I was born in 1949 in Coventry and after attending Barr's Hill School I read Natural Sciences at Newnham College Cambridge. After graduating in 1971 I studied for a PhD at the Institute of Psychiatry, London where I worked on the neurophysiological basis of visual agnosia and neuropsychological aspects of somatosensory perception and spatial orientation. I moved, in 1977, to the MRC Clinical Research Centre, Harrow and worked on the behavioural and cognitive effects of dopaminergic overactivity in relation to the symptoms of psychosis and on the effects of cholinergic blockade in relation to learning impairment. I was also involved in studies of the transmissibility of diseases subsequently known as prion disease, including Creutzfeldt-Jakob disease, Gerstmann-Sträussler-Scheinker disease, bovine spongiform encephalopathy and scrapie. I was part of a team which studied the genetics of prion disease and was particularly interested in the genetic control of age at onset in a wide variety of adult onset diseases, including Huntington’s disease.