Concortium Leader Group (Dr. Béla Völgyi, Hungary)
Previous, related publications
Balogh B, Szarka G, Tengölics ÁJ, Hoffmann G, Völgyi B, Kovács-Öller T. LED-Induced Microglial Activation and Rise in Caspase3 Suggest a Reorganization in the Retina. Int J Mol Sci. 2021 Sep 27;22(19):10418. doi: 10.3390/ijms221910418. PMID: 34638759; PMCID: PMC8508983.
Fusz K, Kovács-Öller T, Kóbor P, Szabó-Meleg E, Völgyi B, Buzás P, Telkes I. Regional Variation of Gap Junctional Connections in the Mammalian Inner Retina. Cells. 2021 Sep 12;10(9):2396. doi: 10.3390/cells10092396. PMID: 34572046; PMCID: PMC8466939.
Szarka G, Balogh M, Tengölics ÁJ, Ganczer A, Völgyi B, Kovács-Öller T. The role of gap junctions in cell death and neuromodulation in the retina. Neural Regen Res. 2021 Oct;16(10):1911-1920. doi: 10.4103/1673-5374.308069. PMID: 33642359; PMCID: PMC8343308.
Völgyi B. Molecular Biology of Retinal Ganglion Cells. Cells. 2020 Nov 15;9(11):2483. doi: 10.3390/cells9112483. PMID: 33203148; PMCID: PMC7697858.
Wang Q, Banerjee S, So C, Qiu C, Lam HC, Tse D, Völgyi B, Pan F. Unmasking inhibition prolongs neuronal function in retinal degeneration mouse model. FASEB J. 2020 Nov;34(11):15282-15299. doi: 10.1096/fj.202001315RR. Epub 2020 Sep 28. PMID: 32985731.
Kovacs-Oller T, Ivanova E, Bianchimano P, Sagdullaev BT. The pericyte connectome: spatial precision of neurovascular coupling is driven by selective connectivity maps of pericytes and endothelial cells and is disrupted in diabetes. Cell Discov 6, 39 (2020). https://doi.org/10.1038/s41421-020-0180-0
Kovács-Öller T, Ivanova E, Szarka G, Tengölics ÁJ, Völgyi B, Sagdullaev BT. Imatinib Sets Pericyte Mosaic in the Retina. Int J Mol Sci. 2020 Apr 5;21(7):2522. doi: 10.3390/ijms21072522. PMID: 32260484; PMCID: PMC7177598.
Kovács-Öller T, Szarka G, Tengölics ÁJ, Ganczer A, Balogh B, Szabó-Meleg E, Nyitrai M, Völgyi B. Spatial Expression Pattern of the Major Ca2+-Buffer Proteins in Mouse Retinal Ganglion Cells. Cells. 2020 Mar 25;9(4):792. doi: 10.3390/cells9040792. PMID: 32218175; PMCID: PMC7226302.
Tengölics ÁJ, Szarka G, Ganczer A, Szabó-Meleg E, Nyitrai M, Kovács-Öller T, Völgyi B. Response Latency Tuning by Retinal Circuits Modulates Signal Efficiency. Sci Rep. 2019 Oct 22;9(1):15110. doi: 10.1038/s41598-019-51756-y. PMID: 31641196; PMCID: PMC6806000.
Völgyi B, Kenyon GT, Marshak DW, Sagdullaev B. Editorial: Encoding Visual Features by Parallel Ganglion Cell Initiated Pathways in the Healthy, Diseased and Artificial Retina. Front Cell Neurosci. 2019 May 24;13:229. doi: 10.3389/fncel.2019.00229. PMID: 31178700; PMCID: PMC6542953.
Telkes I, Kóbor P, Orbán J, Kovács-Öller T, Völgyi B, Buzás P. Connexin-36 distribution and layer-specific topography in the cat retina. Brain Struct Funct. 2019 Jul;224(6):2183-2197. doi: 10.1007/s00429-019-01876-y. Epub 2019 Jun 6. PMID: 31172263; PMCID: PMC6591202.
Kovács-Öller T, Szarka G, Ganczer A, Tengölics Á, Balogh B, Völgyi B. Expression of Ca2+-Binding Buffer Proteins in the Human and Mouse Retinal Neurons. Int J Mol Sci. 2019 May 7;20(9):2229. doi: 10.3390/ijms20092229. PMID: 31067641; PMCID: PMC6539911.
