實驗室成員

許健生 中興大學生醫所博士候選人

Publication:

Kao JK, Hsu TF, Lee MS, Su TC, Lee CH, Hsu CS, Shieh JJ, Wang JY, Yang RC. Subcutaneous injection of recombinant heat shock protein 70 ameliorates atopic dermatitis skin lesions in a mouse model. Kaohsiung J Med Sci. 2020, 36: 186-195. (SCI, impact factor: 1.737, Ranking: 107/138 MEDICINE, RESEARCH & EXPERIMENTAL) .

劉光庭 中興大學生醫所博士生

Publication:

Wang ST, Huang SW, Liu KT, Lee TY, Shieh JJ*, Wu CY*. Atorvastatin-induced senescence of hepatocellular carcinoma is mediated by downregulation of hTERT through the suppression of the IL-6/STAT3 pathway. Cell Death Discovery. 2020, 6:17. (SCI, impact factor: 4.114, Ranking: 76/195 Cell Biology)

李政宜 中興大學生醫所博士生

Publication:

Chuang KC, Chang CR, Chang SH, Huang SW, Chuang SM, Li ZY, Wang ST, Kao JK, Chen YJ, Shieh JJ*. Imiquimod-induced ROS production disrupts the balance of mitochondrial dynamics and increases mitophagy in skin cancer cells. Journal of Dermatological Science. 2020, 98(2): 152-162.(SCI, impact factor: 3.681, Ranking: 12/68 DERMATOLOGY)

International Conference Presentation:

Li, Z.Y., Shieh, J.J., Imiquimod-induced senescence was mediated by increasing K382 acetylation of p53 through Sirt1 downregulation in skin cancer cells. In: The 44^th Annual Meeting of the Japanese Society for Investigative Dermatology, Hotel Aomori, Aomori, Japan, November 8-10, 2019.

王士忠 中興大學生醫所博士生

謝佳偉 中興大學轉譯醫學博士學位學程博士候選人

Publication:

Chang SH, Huang SW, Wang ST, Chung KC, Hsieh CW, Kao JK, Chen YJ, Wu CY*, Shieh JJ*. Imiquimod-induced autophagy is regulated by ER stress-mediated PKR activation in cancer cells. Journal of Dermatological Science. 2017, 87(2): 138-148. (SCI, impact factor: 3.681, Ranking: 12/68 DERMATOLOGY)

鍾牧圻 中興大學轉譯醫學博士學位學程博士生

Publication:

Chung MC, Yu TM, Wu MJ, Chuang YW, Muo CH, Chen CH, Chang CH, Shieh JJ, Hung PH, Chen JW, Chung CJ. Is combined peritoneal dialysis and hemodialysis redundant? A nationwide study from Taiwan. BMC Nephrol. 2020, 21(1): 348. (SCI, impact factor: 1.43）

林裴樂 中興大學生醫所碩士生

許晉銓 中興大學生醫所碩士生

蔡馥庭 中興大學生醫所碩士生

薛鉅諠 中興大學生醫所碩士生

已畢業學生:

張書豪 博士 陽明大學臨床醫學研究所博士 (2021年畢）

目前狀態:

博士論文：

Publication:

Chang SH, Wu CY, Chuang KC, Huang SW, Li ZY, Wang ST, Lai ZL, Chang CC, ChenYJ, Wong TW, Kao JK, Shieh JJ*. Imiquimod Accelerated Antitumor Response by Targeting Lysosome Adaptation in Skin Cancer Cells. Journal of Investigative Dermatology. 2021 Mar17:S0022-202X(21)01002-2. doi: 10.1016/j.jid.2021.01.034. (SCI, impact factor: 7.143, Ranking: 3/68 DERMATOLOGY).

Chuang KC, Chang CR, Chang SH, Huang SW, Chuang SM, Li ZY, Wang ST, Kao JK, Chen YJ, Shieh JJ*. Imiquimod-induced ROS production disrupts the balance of mitochondrial dynamics and increases mitophagy in skin cancer cells. Journal of Dermatological Science. 2020, 98(2): 152-162.(SCI, impact factor: 3.681, Ranking: 12/68 DERMATOLOGY)

Huang SW, Wang ST, Chang SH, Chung KC, Wang HY, Kao JK, Liang SM, Wu CY, Kao SF, Chen YJ, Shieh JJ*. Imiquimod exerts antitumor effects by inducing immunogenic cell death and is enhanced by the glycolytic inhibitor 2-deoxy-glucose. Journal of Investigative Dermatology. 2020, 140: 1771-1783. (SCI, impact factor: 7.143, Ranking: 3/68 DERMATOLOGY).

