I am particularly interested in the process of scar formation in the brain following stroke and the complex interactions between the involved cell types. My expertise lies in animal modeling and imaging techniques, particularly immunohistochemistry. 

Currently, my research focuses on the complex structural changes of fibroblasts involved in forming fibrotic scars post-stroke, using 3D reconstruction and analyzing ultrastructural features through electron microscopy. I am also part of a study investigating differences in the microenvironment of the injury site and scar-forming glial cells in gene knockout mouse models after stroke.

My long-term goal is to deepen my understanding of the intricate and previously unknown interactions of various cell types involved in scar formation following stroke, using photothrombosis and cerebrovascular stroke models.

I enjoy spending time swimming or relaxing in a sauna as a way to unwind after a busy day. In my free time, I usually enjoy watching videos or listening to music while having a drink.

The interactions and 'seeing' the dynamics, changes, and reprogramming between different cells of the brain in response to stroke conditions are of the deepest interest to me. Stroke is a significant health challenge, responsible for about 11% of global deaths, with approximately 5.7 million fatalities recorded each year. Therefore, this proposal aims to contribute to stroke diagnosis and improve therapies for this devastating disease.

In response to this condition, the brain sets into motion a variety of mechanisms, entailing many genetic changes in macrophages. By studying macrophage heterogeneity, I plan to identify apparent differences and functional disparities that exist in interactions with other cells. This will help enhance our pathological understanding of stroke.

While I do various experimental techniques, my favorite is CLEM (Correlative Light and Electron Microscopy). This technique allows us to observe marker expression for cellular phenotypes and examine molecular mechanisms. "Seeing is believing!" - this phrase resonates deeply with me and perfectly aligns with the CLEM methodology.

Outside the lab, I find peace under starlit skies while camping, often capturing these moments in poetry. The vastness of the night sky reminds me of the microscopic universe I explore in my research - both equally mysterious and beautiful in their own ways.

I am deeply passionate about studying the biological mechanisms underlying Alzheimer's disease, one of the most challenging neurodegenerative disorders. My expertise focuses on immunohistochemistry imaging techniques in both human and mouse models.

My current research endeavors involve examining the characteristics of Neuritic plaques and NFTs through light and confocal microscopy using tissue obtained from cadavers, examining their pathways and interactions with immune cells. I am also collaborating on a project that explores histopathological changes in AD mouse models treated with intranasal and intraperitoneal drug administration.

Looking ahead, my ultimate research goal is to discover previously unknown mechanisms of Alzheimer's disease in human tissue and further understand various solutions that could potentially treat neurodegenerative disorders.

In my free time I love spending time with my adorable dog, keeping my home tidy, catching up on OTT content, and exploring charming cafés

Ji Yeon Lee

MS student

2026.01~

B.S. in Medical and Biological Sciences, The Catholic University of Korea

wldus0608a@naver.com

"I am deeply passionate about investigating the biological mechanisms of Alzheimer’s disease (AD), with a particular focus on immunohistochemistry (IHC) imaging in human tissue. My expertise lies in bridging the gap between high-resolution molecular analysis and macro-scale anatomical structures.

My current research endeavors center on three core pillars:

CSF Circulation Dynamics: Using cadaveric specimens to trace the circulation pathways of cerebrospinal fluid (CSF), specifically its drainage from meningeal lymphatic vessels to peripheral lymph nodes.

Gross Anatomy of Head and Neck Lymphatics: Conducting macroscopic examinations of cephalic lymphatic networks to map the definitive exit routes of CSF.

Molecular Atlas Construction: Building a comprehensive molecular map of the human meninges, focusing on the complex interplay between immune, vascular, and stromal cells.

Ultimately, I aim to discover novel pathological markers within human tissue that can lead to transformative solutions for neurodegenerative disorders. Beyond the lab, I find balance by exploring OTT content and visiting famous local restaurants to discover new flavors."