Kántor O, Szarka G, Benkő Z, Somogyvári Z, Pálfi E, Baksa G, Rácz G, Nitschke R, Debertin G, Völgyi B. Strategic Positioning of Connexin36 Gap Junctions Across Human Retinal Ganglion Cell Dendritic Arbors. Front Cell Neurosci. 2018 Nov 22;12:409. doi: 10.3389/fncel.2018.00409. PMID: 30524239; PMCID: PMC6262005.
Ganczer A, Balogh M, Albert L, Debertin G, Kovács-Öller T, Völgyi B. Transiency of retinal ganglion cell action potential responses determined by PSTH time constant. PLoS One. 2017 Sep 12;12(9):e0183436. doi: 10.1371/journal.pone.0183436. PMID: 28898257; PMCID: PMC5595288.
Kovács-Öller T, Debertin G, Balogh M, Ganczer A, Orbán J, Nyitrai M, Balogh L, Kántor O, Völgyi B. Connexin36 Expression in the Mammalian Retina: A Multiple-Species Comparison. Front Cell Neurosci. 2017 Mar 9;11:65. doi: 10.3389/fncel.2017.00065. PMID: 28337128; PMCID: PMC5343066.
Kántor O, Varga A, Nitschke R, Naumann A, Énzsöly A, Lukáts Á, Szabó A, Németh J, Völgyi B. Bipolar cell gap junctions serve major signaling pathways in the human retina. Brain Struct Funct. 2017 Aug;222(6):2603-2624. doi: 10.1007/s00429-016-1360-4. Epub 2017 Jan 10. PMID: 28070649.
Pan F, Toychiev A, Zhang Y, Atlasz T, Ramakrishnan H, Roy K, Völgyi B, Akopian A, Bloomfield SA. Inhibitory masking controls the threshold sensitivity of retinal ganglion cells. J Physiol. 2016 Nov 15;594(22):6679-6699. doi: 10.1113/JP272267. Epub 2016 Aug 2. PMID: 27350405; PMCID: PMC5108909.
Kántor O, Mezey S, Adeghate J, Naumann A, Nitschke R, Énzsöly A, Szabó A, Lukáts Á, Németh J, Somogyvári Z, Völgyi B. Calcium buffer proteins are specific markers of human retinal neurons. Cell Tissue Res. 2016 Jul;365(1):29-50. doi: 10.1007/s00441-016-2376-z. Epub 2016 Feb 22. PMID: 26899253.
Kántor O, Cserpán D, Völgyi B, Lukáts Á, Somogyvári Z. The Retinal TNAP. Subcell Biochem. 2015;76:107-23. doi: 10.1007/978-94-017-7197-9_6. PMID: 26219709.
Kántor O, Benkő Z, Énzsöly A, Dávid C, Naumann A, Nitschke R, Szabó A, Pálfi E, Orbán J, Nyitrai M, Németh J, Szél Á, Lukáts Á, Völgyi B. Characterization of connexin36 gap junctions in the human outer retina. Brain Struct Funct. 2016 Jul;221(6):2963-84. doi: 10.1007/s00429-015-1082-z. Epub 2015 Jul 15. PMID: 26173976.
Debertin G, Kántor O, Kovács-Öller T, Balogh L, Szabó-Meleg E, Orbán J, Nyitrai M, Völgyi B. Tyrosine hydroxylase positive perisomatic rings are formed around various amacrine cell types in the mammalian retina. J Neurochem. 2015 Aug;134(3):416-28. doi: 10.1111/jnc.13144. Epub 2015 Jun 3. PMID: 25940543.
Kántor O, Varga A, Tóth R, Énzsöly A, Pálfi E, Kovács-Öller T, Nitschke R, Szél Á, Székely A, Völgyi B, Négyessy L, Somogyvári Z, Lukáts Á. Stratified organization and disorganization of inner plexiform layer revealed by TNAP activity in healthy and diabetic rat retina. Cell Tissue Res. 2015 Feb;359(2):409-421. doi: 10.1007/s00441-014-2047-x. Epub 2014 Nov 20. PMID: 25411053.
