Embedded Files
List of Journal publications
List of Journal publications
33. Application of synthetic biology in engineered therapeutic antibodies, N Soni, D Trakroo, MP Borah, M Baidya, Synthetic Biology and its Consequences in Present Healthcare, 145-157.
32. Breaking the one-site myth: the multifaceted world of proton sensing in GPCRs. Agrawal M, Singh, SK, Baidya M and Kumari P. FEBS Journal (2025). pp1-14. http://doi.org/10.1111/febs.70145
31. β1-Adrenergic Receptor Endocytosis and Signaling. War AR, Borah MP, Ahmed S and Baidya M*. The Receptors (2025), 2, pp 99–118. doi.org/10.1007/978-3-031-81991-9_5
30. β2-Adrenergic Receptor Endocytosis and Signaling. Borah MP, War AR, Soni N and Baidya M*. The Receptors (2025), 2, pp 119–138. doi.org/10.1007/978-3-031- 81991-9_6
29. Exploring Bias in GPCR Signaling and its Implication in Drug Development: A One-Sided Affair. Borah MP, Trakroo D, Kumari P*, Baidya M* Biochemistry (2024), 64(1):1-14. doi: 10.1021/acs.biochem.4c00676.
28. Structural insights into an intracellular biased agonist for GPCRs. Neeraj, Das T, Baidya M*, Nature Structural & Molecular Biology 30, 1612-1614 (2023). doi: 10.1038/s41594-023-01100-w.
27. Plasma membrane preassociation drives beta-arrestin coupling to receptors and activation. Grimes J, Koszegi Z, Lanoiselée Y, Miljus T, O’Brien SL, Stepniewski TM, Medel-Lacruz B, Baidya M, Makarova M, Mistry R, Goulding J, Drube J, Hoffmann C, Owen DM, Shukla AK, Selent J, Hill SJ and Calebiro D. Cell 186(10):2238-2255.e20 (2023). doi.org/10.1016/j.cell.2023.04.018.
26. Baidya M, Chaturvedi M, Dwivedi-Agnihotri H, Ranjan A, Devost D, Namkung Y, Stepniewski TM, Pandey S, Baruah M, Panigrahi B, Maharana J, Banerjee R, Selent J, Laporte S, Hebert TE, Shukla AK. Allosteric modulation of GPCR-induced β-arrestin trafficking and signaling by a synthetic intrabody. Nature Communications 13(1):4634 (2022). doi:10.1038/s41467-022-32386-x
25. Pandey S*, Kumari P*, Baidya M*, Kise R, Cao Y, Dwivedi-Agnihotri H, Banerjee R, Li XX, Cui CS, Lee JD, Kawakami K, Maharana J, Ranjan A, Chaturvedi M, Jhingan JD, Laporte SA, Woodruff TM, Inoue A and Shukla AK. Intrinsic bias at non-canonical, β-arrestin-coupled seven transmembrane receptors. Molecular Cell 81(22), 4605-4621.e11 (2021). (*Joint first author). doi: 10.1016/j.molcel.2021.09.007.
24. Zhang H, Luginina A, Mishin A, Baidya M, Shukla AK, Cherezov V. Structural insights into ligand recognition and activation of angiotensin receptors. Trends in Pharmacological Sciences 42 (7), P577-587 (2021). doi: 10.1016/j.tips.2021.04.006. (Cover page article)
23. Baidya M, Kumari P, Dwivedi-Agnihotri H, Pandey S, Chaturvedi M, Stepniewski TM., Kawakami K, Cao Y. Laporte S. A., Selent J, Inoue A, Shukla AK. Key phosphorylation sites in GPCRs orchestrate the contribution of β-Arrestin 1 in ERK1/2 activation. EMBO Reports 21, e49886 (2020). doi: 10.15252/embr.201949886.
(Highlighted in a News and Views article by Prof. Richard Premont published in EMBO Reports )
22. Agnihotri, HD*, Chaturvedi M*, Baidya M*, Stepniewski TM, Pandey S, Maharana J, Srivastava A, Caengprasath N, Hanyaloglu A, Selent J and Shukla AK. Distinct phosphorylation sites in a prototypical GPCR differently orchestrate β-arrestin interaction, trafficking. Science Advances 6(37), eabb8368 (2020). (*Joint first author). doi: 10.1126/sciadv.abb8368.
