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The Ramamoorthy Lab, led by Professor Ayyalusamy Ramamoorthy, is at the fore front of research into the structure, dynamics, and function of macromolecules, with a special focus on membrane-associated peptides and proteins. Our work is crucial for understanding fundamental biological processes and developing treatments for various diseases.
We are always looking for passionate and curious minds to join our team. Whether you are a student, researcher, or collaborator, we invite you to explore our work and contribute to our mission.
Research Focus:
Research Focus:
Biocondensation and Amyloid Proteins: Biocondensates including droplets, LLPS and amyloids are investigated. Our studies on misfolded amyloid proteins, including amyloid-beta and islet amyloid polypeptide (IAPP), aim to shed light on diseases like Alzheimer’s and type 2 diabetes.
Antimicrobial Peptides: We explore the mechanisms of peptides that have the potential to combat bacterial infections, and also their cross-talk with amyloids.
Membrane Proteins: We delve into the structure and function of crucial proteins such as cytochrome P450s, P450 reductase, cytochrome b5, and GPCRs.
NMR Techniques: Developing and applying cutting-edge nuclear magnetic resonance (NMR) techniques to investigate biological systems.
News/Lab Updates
News/Lab Updates
This symposium aims to bring together experienced researchers, junior researchers, and industry professionals to discuss and explore the exciting field of research. We also plan to provide educational lectures for new researchers, such as students and post-doctoral fellows, to inspire them to pursue research in this area.
The scientific program will include talks by field experts and in-depth discussions during informal sessions. Our goal is to summarize what is scientifically known and learn about cutting-edge research. Additionally, the symposium will be a great place for new researchers to meet and connect with established investigators.
August 26th, 2024,
FAMU-FSU College of Engineering
"The International Society for Proteinopathies is a student organization dedicated to promoting the understanding and treatment of Proteinopathies, including diseases such as Alzheimer’s, Parkinson’s, and various amyloidosis . Our chapter aims to foster a collaborative environment where students can engage in innovative research, professional development opportunities, and public awareness events, all while unraveling the complexities of protein misfolding diseases."
August 22nd, 2024
FSU News highlighted post-doctoral researcher Sam McCalpin's research led by Professor Ayyalusamy at the FAMU-FSU College of Engineering, which demonstrates how insulin, zinc, and pH levels can prevent harmful protein clumps associated with Type 2 diabetes. Click Here to View Published Article.
August 11th, 2024
The Ramamoorthy Lab was featured in FSU News detailing how we provide undergraduate students with unique opportunities to engage in cutting-edge research through hands-on experience and mentorship.
International Society for Proteinopathies (ISP) has been created
International Society for Proteinopathies (ISP) has been created
The ISP aims to advance research on protein misfolding diseases through basic, clinical, and translational studies. It provides reliable information on these diseases, facilitates idea exchange via an annual conference and website, and fosters interdisciplinary collaborations. The society seeks to deepen understanding of protein misfolding, promote new diagnostic and therapeutic approaches, and garner support from institutions, industry, and our members to fulfill its mission.
Alumni Highlights
Alumni Highlights
Congratulations to the RAMS Lab Alumni
Congratulations to the RAMS Lab Alumni
Dr. Malitha Widanage joins the National Renewable Energy Laboratory.
Dr. Mohammad Hajipour accepts a Research Scientist position at Stanford University.
Dr. Thirupathi Ravula joins NMRFAM, University of Wisconsin - Madison.
Dr. Rui Huang becomes an Assistant Professor of Chemistry position at the University of Guelph, Canada.
Dr. Vojc Kocman accepted a faculty position at the Slovenian NMR Centre, Slovenia.
Dr. Joshua Damron becomes a Scientist at the Oakridge National Lab, Tennessee, USA.
Dr. Jeffrey Brender becomes a Staff Scientist at NCI, NIH.
Dr. Nathaniel Hardin accepts a position at Savannah River National Lab, South Carolina USA.
Nate Hardin obtains his Ph.D.! January 2020. Congratulations, Dr. (Fancy) Nate!
Sarah Cox obtains her Ph.D.! December 2019. Congratulations, Dr. Sarah!
Katie Gentry obtains her Ph.D! December, 2018
Congratulations to Katie for receiving a Rackham Predoctoral Fellowship!
Joshua Damron obtains his Ph.D.! March 14, 2018
Congratulations, Dr. Josh!