Chang SH, Huang SW, Wang ST, Chung KC, Hsieh CW, Kao JK, Chen YJ, Wu CY*, Shieh JJ*. Imiquimod-induced autophagy is regulated by ER stress-mediated PKR activation in cancer cells. Journal of Dermatological Science. 2017, 87(2): 138-148. (SCI, impact factor: 3.681, Ranking: 12/68 DERMATOLOGY)

Kao JK, Wang SC, Ho LW, Huang SW, Chang SH, Yang RC, Ke YY, Wu CY, Wang JY*, Shieh JJ*. Chronic Iron Overload Results in Impaired Bacterial Killing of THP-1 Derived Macrophage through the Inhibition of Lysosomal Acidification. Plos One. 2016, 11(5): e0156713 (SCI, impact factor: 2.740, Ranking: 27/71 MULTIDISCIPLINARY SCIENCES)

Huang SW, Chang SH, Mu SW, Jiang HY, Wang ST, Kao JK, Huang JL, Wu CY, Chen YJ, Shieh JJ*. Imiquimod activates p53-dependent apoptosis in a human basal cell carcinoma cell line. Journal of Dermatological Science. 2016, 81(3): 182-91. (SCI, impact factor: 3.681, Ranking: 12/68 DERMATOLOGY)

International Conference Presentation:

Chang, S.H., Wu, C.Y., Shieh, J.J., Lysosome adaption compensated imiquimod-induced cell death in skin cancer cells. In: The 44^th Annual Meeting of the Japanese Society for Investigative Dermatology, Hotel Aomori, Aomori, Japan, November 8-10, 2019.

Chang, S.H., Huang, S.W., Cheng, C.C., Wu, C.Y., Shieh, J.J. Enhancement of lysosomal function contributes to imiquimod-acquired resistance in skin cancer cells. In: 2019 24^th World Congress of Dermatology, Milan, Italy, June 10-15, 2019.

Chang, S.H., Shieh, J.J., Imiquimod induces ER stress and PKR-mediated autophagy via ROS production in cancer cells. In: Frontiers in Cancer Science 2015. Singapore, November 2-4, 2015.

Chang, S. H., Shieh, J.J., Huang, S.W., Imiquimod induces STAT3-mediated autophagy via ROS production in cancer cells. In: 39th Annual Meeting of the Japanese Society for Investigative Dermatology. Osaka, Japan, December 12-14, 2014.

莊凱程 博士 中興大學生醫所博士 (2021年畢）

目前狀態:

博士論文：

Publication:

Chang SH, Wu CY, Chuang KC, Huang SW, Li ZY, Wang ST, Lai ZL, Chang CC, ChenYJ, Wong TW, Kao JK, Shieh JJ*. Imiquimod Accelerated Antitumor Response by Targeting Lysosome Adaptation in Skin Cancer Cells. Journal of Investigative Dermatology. 2021 Mar17:S0022-202X(21)01002-2. doi: 10.1016/j.jid.2021.01.034. (SCI, impact factor: 7.143, Ranking: 3/68 DERMATOLOGY).

Chuang KC, Chen FW, Tsai MH*, Shieh JJ*. EGR-1 plays a protective role in AMPK inhibitor compound C-induced apoptosis through ROS-induced ERK activation in skin cancer cells. Oncology Letters. 2020, Accepted. (SCI, impact factor: 2.311, Ranking: 182/244 ONCOLOGY).

Chuang KC, Chang CR, Chang SH, Huang SW, Chuang SM, Li ZY, Wang ST, Kao JK, Chen YJ, Shieh JJ*. Imiquimod-induced ROS production disrupts the balance of mitochondrial dynamics and increases mitophagy in skin cancer cells. Journal of Dermatological Science. 2020, 98(2): 152-162.(SCI, impact factor: 3.681, Ranking: 12/68 DERMATOLOGY) ^*

Huang SW, Wang ST, Chang SH, Chuang KC, Wang HY, Kao JK, Liang SM, Wu CY, Kao SF, Chen YJ, Shieh JJ*. Imiquimod exerts antitumor effects by inducing immunogenic cell death and is enhanced by the glycolytic inhibitor 2-deoxy-glucose. Journal of Investigative Dermatology. 2020, 140: 1771-1783. (SCI, impact factor: 7.143, Ranking: 3/68 DERMATOLOGY).

Chang SH, Huang SW, Wang ST, Chuang KC, Hsieh CW, Kao JK, Chen YJ, Wu CY*, Shieh JJ*. Imiquimod-induced autophagy is regulated by ER stress-mediated PKR activation in cancer cells. Journal of Dermatological Science. 2017, 87(2): 138-148. (SCI, impact factor: 3.681, Ranking: 12/68 DERMATOLOGY)

International Conference Presentation:

Chuang, K.C., Shieh, J.J., Imiquimod disrupts mitochondrial dynamic balance and leads to mitophagy. In: The 44^th Annual Meeting of the Japanese Society for Investigative Dermatology, Hotel Aomori, Aomori, Japan, November 8-10, 2019.

