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SCIENCE ART

Jin et al., Nature Neurosci, 2008 (cover)

Van Horn et al., J Neurosci 2017 (submitted)

Tremblay et al., J Neurosci, 2009 (cover)

Sild et al., Neuroscientist, 2011 (cover)

Sild et al., J Neurosci, 2016 (cover)

Kesner et al., Cell Rep., 2020 (submitted)

Gobert et al., Dev Neurobiol, 2020 (cover)

Imaizumi et al, Frontiers in Neural Circuits, 2018 (cover)

cr: Lois Miraucourt

cr: Valerie Higenell

cr: Ed Ruthazer

cr: Vanessa Li

cr: Cynthia Solek

cr: Zahraa Chorghay

FULL LIST OF PEER-REVIEWED JOURNAL ARTICLES

1. Ruthazer, E.S., Gillespie, D.C., Dawson, T.M., Snyder, S.H and Stryker, M.P. (1996) Nitric Oxide Synthase Inhibition Does Not Prevent Ocular Dominance Plasticity in Kitten Visual Cortex. Journal of Physiology, 494.2: 519-527.
2. Ruthazer, E.S. and Stryker, M.P. (1996) The Role of Activity in the Development of Long-Range Horizontal Connections in Area 17 of the Ferret. Journal of Neuroscience, 16(22): 7253–7269.
3. Crair, M.C., Ruthazer,E.S., Gillespie, D.C. and Stryker, M.P. (1997) Ocular Dominance Peaks at Pinwheel Center Singularities of the Orientation Map in Cat Visual Cortex. Journal of Neurophysiology, 77(6): 3381-3385.
4. Crair, M.C., Ruthazer, E.S., Gillespie, D.C. and Stryker, M.P. (1997) Relationship Between the Ocular Dominance and Orientation Maps in Visual Cortex of Monocularly Deprived Cats. Neuron, 19(2): 307-318.
5. Ruthazer, E.S., Baker, G.E. and Stryker, M.P. (1999) Development and Organization of Ocular Dominance Bands in Primary Visual Cortex of the Sable Ferret. Journal of Comparative Neurology, 407(2): 151-65.
6. Yamamoto, N., Inui, K., Matsuyama, Y. Harada, A., Hanamura, K., Murakami, F., Ruthazer,E.S., Rutishauser, U. and Seki, T. (2000) Inhibitory Mechanism by Polysialic Acid for Lamina-Specific Branch Formation of Thalamocortical Axons. Journal of Neuroscience, 20(24): 9145-51.
7. Ruthazer, E.S. and Cline, H.T. (2002) Multiphoton Imaging of Neurons in Living Tissue: Acquisition and Analysis of Time-Lapse Morphological Data. Journal of Real-Time Imaging: Special Issue on Imaging in Bioinformatics, 8: 175-188.
8. Sin, W.C., Haas, K., Ruthazer, E.S. and Cline, H.T. (2002) Dendrite Growth Increased by Visual Activity Requires NMDA Receptor and Rho GTPases. Nature, 419: 475-80.
9. Ruthazer, E.S., Akerman, C.J. and Cline, H.T. (2003) Control of axon branch dynamics by correlated activity in vivo. Science, 301: 66-70.
10. Ruthazer, E.S. and Cline, H.T. (2004) Insights into Activity-Dependent Map Formation from the Retinotectal System: A Middle-of-the-Brain Perspective. Journal of Neurobiology, 59(1): 134-146.
11. Ruthazer, E.S. (2005) You’re Perfect, Now Change – Redefining the Role of Developmental Plasticity. Neuron, 45(6): 825-8.
12. Uesaka, N., Hirai, S., Maruyama, T., Ruthazer, E.S. and Yamamoto, N. (2005) Activity-Dependence of Cortical Axon Branch Formation: A Morphological and Electrophysiological Study Using Organotypic Slice Cultures. Journal of Neuroscience, 25(1): 1-9.
