E, Yamazaki M, Ando Y, Mizuno G, Tsuboi Y, Ohashi K, Ishikawa H, Hagiwara C, Maeda K, Hashimoto S, Suzuki K. Associations between dietary vitamin intake, ABCA1 gene promoter DNA methylation, and lipid profiles in a Japanese population. Am J Clin Nutr. 2019 Nov 1;110(5):1213-1219. doi: 10.1093/ajcn/nqz181. PMID: 31504085.

Yamada H, Munetsuna E, Yamazaki M, Mizuno G, Sadamoto N, Ando Y, Fujii R, Shiogama K, Ishikawa H, Suzuki K, Shimono Y, Ohashi K, Hashimoto S. Maternal fructose-induced oxidative stress occurs viaTfam and Ucp5 epigenetic regulation in offspring hippocampi. FASEB J. 2019 Oct;33(10):11431-11442. doi: 10.1096/fj.201901072R. Epub 2019 Jul 17. PMID: 31314594.

Ando Y, Yamazaki M, Yamada H, Munetsuna E, Fujii R, Mizuno G, Ichino N, Osakabe K, Sugimoto K, Ishikawa H, Ohashi K, Teradaira R, Ohta Y, Hamajima N, Hashimoto S, Suzuki K. Association of circulating miR-20a, miR-27a, and miR-126 with non-alcoholic fatty liver disease in general population. Sci Rep. 2019 Dec 11;9(1):18856. doi: 10.1038/s41598-019-55076-z. PMID: 31827150; PMCID: PMC6906495.

Munetsuna E, Yamada H, Yamazaki M, Ando Y, Mizuno G, Hattori Y, Sadamoto N, Ishikawa H, Ohta Y, Fujii R, Suzuki K, Hashimoto S, Ohashi K. Maternal high-fructose intake increases circulating corticosterone levels via decreased adrenal corticosterone clearance in adult offspring. J Nutr Biochem. 2019 May;67:44-50. doi: 10.1016/j.jnutbio.2019.01.016. Epub 2019 Feb 12. PMID: 30856463.

Yamazaki M, Munetsuna E, Yamada H, Ando Y, Mizuno G, Fujii R, Nouchi Y, Kageyama I, Teshigawara A, Ishikawa H, Suzuki K, Shimono Y, Hashimoto S, Ohashi K. Maternal fructose consumption down-regulates Lxra expression via miR-206-mediated regulation. J Nutr Biochem. 2020 Aug;82:108386. doi: 10.1016/j.jnutbio.2020.108386. Epub 2020 Apr 14. PMID: 32388164.

Kondo M, Yamada H, Munetsuna E, Yamazaki M, Hatta T, Iwahara A, Ohashi K, Ishikawa H, Tsuboi Y, Inoue T, Fujii R, Suzuki K. Associations of serum microRNA-20a, -27a, and -103a with cognitive function in a Japanese population: The Yakumo study. Arch Gerontol Geriatr. 2019 May-Jun;82:155-160. doi: 10.1016/j.archger.2019.01.007. Epub 2019 Feb 8. PMID: 30802839.

Fujii R, Yamada H, Yamazaki M, Munetsuna E, Ando Y, Ohashi K, Ishikawa H, Shimoda H, Sakata K, Ogawa A, Kobayashi S, Suzuki K; RIAS study group. Circulating microRNAs (miR-126, miR-197, and miR-223) are associated with chronic kidney disease among elderly survivors of the Great East Japan Earthquake. BMC Nephrol. 2019 Dec 21;20(1):474. doi: 10.1186/s12882-019-1651-0. PMID: 31864304; PMCID: PMC6925484.

Hishida A, Ugai T, Fujii R, Nakatochi M, Wu MC, Ito H, Oze I, Tajika M, Niwa Y, Nishiyama T, Nakagawa-Senda H, Suzuki S, Koyama T, Matsui D, Watanabe Y, Kawaguchi T, Matsuda F, Momozawa Y, Kubo M, Naito M, Matsuo K, Wakai K. GWAS analysis reveals a significant contribution of PSCA to the risk of Heliobacter pylori-induced gastric atrophy. Carcinogenesis. 2019 Jul 4;40(5):661-668. doi: 10.1093/carcin/bgz016. PMID: 30753327.

Fujii R, Yamada H, Munetsuna E, Yamazaki M, Mizuno G, Tsuboi Y, Ohashi K, Ishikawa H, Ando Y, Hagiwara C, Maeda K, Hashimoto S, Hamajima N, Suzuki K. Dietary vegetable intake is inversely associated with ATP-binding cassette protein A1 (ABCA1) DNA methylation levels among Japanese women. Nutrition. 2019 Sep;65:1-5. doi: 10.1016/j.nut.2019.02.010. Epub 2019 Feb 23. PMID: 31029915.

Fujii R, Hishida A, Nakatochi M, Furusyo N, Murata M, Tanaka K, Shimanoe C, Suzuki S, Watanabe M, Kuriyama N, Koyama T, Takezaki T, Shimoshikiryo I, Arisawa K, Katsuura-Kamano S, Takashima N, Turin TC, Kuriki K, Endoh K, Mikami H, Nakamura Y, Oze I, Ito H, Kubo M, Momozawa Y, Kondo T, Naito M, Wakai K. Association of genetic risk score and chronic kidney disease in a Japanese population. Nephrology (Carlton). 2019 Jun;24(6):670-673. doi: 10.1111/nep.13479. Epub 2019 Apr 29. PMID: 30146708.

Fujii R, Hishida A, Suzuki K, Imaeda N, Goto C, Hamajima N, Wakai K, Kondo T. Cluster of differentiation 36 gene polymorphism (rs1761667) is associated with dietary MUFA intake and hypertension in a Japanese population. Br J Nutr. 2019 Jun;121(11):1215-1222. doi: 10.1017/S0007114519000679. Epub 2019 Mar 29. PMID: 30924431.

Fujii R, Ueyama J, Kanno T, Suzuki K, Hamajima N, Wakai K, Hasegawa Y, Kondo T. Human serum albumin redox state is associated with decreased renal function in a community-dwelling population. Am J Physiol Renal Physiol. 2019 Jan 1;316(1):F214-F218. doi: 10.1152/ajprenal.00138.2018. Epub 2018 Nov 14. PMID: 30427221.

Fujii R, Ueyama J, Aoi A, Ichino N, Osakabe K, Sugimoto K, Suzuki K, Hamajima N, Wakai K, Kondo T. Oxidized human serum albumin as a possible correlation factor for atherosclerosis in a rural Japanese population: the results of the Yakumo Study. Environ Health Prev Med. 2018 Jan 2;23(1):1. doi: 10.1186/s12199-017-0690-z. PMID: 29291718; PMCID: PMC5748967.

Fujii R, Hishida A, Wu MC, Kondo T, Hattori Y, Naito M, Endoh K, Nakatochi M, Hamajima N, Kubo M, Kuriki K, Wakai K. Genome-wide association study for pollinosis identified two novel loci in interleukin (IL)-1B in a Japanese population. Nagoya J Med Sci. 2018 Feb;80(1):109-120. doi: 10.18999/nagjms.80.1.109. PMID: 29581620; PMCID: PMC5857507.