Structural Architecture & Functional Dynamics
An in-depth anatomical exploration of the fundamental units
of human communication: bridging microscopic histology with clinical
significance.
Prepared by: [RAFAL ALI LATEEF]
Master of biomedical engineering
Academic Year 2026
Neurology:
Is the branch of medicine that deals with diseases of the nervous system.
Nervous system divided into:
Central nervous system (CNS)
Peripheral nervous system (PNS)
Autonomic nervous system (ANS)
Structure of a neuron
Central Nervous System (CNS)
Intracranial part:
Cerebrum
Brain stem
Cerebellum
Spinal part:
Spinal cord
Cauda equina
Cerebrum
Two cerebral hemispheres Connected to:
1. each other by the corpus callosum
2 .brain stem by cerebral peduncles
EACH CEREBRAL HEMISPHERE DIVIDED
INTO four lobes:
1. Frontal
2. Parietal
3. Temporal
Brain Stem
Formed of :
Midbrain
Pons
Medulla
Connected to:
1) Cerebral hemisphere by cerebral peduncles
2) Cerbellum by cerebellar peduncles
Located behind the brain stem
Responsible for coordination and balance
Helps control movement and posture
Controls fine motor skills
Spinal cord
• Inside spinal canal
• End at the lower border of L1
• The lowest 3 segments = Conus
• The above 4 segments = Epiconus
• Inner grey mater and outer white
matte
Cauda equina
Peripheral nervous system
. A.H.Cs
. Roots
. Plexuses
. Peripheral nerves
Nervous system
Nervous system is the most complex system in the body.
It is distributed throughout the body.
Nervous system is formed by :
1- Neurons.
2- Neuroglial cells(supporting cells)
Neurons (Nerve Cells)
• Basic structural and functional unit of the nervous system
• Responsible for transmitting electrical and chemical signals
• Main parts:
• Cell body (soma): contains nucleus
• Dendrites: receive signals
• Axon: sends signals
• Function: communication within the body
Neuroglial Cells (Supporting Cells)
Non-excitable supporting cells of the nervous system
• Do not transmit nerve impulses
Functions:
• Support and protect neurons
• Provide nutrients
• Maintain the environment
• Form the myelin sheath (increases signal speed)
Nerve
A nerve is a bundle of nerve fibers (axons)
Surrounded by connective tissue layers: Endoneurium, Perineurium, Epineurium
Contains blood vessels
Appears whitish due to myelin and collagen
Function:
Connects CNS with sense organs and effectors
Types:
Sensory nerves
Motor nerves
Mixed nerves
Nerve Fiber
Nerve Fiber
A nerve fiber = single axon + Schwann cell sheath
May be myelinated or unmyelinated
Structure:
Axon: carries impulses
Myelin sheath: increases speed
Schwann cells: form the sheath
Nodes of Ranvier: gaps that speed transmission
Myelination of nerve fiber
Large axons are engulfed by Schwann cells,
where their plasma membrane fuses with itself around the axon, forming the mesaxon.
The mesaxon wraps around the axon many times, forming the myelin sheath.
Myelin is a lipoprotein complex that is removed by standard histological procedures,
so to demonstrate it, a special stain is used: osmic acid stain,
which appears dark brown or black in light microscopic images.
Ganglia
Ovoid structures consist of neuronal cells, supportive cells, Schwann cells, and satellite cells.
These cells are supported by fibrocollagenous tissue.
They serve as relay stations to transmit nerve impulses.
There are two types of ganglia:
Sensory ganglia
Autonomic ganglia
Nerve endings
Nerve ending is a structure where the distal end of the axon of a nerve fiber terminates.
There are three types of nerve endings:
1- Touch and pressure (mechanoreceptors):
a- Encapsulated: Pacinian corpuscle, Ruffini corpuscle, Merkel discs, Krause corpuscles
b- Free
2- Warmth, cold, and pain receptors
3- Proprioceptive system:
a- Encapsulated: muscle spindle
b- Free: Golgi tendon organ
Final Thoughts: Beyond the Synapse
"As we have explored the integrated neuron system, it becomes clear that our
understanding of neural architecture is constantly evolving. While we have
mapped the classical pathways and cellular classifications, the frontier of
neuroscience—from neuroregeneration to brain-computer interfaces—
continues to expand. This platform serves as a foundational reference,
bridging established anatomical knowledge with the future of clinical
neuroscience. The journey to decode the human nervous system is ongoing,
and the neuron remains its most profound protagonist."