Whether it is in the cardiovascular, the renal or the central nervous systems, there is a lack of consensus on the drug screening protocols currently in place – in many cases, an insufficient number of human cell lines are used in the research phase, rendering it impossible to make pre-clinical predictions on drug success in specific subsets of the population. Consequently, thousands of potential treatments make their way to clinical trials, only to fail prior to approval, which results in excessive expenditure and wasted resources. It also takes patients from 3-10 months to find the drug that is effective and safe for them. This egregious process could be shortened significantly by implementing patient-specific testing prior to drug administration. Currently, there is an unmet need to explore a more effective way to screen, select and evaluate drugs pre-clinically, as well as assess safety. Thus, we are pushing to develop viable and reproducible pre-clinical disease models to reduce the costs of clinical trials and tailor patient care. If your laboratory currently tests novel treatments or medications, our high-quality iPSC lines will offer a reliable testing model for publications and pre-clinical trials.

The key to discovering new therapies and treatments lies in our ability to understand the way a disease develops. As such, disease modelling is crucial in studying the way that our bodies and cells react to disease – we strive to dive deeper into the cellular reasons why some people recover more easily while others struggle to overcome pathological conditions. Our technology provides researchers with a resource to create more reliable patient-specific disease models with lower associated costs – whether you are studying channelopathies, toxicity-induced pathologies, metabolism disorders or developmental dysfunctions at the cellular level, we can help by generating and providing diverse patient iPSCs specifically for your studies.

Organ development and regeneration require an in-depth understanding of the pathways and processes of development. Both also require a high fidelity to the architecture of tissue in vivo. Understanding the developmental phases is crucial for two reasons: 1) to innovate therapies for congenital diseases, and 2) to eventually create transplantable tissues. If you want to recapitulate various mechanisms involved in the development of your organ of interest or look into the determinants of regeneration, iPSCs are a suitable cell source to achieve this goal. Furthermore, organoid research with iPSC-derived cell lines has risen in popularity in recent years in organ development research, due to the iPSCs coming from one unique patient and various protocols being developed in order to generate various cell lineages.

If your research requires a large number of reagents to be tested pre-clinically prior to moving on to trials or approval, our selection of iPSCs is an easily expandable source of cells which you can differentiate according to your preferred protocol. Overall, iPSC-derived cells can be cultured in 2D or 3D arrangements. Large-scale arrays can be performed on iPSC-derived differentiated cells, to allow you to draw accurate conclusions and assessments of product toxicity in vitro.

If you have developed a unique drug and want to test its effects in a large and diverse in vitro population, we have a large biobank of iPSCs derived from patients of the McGill University Health Centre. You can glean crucial information on population-wide effects of your novel treatment by using multiple cell lines derived from different patients. You can purchase smaller quantities of iPSCs per vial, with a large and diverse donor population. Please contact us for more information for iPSC bulk purchases.

If you are working on developing an accurate disease model in 2D or 3D cultures, we provide frozen iPSCs as well as consulting services on various differentiation techniques. In stock, we currently have patient samples derived from healthy donors as well as cardiomyopathic patients. All patient history is recorded and preserved for research purposes.