PUP Lopez Branch was established on February 13, 1979 during the Presidency of Dr. Pablo T. Mateo, Jr. At that time, Philippine Normal College (now PNU) and Eulogio Amang Rodriguez Institute of Science & Technology (EARIST) were then in consortia with PUP Lopez.

PUP Lopez Branch came into existence when Southern Pacific College, a private college, owned by the heirs of the late Don Gregorio C. Yumul, Sr., donated the site and the school buildings with all the facilities therein. There was one concrete three-storey building with 21 classrooms and another two-storey building made of wood, which housed the library, the faculty rooms and administrative offices. The site with total land area of 23,724 square meters is located at Yumul St., Brgy. Del Pilar (now Brgy. Burgos), Lopez, Quezon.