P1 Group (Dr. Stanislao Rizzo, Italy)
Previous, related publications
Cozzupoli GM, Savastano MC, Falsini B, Savastano A, Rizzo S. Possible Retinal Impairment Secondary to Ritonavir Use in SARS-CoV-2 Patients: A Narrative Systematic Review. J Ophthalmol. 2020 Aug 22;2020:5350494. doi: 10.1155/2020/5350494. PMID: 32908681; PMCID: PMC7458545.
Savastano A, Weinberg T, Faraldi F, Caporossi T, Rizzo S. Scleral Buckling Using Chandelier and Releasable Suture: A Useful Surgical Variant. Retina. 2020 May 1. doi: 10.1097/IAE.0000000000002823. Epub ahead of print. PMID: 32366784.
Rizzo S, Pacini B, De Angelis L, Barca F, Savastano A, Giansanti F, Caporossi T. Intrascleral hydration for 23-Gauge Pars Plana Vitrectomy Sclerotomy Closure. Retina. 2022 Dec 1;42(12):2414-2418. doi: 10.1097/IAE.0000000000002703. Epub 2020 Jan 10. PMID: 31929415.
Rizzo S, Tartaro R, Finocchio L, Cinelli L, Biagini I, Barca F, Savastano A, Giansanti F, Virgili G, Caporossi T. Perfluorodecalin as Medium-Term Tamponade in the Case of Retinal Detachment Recurrence With an Inferior Retinal Break, Which Lies Posteriorly to an Encircling Band. Retina. 2022 Jun 1;42(6):1203-1210. doi: 10.1097/IAE.0000000000002381. PMID: 30418388.
Savastano A, Barca F, Tartaro R, Caporossi T, Rizzo S. Post-Traumatic Giant Retinal Tear Without Posterior Vitreous Detachment: A Case Series. Ophthalmic Surg Lasers Imaging Retina. 2018 Sep 1;49(9):686-690. doi: 10.3928/23258160-20180831-06. PMID: 30222803.
Rizzo S, Tartaro R, Finocchio L, Giorni A, Bacherini D, Savastano A. Evaluation of ocular perforation during retrobulbar block using high-resolution spectral domain-optical coherence tomography and optical coherence tomography angiography. Eur J Ophthalmol. 2018 Jul;28(4):NP7-NP10. doi: 10.1177/1120672117747041. Epub 2018 Apr 6. PMID: 29623721.
Rizzo S, Abbruzzese G, Savastano A, Giansanti F, Caporossi T, Barca F, Faraldi F, Virgili G. 3D SURGICAL VIEWING SYSTEM IN OPHTHALMOLOGY: Perceptions of the Surgical Team. Retina. 2018 Apr;38(4):857-861. doi: 10.1097/IAE.0000000000002018. PMID: 29283980.
Rizzo S, Savastano A, Bacherini D, Savastano MC. Vascular Features of Full-Thickness Macular Hole by OCT Angiography. Ophthalmic Surg Lasers Imaging Retina. 2017 Jan 1;48(1):62-68. doi: 10.3928/23258160-20161219-09. PMID: 28060396.
Rizzo S, Cinelli L, Savastano A. Red-Free Photograph of Argus II in Retinitis Pigmentosa. Ophthalmol Retina. 2017 Jul-Aug;1(4):303. doi: 10.1016/j.oret.2017.01.015. Epub 2017 Jun 30. PMID: 31047515.
Rizzo S, Fantoni G, de Santis G, Lue JL, Ciampi J, Palla M, Genovesi Ebert F, Savastano A, De Maria C, Vozzi G, Brant Fernandes RA, Faraldi F, Criscenti G. EFFECTS OF A MODIFIED VITRECTOMY PROBE IN SMALL-GAUGE VITRECTOMY: An Experimental Study on the Flow and on the Traction Exerted on the Retina. Retina. 2017 Sep;37(9):1765-1774. doi: 10.1097/IAE.0000000000001411. PMID: 27930456.
Rizzo S, Giorni A, Savastano A. Imaging of Ocular Perforation After Retrobulbar Block. JAMA Ophthalmol. 2016 Nov 10;134(11):e162716. doi: 10.1001/jamaophthalmol.2016.2716. Epub 2016 Nov 10. PMID: 27832280.
P2 Group (Dr. Karin Dedek, Germany)
Previous, related publications
Dedek K, Schultz K, Pieper M, Dirks P, Maxeiner S, Willecke K, Weiler R, Janssen-Bienhold U (2006) Localization of heterotypic gap junctions composed of connexin45 and connexin36 in the rod pathway of the mouse retina. Eur J Neurosci 24:1675–1686.
