Publication
-2024-
76. Kang MG† Kim HR†, Lee HY†, Kwak C, Koh H, Kang BH, Roe JS*, Rhee HW*, Mitochondrial thermogenesis can trigger heat-shock response in the nucleus, ACS Cent. Sci. 2024, accepted (†equally contributed) [Biorxiv-PDF]
75. Shin S†, Lee SY†, Kang MG, Jang DG, Kim J, Rhee HW*, Kim JS* Super-resolution proximity labeling with enhanced direct identification of biotinylation sites. Commun Biol. 2024, 7, 554 (†equally contributed) [PDF]
74. Lee YB, Rhee HW* Spray-Type Modifications: An Emerging Paradigm in Post-translational Modifications, Trends Biochem. Sci. 2024, 3, 208-223 [PDF]
73. Sharma N†, Jung M†, Mishra PK, Mun JY*, Rhee HW* FLEX: genetically encodable enzymatic fluorescence signal amplification using engineered peroxidase, Cell Chem. Biol. 2024, 3, 502-513 (†equally contributed) [PDF]
72. Park I†, Kim KE†, Kim J†, AK Kim, Bae S, Jung M, Choi J, Mishra PK, TM Kim, Kwak C, Kang MG, Yoo CM, Mun JY, Liu KH, Lee KS*, Kim JS*, Suh JM*, Rhee HW* Mitochondrial matrix RTN4IP1/OPA10 is an oxidoreductase for coenzyme Q synthesis , Nature Chemical Biology, 2024, 20, 221-233 (†equally contributed, Highlighted in Nature Chemical Biology) [PDF]
71. Lee A, Sung G, Shin S, Lee SY, Sim J, Nhung TTM, Nghi TD, Park SK, Sathieshkumar PP, Kang I, Mun JY, Kim JS*, Rhee HW*, Park KM*, Kim K*. OrthoID: profiling dynamic proteomes through time and space using mutually orthogonal chemical tools, Nat Commun, 2024, 1851. [PDF]
70. Kim JE, Park SY, Kwak C, Lee Y, Song DG, Jung JW, Lee H, Shin EA, Pinanga Y, Pyo KH, Lee EH, Kim W, Kim S, Jun CD, Yun J, Choi S, Rhee HW, Liu KH*, Lee JW* Glucose-mediated mitochondrial reprogramming by cholesterol export at TM4SF5-enriched mitochondria-lysosome contact sites. Cancer Commun. 2024, 44, 47-75
69. Kwak C†, Finan GM†, Park YR, Garg A, Harari O, Mun JY*, Rhee HW*, Kim TW*. Proximity Proteome Analysis Reveals Novel TREM2 Interactors in the ER-Mitochondria Interface of Human Microglia. BioRxiv. 2023 (†equally contributed) [PDF]
-2023-
68. Heo J, Park YJ, Kim Y, Lee HS, Kim J, Kwon SH, Kang MG, Rhee HW, Sun W, Lee JH*, Cho H*. Mitochondrial E3 ligase MARCH5 is a safeguard against DNA-PKcs-mediated immune signaling in mitochondria-damaged cells. Cell Death Dis. 2023, 14, 788
67. Mishra PK*, Sharma N, Kim H, Lee C, Rhee HW* GEN-Click: Genetically Encodable Click Reactions for Spatially Restricted Metabolite Labeling, ACS Central Science, 2023, 9, 1650–1657 [PDF]
66. Lee YB, Jung M, Kim J, Charles A, Christ W, Kang J, Kang MG, Kwak C, Klingström J, Smed-Sörensen A, Kim JS*, Mun JY*, Rhee HW* Super-resolution proximity labeling reveals antiviral protein network and its structural changes against SARS-CoV-2 viral proteins. Cell Reports, 2023, 42, 112835 [PDF]
65. Kim Y, Kwak C, Park JB, Nam DH*, Rhee HW*, Kim SS* The Regulatory Roles of Mitochondrial Metabolism Dynamics and Mitochondria Calcium Uniporter (MCU) in Bevacizumab Resistance of GBM, Advanced Therapeutics, 2023, 2300067.
