Publications

BOOKS (Online)

Research Articles

Book Chapters

Multimedia

Case Reports

BOOKS (Online)

Please note that the online versions are a work in progress.

Selvaratnam, R., (2024). Blood Gases and Electrolytes - Essential Questions

Open Online Book

Selvaratnam, R., (2024). Gastrointestinal & Pancreatic Disorders - Essential Questions

Open Online Book

Research Articles

All articles below have PDF files that can be downloaded. If something is missing or not working, please email me for a copy of the intended file or manuscript.

Pinard, L., Ullur, A. R., Everest, L., Zhan, L. J., Selvaratnam, R., Balaratnam, K., ... & Kitchlu, A. (2025). Real-World Creatinine-Based Estimates of Acute and Chronic Kidney Dysfunction in Patients with Advanced ALK-Rearranged Non-Small-Cell Lung Cancer Receiving Tyrosine Kinase Inhibitors. Clinical Lung Cancer.

Brinc, D., Lu, C. Y., Rodrigues, O., Rokhforooz, F., Leung, F., Nyholt, D., & Selvaratnam, R. (2025). Assay-dependent effects of EDTA contamination on Magnesium and Iron. Clinica Chimica Acta, 120453.

Bohn, M. K., Asare-Werehene, M., Leung, F., Brinc, D., & Selvaratnam, R. Discordance between creatinine and cystatin C-based estimation of glomerular filtration rate (eGFR) in solid organ transplant recipients. Clinical Biochemistry, 2024 110853.

Selvaratnam R, Srivastava P, Tacker DH, Thebo J, Wheeler SE. Comparison of quantitative and qualitative anti-dsDNA assays. Laboratory Medicine. 2024 May 27:lmae035.

Zhou, J., Fabros, A., Lam, S. J., Coro, A., Selvaratnam, R., Brinc, D., & Di Meo, A. (2024). The stability of 65 biochemistry analytes in plasma, serum, and whole blood. Clinical Chemistry and Laboratory Medicine: CCLM / FESCC, 0(0), 1–13.

Bharti, V., Jung, B., Lam, S., Fabros, A., Selvaratnam, R. (2023). Stability and Analytical Characterization of Voriconazole as Measured by Immunoassay. The Journal of Applied Laboratory Medicine. 2024 May;9(3):565-72.

Leung, F., Logan, S., Selvaratnam, R. (2023). The Forgotten Mountain Plot - An Illustration of Bias Across Lipase Methods. The Journal of Applied Laboratory Medicine. 2024 Mar;9(2):412-4.

Logan S, Randhawa HK, Selvaratnam R. Unification of Triglyceride Limits for Hypertriglyceridemia. The Canadian Journal of Cardiology. 2023 Oct 14:S0828-282X.

Miller, J. J., Bohn, M. K., Higgins, V., Nichols, M., Mohammed-Ali, Z., Henderson, T., Selvaratnam, R., Sepiashvili, L., & Adeli, K. (2023). Pediatric reference intervals for endocrine markers in healthy children and adolescents on the Liaison XL (DiaSorin) immunoassay system. Clinical Biochemistry, 120(110644), 110644.

Logan, S., & Selvaratnam, R. (2023). Factors to consider with estimated low-density lipoprotein cholesterol using the new Sampson-NIH equation. Clinical Biochemistry, 110633.

Karin. A., Higgins, V., Miller J., Brinc, D., Kulasingham, V., Selvaratnam, R. (2023). Evaluation of hemolysis, lipemia, and icterus interference with common clinical immunoassays. Clinical Chemistry and Laboratory Medicine.

Ivica, J., Sanmugalingham, G., & Selvaratnam, R. (2022). Alerting to Acute Kidney Injury-Challenges, benefits, and strategies. Practical Laboratory Medicine, e00270.

Dent, A., & Selvaratnam, R. (2022). Measuring magnesium–Physiological, clinical and analytical perspectives. Clinical Biochemistry, 105, 1-15.

Mohamed, H., Baryar, U., Bashiri, A., Selvaratnam, R., VanSchouwen, B., & Melacini, G. (2022). Identification of core allosteric sites through temperature-and nucleus-invariant chemical shift covariance. Biophysical Journal, 121(11), 2035-2045.

Higgins, V., Cheng, P. L., Selvaratnam, R., & Brinc, D. (2021). Optimizing Measurement and Interpretation of the G6PD/Hb Ratio. The Journal of Applied Laboratory Medicine, 6(5), 1251-1263.