13. Uesaka, N., Ruthazer, E.S. and Yamamoto, N. (2006) The role of neural activity in cortical axon branching. The Neuroscientist, 12(2): 102-106.
14. Ruthazer, E.S., Li, J.L. and Cline, H.T. (2006) Stabilization of Axon Branch Dynamics by Synaptic Maturation. Journal of Neuroscience, 26(13): 3594-3603.
15. Jin, J.Z., Weng, C., Yeh, C.I., Gordon, J.A., Ruthazer, E.S., Stryker, M.P., Swadlow, H.A., and Alonso, J.M. (2008) On and Off Domains of Geniculate Afferents in Cat Primary Visual Cortex. Nature Neuroscience, 11(1): 88-94.
16. Feller, M.B. and Ruthazer, E.S. (2009) "Activity in Visual Development" in Encyclopedia of Neuroscience 1: 47-51.
17. Latefi,N.S., Pedraza,L., Schohl, A., Li, Z. and Ruthazer, E.S. (2009) N-cadherin Prodomain Cleavage Regulates Synapse Formation In Vivo. Developmental Neurobiology 69(8): 518-529.
18. Schwartz, N. Schohl, A. and Ruthazer, E.S. (2009) Neural Activity Regulates Synaptic Properties and Dendritic Structure In Vivo through Calcineurin/NFAT Signaling. Neuron 62: 655–669
19. Tremblay, M., Fugère, V., Tsui, J., Schohl, A., Tavakoli, A., Travençolo, B.A.N., Costa,L, and Ruthazer E.S. (2009) Regulation of Radial Glial Motility by Visual Experience. J Neuroscience 29: 14066-76.
20. Lee, R.H., Mills, E.A., Schwartz,N., Bell, M.R., Deeg,K.E., Ruthazer,E.S., Marsh-Armstrong, N., and Aizenman, C.D. (2010) Neurodevelopmental Effects of Chronic Exposure to Elevated Levels of Pro-inflammatory Cytokines in a Developing Visual System. Neural Development 5: 2.
21. Ruthazer, E.S. and Aizenman, C.D. (2010) Learning to See: Patterned Visual Activity and the Development of Visual Function. Trends in Neuroscience 33: 183-92.
22. Higenell, V. and Ruthazer, E.S. (2010) Layers upon Layers: MHC Class I Acts in the Retina to Influence Thalamic Segregation. Neuron 65: 439-41.
23. Tsui, J., Schwartz, N. and Ruthazer, E.S. (2010) A Developmental Sensitive Period for Spike Timing-dependent Plasticity in the Retinotectal Projection. Frontiers in Synaptic Neuroscience, 11 June 2010. Special Topic on STDP, edited by H. Markram, J. Sjöström and W. Gerstner.
24. Ruthazer, E.S., Bachleda, A.R. and Olavarria, J.F. (2010) The Role of Interstitial Branching in the Development of Visual Corticocortical Connections: A Time-lapse and Fixed-tissue Analysis. Journal of Comparative Neurology 518: 4963–79.
25. Dhande, O., Hua,E., Guh,E., Yeh,J., Bhatt,S., Zhang,Y., Ruthazer,E.S., Feller,M.B. and Crair,M.C. (2011) Development of Single Retinofugal Axon Arbors in Normal and ß2 Knock-Out Mice. Journal of Neuroscience 31: 3384-99.
26. Sild, M. and Ruthazer, E.S. (2011) Radial Glia: Progenitor, Pathway and Partner. The Neuroscientist 17(3): 288-302.
27. Schwartz, N., Schohl, A. and Ruthazer, E.S. (2011) Activity-dependent Transcription of BDNF Enhances Visual Acuity During Development. Neuron 70(3): 455-67.