64. Kim N, Kim TH, Kim C, Lee JE, Kang MG, Shin S, Jung M, Kim JS, Mun JY, Rhee HW, Park SY, Shin Y, Yoo JY* Intrinsically disordered region-mediated condensation of IFN-inducible SCOTIN/SHISA-5 inhibits ER-to-Golgi vesicle transport. Developmental Cell 2023, 58, 1950-1966.
63. Thi My Nhung T, Phuoc Long N, Diem Nghi T, Suh Y, Hoang Anh N, Jung CW, Minh Triet H, Jung M, Woo Y, Yoo J, Noh S, Kim SJ, Lee SB, Park S, Thomas G, Simmen T, Mun J, Rhee HW, Kwon SW, Park SK* Genome-wide kinase-MAM interactome screening reveals the role of CK2A1 in MAM Ca2+ dynamics linked to DEE66, PNAS, 2023, 120, e2303402120
62. Park A†, Kim KE†, Park I, Lee SH, Park KY, Jung M, Li X, Sleiman MB, Lee SJ, Kim DS, Kim J, Lim DS, Woo EJ, Lee EW, Han BS, Oh KJ, Lee SC, Auwerx J, Mun JY, Rhee HW, Kim WK*, Bae KH*, Suh JM*. Mitochondrial matrix protein LETMD1 maintains thermogenic capacity of brown adipose tissue in male mice. Nat Commun. 2023, 14, 3746.
61. Yun SI, Kwak C, Lee SY, Shin S, Oh C, Kim JS, Rhee HW*, Kim KK*. Binding of USP4 to cortactin enhances cell migration in HCT116 human colon cancer cells. FASEB J. 2023 , 37, e22900.
60. Sharma N, Mishra PK, Yoo CM, Jung M, Mun JY, Rhee HW*. A multifunctional peroxidase-based reaction for imaging, sensing and networking of spatial biology. Biochim. Biophys. Acta Mol. Cell. Res. 2023, 119428
-2022-
59. Li M, Xu Y, Rhee HW, Kim JS*, Deep-red-light photocatalytic protein proximity labeling, Chem, 2022, 8, 3171-3174.
58. Kwak C†, Park C†, Ko M, Im CY, Moon H, Park YH, Kim SY, Lee S, Kang MG, Kwon HJ*, Hong E*, Seo JK*, Rhee HW* Identification of compound-binding target proteins in live cells by proximity labeling (PROCID), Cell Chem. Biol. 2022, 29, 1739-1753(†equally contributed) [PDF]
57. Mishra PK†, Park I†, Sharma N, Yoo CM, Lee HY, Rhee HW* Enzymatic recording of local hydrogen peroxide generation using genetically encodable enzyme, Anal. Chem. 2022, 94, 14869-14877 (†equally contributed)
56. Kang MG, Rhee HW* Molecular Spatiomics by Proximity Labeling, Acc. Chem. Res. 2022 , 55, 1411–1422 (Invited review article) [PDF]
55. Tran Q, Lee H, Jung JH, Chang SH, Shrestha R, Kong G, Park J, Kim SH, Park KS, Rhee HW, Yun J, Cho MH*, Kim KP*, Park J* Emerging role of LETM1/GRP78 axis in lung cancer. Cell Death Dis. 2022, 13, 543.
54. Beon J, Han S, Yang H, Park SE, Hyun K, Lee SY, Rhee HW, Seo JK, Kim J, Kim S*, Lee D* Inositol polyphosphate multikinase physically binds to the SWI/SNF complex and modulates BRG1 occupancy in mouse embryonic stem cells. eLife. 2022, 11, e73523.