王馨葶 博士 中興大學生醫所博士(2017年畢）

目前狀態: 台中榮總皮膚科博士後研究員

博士論文：AMPK作為imiquimod及simvastatin的分子標靶以抑制腫瘤細胞生長之機制研究

Publication:

Wang ST, Huang SW, Liu KT, Lee TY, Shieh JJ*, Wu CY*. Atorvastatin-induced senescence of hepatocellular carcinoma is mediated by downregulation of hTERT through the suppression of the IL-6/STAT3 pathway. Cell Death Discovery. 2020, 6:17. (SCI, impact factor: 4.114, Ranking: 76/195 Cell Biology)

Chuang KC, Chang CR, Chang SH, Huang SW, Chuang SM, Li ZY, Wang ST, Kao JK, Chen YJ, Shieh JJ*. Imiquimod-induced ROS production disrupts the balance of mitochondrial dynamics and increases mitophagy in skin cancer cells. Journal of Dermatological Science. 2020, 98(2): 152-162.

Huang SW, Wang ST, Chang SH, Chung KC, Wang HY, Kao JK, Liang SM, Wu CY, Kao SF, Chen YJ, Shieh JJ*. Imiquimod exerts antitumor effects by inducing immunogenic cell death and is enhanced by the glycolytic inhibitor 2-deoxy-glucose. Journal of Investigative Dermatology. 2020, 140: 1771-1783. (SCI, impact factor: 7.143, Ranking: 3/68 DERMATOLOGY).

Chang SH, Huang SW, Wang ST, Chung KC, Hsieh CW, Kao JK, Chen YJ, Wu CY*, Shieh JJ*. Imiquimod-induced autophagy is regulated by ER stress-mediated PKR activation in cancer cells. Journal of Dermatological Science. 2017,87(2):138-148. (SCI, impact factor: 3.739, Ranking: 7/61 DERMATOLOGY)

Wang ST, Ho HJ, Lin JT, Shieh JJ*, Wu CY*. Simvastatin-induced cell cycle arrest though inhibition of STAT3/SKP2 axis and activation of AMPK to promote p27 and p21 accumulation in hepatocellular carcinoma cells. Cell Death and Disease. 2017, 8, e2626. (SCI, impact factor: 5.378, Ranking: 38/187 Cell Biology)

Huang SW, Chen YJ, Wang ST, Ho LW, Kao JK, Takahashi M, Narita M, Wu CY, Cheng HY, Shieh JJ*. Azithromycin Impairs TLR7 Signaling in Dendritic Cells and Improves the Severity of Imiquimod-Induced Psoriasis-Like Skin Inflammation in Mice. Journal of Dermatological Science. 2016, 84(1)59-70. (SCI, impact factor: 3.419, Ranking: 9/62 DERMATOLOGY)

Huang SW, Chang SH, Mu SW, Jiang HY, Wang ST, Kao JK, Huang JL, Wu CY, Chen YJ, Shieh JJ*. Imiquimod activates p53-dependent apoptosis in a human basal cell carcinoma cell line. Journal of Dermatological Science. 2016, 81(3): 182-91.(SCI, impact factor: 3.419, Ranking: 9/62 DERMATOLOGY)

Wang ST, Huang SW, Kao JK, Liang SM, Chen YJ, Chen YY, Wu CY, Shieh JJ*. Imiquimod-induced AMPK activation causes translation attenuation and apoptosis but not autophagy. Journal of Dermatological Science. 2015; 78(2): 108-116 (SCI, impact factor: 3.335, Ranking: 9/61 DERMATOLOGY)

Huang SW, Kao JK, Wu CY, Wang ST, Lee HC, Liang SM, Chen YJ, Shieh JJ*. Targeting aerobic glycolysis and HIF-1 alpha expression enhance imiquimod0induced apoptosis in cancer cells. Oncotarget, 2014, 5(5): 1363-1381. (SCI, impact factor: 6.636, Ranking: 21/197 ONCOLOGY)

International Conference Presentation:

Wang, S.T., Shieh, J.J., Wu, C.Y., Statins inhibit hepatocellular carcinoma progression: population-based and in vitro studies. In: Frontiers in Cancer Science 2015. Singapore, November 2-4, 2015.

Wang, S.T., Shieh, J.J., Huang, S.W., Wu, C.Y., IMQ induced AMPK activation causes translation inhibition and apoptosis but not autophagy. In: 39th Annual Meeting of the Japanese Society for Investigative Dermatology. Osaka, Japan, December 12-14, 2014.

高峻凱 醫師 中興大學生醫所博士 (2016年畢）

目前狀態: 彰化基督教醫院小兒科主治醫師

博士論文：鐵素過多對於單核球細胞及其分化之巨噬細胞之影響

Publication:

Kao JK, Wang SC, Ho LW, Huang SW, Lee CH, Lee MS, Yang RC, Shieh JJ*. M2-like polarization of THP-1 monocyte-derived macrophages under chronic iron overload. Annals of Hematology. 2020, 99(3):431-441. (SCI, impact factor: 2.904, Ranking: 35/76 HEMATOLOGY).