Dorgau B, Herrling R, Schultz K, Greb H, Segelken J, Ströh S, Bolte P, Weiler R, Dedek K, Janssen-Bienhold U (2015) Connexin50 couples axon terminals of mouse horizontal cells by homotypic gap junctions. J Comp Neurol 523:2062–2081.
Hilgen G, von Maltzahn J, Willecke K, Weiler R, Dedek K (2011) Subcellular distribution of connexin45 in OFF bipolar cells of the mouse retina. J Comp Neurol 519:433–450.
Janssen-Bienhold U, Trümpler J, Hilgen G, Schultz K, Müller LPDS, Sonntag S, Dedek K, Dirks P, Willecke K, Weiler R (2009) Connexin57 is expressed in dendro-dendritic and axo-axonal gap junctions of mouse horizontal cells and its distribution is modulated by light. J Comp Neurol 513:363–374.
Kranz K, Paquet-Durand F, Weiler R, Janssen-Bienhold U, Dedek K (2013) Testing for a gap junction-mediated bystander effect in retinitis pigmentosa: secondary cone death is not altered by deletion of connexin36 from cones. PLoS One 8:e57163.
Maxeiner S, Dedek K, Janssen-Bienhold U, Ammermüller J, Brune H, Kirsch T, Pieper M, Degen J, Krüger O, Willecke K, Weiler R (2005) Deletion of connexin45 in mouse retinal neurons disrupts the rod/cone signaling pathway between AII amacrine and ON cone bipolar cells and leads to impaired visual transmission. J Neurosci 25:566–576.
Meyer A, Hilgen G, Dorgau B, Sammler EM, Weiler R, Monyer H, Dedek K, Hormuzdi SG (2014) AII amacrine cells discriminate between heterocellular and homocellular locations when assembling connexin36-containing gap junctions. J Cell Sci 127:1190–1202.
Meyer A, Tetenborg S, Greb H, Segelken J, Dorgau B, Weiler R, Hormuzdi SG, Janssen-Bienhold U, Dedek K (2016) Connexin30.2: In Vitro Interaction with Connexin36 in HeLa Cells and Expression in AII Amacrine Cells and Intrinsically Photosensitive Ganglion Cells in the Mouse Retina. Front Mol Neurosci 9:36.
Meyer A, Yadav SC, Dedek K (2018) Phenotyping of Gap-Junctional Coupling in the Mouse Retina. Methods Mol Biol 1753:249–259.
Shelley J, Dedek K, Schubert T, Feigenspan A, Schultz K, Hombach S, Willecke K, Weiler R (2006) Horizontal cell receptive fields are reduced in connexin57-deficient mice. Eur J Neurosci 23:3176–3186.
Tetenborg S, Wang HY, Nemitz L, Depping A, Espejo AB, Aseervatham J, Bedford MT, Janssen-Bienhold U, O’Brien J, Dedek K (2020) Phosphorylation of Connexin36 near the C-terminus switches binding affinities for PDZ-domain and 14-3-3 proteins in vitro. Sci Rep 10:18378.
Tetenborg S, Yadav SC, Brüggen B, Zoidl GR, Hormuzdi SG, Monyer H, van Woerden GM, Janssen-Bienhold U, Dedek K (2019) Localization of Retinal Ca2+/Calmodulin-Dependent Kinase II-β (CaMKII-β) at Bipolar Cell Gap Junctions and Cross-Reactivity of a Monoclonal Anti-CaMKII-β Antibody With Connexin36. Front Mol Neurosci 12:206.
Tetenborg S, Yadav SC, Hormuzdi SG, Monyer H, Janssen-Bienhold U, Dedek K (2017) Differential Distribution of Retinal Ca2+/Calmodulin-Dependent Kinase II (CaMKII) Isoforms Indicates CaMKII-β and -δ as Specific Elements of Electrical Synapses Made of Connexin36 (Cx36). Front Mol Neurosci 10:425.
Yadav SC, Tetenborg S, Dedek K (2019) Gap Junctions in A8 Amacrine Cells Are Made of Connexin36 but Are Differently Regulated Than Gap Junctions in AII Amacrine Cells. Front Mol Neurosci 12:99.