Stress and Long Term Memory
Lead by Prof. Jelena Radulovic
The project aims to understand the molecular and circuit mechanisms contributing to the long-term representation of negative memories in hippocampal-cortical circuits. Such mechanisms are investigated in the framework of stress (un)certainty, brain states, genetic and sex factors. The main goal is to identify the key neurobiological determinants of negative memory valence and memory persistence.
Maladaptive Memory in Hippocampal-Thalamo-Cortical Network
Lead by Assoc. Prof. Naoki Yamawaki
The project aims to establish a cell-type-specific circuit mechanism for stress-induced memory impairment. Using a mouse as a model, the project focuses on the circuit formed between the retrosplenial cortex (RSC), hippocampus, and thalamus, which are critical for spatial/contextual memory, and test how neuromodulatory systems alter their interaction and trigger maladaptive memory in stress.