Chuang KC, Chang CR, Chang SH, Huang SW, Chuang SM, Li ZY, Wang ST, Kao JK, Chen YJ, Shieh JJ*. Imiquimod-induced ROS production disrupts the balance of mitochondrial dynamics and increases mitophagy in skin cancer cells. Journal of Dermatological Science. 2020, 98(2): 152-162.(SCI, impact factor: 3.681, Ranking: 12/68 DERMATOLOGY)

Huang SW, Wang ST, Chang SH, Chung KC, Wang HY, Kao JK, Liang SM, Wu CY, Kao SF, Chen YJ, Shieh JJ*. Imiquimod exerts antitumor effects by inducing immunogenic cell death and is enhanced by the glycolytic inhibitor 2-deoxy-glucose. Journal of Investigative Dermatology. 2020, 140: 1771-1783. (SCI, impact factor: 7.143, Ranking: 3/68 DERMATOLOGY).

Kao JK, Hsu TF, Lee MS, Su TC, Lee CH, Hsu CS, Shieh JJ, Wang JY, Yang RC. Subcutaneous injection of recombinant heat shock protein 70 ameliorates atopic dermatitis skin lesions in a mouse model. Kaohsiung J Med Sci. 2020, 36: 186-195. (SCI, impact factor: 1.737, Ranking: 107/138 MEDICINE, RESEARCH & EXPERIMENTAL)

Chang SH, Huang SW, Wang ST, Chung KC, Hsieh CW, Kao JK, Chen YJ, Wu CY*, Shieh JJ*. Imiquimod-induced autophagy is regulated by ER stress-mediated PKR activation in cancer cells. Journal of Dermatological Science. 2017,87(2):138-148. (SCI, impact factor: 3.739, Ranking: 7/61 DERMATOLOGY)

Huang SW, Chen YJ, Wang ST, Ho LW, Kao JK, Takahashi M, Narita M, Wu CY, Cheng HY, Shieh JJ*. Azithromycin Impairs TLR7 Signaling in Dendritic Cells and Improves the Severity of Imiquimod-Induced Psoriasis-Like Skin Inflammation in Mice. Journal of Dermatological Science. 2016, 84(1)59-70. (SCI, impact factor: 3.419, Ranking: 9/62 DERMATOLOGY)

Kao JK, Wang SC, Ho LW, Huang SW, Chang SH, Yang RC, Ke YY, Wu CY, Wang JY*, Shieh JJ*. Chronic Iron Overload Results in Impaired Bacterial Killing of THP-1 Derived Macrophage through the Inhibition of Lysosomal Acidification. Plos One. 2016, 11(5): e0156713 (SCI, impact factor: 3.234, Ranking: 9/57 MULTIDISCIPLINARY SCIENCES)

Huang SW, Chang SH, Mu SW, Jiang HY, Wang ST, Kao JK, Huang JL, Wu CY, Chen YJ, Shieh JJ*. Imiquimod activates p53-dependent apoptosis in a human basal cell carcinoma cell line. Journal of Dermatological Science. 2016, 81(3): 182-91. (SCI, impact factor: 3.419, Ranking: 9/62 DERMATOLOGY)

Kao JK, Lee CH, Lee MS, Hsu CS, Tsao LY, Tsai YG, Shieh JJ*, Yang RC*. Heat shock pretreatment reduces expression and release of TSLP from keratinocytes under Th2 environment. Pediatric Allergy and Immunology. 2016; 27(1): 62-9.(SCI, impact factor: 3.397, Ranking: 9/119 PEDIATRICS)

Wang ST, Huang SW, Kao JK, Liang SM, Chen YJ, Chen YY, Wu CY, Shieh JJ. Imiquimod-induced AMPK activation causes translation attenuation and apoptosis but not autophagy. Journal of Dermatological Science. 2015; 78(2): 108-116(SCI, impact factor: 3.335, Ranking: 9/61 DERMATOLOGY)

Huang SW, Kao JK, Wu CY, Wang ST, Lee HC, Liang SM, Chen YJ, Shieh JJ*. Targeting aerobic glycolysis and HIF-1 alpha expression enhance imiquimod0induced apoptosis in cancer cells. Oncotarget, 2014, 5(5): 1363-1381. (SCI, impact factor: 6.636, Ranking: 21/197 ONCOLOGY)

Huang SW, Wu CY, Wang YT, Kao JK, Lin CC, Chang CC, Mu SW, Chen YY, Chiu HW, Chang CH, Liang SM, Chen YJ, Huang JL, Shieh JJ*. p53 modulates the AMPK inhibitor compound C induced apoptosis in human skin cancer cells. Toxicology and Applied Pharmacology. 2013, 267: 113-124.(SCI, impact factor: 4.447, Ranking:10/83 TOXICOLOGY)

黃士維 博士 中興大學生醫所博士(2015畢）

目前狀態:中國醫藥大學附設醫院助研究員

博士論文：Imiquimod誘導細胞死亡之機制及應用研究

Publication:

Kao JK, Wang SC, Ho LW, Huang SW, Lee CH, Lee MS, Yang RC, Shieh JJ*. M2-like polarization of THP-1 monocyte-derived macrophages under chronic iron overload. Annals of Hematology. 2020, 99(3):431-441. (SCI, impact factor: 2.904, Ranking: 35/76 HEMATOLOGY). ^*Corresponding author.

