R2 - A Dangerous Idea - Eugenics
DEATH by PEGylation
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A Dangerous Idea: The History of Eugenics in America
A Dangerous Idea: The History of Eugenics in America
Exactly 92 years after the infamous Buck v. Bell decision, the Center presents a partial screening of “A Dangerous Idea: Eugenics, Genetics and the American Dream”—an award-winning documentary exploring the legal history of the eugenics movement in the United States. Following the screening, join the film’s co-writer and executive producer Andrew Kimbrell, acclaimed author and journalist Daniel Okrent, and law and bioethics scholars Paul Lombardo and Dorothy Roberts for a conversation exploring the dark history of eugenics and the Constitution.
Jeffrey Rosen, president and CEO of the National Constitution Center, moderates.
Use of Human Embryonic Parts in Vaccines
"The best-known human cell line is MRC5; these cells derive from the lung of a 14-week-old male fetus from a pregnancy that was terminated for medical reasons in 1966. This cell line is used to grow viruses for vaccines against rubella, chickenpox and hepatitis A.
Other fetal cell lines, collected in the 1970s and 1980s, have been used for other vaccines, including influenza and some of the new COVID-19 vaccines. No fetal material is present in the final vaccine."
Monkey Business in Your Vaccine?!?
Viral vector
Viral vector
The Oxford–AstraZeneca vaccine is made from a cold-causing adenovirus that was isolated from the stool of chimpanzees and modified so that it no longer replicates in cells. When injected, the vaccine instructs human cells to produce the SARS-CoV-2 spike protein — the immune system’s main target in coronaviruses.
PEG is considered biologically inert and safe by the FDA.
However, a growing body of evidence shows the existence of a detectable level of anti-PEG antibodies in approximately 72% of the population, never treated with PEGylated drugs, based on plasma samples from 1990–1999.[40][further explanation needed] Due to its ubiquity in a multitude of products and the large percentage of the population with antibodies to PEG, hypersensitive reactions to PEG are an increasing concern.[41][42] Allergy to PEG is usually discovered after a person has been diagnosed with an allergy to an increasing number of seemingly unrelated products, including processed foods, cosmetics, drugs, and other substances that contain PEG or were manufactured with PEG.[41]
Such immunogenicity and adverse reactivities of PEGylated nanocarriers may be of potential concern for the clinical use of PEGylated therapeutics. Accordingly, screening of the immunogenicity and CARPA reactogenicity of nanocarrier-based therapeutics should be a prerequisite before they can proceed into clinical studies.
Published online 2019 Jun 26.
ABSTRACT
ABSTRACT
A commonly held view is that nanocarriers conjugated to polyethylene glycol (PEG) are non-immunogenic. However, many studies have reported that unexpected immune responses have occurred against PEG-conjugated nanocarriers. One unanticipated response is the rapid clearance of PEGylated nanocarriers upon repeat administration, called the accelerated blood clearance (ABC) phenomenon. ABC involves the production of antibodies toward nanocarrier components, including PEG, which reduces the safety and effectiveness of encapsulated therapeutic agents. Another immune response is the hypersensitivity or infusion reaction referred to as complement (C) activation-related pseudo allergy (CARPA). Such immunogenicity and adverse reactivities of PEGylated nanocarriers may be of potential concern for the clinical use of PEGylated therapeutics. Accordingly, screening of the immunogenicity and CARPA reactogenicity of nanocarrier-based therapeutics should be a prerequisite before they can proceed into clinical studies. This review presents PEGylated liposomes, immunogenicity of PEG, the ABC phenomenon, C activation and lipid-induced CARPA from a toxicological point of view, and also addresses the factors that influence these adverse interactions with the immune system.
ALCHEMY - How to Turn A Cheap Material (PEG) Into VAXGOLD
Polyethylene Glycol (PEG)
An Alcohol Spirit By Any Other Name
What We Know About PEG, Suspected as the Cause of Reactions to Pfizer’s COVID-19 Vaccine
"Currently, there is only limited awareness of the role of PEGs in reactions to medications where they are present as an ingredient. The degree to which PEG hypersensitivity might be a problem in the United States and the mechanism for PEG and polysorbate reactions are therefore not well understood. " The Journal of Allergy and Clinical Immunology: In Practice
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