28. Higenell, V., Han, S.M., Feldheim, D.A., Scalia, F. and Ruthazer, E.S. (2012) Expression Patterns of Ephs and Ephrins Throughout Retinotectal Development in Xenopus Laevis. Developmental Neurobiology, doi: 10.1002/dneu.20930.
29. Miraucourt, L.S., Santos da Silva, J., Burgos, K., Li, J.L., Abe, H., *Ruthazer, E.S. and *Cline, H.T. (2012) GABA Expression and Regulation by Sensory Experience in the Developing Visual System. PLOS One, 7(1): e29086. doi:10.1371/journal.pone.0029086.
30. Coupé, P., Munz, M., Manjon, J.V., Ruthazer, E.S. and Collins, D.L. (2012) A CANDLE for Deeper In Vivo Insight. Medical Image Analysis, 16(4): 849-64.
31. Horn, K.E., Xu, B., Gobert, D., Hamam, B.N., Thompson, K.M., Wu, C.L., Bouchard, J.F., Uetani, N., Racine, R.J., Tremblay, M.L., Ruthazer, E.S., Chapman, C.A. and Kennedy, T.E. (2012) Receptor Protein Tyrosine Phosphatase Sigma Regulates Synapse Structure, Function and Plasticity. J Neurochem, 122:147-61.
32. Van Horn, M.R. and Ruthazer, E.S. (2012) Listening to Npas4: a Transcription Factor is the Prescription for Restoring Youthful Plasticity in the Mature Brain. J Physiology, 590: 4637-4638.
33. Horn, K.E., Glasgow, S.D., Gobert, D., Bull, S.J., Luk, T., Girgis, J., Tremblay, M.E., McEachern, D., Bouchard, J.F., Haber, M., Hamel, E., Krimpenfort, P., Murai, K.K., Berns, A., Doucet, G., Chapman, C.A., Ruthazer, E.S. and Kennedy, T.E. (2013) DCC Expression by Neurons Regulates Synaptic Plasticity in the Adult Brain. Cell Reports, 3: 173-85.
34. Van Horn, M.R., Sild, M. and Ruthazer ES (2013) D-serine as a gliotransmitter and its roles in brain development and disease. Frontiers in Cellular Neurosci, 7: 39.
35. Ruthazer, E.S., Schohl, A., Schwartz, N., Tavakoli, A., Tremblay, M. and Cline, H.T. (2013) Dye Labeling Retinal Ganglion Cell Axons in Live Xenopus Tadpoles. Cold Spring Harbor Protocols, Sep 1;2013(8):768-70 doi: 10.1101/pdb.prot076463.
36. Ruthazer, E.S., Schohl, A., Schwartz, N., Tavakoli, A., Tremblay, M. and Cline, H.T. (2013) Bulk Electroporation of Retinal Ganglion Cells in Live Xenopus Tadpoles. Cold Spring Harbor Protocols, Sep 1;2013(8):771-5 doi: 10.1101/pdb.prot076471.
37. Ruthazer, E.S., Schohl, A., Schwartz, N., Tavakoli, A., Tremblay, M. and Cline, H.T. (2013) Labeling Individual Neurons in the Brains of Live Xenopus Tadpoles by Electroporation of Dyes or DNA. Cold Spring Harbor Protocols, Sep 1;2013(9) doi:pii: pdb.prot077149.10.1101/pdb.prot077149.
38. Ruthazer, E.S., Schohl, A., Schwartz, N., Tavakoli, A., Tremblay, M. and Cline, H.T. (2013) In Vivo Time-lapse Imaging of Neuronal Development in Xenopus. Cold Spring Harbor Protocols, Sep 1;2013(9) doi:pii:pdb.top077156.10.1101/pdb.top077156.
39. Belkaid, W., Thostrup, P., Yam, P.T., Juzwik, C.A., Ruthazer, E.S., Dhaunchak, A.S. and Colman, D.R. (2013) Cellular Response to Micropatterned Growth Promoting and Inhibitory Substrates. BMC Biotechnology, 13: 86.
