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extensively described and relevant literature on the outcomes of IP surgery is presented to the reader.Wound healing following ESS remains a significant element for the particular patient. Prolonged inflammation, scarring and synechiae can adversely influence the postoperative outcome. This is the reason why researchers are strongly interested in the generation of materials that may improve postoperative wound healing. Manciula et al. [22] examined in an experimental study the effects of astaxanthin—a powerful antioxidant—on nasal mucosa healing following surgery. The temporal evolution of wound healing was assessed through several parameters evaluating epithelial thickness, subepithelial thickness, goblet cells, and subepithelial fibrosis. The authors clearly demonstrate that astaxanthin given in the postoperative period significantly decreases fibrosis and prevents synechia development. Wound healing is clinically assessed in a clinical study by Trombitas et al. [23] Middle meatus antrostomy (MMA) stenosis is still reported as an unfavorable outcome in patients undergoing surgery. The authors present a prospective within-subject, randomized, controlled trial assessing the effect of spray cryotherapy on wound healing. Included were 26 patients with bilateral CRS without polyps. The outcomes were represented by MMA diameter and area, histology, and symptoms. The MMA diameter and area were significantly increased in the cryotherapy group. Nasal obstruction and discharge were significantly improved following cryotherapy. Moreover, cryotherapy significantly decreases inflammation, edema and goblet cell hyperplasia. As demonstrated by the diversity of papers selected in this Special Issue of JCM, there is something interesting for all readers of the journal. Clinicians interested in rhinology, endoscopic surgeons, basic science researchers, public health providers, and internal medicine physicians will find something of interest in this issue. The cautious selection of such articles speaks for the ongoing success of JCM as a leading reference among open access publications.