53. Yasuda K, Watanabe TM, Kang MG, Seo JK, Rhee HW, Tate SI* Valosin-containing protein regulates the stability of fused in sarcoma granules in cells by changing ATP concentrations. FEBS Lett. 2022, 596, 1412-1423
52. Mishra PK†, Kang MG†, Lee H, Kim S, Choi S, Sharma N, Park CM, Ko J, Lee C*, Seo JK*, Rhee HW* A Chemical Tool for Blue Light-Inducible Proximity Photo-crosslinking in Live Cells. Chem. Sci. 2022, 13, 955-966 (†equally contributed) [pdf]
51. Choi CR, Rhee HW*, Proximity labeling: An Enzymatic Tool for Spatial Biology, Trends Biotechnol. 2022, 40, 145-148 [pdf]
- 2021-
50. Sohn JH, Ji Y, Cho CY, Nahmgoong H, Lim S, Jeon YG, Han SM, Han JS, Park I, Rhee HW, Kim S, Kim JB* Spatial Regulation of Reactive Oxygen Species via G6PD in Brown Adipocytes Supports Thermogenic Function. Diabetes 2021, 70, 2756-2770.
49. Kim KE†, Park I†, Kim J, Kang MG, Choi WG, Shin H, Kim JS*, Rhee HW*, Suh JM* Dynamic tracking and identification of tissue-specific secretory proteins in the circulation of live mice. Nat. Commun. 2021, 12, 5204 (†equally contributed) [pdf]
48. Lee YG, Kim HW, Nam Y, Shin KJ, Lee YJ, Park DH, Rhee HW, Seo JK, Chae YC*. LONP1 and ClpP cooperatively regulate mitochondrial proteostasis for cancer cell survival. Oncogenesis. 2021, 26, 10, 18.
47. Lee C†, Nam JS†, Lee CG, Park M, Yoo CM, Rhee HW, Seo JK*, Kwon TH* Analysing the mechanism of mitochondrial oxidation-induced cell death using a multifunctional iridium(III) photosensitiser, Nat. Commun. 2021, 12, 26.
- 2020 -
46. Mishra PK, Kang, MG, Rhee HW,* Optical Imaging Probes for Amyloid Diseases in Brain, Neurohistology and Imaging Techniques (Springer), 2020, 153, 157-182 (Invited Book Chapter)
45. Cho KF, Branon TC, Rajeev S, Svinkina T, Udeshi ND, Thoudam T, Kwak C, Rhee HW, Lee IK, Carr SA, Ting AY* Split-TurboID enables contact-dependent proximity labeling in cells, PNAS, 2020, 117, 12143-12154.
44. Kwak C†, Shin S†, Park JS†, Jung M, Nhung TTM, Kang MG, Lee C, Kwon TH, Park SK*, Mun JY*, Kim JS*, Rhee HW* Contact-ID, a tool for profiling organelle contact site, reveals regulatory proteins of mitochondrial-associated membrane formation, PNAS, 2020, 117, 12109-12120 (†equally contributed).
43. Kwon J†, Park JS†, Kang M, Choi S, Park J, Kim KT, Lee C, Cha S, Rhee HW*, Shim SH*, Bright ligand-activatable fluorescent protein for high-quality multicolor live-cell super-resolution microscopy, Nat. Commun. 2020, 11, 273 (†equally contributed).
42. Sung G, Lee SY, Kang MG, Kim KL, An J, Sim J, Kim S, Kim S, Ko J, Rhee HW*, Park KM*, Kim K*, Supra-blot: an accurate and reliable assay for detecting target proteins with a synthetic host molecule-enzyme hybrid. Chem. Commun. 2020, 56, 1549-1552.
41. Mishra PK, Yoo CM, Hong E, Rhee HW* Photo-crosslinking: An emerging chemical tool for investigating molecular networks in live cells, Chembiochem , 2020, 21, 924-932 (Invited Minireview).
40. Yoo CM, Rhee HW* APEX, a master key to resolve membrane topology in live cells, Biochemistry (Perspective), 2020, 59, 250-259 (Invited Article in Future of Biochemistry issue).