Higgins, V., Patel, K., Kulasingam, V., Beriault, D. R., Rutledge, A. C., Selvaratnam, R. (2020). Analytical performance evaluation of thyroid-stimulating hormone receptor antibody (TRAb) immunoassays. Clinical Biochemistry.

Mohammed-Ali Z, Selvaratnam R. Response to'ROC can be used to determine the optimal threshold of ALT for reflex to AST testing'. Clinical Biochemistry. 2020 Jun 21;83:94-5.

Mohammed-Ali, Z., Brinc D., Kulasingam V., Selvaratnam, R. (2020). Defining appropriate utilization of AST testing. Clin Biochem, 79, 75-7.

Boulton, S., Selvaratnam, R., Ahmed, R., Van, K., Cheng, X., & Melacini, G. (2019). Mechanisms of Specific versus Nonspecific Interactions of Aggregation-Prone Inhibitors and Attenuators. Journal of medicinal chemistry.

Boulton, S., Selvaratnam, R., Blondeau, J. P., Lezoualc’h, F., & Melacini, G. (2018). Mechanism of Selective Enzyme Inhibition through Uncompetitive Regulation of an Allosteric Agonist. Journal of the American Chemical Society, 140(30), 9624-9637.

Rodriguez, F., Selvaratnam, R., Mann, P., Kalariya, R., & Petersen, J. R. (2018). What’s a Lab to Do During and After a Hurricane? Laboratory medicine, 49(2), e23-e28.

Rodriguez Jr, F. H., Petersen, J., Selvaratnam, R., Mann, P., & Hoyne, J. B. (2018). Hurricanes: Are You Prepared? Laboratory medicine, 49(2), e18-e22.

Selvaratnam, R., & Karger, A. B. (2017). The Importance of Verifying Reference Intervals for Calculated Results. Journal of Applied Laboratory Medicine. 2(3), 466 – 468.

2017 - JALM - The importance of verifying reference intervals for calculated results.pdf

2017 - JALM - [podcast Transcripts] The importance of verifying reference intervals for calculated results.pdf

VanSchouwen, B., Selvaratnam, R., Giri, R., Lorenz, R., Herberg, F. W., Kim, C., & Melacini, G. (2015). Mechanism of cAMP partial agonism in protein kinase G (PKG). Journal of Biological Chemistry, 290(48), 28631-28641.

Boulton, S., Akimoto, M., Selvaratnam, R., Bashiri, A., & Melacini, G. (2014). A tool set to map allosteric networks through the NMR chemical shift covariance analysis. Scientific reports, 4, 7306.

Akimoto, M., Zhang, Z., Boulton, S., Selvaratnam, R., VanSchouwen, B., Gloyd, M., ... & Melacini, G. (2014). A mechanism for the auto-inhibition of hyperpolarization-activated cyclic nucleotide-gated (HCN) channel opening and its relief by cAMP. Journal of Biological Chemistry, jbc-M114.

Matthews, L. A., Selvaratnam, R., Jones, D. R., Akimoto, M., McConkey, B. J., Melacini, G., ... & Guarné, A. (2014). A novel non-canonical forkhead-associated (FHA) domain-binding interface mediates the interaction between Rad53 and Dbf4 proteins. Journal of Biological Chemistry, 289(5), 2589-2599.

Huang, G. Y., Kim, J. J., Reger, A. S., Lorenz, R., Moon, E. W., Zhao, C., Casteel D.E., Bertinetti D., VanSchouwen B., Selvaratnam, R., Pflugrath, J. W., Sankaran B., Melacini G., Herberg F.W., Kim C. (2014). Structural basis for cyclic-nucleotide selectivity and cGMP-selective activation of PKG I. Structure, 22(1), 116-124.

Son, I., Selvaratnam, R., Dubins, D. N., Melacini, G., & Chalikian, T. V. (2013). Ultrasonic and densimetric characterization of the association of cyclic AMP with the cAMP-binding domain of the exchange protein EPAC1. The Journal of Physical Chemistry B, 117(37), 10779-10784.

Akimoto, M., Selvaratnam, R., McNicholl, E. T., Verma, G., Taylor, S. S., & Melacini, G. Signaling through dynamic linkers as revealed by PKA. Proceedings of the National Academy of Sciences, 2013, 110(35), 14231–14236.