Wang ST, Huang SW, Liu KT, Lee TY, Shieh JJ*, Wu CY*. Atorvastatin-induced senescence of hepatocellular carcinoma is mediated by downregulation of hTERT through the suppression of the IL-6/STAT3 pathway. Cell Death Discovery. 2020, 6:17. (SCI, impact factor: 4.114, Ranking: 76/195 Cell Biology) ^*Corresponding author.

Chuang KC, Chang CR, Chang SH, Huang SW, Chuang SM, Li ZY, Wang ST, Kao JK, Chen YJ, Shieh JJ*. Imiquimod-induced ROS production disrupts the balance of mitochondrial dynamics and increases mitophagy in skin cancer cells. Journal of Dermatological Science. 2020, 98(2): 152-162.(SCI, impact factor: 3.681, Ranking: 12/68 DERMATOLOGY) ^*Corresponding author.

Huang SW, Wang ST, Chang SH, Chung KC, Wang HY, Kao JK, Liang SM, Wu CY, Kao SF, Chen YJ, Shieh JJ*. Imiquimod exerts antitumor effects by inducing immunogenic cell death and is enhanced by the glycolytic inhibitor 2-deoxy-glucose. Journal of Investigative Dermatology. 2020, 140: 1771-1783. (SCI, impact factor: 7.143, Ranking: 3/68 DERMATOLOGY).

Chang SH, Huang SW, Wang ST, Chung KC, Hsieh CW, Kao JK, Chen YJ, Wu CY*, Shieh JJ*. Imiquimod-induced autophagy is regulated by ER stress-mediated PKR activation in cancer cells. Journal of Dermatological Science. 2017, 87(2):138-148. (SCI, impact factor: 3.739, Ranking: 7/61 DERMATOLOGY)

Huang SW, Chen YJ, Wang ST, Ho LW, Kao JK, Takahashi M, Narita M, Wu CY, Cheng HY, Shieh JJ*. Azithromycin Impairs TLR7 Signaling in Dendritic Cells and Improves the Severity of Imiquimod-Induced Psoriasis-Like Skin Inflammation in Mice. Journal of Dermatological Science. 2016, 84(1)59-70. (SCI, impact factor: 3.419, Ranking: 9/62 DERMATOLOGY)

Kao JK, Wang SC, Ho LW, Huang SW, Chang SH, Yang RC, Ke YY, Wu CY, Wang JY*, Shieh JJ*. Chronic Iron Overload Results in Impaired Bacterial Killing of THP-1 Derived Macrophage through the Inhibition of Lysosomal Acidification. Plos One. 2016, 11(5): e0156713 (SCI, impact factor: 3.234, Ranking: 9/57 MULTIDISCIPLINARY SCIENCES)

Huang SW, Chang SH, Mu SW, Jiang HY, Wang ST, Kao JK, Huang JL, Wu CY, Chen YJ, Shieh JJ*. Imiquimod activates p53-dependent apoptosis in a human basal cell carcinoma cell line. Journal of Dermatological Science. 2016, 81(3): 182-91. (SCI, impact factor: 3.419, Ranking: 9/62 DERMATOLOGY)

Wang ST, Huang SW, Kao JK, Liang SM, Chen YJ, Chen YY, Wu CY, Shieh JJ. Imiquimod-induced AMPK activation causes translation attenuation and apoptosis but not autophagy. Journal of Dermatological Science. 2015; 78(2): 108-116 (SCI, impact factor: 3.335, Ranking: 9/61 DERMATOLOGY)

Huang SW, Kao JK, Wu CY, Wang ST, Lee HC, Liang SM, Chen YJ, Shieh JJ*. Targeting aerobic glycolysis and HIF-1 alpha expression enhance imiquimod0induced apoptosis in cancer cells. Oncotarget, 2014, 5(5):1363-1381. (SCI, impact factor: 6.636, Ranking: 21/197 ONCOLOGY)

Huang SW, Wu CY, Wang YT, Kao JK, Lin CC, Chang CC, Mu SW, Chen YY, Chiu HW, Chang CH, Liang SM, Chen YJ, Huang JL, Shieh JJ*. p53 modulates the AMPK inhibitor compound C induced apoptosis in human skin cancer cells. Toxicology and Applied Pharmacology. 2013, 267: 113-124 (SCI, impact factor: 4.447, Ranking:10/83 TOXICOLOGY)

Shieh JJ, Lu YH, Huang SW, Huang YH, Sun CH, Chiou HJ, Liu C, Lo MY, Lin CY, Niu DM. Misdiagnosis as steatohepatitis in a family with mild glycogen storagedisease type 1a. Gene. 2012; 509(1): 154-7 (SCI, impact factor: 2.341, Ranking: 92/157 GENETICS & HEREDITY)

Huang SW, Chang CC, Lin CC, Tsai JJ, Chen YJ, Wu CY, Liu KT, Shieh JJ^*. Mcl-1 determines the imiquimod-induced apoptosis but not imiquimod-induced autophagy in skin cancer cells. Journal of Dermatological Science. 2012; 65(3):170-8 (SCI, impact factor: 3.712, Ranking: 7/54 DERMATOLOGY)