Kian Kamgar-Parsi obtains his Ph.D! December 14, 2017
Congratulations, Dr. Kian!
Congratulations to Kian and Sarah for both winning a poster competition award! - International Conference on Protein Misfolded Diseases, Catania, Sicily, Italy (July 31-August 3 2017)
Kyle Korshavn obtains his Ph.D! December 14, 2016
Congratulations, Dr. Kyle!
Congratulations to Rams for winning a Distinguished Faculty Achievement Award!
Read the article here!
Congratulations to Kyle for winning a Conference Travel Grant for his wonderful talk at the Karle Symposium!
Congratulations to Kyle for receiving the Henry Earle Riggs Dissertation Fellowship!
Meng Zhang obtains her Ph.D! May 13, 2016
Congratulations, Dr. Meng!
Congratulations to Meng and Kyle for the 2016 Summer Research Award from the Chemistry Department!
Amit Pithadia obtains his Ph.D. December 11, 2015
Congratulations, Dr. Amit!
Samuel Kotler obtains his Ph.D. August 3, 2015
Congratulations, Dr. Sam!
Josh receives an NSF fellowship 2015
Congratulations, Josh!
Nirbhay Jain receives the 2015 Walter Yates Award 2015
Congratulations, Nirbhay!
Rams has been appointed as Hans Fischer Senior Fellow in the Institute for Advanced Study at Technische Universitat Munchen, Munich, Germany
Ali and Michael receive the Undergraduate Research Fellowship 2015
Congratulations, Ali and Michael!
2023
2023
Prof. Rams Ramamoorthy joined NHMFL+FSU on Aug. 01, 2023.
Samuel McCalpin (jointly with Dr. Ivanova), Volodymyr Hiiuk (jointly with Prof. Nagorny), Gaurav Sharma (jointly with Dr. Ivanova), and Zhizhuo Zhang (jointly with Dr. Ivanova) are continuing at Michigan.
Transition: Prof. Ramamoorthy will be joining NHMFL (https://nationalmaglab.org/) and the Chemical & Biomedical Engineering (https://eng.famu.fsu.edu/cbe) at FAMU-FSU in Tallahassee.
Congratulations, Krishna, Gaurav, and Thiru!
"Characterization of nanodisc-forming peptides for membrane protein studies", Krishnarjuna B, Sharma G, Im SC, Auchus R, Anantharamaiah GM, Ramamoorthy A. J Colloid Interface Sci. 2023 Sep 29;653(Pt B):1402-1414.
Congratulations, Sam, Malitha, and Riqiang!
"On-Pathway Oligomer of Human Islet Amyloid Polypeptide Induced and Stabilized by Mechanical Rotation During MAS NMR", McCalpin, Samuel; Widanage, Malitha ; Fu, Riqiang; Ramamoorthy, Ayyalusamy. J. Phys. Chem. Letters.
Congratulations, Bikash!
"Direct interaction between the transmembrane helices stabilize cytochrome P450 2B4 and cytochrome b5 redox complex", Bikash R. Sahoo, Ayyalusamy Ramamoorthy, Biophys. Chem.
Congratulations, Manjeet!
'Non-micellar ganglioside GM1 induces an instantaneous conformational change in Aβ42 leading to the modulation of the peptide amyloid-fibril pathway, Manjeet Kumar, Magdalena Ivanova, Ayyalusamy Ramamoorthy, Biophys. Chem.
Krishna has accepted an offer from Michigan State University to join the Tuo Wang lab. Congratulations, Krishna!
Congratulations, Manjeet!
Kumar M, I Ivanova M, Ramamoorthy A. Ganglioside GM1 produces stable, short, and cytotoxic Aβ40 protofibrils. Chem Commun (Camb). 2023 Jun 6;59(46):7040-7043.
Welcoming Lina-Cerine Mechakra, Visiting Master's Student, CY Cergy Paris Universite, France.
Congratulations Mary Muter & Zhizhuo Zhang for the summer fellowship award!
Welcoming Volodymyr Hiiuk, Research Fellow!
Welcoming Dr. Malitha C Dickwella Widanage, a post-doctoral fellow!
Congratulations, Sam!
Magnetically aligned nanodiscs enable direct measurement of 17O residual quadrupolar coupling for small molecules. McCalpin SD, Fu R, Ravula T, Wu G, Ramamoorthy A. J Magn Reson. 2023 Jan;346:107341.
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