- 2019 -
39. Van Haute L, Lee SY, McCann BJ, Powell CA, Bansal D, Vasiliauskaitė L, Garone C, Shin S, Kim JS, Frye M, Gleeson JG, Miska EA, Rhee HW, Minczuk M* NSUN2 introduces 5-methylcytosines in mammalian mitochondrial tRNAs. Nucleic Acids Res. 2019, 47, 8720-8733.
38 .Kang J, Nam JS, Lee HJ, Nam G, Rhee HW, Kwon TH*, Lim MH* Chemical strategies to modify amyloidogenic peptides using iridium(iii) complexes: coordination and photo-induced oxidation. Chem Sci. 2019, 10, 6855-6862.
37. Lee SY, Seo JK, Rhee HW* Direct Identification of Biotinylated Proteins from Proximity Labeling (Spot-BioID) , Methods Mol. Biol. 2019 , 97-105 (Invited Book Chapter)
36. Park J†, Lee SY†, Jeong H, Kang MG, Haute L, Minczuk M, Seo JK, Jun Y, Myung K, Rhee HW*, Lee C* The structure of human EXD2 reveals a chimeric 3′ to 5′ exonuclease domain that discriminates substrates via metal coordination, Nucleic Acid Res. 2019, 47, 7078-7093 (†equally contributed).
35. Thoudam T, Ha CM, Leem J, Chanda D, Park JS, Kim HJ, Jeon JH, Choi YK, Liangpunsakul S, Huh YH, Kwon TH, Park KG, Harris RA, Park KS, Rhee HW, Lee IK* PDK4 Augments ER-Mitochondria Contact to Dampen Skeletal Muscle Insulin Signaling During Obesity, Diabetes, 2019, 68, 571-558.
- 2018/2017 -
34. Kim Y*, Park J, Kim S, Kim M, Kang MG, Kwak C, Kang M, Kim B, Rhee HW, Kim VN* PKR Senses Nuclear and Mitochondrial Signals by Interacting with Endogenous Double-Stranded RNAs. Mol. Cell. 2018, 71, 1051-1063.
33. Park H, Choi Y, Jeena MT, Ahn E, Choi Y, Kang MG, Lee CG, Kwon TH, Rhee HW, Ryu JH, Kim BS* Reduction-Triggered Self-Cross-Linked Hyperbranched Polyglycerol Nanogels for Intracellular Delivery of Drugs and Proteins. Macromol. Biosci. 2018, 18, e1700356.
32. Kang MG†, Lee H†, Kim BH, Dunbayev Y, Seo JK, Lee C*, Rhee HW*, Structure-Guided Synthesis of a Protein-Based Fluorescent Sensor for Alkyl Halides, Chem. Commun. 2017, 53, 9226-9229. (†equally contributed)
31. Jeena MT, Palanikumar L, Go EM, Kim I, Kang MG, Lee S, Park S, Choi H, Kim C, Jin SM, Bae SC, Rhee HW, Lee E*, Kwak SK*, Ryu JH*, Mitochondria localization induced self-assembly of peptide amphiphiles for cellular dysfunction. Nat. Commun. 2017, 8, 26.
30. Lee SY, Kang MG, Shin S, Kwak C, Kwon T, Seo JK*, Kim JS*, Rhee HW*, Architecture Mapping of the Inner Mitochondrial Membrane Proteome by Cheimcal Tools in Live Cells. J. Am. Chem. Soc. 2017, 139, 3651-3662. (Highlighted in JACS Young Investigators issue-2018)
29. Kang MG, Park J, Balboni G, Lim MH, Lee C, Rhee HW* Genetically Encodable Bacterial Flavin Transferase for Fluorogenic Protein Modification in Mammalian Cells. ACS Synth. Biol. 2017, 6, 667-677.