Huang SW, Liu KT, Chang CC, Chen YJ, Wu CY, Tsai JJ, Lu WC, Wang YT, Liu CM, Shieh JJ^*. Imiquimod Simultaneously Induces Autophagy and Apoptosis in Human Basal Cell Carcinoma Cells. Brit J Dermatol. 2010; 163(2):310-20 (SCI, impact factor: 4.260, Ranking: 4/43 DERMATOLOGY)

Shieh JJ^*, Liu KT, Huang SW, Chen YJ, Hsieh TY. Modification of alternative splicing of Mcl-1 pre-mRNA using antisense morpholino oligonucleotides induces apoptosis in basal cell carcinoma cells. J Invest Dermatol. 2009; 129(10):2497-506 (SCI, impact factor: 5.543, Ranking: 1/43 DERMATOLOGY)

International Conference Presentation:

Huang, S.W., Wang, S.T., Wu, C.Y., Chen, Y.J., Shieh, J.J., Imiquimod activates p53-dependent apoptosis in human skin cancer cells. In: Frontiers in Cancer Science 2015. Singapore, November 2-4, 2015.

Huang, S.W., Shieh, J.J., The antibiotic azithromycin improves the severity with imiquimod-induced psoriasis like skin inflammation in mice. In: 39th Annual Meeting of the Japanese Society for Investigative Dermatology. Osaka, Japan, December 12-14, 2014.

Wang, S.T., Shieh, J.J., Huang, S.W., Wu, C.Y., IMQ induced AMPK activation causes translation inhibition and apoptosis but not autophagy. In: 39th Annual Meeting of the Japanese Society for Investigative Dermatology. Osaka, Japan, December 12-14, 2014.

Chang, S. H., Shieh, J.J., Huang, S.W., Imiquimod induces STAT3-mediated autophagy via ROS production in cancer cells. In: 39th Annual Meeting of the Japanese Society for Investigative Dermatology. Osaka, Japan, December 12-14, 2014.

Huang, S.W., Chen, Y.J., Cheng, H.Y., Wang, S.T., Shieh, J.J. Antibiotic Azithromycin improves the severity of mice with imiquimod-induced psoriasis like skin inflammation. In: 2013 Asia Pacific Congress of Allergy, Asthma and Clinical Immunology. Taipei, Taiwan, November 14-17, 2013.

Shieh, J.J., Huang, S.W., The glucose availability and the induction of HIF-1 alpha expression determine thee imiquimod induced apoptosis in cancer cells. In: 37th Annual Meeting of the Japanese Society for Investigative Dermatology. Okinawa, Japan, December, 7-9, 2012.

Shieh, J.J., Huang, S.W., Mu, S.W., Chen, Y.Y. p53 modulates the AMPK inhibitor compound C induced apoptosis in human skin cancer cells. In: 36th Annual Meeting of the Japanese Society for Investigative Dermatology. Kyoto, Japan, December, 9-11, 2011.

Huang, S.W., Shieh, J.J. Mcl-1 over-expression causes resistance to imiquimod-induced apoptosis but not imiquimod-induced autophagy in basal cell carcinoma cells. In 22^nd World Congress of Dermatology. Seoul, Korea, May, 24-29, 2011. (Silver Award of E. Poster)

Huang, S.W., Liu, K.T., Shieh, J.J. The Interplay between Imiquimod Induced Autophagy and Apoptosis in Human Basal Cell Carcinoma Cells. In: 34th Annual Meeting of the Japanese Society for Investigative Dermatology. Fukuoka, Japan, December, 4-6, 2009.

Award:

1. 2013年中興大學生物醫學研究所retreat meeting暨博士班學生進 度報告競賽第一名

2. 2012年中興大學生物醫學研究所retreat meeting暨博士班學生進 度報告競賽第一名

3. 22nd World Congress of Dermatology (Seoul, Korea), Silver Award of e-poster (2011)

4. 99學年度生命科學院獎學金

5. 2011年中興大學生物醫學研究所retreat meeting暨博士班學生進度報告競賽第二名

6. 2009年基因體與蛋白質體學術研討會壁報比賽第二名(2009)

洪婉如 中興大學碩士在職專班碩士(2007畢）

目前狀態: 彰化基督教醫院醫檢師

碩士論文：探討葡萄醣六磷酸運輸蛋白mRNA於小鼠肌肉細胞株進行另類剪接之機制

Presentation:

Shieh, J.J., Chen, C.T., Huang, W.R. The variant glucose-6-phosphate transporter decreases protein stability and requires MyoD-dependent alternative splicing during myogenesis of muscle cells. Experimental Biology 2007 Annual Meeting. Washington D.C., USA, April 28-May 2, 2007.

