Program
Program
Monday June 27th, Salle Conf IV ENS (24 Rue Lhomond, Paris)
Neoantigens recognition and cancer vaccines
Morning
9h00-10h00 Laurence Zitvogel (Institut Gustave Roussy, Villejuif) - Antigen mimicry between cancer and microbial antigens from the gut
10h00-10h30 Coffee break
10h30-11h30 Vinod P Balachandran (Memorial Sloan Kettering Cancer Center, New York) - mRNA Neoantigen Vaccines for Pancreatic Cancer
11h30-12h30 Sine R Hadrup (Danmarks Tekniske Universitet, Lyngby) - What T cells see in the context of cancer
Afternoon
14h00-14h30 Barbara Bravi (Imperial College London, London) - Modelling neoantigen presentation and recognition via flexible and interpretable machine learning models
14h30-15h00 Marianne Burbage (Institut Curie, Paris) - Epigenetically-controlled tumor antigens derived from splice junctions between exons and transposable elements
15h00-15h30 Coffee break
15h30-15h35 Maria Ruiz (École Normale Supérieure, Paris) - Statistical analysis of sharing in antibody repertoires
(flash talk + poster)
15h35-15h40 Marco Molari (University of Basel, Basel) - Modeling the effect of antigen dosage on the affinity distribution of B-cells elicited by immunization (flash talk + poster)
15h40-15h45 Eugenio Mauri (École Normale Supérieure, Paris) - Mutational pathways in protein sequence landscapes: from sampling to low-dimensional characterisation (flash talk + poster)
15h45-15h50 Daniel Tadros (Université de Lausanne, Lausanne) - How much does Dissimilarity-to-Self translate into neo-epitope immunogenicity? (flash talk + poster)
15h50-15h55 Francesco Camaglia (École Normale Supérieure, Paris) - Population based selection shapes the T cell receptor repertoire during thymic development (flash talk + poster)
15h55-16h00 Cyril Malbranke (École Normale Supérieure, Paris) - Design of novel Cas9 with evolution-based modeling and FoldX (flash talk + poster)
16h00-17h00 Poster session
Tuesday June 28th, Amphitheatre FRESK (10 Rue d'Oradour-sur-Glane, Paris)
Antigen recognition by innate and adaptive immune system and vaccines
Morning
9h00-10h00 Benjamin D Greenbaum (Memorial Sloan Kettering Cancer Center, New York) - Understanding the basis of immune recognition in cancer
10h00-10h30 Coffee break
10h30-11h30 Morten Nielsen (Danmarks Tekniske Universitet, Lyngby) - Predicting neoantigens. Do properties other than HLA binding and presentation matter?
11h30-12h00 Anastassia V Komarova (Institut Pasteur, Paris) - Viral and endogenous RLR ligands across RNA virus infections
12h00-12h30 Andreas Mayer (University College London) - Quantifying structure in immune receptor epitope maps
Afternoon
14h00-14h30 Julien Racle (Université de Lausanne, Lausanne) - Robust prediction of pan-HLA class II epitopes by deep motif deconvolution of immunopeptidomes
14h30-15h00 Paolo Pierobon (Institut Curie, Paris) - Mechanics of B cell polarity: new tools to study lymphocyte activation
15h00-15h30 Coffee break
15h30-15h45 Joshua Waterfall (Institut Curie, Paris) - Public, tumor-specific neotranscripts in pediatric cancer: potential for neoantigen directed immunotherapy
15h45-16h00 Jérôme Tubiana (Tel Aviv University, Tel Aviv) - Mapping antibody epitopes onto protein structures with interpretable geometric deep learning
16h00-16h15 Giancarlo Croce (Université de Lausanne, Lausanne) - Deep learning models to decipher T cell specificity
16h15-16h30 Natanael Spisak (École Normale Supérieure, Paris) - Insights into evolutionary dynamics of B cells from a snapshot of the repertoire
16h30-17h00 Concluding remarks