USAID’s Reaching Impact Saturation and Epidemic Control (RISE) program is saving lives and improving health by controlling the HIV pandemic and strengthening global health security to limit the spread of deadly disease outbreaks. RISE uses evidence-based practices from over 20 years of PEPFAR implementation to address critical HIV and global health security priorities. RISE is also able to support maternal, newborn, and child health (MNCH), tuberculosis (TB), and malaria programming, along with support for data systems, supply chain and commodity management, and other cross-cutting areas. RISE is a multi-year project running through 2027, with an award ceiling of $391 million.