劉光庭 中興大學醫學科技研究所碩士(2008畢）

目前狀態: 桃園國軍醫院醫檢師; 中興大學生醫所博士生

碩士論文：修飾Mcl-1前體RNA選擇性剪接之探討Mcl-1S蛋白於基底細胞癌細胞調控細胞凋亡角色

Publication:

Shieh JJ^*, Liu KT, Huang SW, Chen YJ, Hsieh TY. Modification of alternative splicing of Mcl-1 pre-mRNA using antisense morpholino oligonucleotides induces apoptosis in basal cell carcinoma cells. J Invest Dermatol. 2009; 129(10):2497-506 (SCI, impact factor: 5.543, Ranking: 1/43 DERMATOLOGY)

Huang SW, Liu KT, Chang CC, Chen YJ, Wu CY, Tsai JJ, Lu WC, Wang YT, Liu CM, Shieh JJ^*. Imiquimod Simultaneously Induces Autophagy and Apoptosis in Human Basal Cell Carcinoma Cells. Brit J Dermatol. 2010; 163(2):310-20 (SCI, impact factor: 4.260, Ranking: 4/43 DERMATOLOGY)

Presentation:

Liu, K.T., Shieh, J.J. Modification of Alternative Splicing of Mcl-1 Pre-mRNA: Role of Mcl-1S-mediated Apoptosis in Basal Cell Carcinoma. In: 23^nd Joint Annual Conference of Biomedical Sciences, Taipei, Taiwan, March, 29-30, 2008.

Award: 九十七年醫學科技研究所論文競賽第一名(2008)

黃士維 中興大學醫學科技研究所碩士(2009畢）

目前狀態:中興大學生醫所博士

碩士論文：以imiquimod誘導人類基底細胞癌細胞進行細胞自噬和細胞凋亡中Mcl-1蛋白的差別角色

Publication: Please see above.

Presentation: Huang, S.W., Liu, K.T., Shieh, J.J. The differential role of Mcl-1 in imiquimod induced autophagy and apoptosis in basal cell carcinoma cells. In: 24^nd Joint Annual Conference of Biomedical Sciences, Taipei, Taiwan, March, 21-22, 2009.

蕭安恬 中興大學醫學科技研究所碩士(2009畢）

目前狀態:補習班名師

碩士論文：Imiquimod對非皮膚癌細胞株之作用探討

Presentation:

Hsiao, A.T., Shieh, J.J. The effect of imiquimod on non-skin tumor cell lines. In: 24^nd Joint Annual Conference of Biomedical Sciences, Taipei, Taiwan, March, 21-22, 2009.

陳育瑜 中興大學生醫所碩士(2011畢）

目前狀態: 諾貝爾生物有限公司業務代表

碩士論文：腺苷磷酸活化激酶在imiquimod與compound C誘導之細胞自噬所扮演之角色

Publication:

Wang ST, Huang SW, Kao JK, Liang SM, Chen YJ, Chen YY, Wu CY, Shieh JJ. Imiquimod-induced AMPK activation causes translation attenuation and apoptosis but not autophagy. Journal of Dermatological Science. 2015; 78(2): 108-116 (SCI, impact factor: 3.335, Ranking: 9/61 DERMATOLOGY)

Huang SW, Wu CY, Wang YT, Kao JK, Lin CC, Chang CC, Mu SW, Chen YY, Chiu HW, Chang CH, Liang SM, Chen YJ, Huang JL, Shieh JJ*. p53 modulates the AMPK inhibitor compound C induced apoptosis in human skin cancer cells. Toxicology and Applied Pharmacology. 2013, 267: 113-124 (SCI, impact factor: 4.447, Ranking:10/83 TOXICOLOGY)

Presentation:

Chen, Y.Y., Huang, S.W., Shieh, J.J. The AMPK inhibitor compound C is a potent inducer of autophagy. In: 25^nd Joint Annual Conference of Biomedical Sciences, Taipei, Taiwan, March, 27-28, 2010.

樂以梅 中興大學生醫所碩士(2011畢)

目前狀態:清水國中生物老師

碩士論文：在Ramos B細胞株中類擇受體7接合子誘發細胞自噬極其對B細胞抗原接受器造成之細胞凋亡影響之研究

Presentation:

Yueh, Y.M., Shieh, J.J. Toll-like receptor 7 ligands induce autophagy and their Effect on B cell antigen receptor mediated apoptosis in Ramos B cells. In: 26^nd Joint Annual Conference of Biomedical Sciences, Taipei, Taiwan, March, 19-20, 2011.

穆思維 中興大學生醫所碩士 (2011畢)

目前狀態:台灣阿斯特捷利康, 醫藥代表

碩士論文：探討p53蛋白在imiquimod和compound C誘發癌細胞珠凋亡過程中扮演之角色

Publication:

Huang SW, Chang SH, Mu SW, Jiang HY, Wang ST, Kao JK, Huang JL, Wu CY, Chen YJ, Shieh JJ*. Imiquimod activates p53-dependent apoptosis in a human basal cell carcinoma cell line. Journal of Dermatological Science. 2015, Accepted (SCI, impact factor: 3.419, Ranking: 9/62 DERMATOLOGY) ^*Corresponding author.