21. Baidya M, Kumari P, Dwivedi-Agnihotri H, Pandey S, Sokrat B, Sposini S, Chaturvedi M, Srivastava A, Roy D, Hanyaloglu AC, Bouvier M, Shukla AK. Genetically Encoded Intrabody Sensors Report the Interaction and Trafficking of β-arrestin 1 Upon Activation of G Protein-Coupled Receptors. Journal of Biological Chemistry. 295, 10153-10167 (2020). doi: 10.1074/jbc.RA120.013470.
(Selected as the Paper of the Year in Signal-transduction category by the journal for 2020 )
20. Min K, Yoon HJ, Park JY, Baidya M, Dwivedi-Agnihotri H, Maharana J, Chaturvedi M, Chung KY, Shukla AK, Lee HH. Crystal structure of β-Arrestin 2 in complex with CXCR7 Phosphopeptide. Structure. S0969-2126(20)30205-7 (2020). doi: 10.1016/j.str.2020.06.002. (Cover page article)
19. Goncharuk MV, Roy D, Dubinnyi MA, Nadezhdin KD, Srivastava A. Baidya, M.; Dwivedi-Agnihotri, H.; Arseniev A. S., Shukla, A. K. Purification of native CCL7 and its functional interaction with selected chemokine receptors. Protein Expression and Purification 171, 105617 (2020). doi: 10.1016/j.pep.2020.105617.
18. Ghosh E, Dwivedi H, Baidya M, Srivastava A, Kumari P, Stepniewski T, Kim HR, Lee MH, van Gastel J, Chaturvedi M, Roy D, Pandey S, Maharana J, Guixà-González R, Luttrell LM, Chung KY, Dutta S, Selent J, Shukla AK. Conformational Sensors and Domain Swapping Reveal Structural and Functional Differences between β-Arrestin Isoforms. Cell Reports 28, 3287-3299 (2019). doi: 10.1016/j.celrep.2019.08.053.
17. Pandey, S.; Li, X. X., Srivastava, A.; Baidya, M.; Kumari, P.; Dwivedi, H.; Chaturvedi, M.; Ghosh, E.; Woodruff, T. M.; Shukla, A. K. Partial ligand-receptor engagement yields functional bias at the human complement receptor, C5aR1. Journal of Biological Chemistry. 294,9416-9429 (2019). doi: 10.1074/jbc.RA119.007485.
16. Baidya, M; Kumari, P; Shukla A. K. Entering the Pocket, Crystal Structure of a Prostaglandin D2 Receptor. Molecular Cell 72 (1), P3-6 (2018). doi: 10.1016/j.molcel.2018.09.024.
15. Sente A, Peer R, Srivastava A, Baidya M, Lesk AL, Balaji, Shukla AK, Babu MM, Flock T. Molecular mechanism of modulating arrestin conformation by GPCR phosphorylation. Nature Structural & Molecular Biology 25, 538-545 (2018). doi: 10.1038/s41594-018-0071-3.
14. Dwivedi, H; Baidya, M; Shukla, A. K. The Interplay of Gαi and β-arrestin. Current Biology 28, R324-R327 (2018). doi: 10.1016/j.cub.2018.02.027.
13. Baidya, M; Dwivedi, H; Shukla, A. K. Frozen in action, cryo-EM structure of a GPCR–G-protein complex. Nature Structural & Molecular Biology 24, 500-502 (2017). doi: 10.1038/nsmb.3418.
12. Ranjan, R; Dwivedi, H; Baidya, M; Kumar, M; Shukla, A. K. Novel Structural Insights into GPCR–β-Arrestin Interaction and Signaling. Trends in Cell Biology 27, 851-862 (2017). doi: 10.1016/j.tcb.2017.05.008.
11. Samanta, S. K.; Varghese, S. S.; Krishnan, D.; Baidya, M.; Nayak, D.; Mukherjee, S; Ghosh, S. K. A novel encystation specific protein kinase regulates chitin synthesis in Entamoeba invadens. Molecular Biochemical Parasitology 220, 19-27. (2018). doi: 10.1016/j.molbiopara.2018.01.003.
10. Ghosh E, Srivastav A, Baidya M, Kumari P, Dwivedi H, Nidhi K, Ranjan R, Dogra S, Koide A, Yadav PN, Sidhu SS, Koide S, Shukla AK. A synthetic intrabody-based selective and generic inhibitor of GPCR endocytosis. Nature Nanotechnology 12, 1190-1198 (2017). doi: 10.1038/nnano.2017.188.