28. Kang J, Lee SJ, Nam JS, Lee HJ, Kang MG, Korshavn KJ, Kim HT, Cho J, Ramamoorthy A, Rhee HW*, Kwon TH*, Lim MH* An Iridium(III) Complex as a Photoactivatable Tool for Oxidation of Amyloidogenic Peptides with Subsequent Modulation of Peptide Aggregation. Chem. Eur. J. 2017, 23, 1645-1653.
- 2016 -
27. Nam JS†, Kang MG†, Kang J†, Park SY†, Lee SJ, Kim HT, Seo JK, Kwon OH, Lim MH*, Rhee HW*, Kwon TH* Endoplasmic Reticulum-Localized Iridium(III) Complexes as Efficient Photodynamic Therapy Agents via Protein Modifications. J. Am. Chem. Soc. 2016, 138, 10968-10977.(†equally contributed)
26. Lee SY†, Lee H†, Lee HK, Lee SW, Ha SC, Kwon T, Seo JK*, Lee C*, Rhee HW* Proximity-Directed Labeling Reveals a New Rapamycin-Induced Heterodimer of FKBP25 and FRB in Live Cells. ACS Cent. Sci. 2016, 2, 506-516. (†equally contributed) [pdf]
25. Park JS, Nam E, Lee HK, Lim MH*, Rhee HW* In Cellulo Mapping of Subcellular Localized Bilirubin. ACS Chem. Biol. 2016, 11, 2177-2185.
24. Lee SY, Kang MG, Park JS, Lee G, Ting AY*, Rhee HW* APEX fingerprinting reveals the subcellular localization of proteins of interest. Cell Rep. 2016, 15, 1837-1847. [pdf]
23. Saha P, Jeon H, Mishra PK, Rhee HW*, Kwak JH* N-H and S-H Insertions over Cu(I)-Zeolites as Heterogeneous Catalysts. J. Mol. Catal. A. 2016, 417, 10-18.
22. Rhee HW* Proteomic Mapping by Enzyme-Mediated Reactions (효소화학반응을 이용한 단백질체 맵핑). 2016, 화학세계 1월호, Korean Chemical Society (mini-review, written in Korean)
- 2014/2015-
21. Lee J, Song EK, Bae Y, Min J, Rhee HW, Park TJ, Kim M*, Kang S* An Enhanced Ascorbate Peroxidase 2/Antibody Binding Domain Fusion Protein (APEX2-ABD) as a Recombinant Target Specific Signal Amplifier, Chem. Commun. 2015, 10945-10948.
20. Oh JR, Rhee HW, Hong JI* Ch6. Synthetic Receptor for Nucleosides/Nucleotides, Synthetic Receptors for Biomolecules, RSC Publishing (invited book chapter), 2015.
19. Shin IS, Chand R, Lee SW, Rhee HW, Kim YS*, Hong JI* Homogeneous Electrochemical Assay for Protein Kinase Activity. Anal. Chem. 2014, 86, 10992-10995.
18. Xu W, Ren C, Teoh CL, Peng J, Gadre SH, Rhee HW*, Lee CL*, Chang YT* An Artificial Tongue Fluorescent Sensor Array for Identification and Quantitation of Various Heavy Metal Ions , Anal. Chem.2014, 86, 8763–8769.
17. Hung V, Zou P, Rhee HW, Udeshi ND, Cracan V, Svinkina T, Carr SA, Mootha VK, Ting AY* Proteomic mapping of the human mitochondrial intermembrane space in live cells via ratiometric APEX tagging. Mol. Cell 2014, 55, 332-341.
16. Lee SH, Rhee HW, van Noort D, Lee HJ, Park HH, Shin IS, Hong JI*, Park TH* Microfluidic bead-based sensing platform for monitoring kinase activity, Biosens. Bioelectron. 2014, 57, 1-9
- 2013 -
15. Lee SW, Rhee HW, Chang YT, Hong JI* Ratiometric Fluorescent Probes for Hydrogen Peroxide from a Focused Library, Chem. Eur. J. 2013, 19, 14791–14794.