40. Goldman, J.S., Ashour, M.A., Magdesian, M.H., Tritsch, N.X., Christofi, N., Chemali, R., Stern, Y.E., Thompson-Steckel, G., Harris, S.N., Gris, P., Glasgow, S.D., Grutter, P., Bouchard, J.F., Ruthazer, E.S., Stellwagen, D. and Kennedy, T.E. (2013) Netrin-1 Promotes Excitatory Synaptogenesis Between Cortical Neurons by Initiating Synapse Assembly. J Neurosci, 33(44): 17278–89.
41. Sild, M., Chatelain, R.P. and Ruthazer, E.S. (2013) Improved Method for the Quantification of Motility in Glia and Other Morphologically Complex Cells. Neural Plasticity, vol. 2013, Article ID 853727.
42. *Polcari, D., *Kwan, A., Van Horn, M.R., Danis, L., Pellegioni, L., *Ruthazer, E.S. and *Mauzeroll, J. (2014) A Disk-Shaped Amperometric Enzymatic Biosensor for In Vivo Detection of D-Serine. Anal Chem, 86: 3501-7.
43. *Munz, M., *Gobert, D., Schohl, A., Poquérusse, J., Podgorski, K., Spratt, P. and Ruthazer, E.S. (2014) Rapid Hebbian Axonal Remodeling Mediated by Visual Stimulation. Science, 344(6186): 904-9.
44. Wu, J., Abdelfattah, A.S., Miraucourt, L.S., Kutsarova, E., Ruangkittisakul, A., Zhou, H., Ballanyi, K., Wicks, G., Drobizhev, M., Rebane, A., Ruthazer, E.S. and Campbell, R.E. (2014) A Long Stokes Shift Red Fluorescent Ca2+ Indicator Protein for Two-photon and Ratiometric Imaging. Nature Communications, DOI: 10.1038/ncomms6262.
45. Kesner, P., Gobert, D. and Ruthazer, E.S. (2015) Formula for Unsilencing Plasticity: Spike with GABA. Neuron, 87: 915-7.
46. Sild, M., Van Horn, M.R., Schohl, A., Jia, D. and Ruthazer, E.S. (2016) Neural Activity-Dependent Regulation of Radial Glial Filopodial Motility Is Mediated by Glial cGMP-Dependent Protein Kinase 1 and Contributes to Synapse Maturation in the Developing Visual System. J Neurosci, 36: 5279-88.
47. Miraucourt, L.S., Tsui, J., Gobert, D., Desjardins, J.F., Schohl, A., Sild, M., Spratt, P., Castonguay, A., De Koninck, Y., Marsh-Armstrong, N., Wiseman, P.W. and Ruthazer, E.S. (2016) Endocannabinoid Signaling Enhances Visual Responses Through Modulation of Intracellular Chloride Levels in Retinal Ganglion Cells. eLife, 10.7554/eLife.15932.
48. Kutsarova, E., Munz, M. and Ruthazer, E.S. (2016) Rules for Shaping Neural Connections in the Developing Brain. Frontiers in Neural Circuits, 10, 111. http://doi.org/10.3389/fncir.2016.00111.
49. Van Horn, M.R., Strasser, A., Miraucourt, L.S., Pollegioni, L. and Ruthazer, E.S. (2017) The Gliotransmitter D-serine Promotes Synapse Maturation and Axonal Stabilization In Vivo. J Neurosci, 37: 6277-88.
50. Sild, M., Ruthazer, E.S. and Booij, L. (2017) Major Depressive Disorder and Anxiety Disorders from the Glial Perspective: Etiological Mechanisms, Intervention and Monitoring. Neuroscience & Biobehavioral Reviews, pii: S0149-7634(17)30472-4.
51. *Solek, C.M., *Farooqi, N., Verly, M., Lim, T.K. and Ruthazer, E.S. (2018) Maternal Immune Activation in Neurodevelopmental Disorders. Developmental Dynamics, doi:10.1002/dvdy.24612.
