Unlike gender or race, class is rarely a focus of research or DEI efforts in elite US occupations. Should it be? In this paper, we document a large class gap in career progression in one labor market: US tenure-track academia. Using parental education to proxy for socioeconomic background, we compare career outcomes of people who got their PhDs in the same institution and field (excluding those with PhD parents). First-generation college graduates are 13% less likely to end up tenured at an R1, and are on average tenured at institutions ranked 9% lower, than their PhD classmates with a parent with a (non-PhD) graduate degree. We explore three mechanisms: (1) productivity, (2) preferences, and (3) discrimination. Research productivity can explain at most a third of the class gap, meaning first-gen college grads are “underplaced” at lower-ranked institutions than their research record would predict. Preferences explain almost none of the class gap. Discrimination likely explains the residual. Specifically, systemic or direct discrimination may arise from a lack of social and cultural capital. We find evidence consistent with this in analyses of coauthor networks and NSF awards. Finally, examining PhDs who work in industry we find a class gap in pay and in managerial responsibilities which widens over the career. This establishes that a class gap in career progression exists in other US occupations beyond academia.