Translational Research Lab

Ganesh S, Cortes-Briones J, Ranganathan M, Radhakrishnan R, Skosnik PD, D'Souza DC. Psychosis-relevant effects of intravenous delta-9-tetrahydrocannabinol - A mega analysis of individual participant-data from human laboratory studies. Int J Neuropsychopharmacol. 2020 May 9:pyaa031. doi: 10.1093/ijnp/pyaa031. Epub ahead of print. PMID: 32385508.

Hindley G, Beck K, Borgan F, Ginestet CE, McCutcheon R, Kleinloog D, Ganesh S, Radhakrishnan R, D'Souza DC, Howes OD. Psychiatric symptoms caused by cannabis constituents: a systematic review and meta-analysis. Lancet Psychiatry. 2020 Apr;7(4):344-353. doi: 10.1016/S2215-0366(20)30074-2. Epub 2020 Mar 17. PMID: 32197092.

Radhakrishnan R, Matuskey D, Nabulsi N, Gaiser E, Gallezot JD, Henry S, Planeta B, Lin SF, Ropchan J, Huang Y, Carson RE, D'Souza DC. In vivo 5-HT6 and 5-HT2A receptor availability in antipsychotic treated schizophrenia patients vs. unmedicated healthy humans measured with [11C]GSK215083 PET. Psychiatry Res Neuroimaging. 2020 Jan 30;295:111007. doi: 10.1016/j.pscychresns.2019.111007. Epub 2019 Nov 12. PMID: 31760336.

Pradeep JR, Acharya MS, Radhakrishnan R, Srinivasan K. Elevated Unconjugated Bilirubin in Schizophrenia Compared to Bipolar Affective Disorder. Prim Care Companion CNS Disord. 2019 Jul 25;21(4):19m02448. doi: 10.4088/PCC.19m02448. PMID: 31364826.

Ranganathan M, De Aquino JP, Cortes-Briones JA, Radhakrishnan R, Pittman B, Bhakta S, D'Souza DC. Highs and lows of cannabinoid-dopamine interactions: effects of genetic variability and pharmacological modulation of catechol-O-methyl transferase on the acute response to delta-9-tetrahydrocannabinol in humans. Psychopharmacology (Berl). 2019 Nov;236(11):3209-3219. doi:10.1007/s00213-019-05273-5. Epub 2019 Jun 11. PMID: 31187152.

Radhakrishnan R, Ranganathan M, D'Souza DC. Medical Marijuana: What Physicians Need to Know. J Clin Psychiatry. 2019 May 7;80(5):18ac12537. doi: 10.4088/JCP.18ac12537. PMID: 31087827.

Orr C, Spechler P, Cao Z, Albaugh M, Chaarani B, Mackey S, D'Souza D, Allgaier N, Banaschewski T, Bokde ALW, Bromberg U, Büchel C, Burke Quinlan E, Conrod P, Desrivières S, Flor H, Frouin V, Gowland P, Heinz A, Ittermann B, Martinot JL, Martinot MP, Nees F, Papadopoulos Orfanos D, Paus T, Poustka L, Millenet S, Fröhner JH, Radhakrishnan R, Smolka MN, Walter H, Whelan R, Schumann G, Potter A, Garavan H. Grey Matter Volume Differences Associated with Extremely Low Levels of Cannabis Use in Adolescence. J Neurosci. 2019 Mar 6;39(10):1817-1827. doi: 10.1523/JNEUROSCI.3375-17.2018. Epub 2019 Jan 14. PMID: 30643026; PMCID: PMC6407302.

D'Souza DC, Cortes-Briones J, Creatura G, Bluez G, Thurnauer H, Deaso E, Bielen K, Surti T, Radhakrishnan R, Gupta A, Gupta S, Cahill J, Sherif MA, Makriyannis A, Morgan PT, Ranganathan M, Skosnik PD. Efficacy and safety of a fatty acid amide hydrolase inhibitor (PF-04457845) in the treatment of cannabis withdrawal and dependence in men: a double-blind, placebo-controlled, parallel group, phase 2a single-site randomised controlled trial. Lancet Psychiatry. 2019 Jan;6(1):35-45. doi: 10.1016/S2215-0366(18)30427-9. Epub 2018 Dec 6. PMID:30528676.