52. Imaizumi, K., Ruthazer, E.S., MacLean, J.N. and Lee, C.C. (2018) Editorial: Spontaneous Activity in Sensory Systems. Frontiers in Neural Circuits, doi:10.3389/fncir.2018.00027.
53. Glasgow, S.D., Labrecque, S., Beamish, I.V., Aufmkolk, S., Gibon, J., Harris, S.N., Dufresne, P., Wiseman, P.W., McKinney, R.A., Séguéla, P., De Koninck, P., Ruthazer, E.S. and Kennedy, T.E. (2018) Activity-Dependent Netrin-1 Secretion Drives Synaptic Insertion of GluA1-Containing AMPA Receptors in the Hippocampus. Cell Reports, 25: 168-82.
54. Chorghay, Z,, Káradóttir, R.T. and Ruthazer, E.S. (2018) White Matter Plasticity Keeps the Brain in Tune: Axons Conduct While Glia Wrap. Frontiers in Cellular Neuroscience, doi: 10.3389/fncel.2018.00428.
55. Van Horn, M.R. and Ruthazer, E.S. (2019) Glial Regulation of Synapse Maturation and Stabilization in the Developing Nervous System. Current Opinion in Neurobiology, 54: 113-9.
56. *Wong, E., *Glasgow, S.D., Trigiani, L.J., Chitsaz, D., Rymar, V., Sadikot, A., Ruthazer, E.S., Hamel, E. and Kennedy, T.E. (2019) Spatial Memory Requires Netrin-1 Expression by Neurons in the Adult Mammalian Brain. Learning and Memory 26:77–83.
57. Glasgow, S.D., McPhedrain, R., Madranges, J.F., Kennedy, T.E. and Ruthazer, E.S. (2019) Approaches and Limitations in the Investigation of Synaptic Transmission and Plasticity. Frontiers in Synaptic Neuroscience doi: 10.3389/fnsyn.2019.00020.
58. Glasgow, S.D., Wong, E.W., Thompson-Steckel, G., Marcal, N., Séguéla, P., Ruthazer, E.S. and Kennedy, T.E. (2020) Pre- and Post-synaptic Roles for DCC in Memory Consolidation in the Adult Mouse Hippocampus. Mol Brain, 13: 56.
59. Rahman, T.N., Munz, M., Kutsarova, E., Bilash, O.M. and Ruthazer, E.S. (2020) Stentian Structural Plasticity in the Developing Visual System. PNAS, 117: 10636-10638.
60. Kesner, P., Schohl, A., Warren, E., Ma, F. and Ruthazer, E.S (2020) Postsynaptic and Presynaptic NMDARs Have Distinct Roles in Neural Circuit Development. Cell Reports, 32: 107955.
61. Schohl, A., Chorghay, Z. and Ruthazer, E.S. (2020) A Simple and Efficient Method for Visualizing Individual Cells In Vivo by Cre-Mediated Single-Cell Labeling by Electroporation (CREMSCLE). Frontiers in Neural Circuits, 14: 47.
62. Gobert, D., Schohl, A., Kutsarova, E. and Ruthazer, E.S. (2020) TORC1 Selectively Regulates Synaptic Maturation and Input Convergence in the Developing Visual System. Dev Neurbiol, doi:10.1002/dneu.22782.
63. Qian, Y., Orozco Cosio, D.M., Piatkevich, K.D., Aufmkolk, S., Su, W.C., Celiker, O.T., Schohl, A., Murdock, M.H., Aggarwal, A., Chang, Y.F., Wiseman, P.W., Ruthazer, E.S., Boyden, E.S. and Campbell, R.E. (2020) Improved Genetically Encoded Near-Infrared Fluorescent Calcium Ion Indicators for In Vivo Imaging. PLOS Biology, 18(11): e3000965.
64. Glasgow, S.D., Ruthazer, E.S. and Kennedy, T.E. (2021) Guiding Synaptic Plasticity: Novel Roles for Netrin-1 in Synaptic Plasticity and Memory Formation in the Adult Brain. J Physiology, doi: 10.1113/JP278704.
