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1. Richards-Gross, Sarah E.E. 1993. Natural products chemistry of taxonomicallydiverse ascidians from southern Californian and Caribbean waters. Univ. Calif.San Diego M.S. thesis with Dr. W.H. Fenical. 

The presence of secondary metabolites in marine invertebrates, especiallythose in tropical waters where competition and predation are more intense,has long been recognized. Recently, animals of the class Ascidiacea haveproven especially rich chemically, possessing many novel compounds, oftenwith unique antiviral or antitumor activity. Relatively little is knownabout the natural products chemistry of these animals and even less aboutthe ecological and developmental implications of these metabolites. Ascidiansfrom the tropical Caribbean waters have been investigated. Several speciesof colonial ascidians present in the mangrove and reef habitats were assayedfor chemically based feeding deterrence. Four novel structures, the didemneimidesA-D, composed of indole, maleimide, and imidazole moieties, have been isolatedand identified. Ascidians from the temperate waters off La Jolla, Californiawere similarly investigated. A broad screening program was undertaken toidentify the chemical resources of this area. More than 20 species werecollected at a variety of habitats and seasons. 

 Pharmacological activities as well as potential chemical defense mechanisms were tested. The colonial species __________________ was found to use chemical mediation to maintain a surface free of fouling organisms. 

An extensive review of the chemical literature and the chemical ecology of ascidians through 1992 is included. 5376163bf9

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