Hydrogels, three-dimensional mesh-like networks composed of hydrophilic polymers, offer enhanced binding kinetics, reduced steric hindrance, and improved probe-loading density. Furthermore, hydrogels can serve as independent reaction compartments for compartmentalized biochemical processes. We aim to develop novel hydrogel-based diagnostic platforms designed to provide highly sensitive, specific, multiplexed detection with increased portability, facilitating rapid and precise biomarker analysis.

Transcriptomics integrating temporal and spatial resolution provides a significantly deeper and more precise understanding of complex biological phenomena, such as disease progression and pharmacological responses. Conventional methodologies typically require cell lysis or fixation, thereby limiting longitudinal analyses on identical samples. To overcome this limitation, our goal is to develop novel temporal and spatial transcriptomics platforms based on nanostructures, including nanowires and nanostraws, capable of extracting transcriptomic data non-destructively, thus preserving cell viability for continuous monitoring.

Many therapeutic agents face challenges such as poor solubility, limited bioavailability, and narrow therapeutic index, which requires the development of advanced smart drug delivery systems to address these challenges. We aim to develop responsive drug delivery platforms that release therapeutic agents in a controlled, stimulus-triggered manner, enabling precise, targeted, and on-demand drug release, thus significantly enhancing therapeutic efficacy and reducing adverse side effects.