65. Moussa, S., Van Horn, M.R., Shah, A., Pollegioni, L., Thibodeaux, C.J., Ruthazer, E.S. and Mauzeroll, J. (2021) Editors’ Choice—A Miniaturized Enzymatic Biosensor for Detection of Sensory-Evoked D-serine Release in the Brain. J Electrochem Soc, 168025502.
66. Lim, T.K. and Ruthazer, E.S. (2021) Microglial Trogocytosis and the Complement System Regulate Axonal Pruning In Vivo. eLife, 10:e62167.
67. *Solek, C.M., *Farooqi, N.A.I., Brake, N., Kesner, P., Schohl, A., Antel, J.P., Ruthazer, E.S. (2021) Early inflammation dysregulates neuronal circuit formation in vivo via upregulation of IL-1ß. J Neurosci, Jun 8:JN-RM-2159-20.
68. Benfey, N., Li, V.J., Schohl, A., Ruthazer, E.S. (2021) Sodium-Calcium Exchanger Mediates Sensory-Evoked Glial Calcium Transients in the Developing Retinotectal System. Cell Reports, 37, 109791.
69. Chorghay, Z., MacFarquhar, D., Li, V.J., Aufmkolk, S., Schohl, A., Wiseman, P.W., Káradóttir, R.T., Ruthazer, E.S. (2021) Activity-dependent alteration of early myelin ensheathment in a developing sensory circuit. The Journal of Comparative Neurology, doi: 10.1002/cne.25253
70. Benfey, N., Foubert, D., Ruthazer, E.S. (2022) Glia regulate the development, function, and plasticity of the visual system from retina to cortex. Front. Neural Circuits doi: 10.3389/fncir.2022.826664
71. Li, V.J. Schohl, A., Ruthazer, E.S. (2022) Topographic map formation and the effects of NMDA receptor blockade in the developing visual system. PNAS, 119 (8) e2107899119.
72. Ruthazer, E.S., Béïque, J.C., De Koninck, Y (2022) Editorial on the research topic: Shedding Light on the Nervous System: Progress in Neurophotonics Research. Front. Neural Circuits, doi: 10.3389/fncir.2022.901376
73. Li, V.J., Chorghay, Z., Ruthazer, E.S. (2022) A Guide for the Multiplexed: The Development of Visual Feature Maps in the Brain, Neuroscience https://doi.org/10.1016/j.neuroscience.2022.07.026.
74. Kutsarova, E., Schohl, A., Munz, M., Wang, A., Zhang, Y. Y., Bilash, O. M., & Ruthazer, E. S. (2023). BDNF signaling in correlation-dependent structural plasticity in the developing visual system. PLoS biology, 21(4), e3002070. https://doi.org/10.1371/journal.pbio.3002070
75. Chorghay, Z, Li, V.J., Schohl, A. Ghosh, A., Ruthazer, E.S. (2023) The effects of the NMDAR co-agonist D-serine on the structure and function of optic tectal neurons in the developing visual system Scientific Reports, Aug 17;13(1):13383 https://doi.org/10.1038/s41598-023-39951-4
76. Foubert, D., Cookson, F. Ruthazer, E.S. (2023) Capturing a rising star - the emerging role of astrocytes in neural circuit wiring and plasticity- lessons from the visual system. Neurophotonics, 10(4), 044408 (2023), doi: 10.1117/1.NPh.10.4.044408.
77. Glasgow SD, Wong EW, Beamish IV, Lancon K, Gibon J, Séguéla P, Ruthazer ES, Kennedy TE. (2024) Acetylcholine synergizes with netrin-1 to drive persistent firing in the entorhinal cortex, Cell Reports, 43(2):113812.