14. Rhee HW†, Lee SW†, Lee JS, Chang YT*, Hong JI* Focused Fluorescent Probe Library for Metal Cations and Biological Anions , ACS Comb. Sci. 2013, 15, 483–490. (†equally contributed)
13. Rhee HW†, Zou P†, Udeshi ND, Martell JD, Mootha VK, Carr SA, Ting AY* Proteomic Mapping of Mitochondria in Living Cells via Spatially Restricted Enzymatic Tagging. Science 2013, 339, 1328-1331. (Highlighted in Nature Methods, Nature Reviews Molecular Cell Biology, †equally contributed)
12. Kim SJ†, Rhee HW†, Park HJ, Kim HY, Kim HS, Hong JI* Fluorescent probes designed for detecting human serum albumin on the basis of its pseudo-esterase activity Bioorg. Med. Chem. Lett. 2013, 23, 2093-2097.(†equally contributed)
11. Choi SJ, Rhee HW, Kim J, Chung DS, Hong JI*, Fluorescent Assay of Cyclic Nucleotide Phosphodiesterase Activity in a Neutral Aqueous Solution, Bull. Korean Chem. Soc. 2013, 34, 31
- Prior to 2013-
10. Park HJ, Rhee HW, Hong JI* Activity-based fluorescent probes for monitoring sulfatase activity. Bioorg. Med. Chem. Lett. 2012, 4939-4941
9. Yu SY, Rhee HW, Hong JI* Fluorescent sensing system for palladium(II) based on the Heck reaction, Tetrahedron Lett. 2011, 52, 1512-1514.
8. Sun D, Lee G, Lee JH, Kim HY, Rhee HW, Park SY, Kim KJ, Kim Y, Kim BY, Hong JI, Park C, Choy HE, Kim JH, Jeon YH*, Chung J* A metazoan ortholog of SpoT hydrolyzes ppGpp and functions in starvation responses. Nat. Struct. Mol. Biol. 2010, 17, 1188-94.
7. Gao W, Chua K, Davies JK, Newton HJ, Seemann T, Harrison PF, Holmes NE, Rhee HW, Hong JI, Hartland EL, Stinear TP*, Howden BP* Two novel point mutations in clinical Staphylococcus aureus reduce linezolid susceptibility and switch on the stringent response to promote persistent infection. PLoS Pathog. 2010, 6, e1000944.
6. Rhee HW, Lee SH, Park HH, Han K, Park TH*, Hong JI* Detection of kinase activity using versatile fluorescence quencher probes. Angew. Chem. Int. Ed. Engl. 2010, 49, 4919-4923.
5. Rhee HW, Kim KS, Han PL, Hong JI* Label-free fluorescent real-time monitoring of adenylyl cyclase. Bioorg. Med. Chem. Lett. 2010, 20, 1145-1147.
4. Rhee HW, Choi SJ, Yoo SH, Jang YO, Park HH, Pinto RM, Cameselle JC, Sandoval FJ, Roje S, Han K, Chung DS, Suh J*, Hong JI* A bifunctional molecule as an artificial flavin mononucleotide cyclase and a chemosensor for selective fluorescent detection of flavins. J. Am. Chem. Soc. 2009, 131, 10107-1011
3. Kim YS, Park HH, Rhee HW, Hong JI, Han K* Neutrophils with toxic granulation show high fluorescence with bis(Zn2+-dipicolylamine) complex. Ann Clin Lab Sci. 2009, 39,114-119.
2. Rhee HW, Lee CR, Cho SH, Song MR, Cashel M, Choy HE, Seok YJ, Hong JI* Selective fluorescent chemosensor for the bacterial alarmone (p)ppGpp. J. Am. Chem. Soc. 2008, 130, 784-785. (Highlighted in JACS Select )
1. Rhee HW, Choi HY, Han K, Hong JI* Selective fluorescent detection of flavin adenine dinucleotide in human eosinophils by using bis(Zn2+-dipicolylamine) complex. J. Am. Chem. Soc. 2007, 129, 4524-4525.