Huang SW, Wu CY, Wang YT, Kao JK, Lin CC, Chang CC, Mu SW, Chen YY, Chiu HW, Chang CH, Liang SM, Chen YJ, Huang JL, Shieh JJ*. p53 modulates the AMPK inhibitor compound C induced apoptosis in human skin cancer cells. Toxicology and Applied Pharmacology. 2013, 267: 113-124 (SCI, impact factor: 4.447, Ranking:10/83 TOXICOLOGY)

Presentation:

Mu, S.W., Shieh, J.J. Imiquimod activates p53 and induces a p53 dependent apoptosis in cancer cells. In: 26^nd Joint Annual Conference of Biomedical Sciences, Taipei, Taiwan, March, 19-20, 2011.

吳柏萱 中興大學生醫所碩士 (2012畢)

目前狀態:

碩士論文：Imiquimod和BH3類似物ABT-737進行協同作用由降低Mcl-1表現以毒殺膀胱癌細胞

陳範雯 中興大學生科所碩士 (2012畢)

目前狀態:

碩士論文：探討在皮膚癌細胞中由腺苷磷酸活化激酶抑制劑-Compound C所誘導Egr-1分子之表現機轉及其生物效應

Publication:

Chuang KC, Chen FW, Tsai MH*, Shieh JJ*. EGR-1 plays a protective role in AMPK inhibitor compound C-induced apoptosis through ROS-induced ERK activation in skin cancer cells. Oncology Letters. 2020, Accepted. (SCI, impact factor: 2.311, Ranking: 182/244 ONCOLOGY).

鄭亘佑 中興大學生醫所碩士 (2013畢)

目前狀態:

碩士論文：Imiquimod誘導類似乾癬皮膚發炎之小鼠模式的發展與抗生素Azithromycin改善乾癬之評估

Publication:

Huang SW, Chen YJ, Wang ST, Ho LW, Kao JK, Takahashi M, Narita M, Wu CY, Cheng HY, Shieh JJ*. Azithromycin Impairs TLR7 Signaling in Dendritic Cells and Improves the Severity of Imiquimod-Induced Psoriasis-Like Skin Inflammation in Mice. Journal of Dermatological Science. 2016, 84(1): 59-70. (SCI, impact factor: 3.681, Ranking: 12/68 DERMATOLOGY)

江欣宜 中興大學生醫所碩士 (2014畢)

目前狀態:

碩士論文：在皮膚細胞探討Imiquimod誘導DNA損傷之研究

Publication:

Huang SW, Chang SH, Mu SW, Jiang HY, Wang ST, Kao JK, Huang JL, Wu CY, Chen YJ, Shieh JJ*. Imiquimod activates p53-dependent apoptosis in a human basal cell carcinoma cell line. Journal of Dermatological Science. 2016, 81(3): 182-91. (SCI, impact factor: 3.681, Ranking: 12/68 DERMATOLOGY)

李俊賢 中興大學生醫所碩士 (2014畢)

目前狀態: 台中澄清醫院放射師

碩士論文：建立偵測細胞自噬之篩選平台

張書豪 中興大學生醫所碩士 (2015畢)

目前狀態: 陽明大學臨床醫學研究所博士候選人

碩士論文：Imiquimod在癌症細胞中所引起細胞自噬機制之探討

Publication:

Kao JK, Wang SC, Ho LW, Huang SW, Chang SH, Yang RC, Ke YY, Wu CY, Wang JY*, Shieh JJ*. Chronic Iron Overload Results in Impaired Bacterial Killing of THP-1 Derived Macrophage through the Inhibition of Lysosomal Acidification. Plos One. 2016, 11(5): e0156713 (SCI, impact factor: 2.740, Ranking: 27/71 MULTIDISCIPLINARY SCIENCES)

Huang SW, Chang SH, Mu SW, Jiang HY, Wang ST, Kao JK, Huang JL, Wu CY, Chen YJ, Shieh JJ*. Imiquimod activates p53-dependent apoptosis in a human basal cell carcinoma cell line. Journal of Dermatological Science. 2016, 81(3): 182-91. (SCI, impact factor: 3.681, Ranking: 12/68 DERMATOLOGY)

廖文倩 中興大學生醫所碩士 (2017畢)

目前狀態:

碩士論文：探討p53在imiquimod誘導的皮膚腫瘤細胞老化所扮演的角色

鄭振謹 中興大學生醫所碩士 (2017畢)

目前狀態:

碩士論文：具imiquimod藥物抗性基底細胞癌細胞株其特徵之探討

王昕妤 中興大學生醫所碩士 (2017畢)

目前狀態: 台中榮總研究助理

碩士論文：探討imiquimod為佐劑增強以免疫性細胞死亡為基礎之樹突細胞疫苗抑制腫瘤的可行性

Publication:

Huang SW, Wang ST, Chang SH, Chung KC, Wang HY, Kao JK, Liang SM, Wu CY, Kao SF, Chen YJ, Shieh JJ*. Imiquimod exerts antitumor effects by inducing immunogenic cell death and is enhanced by the glycolytic inhibitor 2-deoxy-glucose. Journal of Investigative Dermatology. 2020, 140: 1771-1783. (SCI, impact factor: 7.143, Ranking: 3/68 DERMATOLOGY).