Radhakrishnan R, Guloksuz S, Ten Have M, de Graaf R, van Dorsselaer S, Gunther N, Rauschenberg C, Reininghaus U, Pries LK, Bak M, van Os J. Interaction between environmental and familial affective risk impacts psychosis admixture in states of affective dysregulation. Psychol Med. 2019 Aug;49(11):1879-1889. doi:10.1017/S0033291718002635. Epub 2018 Oct 4. PMID: 30284529.

Reininghaus U, Rauschenberg C, Ten Have M, de Graaf R, van Dorsselaer S, Simons CJP, Gunther N, Pries LK, Guloksuz S, Radhakrishnan R, Bak M, van Os J. Reasoning bias, working memory performance and a transdiagnostic phenotype of affective disturbances and psychotic experiences in the general population. Psychol Med. 2019 Aug;49(11):1799-1809. doi: 10.1017/S0033291718002209. Epub 2018 Aug 30. PMID: 30160228.

Pries LK, Guloksuz S, Ten Have M, de Graaf R, van Dorsselaer S, Gunther N, Rauschenberg C, Reininghaus U, Radhakrishnan R, Bak M, Rutten BPF, van Os J. Evidence That Environmental and Familial Risks for Psychosis Additively Impact a Multidimensional Subthreshold Psychosis Syndrome. Schizophr Bull. 2018 Jun 6;44(4):710-719. doi: 10.1093/schbul/sby051. PMID: 29701807; PMCID: PMC6007403.

De Aquino JP, Sherif M, Radhakrishnan R, Cahill JD, Ranganathan M, D'Souza DC. The Psychiatric Consequences of Cannabinoids. Clin Ther. 2018 Sep;40(9):1448-1456. doi: 10.1016/j.clinthera.2018.03.013. Epub 2018 Apr 17. PMID: 29678279.

Radhakrishnan R, Nabulsi N, Gaiser E, Gallezot JD, Henry S, Planeta B, Lin SF, Ropchan J, Williams W, Morris E, D'Souza DC, Huang Y, Carson RE, Matuskey D. Age-Related Change in 5-HT₆ Receptor Availability in Healthy Male Volunteers Measured with 11C-GSK215083 PET. J Nucl Med. 2018 Sep;59(9):1445-1450. doi: 10.2967/jnumed.117.206516. Epub 2018 Apr 6. PMID: 29626125; PMCID: PMC6126437.

Radhakrishnan R, Ross DA. From "Azalla" to Anandamide: Distilling the Therapeutic Potential of Cannabinoids. Biol Psychiatry. 2018 Jan 15;83(2):e27-e29. doi: 10.1016/j.biopsych.2017.11.017. PMID: 29223222; PMCID:PMC5752109.

Radhakrishnan R, Kaser M, Guloksuz S. The Link Between the Immune System, Environment, and Psychosis. Schizophr Bull. 2017 Jul 1;43(4):693-697. doi:10.1093/schbul/sbx057. PMID: 28969353; PMCID: PMC5472105.

Radhakrishnan R, Wasser T, Picon F, Puspanathan P, da Costa MP, Nakamae T, Elkholy H. Editorial training models for early-career psychiatrists. Lancet Psychiatry. 2017 Jul;4(7):515-516. doi: 10.1016/S2215-0366(17)30133-5. PMID: 28652036.

Ranganathan M, Radhakrishnan R, Addy PH, Schnakenberg-Martin AM, Williams AH, Carbuto M, Elander J, Pittman B, Andrew Sewell R, Skosnik PD, D'Souza DC. Tetrahydrocannabinol (THC) impairs encoding but not retrieval of verbal information. Prog Neuropsychopharmacol Biol Psychiatry. 2017 Oct 3;79(Pt B):176-183. doi: 10.1016/j.pnpbp.2017.06.019. Epub 2017 Jun 20. PMID: 28642081.