9. Chowdhury, N.; Gangopadhyay, M.; Karthik, S.; Pradeep Singh, N.D.; Baidya, M.; Ghosh, S.K. Synthesis, photochemistry, DNA cleavage/binding and cytotoxic properties of fluorescent quinoxaline and quinoline hydroperoxides. Journal of Photochemistry and Photobiology B, Biology 130, 188–198 (2014). doi: 10.1016/j.jphotobiol.2013.11.010.
8. Saha, S.; Agarwalla, H.; Gupta, H.; Baidya, M.; Suresh, E.; Ghosh, S. K.; Das, A. New chemodosimetric probe for the specific detection of Hg2+ in physiological condition and its utilisation for cell imaging studies. Dalton Transaction 42, 15097 (2013). doi: 10.1039/c3dt51744f.
7. Das, P.; Mandal, A. K.; Reddy G. U.; Baidya, M.; Ghosh S. K.; Das, A. Designing a thiol specific fluorescent probe for possible use as a reagent for intracellular detection and estimation in blood serum, kinetic analysis to probe the role of intramolecular hydrogen bonding. Organic and Biomolecular Chemistry 38, 6604-6614 (2013). doi: 10.1039/c3ob41284a.
6. Reddy, G. U.; Das, P.; Saha, S.; Baidya, M.; Ghosh, S. K.; Das, A. A CN- specific turnon phosphorescent probe with the probable application for enzymatic assay and as an imaging reagent. Chem. Comm. 49, 255–257 (2013). doi: 10.1039/c2cc37243f.
5. Saha, S.; Mahato, P.; Baidya, M.; Ghosh, S. K.; Das, A. An interrupted PET coupled TBET process for the design of a specific receptor for Hg2+ and its intracellular detection in MCF7 cells. Chem. Comm. (Camb). 48, 9293-9295 (2012). doi: 10.1039/c2cc34490d.
4. Das, P.; Mandal, A. K.; Chandar, N. B.; Baidya, M.; Bhatt, H. B.; Ganguly, B.; Ghosh, S.K.; Das, A. New chemodosimetric reagents as ratiometric probes for cysteine and homocysteine and possible detection in living cells and blood plasma. Chemistry, A European Journal 18, 15382–15393 (2012). doi: 10.1002/chem.201201621.
3. Mandal, A. K.; Suresh, M.; Das, P.; Suresh, E.; Baidya, M.; Ghosh, S. K.; Das, A. Recognition of Hg2+ ion through restricted imine isomerization, crystallographic evidence and imaging in live cells. Organic Letters 14, 2980–2983 (2012). doi: 10.1021/ol3009733.
2. Chowdhury, N.; Dutta, S.; Dasgupta, S.; Singh, N. D.; Baidya, M.; Ghosh, S. K. Synthesis, photophysical, photochemical, DNA cleavage/binding and cytotoxic properties of pyreneoxime ester conjugates. Photochemical and Photobiological Sciences 11, 1239– 1250 (2012). doi: 10.1039/c2pp25033k.
1. Saha, S.; Mahato, P.; Reddy, G. U.; Suresh, E.; Chakrabarty, A.; Baidya, M.; Ghosh, S. K.; Das, A. Recognition of Hg2+ and Cr3+ in physiological conditions by a rhodamine derivative and its application as a reagent for cell-imaging studies. Inorganic Chemistry 51, 336-345 (2012). doi: 10.1021/ic2017243.
List of Book Chapters
List of Book Chapters
2. Measuring agonist-induced ERK MAP kinase phosphorylation for G protein-coupled receptors. Kumari, P; Dwivedi, H; Baidya, M and Shukla A. K. Methods in Cell Biology, 149, 141-153 (2018).
2. Measuring agonist-induced ERK MAP kinase phosphorylation for G protein-coupled receptors. Kumari, P; Dwivedi, H; Baidya, M and Shukla A. K. Methods in Cell Biology, 149, 141-153 (2018).
1. Site-directed labeling of β-arrestin with monobromobimane for measuring their interaction with G protein-coupled receptors. Srivastava, A; Baidya, M; Dwivedi-Agnihotri, H; Shukla, A. K. Methods in Enzymology, 633, 271-280 (2019).
1. Site-directed labeling of β-arrestin with monobromobimane for measuring their interaction with G protein-coupled receptors. Srivastava, A; Baidya, M; Dwivedi-Agnihotri, H; Shukla, A. K. Methods in Enzymology, 633, 271-280 (2019).
List of presentations at conferences and invited talks
List of presentations at conferences and invited talks
11. Regional Young Investigators' Meeting, University of Srinagar, September 2023.
10. Receptor phosphorylation pattern drives β-arrestin conformation. European Research Network on Signal Transduction, GPCR ECI Zoominar, March 2023 (Invited talk).