Selvaratnam, R., Akimoto, M., VanSchouwen, B., & Melacini, G. (2012). cAMP-dependent allostery and dynamics in Epac: an NMR view. Biochemical Society Transactions Jan 19, 2012, 40 (1) 219-223;

Selvaratnam, R., Mazhab-Jafari, M. T., Das, R., & Melacini, G. (2012). The auto-inhibitory role of the EPAC hinge helix as mapped by NMR. PloS one, 7(11), e48707.

Selvaratnam, R., VanSchouwen, B., Fogolari, F., Mazhab-Jafari, M. T., Das, R., & Melacini, G. (2012). The projection analysis of NMR chemical shifts reveals extended EPAC autoinhibition determinants. Biophysical journal, 102(3), 630-639.

Selvaratnam, R., Chowdhury, S., VanSchouwen, B., & Melacini, G. Mapping allostery through the covariance analysis of NMR chemical shifts. Proceedings of the National Academy of Sciences, 2011, 108(15), 6133–6138.

2011 - Selvaratnam - Mapping Allostery through the covariance analysis of NMR chemical chifts.pdf

VanSchouwen, B., Selvaratnam, R., Fogolari, F., & Melacini, G. (2011). Role of dynamics in the auto-inhibition and activation of the exchange protein directly activated by cyclic AMP (EPAC). Journal of Biological Chemistry, jbc-M111.

Das, R., Chowdhury, S., Mazhab-Jafari, M. T., SilDas, S., Selvaratnam, R., & Melacini, G. (2009). Dynamically driven ligand selectivity in cyclic nucleotide binding domains. Journal of Biological Chemistry, jbc-M109.

Das, R., Mazhab-Jafari, M. T., Chowdhury, S., SilDas, S., Selvaratnam, R., & Melacini, G. (2008). Entropy-driven cAMP-dependent allosteric control of inhibitory interactions in exchange proteins directly activated by cAMP. Journal of Biological Chemistry, 283(28), 19691-19703.

Book Chapters

Boulton, S., Selvaratnam, R., Ahmed, R., & Melacini, G. (2018). Implementation of the NMR CHEmical Shift Covariance Analysis (CHESCA): A Chemical Biologist’s Approach to Allostery. In Protein NMR (pp. 391-405). Humana Press, New York, NY.

2018 - Implementation of the NMR CHEmical Shift Covariance Analysis (CHESCA) - A chemical biologist's approach to allostery.pdf

Selvaratnam, R., Cao, J., Karger, A. B. (2016). Serum Free Light Chain Analysis. In Plasma Cell Neoplasms (pp. 25-42). Springer International Publishing.

2016 - Chapter_SerumFreeLightChainAnalysis.pdf

Multimedia

Selvaratnam, R., & Kaye, R., Podcast on “The Importance of Verifying Reference Intervals for Calculated Results” by The Journal of Applied Medicine.

Podcast link: http://traffic.libsyn.com/aaccjalm/JALM_201711_Selvaratnam.mp3

Transcript link: https://www.aacc.org/-/media/Files/Transcripts/JALMTALK/2017/JALM_201711_Selvaratnam.pdf

2017 - JALM - [podcast Transcripts] The importance of verifying reference intervals for calculated results.pdf

Selvaratnam, R.,Acute Kidney Injury – Pearls of Laboratory Medicine. Clinical Chemistry Trainee Council – American Association for Clinical Chemistry. April 2019

Case Reports

Asare-Werehene, M., Bohn, M. K., Ming-Freckleton, A., & Selvaratnam, R. (2025). The case of a bloody mess–Bictegravir/emtricitabine/tenofovir alafenamide induced colitis. Clinical Biochemistry, 137, 110910.

2025 - Fecal Calprotectin Case report.pdf

Selvaratnam, R. (2023). Hypomagnesemia from Kidney Transplant. American Society for Clinical Pathology (ASCP) Case Reports.

2023 - ASCP Case - Hypomagnesemia Kidney Tx - CC2305_Final.pdf

Zhou, Q., Selvaratnam, R.,(2022). Schnitzler Syndrome. American Society for Clinical Pathology (ASCP) Case Reports.

Selvaratnam, R., & Karger, A. B. (2016). A Newborn with Distended Abdomen. Clinical Chemistry, 62(8), 1061-1064.

2016-Newborn with Distended Abdomen.pdf

Selvaratnam, R. (2023). Hypomagnesemia from Kidney Transplant. American Society for Clinical Pathology (ASCP) Case Reports.

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