Muzyk AJ, Gagliardi JP, Rakesh G, Jiroutek MR, Radhakrishnan R, Pae CU, Masand PS, Szabo ST. Development of a Diverse Learning Experience for Diverse Psychiatry Resident Needs: A Four-Year Biological Psychiatry Curriculum Incorporating Principles of Neurobiology, Psychopharmacology, and Evidence-Based Practice. Psychiatry Investig. 2017 May;14(3):289-297. doi: 10.4306/pi.2017.14.3.289. Epub 2017 May 16. PMID: 28539947; PMCID: PMC5440431.

Radhakrishnan R, Garakani A, Gross LS, Goin MK, Pine J, Slaby AE, Sumner CR, Baron DA. Neuropsychiatric aspects of concussion. Lancet Psychiatry. 2016 Dec;3(12):1166-1175. doi: 10.1016/S2215-0366(16)30266-8. PMID: 27889010.

Wilkinson ST, Radhakrishnan R, D'Souza DC. A Systematic Review of the Evidence for Medical Marijuana in Psychiatric Indications. J Clin Psychiatry. 2016 Aug;77(8):1050-64. doi: 10.4088/JCP.15r10036. PMID: 27561138.

Wasser T, Richards M, Radhakrishnan R, Freedman R. The American Journal of Psychiatry Residents' Journal: Training the Next Generation of Academic Psychiatrists. Am J Psychiatry. 2016 May 1;173(5):461-4. doi: 10.1176/appi.ajp.2015.15101267. PMID: 27133407.

Charoensook J, Sidaros R, Pier K, Millard H, Wasser T, Richards M, Radhakrishnan R. Reflections on an Innovation: The First Trainee-Led Academic Psychiatry Journal. Acad Psychiatry. 2016 Jun;40(3):564-5. doi: 10.1007/s40596-016-0527-x. Epub 2016 Mar 17. PMID: 26988840.

Radhakrishnan R, Kiluk BD, Tsai J. A Meta-analytic Review of Non-specific Effects in Randomized Controlled Trials of Cognitive Remediation for Schizophrenia. Psychiatr Q. 2016 Mar;87(1):57-62. doi: 10.1007/s11126-015-9362-6. PMID: 25952944; PMCID: PMC4637248.

Sherif M, Radhakrishnan R, D'Souza DC, Ranganathan M. Human Laboratory Studies on Cannabinoids and Psychosis. Biol Psychiatry. 2016 Apr 1;79(7):526-38. doi: 10.1016/j.biopsych.2016.01.011. Epub 2016 Feb 2. PMID: 26970363.

D'Souza DC, Radhakrishnan R, Sherif M, Cortes-Briones J, Cahill J, Gupta S, Skosnik PD, Ranganathan M. Cannabinoids and Psychosis. Curr Pharm Des. 2016;22(42):6380-6391. doi: 10.2174/1381612822666160826105628. PMID: 27568729.

Freedman R, Lewis DA, Michels R, Pine DS, Rush AJ, Schultz SK, Tamminga CA, Radhakrishnan R. 2015 in Review. Am J Psychiatry. 2015 Dec;172(12):1179-81. doi:10.1176/appi.ajp.2015.15091218. PMID: 26619771.

Wilkinson ST, Yarnell S, Radhakrishnan R, Ball SA, D'Souza DC. Marijuana Legalization: Impact on Physicians and Public Health. Annu Rev Med. 2016;67:453-66. doi: 10.1146/annurev-med-050214-013454. Epub 2015 Oct 19. PMID: 26515984; PMCID: PMC4900958.

Chandra RM, Arora L, Mehta UM, Asnaani A, Radhakrishnan R. Asian Indians in America: The influence of values and culture on mental health. Asian J Psychiatr. 2016 Aug;22:202-9. doi: 10.1016/j.ajp.2015.09.011. Epub 2015 Sep 28. PMID: 26442987.

Ranganathan M, Cortes-Briones J, Radhakrishnan R, Thurnauer H, Planeta B, Skosnik P, Gao H, Labaree D, Neumeister A, Pittman B, Surti T, Huang Y, Carson RE, D'Souza DC. Reduced Brain Cannabinoid Receptor Availability in Schizophrenia. Biol Psychiatry. 2016 Jun 15;79(12):997-1005. doi: 10.1016/j.biopsych.2015.08.021. Epub 2015 Aug 29. PMID: 26432420; PMCID: PMC4884543.