9. Regulation of G protein-coupled receptor: Role of β-Arrestins. St. Jude Children's Research Hospital, Memphis, TN, Dec 2022 (Invited talk).
9. Regulation of G protein-coupled receptor: Role of β-Arrestins. St. Jude Children's Research Hospital, Memphis, TN, Dec 2022 (Invited talk).
8. Breaking the code: Barcoding in Cell Signaling. ADMAS University, Kolkata, Nov 2022 (Invited talk).
8. Breaking the code: Barcoding in Cell Signaling. ADMAS University, Kolkata, Nov 2022 (Invited talk).
7. Structure and function of G protein-coupled receptors. An integrative course in cellular and molecular biology, with an emphasis on data acquisition and in silico data analysis. Organized by JIS University, Kolkata, Nov 2021 (Invited talk).
7. Structure and function of G protein-coupled receptors. An integrative course in cellular and molecular biology, with an emphasis on data acquisition and in silico data analysis. Organized by JIS University, Kolkata, Nov 2021 (Invited talk).
6. Breaking the code: Key phosphorylation sites in GPCRs can contribute to distinct functional outcomes. Baidya, M. COMPARE ECR GPCR Symposium by Birmingham University and Nottingham University, September 2020 (Invited talk).
6. Breaking the code: Key phosphorylation sites in GPCRs can contribute to distinct functional outcomes. Baidya, M. COMPARE ECR GPCR Symposium by Birmingham University and Nottingham University, September 2020 (Invited talk).
5. Structure and function of G protein-coupled receptors. Baidya, M; Shukla, AK. BioTerm, International Conference on Biomaterial-based Therapeutic Engineering and Regenerative Medicine, Nov 2019, IIT Kanpur (Oral Presentation).
5. Structure and function of G protein-coupled receptors. Baidya, M; Shukla, AK. BioTerm, International Conference on Biomaterial-based Therapeutic Engineering and Regenerative Medicine, Nov 2019, IIT Kanpur (Oral Presentation).
4. Intrabody-based sensor reveals conformational diversity of receptor-bound ß-arrestins. Baidya, M; Kumari, P; Dwvedi, H; Ghosh, E; Pandey, S; Shukla, AK. Molecular Pharmacology, Gordon Research Conference, Feb, 2019, Ventura, California, USA (Poster Presentation)
4. Intrabody-based sensor reveals conformational diversity of receptor-bound ß-arrestins. Baidya, M; Kumari, P; Dwvedi, H; Ghosh, E; Pandey, S; Shukla, AK. Molecular Pharmacology, Gordon Research Conference, Feb, 2019, Ventura, California, USA (Poster Presentation)
3. A variation on a theme – Exclusively β-arrestin-coupled seven-transmembrane receptors. Baidya, M; Kumari, P; Ranjan, R; Ghosh, E; Srivastav, A; Shukla, AK. 86th annual meeting of Society of Biological Chemists, New Delhi, 2017 (Poster presentation)
3. A variation on a theme – Exclusively β-arrestin-coupled seven-transmembrane receptors. Baidya, M; Kumari, P; Ranjan, R; Ghosh, E; Srivastav, A; Shukla, AK. 86th annual meeting of Society of Biological Chemists, New Delhi, 2017 (Poster presentation)
2. Novel Transmembrane Protein Kinases as a Prospective Stress Sensor in Entamoeba. Baidya, M. Nayak, S; Singh, T; Das, AK; Ghosh, SK. 82nd annual meeting of Society of Biological Chemists, Hyderabad, 2013 (Poster presentation)
2. Novel Transmembrane Protein Kinases as a Prospective Stress Sensor in Entamoeba. Baidya, M. Nayak, S; Singh, T; Das, AK; Ghosh, SK. 82nd annual meeting of Society of Biological Chemists, Hyderabad, 2013 (Poster presentation)
1. Novel Encystation Specific Protein Kinases in Entamoeba invadens. Samanta, SK; Baidya, M; Saha, B; Singh, T; Ghosh, SK. 81st annual meeting of Society of Biological Chemists, Kolkata, 2012 (Poster presentation)
1. Novel Encystation Specific Protein Kinases in Entamoeba invadens. Samanta, SK; Baidya, M; Saha, B; Singh, T; Ghosh, SK. 81st annual meeting of Society of Biological Chemists, Kolkata, 2012 (Poster presentation)
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