Radhakrishnan R, Skosnik PD, Cortes-Briones J, Sewell RA, Carbuto M, Schnakenberg A, Cahill J, Bois F, Gunduz-Bruce H, Pittman B, Ranganathan M, D'Souza DC. GABA Deficits Enhance the Psychotomimetic Effects of Δ9-THC. Neuropsychopharmacology. 2015 Jul;40(8):2047-56. doi: 10.1038/npp.2015.58. Epub 2015 Mar 2. PMID: 25728472; PMCID: PMC4839528.

Wilkinson ST, Radhakrishnan R, D'Souza DC. Impact of Cannabis Use on the Development of Psychotic Disorders. Curr Addict Rep. 2014 Jun 1;1(2):115-128. doi: 10.1007/s40429-014-0018-7. PMID: 25767748; PMCID: PMC4352721.

Manu P, Khan S, Radhakrishnan R, Russ MJ, Kane JM, Correll CU. Body mass index identified as an independent predictor of psychiatric readmission. J Clin Psychiatry. 2014 Jun;75(6):e573-7. doi: 10.4088/JCP.13m08795. PMID: 25004198.

Radhakrishnan R, Wilkinson ST, D'Souza DC. Gone to Pot - A Review of the Association between Cannabis and Psychosis. Front Psychiatry. 2014 May 22;5:54. doi: 10.3389/fpsyt.2014.00054. PMID: 24904437; PMCID: PMC4033190.

Ranganathan M, Sewell RA, Carbuto M, Elander J, Schnakenberg A, Radhakrishnan R, Pittman B, D'Souza DC. Effects of Δ9-tetrahydrocannabinol in individuals with a familial vulnerability to alcoholism. Psychopharmacology (Berl). 2014 Jun;231(12):2385-93. doi: 10.1007/s00213-013-3402-4. Epub 2014 Jan 15. PMID: 24424782.

Radhakrishnan R, Calvin S, Singh JK, Thomas B, Srinivasan K. Thyroid dysfunction in major psychiatric disorders in a hospital based sample. Indian J Med Res. 2013 Dec;138(6):888-93. PMID: 24521631; PMCID: PMC3978977.

Cortes JA, Radhakrishnan R. A case of amelioration of venlafaxine- discontinuation "brain shivers" with atomoxetine. Prim Care Companion CNS Disord. 2013;15(2):PCC.12l01427. doi: 10.4088/PCC.12l01427. PMID: 23930231; PMCID: PMC3733524.

Sewell RA, Schnakenberg A, Elander J, Radhakrishnan R, Williams A, Skosnik PD, Pittman B, Ranganathan M, D'Souza DC. Acute effects of THC on time perception in frequent and infrequent cannabis users. Psychopharmacology (Berl). 2013 Mar;226(2):401-13. doi: 10.1007/s00213-012-2915-6. Epub 2012 Nov 24. PMID: 23179965; PMCID: PMC3581701.

D'Souza DC, Radhakrishnan R, Perry E, Bhakta S, Singh NM, Yadav R, Abi-Saab D, Pittman B, Chaturvedi SK, Sharma MP, Bell M, Andrade C. Feasibility, safety, and efficacy of the combination of D-serine and computerized cognitive retraining in schizophrenia: an international collaborative pilot study. Neuropsychopharmacology. 2013 Feb;38(3):492-503. doi: 10.1038/npp.2012.208. Epub 2012 Oct 24. PMID: 23093223; PMCID: PMC3547200.

Radhakrishnan R, Andrade C. Suicide: An Indian perspective. Indian J Psychiatry. 2012 Oct;54(4):304-19. doi: 10.4103/0019-5545.104793. PMID: 23372232; PMCID: PMC3554961.

Pradeep J, Sambashivaiah S, Thomas T, Radhakrishnan R, Vaz M, Srinivasan K. Heart rate variability responses to standing are attenuated in drug naive depressed patients. Indian J Physiol Pharmacol. 2012 Jul-Sep;56(3):213-21. PMID:23734434.

Radhakrishnan R, Kanigere M, Menon J, Calvin S, Srinivasan K. Comparison of three a-priori models in the prediction of serum lithium concentration. Indian J Pharmacol. 2012 Mar;44(2):234-7. doi: 10.4103/0253-7613.93856. PMID: 22529482; PMCID: PMC3326919.

Ranganathan M, Carbuto M, Braley G, Elander J, Perry E, Pittman B, Radhakrishnan R, Sewell RA, D'Souza DC. Naltrexone does not attenuate the effects of intravenous Δ9-tetrahydrocannabinol in healthy humans. Int J Neuropsychopharmacol. 2012 Oct;15(9):1251-64. doi: 10.1017/S1461145711001830. Epub 2012 Jan 16. PMID: 22243563.

Radhakrishnan R, Menon J, Kanigere M, Ashok M, Shobha V, Galgali RB. Domains and determinants of quality of life in schizophrenia and systemic lupus erythematosus. Indian J Psychol Med. 2012 Jan;34(1):49-55. doi:10.4103/0253-7176.96159. PMID: 22661808; PMCID: PMC3361843.

Andrade C, Radhakrishnan R, Fernandes PP. Psychopharmacology of schizophrenia: The Future Looks Bleak. Mens Sana Monogr. 2012 Jan;10(1):4-12. doi: 10.4103/0973-1229.91293. PMID: 22654378; PMCID: PMC3353605.

Tsai J, Radhakrishnan R. Characterizing Asian American and Pacific Islander veterans who use health services. Mil Med. 2012 Jan;177(1):1-3. doi: 10.7205/milmed-d-11-00276. PMID: 22338968.

Andrade C, Radhakrishnan R. Prayer, randomized controlled trials and distance healing: A response to Dr. Jana. Indian J Psychiatry. 2011 Jul;53(3):274. doi: 10.4103/0019-5545.86824. PMID: 22135451; PMCID: PMC3221189.

Radhakrishnan R, Kanigere M, Menon J, Calvin S, Janish A, Srinivasan K. Association between unconjugated bilirubin and schizophrenia. Psychiatry Res. 2011 Oct 30;189(3):480-2. doi: 10.1016/j.psychres.2011.03.003. Epub 2011 Apr 5. PMID: 21470692.

Rao TS, Radhakrishnan R, Andrade C. Standard operating procedures for clinical practice. Indian J Psychiatry. 2011 Jan;53(1):1-3. doi:10.4103/0019-5545.75542. PMID: 21430999; PMCID: PMC3056180.

Andrade C, Radhakrishnan R. Prayer, randomized controlled trials and healing: A response to Prof. Abraham Verghese. Indian J Psychiatry. 2010 Apr;52(2):193-4. doi: 10.4103/0019-5545.64589. PMID: 20838511; PMCID: PMC2927894.

Radhakrishnan R, Andrade C. The evolution of Indian psychiatric research: An examination of the early decades of the Indian Journal of Psychiatry. Indian J Psychiatry. 2010 Jan;52(Suppl 1):S19-25. doi: 10.4103/0019-5545.69199. PMID:21836678; PMCID: PMC3146197.

Andrade C, Radhakrishnan R. Prayer and healing: A medical and scientific perspective on randomized controlled trials. Indian J Psychiatry. 2009 Oct- Dec;51(4):247-53. doi: 10.4103/0019-5545.58288. PMID: 20048448; PMCID: PMC2802370.

Andrade C, Radhakrishnan R. Maintenance electroconvulsive therapy: implementing the STABLE algorithm. J ECT. 2009 Sep;25(3):224-5. doi:10.1097/YCT.0b013e3181996672. PMID: 19730033.

Andrade C, Radhakrishnan R. Safety and efficacy of antipsychotic drugs for the behavioral and psychological symptoms of dementia. Indian J Psychiatry. 2009 Jan;51 Suppl 1(Suppl1):S87-92. PMID: 21416025; PMCID: PMC3038527.

Andrade C, Radhakrishnan R. The prevention and treatment of cognitive decline and dementia: An overview of recent research on experimental treatments. Indian J Psychiatry. 2009 Jan;51(1):12-25. doi: 10.4103/0019-5545.44900. PMID: 19742190; PMCID: PMC2738400.