Lam Lab - Publications

Publications

Lam PY. Longitudinal in vivo imaging of adult Danionella cerebrum using standard confocal microscopy. Dis Model Mech. 2022 Dec 1;15(12). doi: 10.1242/dmm.049753. Epub 2022 Dec 22. PubMed PMID: 36398624.

Editor's choice

Lam PY, Thawani AR, Balderas E, White AJP, Chaudhuri D, Fuchter MJ, Peterson RT. TRPswitch-A Step-Function Chemo-optogenetic Ligand for the Vertebrate TRPA1 Channel. J Am Chem Soc. 2020 Oct 5;. doi: 10.1021/jacs.0c06811. [Epub ahead of print] PubMed PMID: 32966062.

Houseright RA, Rosowski EE, Lam PY, Tauzin SJM, Mulvaney O, Dewey CN, Huttenlocher A. Cell type specific gene expression profiling reveals a role for complement component C3 in neutrophil responses to tissue damage. Sci Rep. 2020 Sep 24;10(1):15716. doi: 10.1038/s41598-020-72750-9. PubMed PMID: 32973200; PubMed Central PMCID: PMC7518243.

Lam PY, Kutchukian P, Anand R, Imbriglio J, Andrews C, Padilla H, Vohra A, Lane S, Parker DL Jr, Cornella Taracido I, Johns DG, Beerens M, MacRae CA, Caldwell JP, Sorota S, Asnani A, Peterson RT. Cyp1 Inhibition Prevents Doxorubicin-Induced Cardiomyopathy in a Zebrafish Heart-Failure Model. Chembiochem. 2020 Jul 1;21(13):1905-1910. doi: 10.1002/cbic.201900741. Epub 2020 Mar 6. PubMed PMID: 32003101; PubMed Central PMCID: PMC7500981.

Torres JP, Lin Z, Fenton DS, Leavitt LU, Niu C, Lam PY, Robes JM, Peterson RT, Concepcion GP, Haygood MG, Olivera BM, Schmidt EW. Boholamide A, an APD-Class, Hypoxia-Selective Cyclodepsipeptide. J Nat Prod. 2020 Apr 24;83(4):1249-1257. doi: 10.1021/acs.jnatprod.0c00038. Epub 2020 Mar 18. PubMed PMID: 32186874.

Fischer RS, Lam PY, Huttenlocher A, Waterman CM. Filopodia and focal adhesions: An integrated system driving branching morphogenesis in neuronal pathfinding and angiogenesis. Dev Biol. 2019 Jul 1;451(1):86-95. doi: 10.1016/j.ydbio.2018.08.015. Epub 2018 Sep 5. Review. PubMed PMID: 30193787; PubMed Central PMCID: PMC7082808.

Lam PY, Peterson RT. Developing zebrafish disease models for in vivo small molecule screens. Curr Opin Chem Biol. 2019 Jun;50:37-44. doi: 10.1016/j.cbpa.2019.02.005. Epub 2019 Mar 28. Review. PubMed PMID: 30928773; PubMed Central PMCID: PMC6800242.

Tsai TY, Collins SR, Chan CK, Hadjitheodorou A, Lam PY, Lou SS, Yang HW, Jorgensen J, Ellett F, Irimia D, Davidson MW, Fischer RS, Huttenlocher A, Meyer T, Ferrell JE Jr, Theriot JA. Efficient Front-Rear Coupling in Neutrophil Chemotaxis by Dynamic Myosin II Localization. Dev Cell. 2019 Apr 22;49(2):189-205.e6. doi: 10.1016/j.devcel.2019.03.025. PubMed PMID: 31014479; PubMed Central PMCID: PMC6708378.

Jin YN, Schlueter PJ, Jurisch-Yaksi N, Lam PY, Jin S, Hwang WY, Yeh JJ, Yoshigi M, Ong SE, Schenone M, Hartigan CR, Carr SA, Peterson RT. Noncanonical translation via deadenylated 3' UTRs maintains primordial germ cells. Nat Chem Biol. 2018 Sep;14(9):844-852. doi: 10.1038/s41589-018-0098-0. Epub 2018 Jul 9. PubMed PMID: 29988067; PubMed Central PMCID: PMC6800240.

Barros-Becker F, Lam PY, Fisher R, Huttenlocher A. Live imaging reveals distinct modes of neutrophil and macrophage migration within interstitial tissues. J Cell Sci. 2017 Nov 15;130(22):3801-3808. doi: 10.1242/jcs.206128. Epub 2017 Sep 28. PubMed PMID: 28972134; PubMed Central PMCID: PMC5702045.

Lam PY, Mendu SK, Mills RW, Zheng B, Padilla H, Milan DJ, Desai BN, Peterson RT. A high-conductance chemo-optogenetic system based on the vertebrate channel Trpa1b. Sci Rep. 2017 Sep 19;7(1):11839. doi: 10.1038/s41598-017-11791-z. PubMed PMID: 28928472; PubMed Central PMCID: PMC5605526.

Vincent WJ, Freisinger CM, Lam PY, Huttenlocher A, Sauer JD. Macrophages mediate flagellin induced inflammasome activation and host defense in zebrafish. Cell Microbiol. 2016 Apr;18(4):591-604. doi: 10.1111/cmi.12536. Epub 2015 Nov 4. PubMed PMID: 26468080; PubMed Central PMCID: PMC5027955.

Lam PY, Mangos S, Green JM, Reiser J, Huttenlocher A. In vivo imaging and characterization of actin microridges. PLoS One. 2015;10(1):e0115639. doi: 10.1371/journal.pone.0115639. eCollection 2015. PubMed PMID: 25629723; PubMed Central PMCID: PMC4309568.

Tauzin S, Starnes TW, Becker FB, Lam PY, Huttenlocher A. Redox and Src family kinase signaling control leukocyte wound attraction and neutrophil reverse migration. J Cell Biol. 2014 Dec 8;207(5):589-98. doi: 10.1083/jcb.201408090. PubMed PMID: 25488917; PubMed Central PMCID: PMC4259815.

Lam PY, Fischer RS, Shin WD, Waterman CM, Huttenlocher A. Spinning disk confocal imaging of neutrophil migration in zebrafish. Methods Mol Biol. 2014;1124:219-33. doi: 10.1007/978-1-62703-845-4_14. PubMed PMID: 24504955; PubMed Central PMCID: PMC4087032.

Lam PY, Harvie EA, Huttenlocher A. Heat shock modulates neutrophil motility in zebrafish. PLoS One. 2013;8(12):e84436. doi: 10.1371/journal.pone.0084436. eCollection 2013. PubMed PMID: 24367659; PubMed Central PMCID: PMC3868611.

Lam PY, Kamei CN, Mangos S, Mudumana S, Liu Y, Drummond IA. odd-skipped related 2 is required for fin chondrogenesis in zebrafish. Dev Dyn. 2013 Nov;242(11):1284-92. doi: 10.1002/dvdy.24026. Epub 2013 Sep 6. PubMed PMID: 23913342; PubMed Central PMCID: PMC4041527.

Lam PY, Huttenlocher A. Interstitial leukocyte migration in vivo. Curr Opin Cell Biol. 2013 Oct;25(5):650-8. doi: 10.1016/j.ceb.2013.05.007. Epub 2013 Jun 21. Review. PubMed PMID: 23797028; PubMed Central PMCID: PMC3782709.

*Yoo SK, *Lam PY, Eichelberg MR, Zasadil L, Bement WM, Huttenlocher A. The role of microtubules in neutrophil polarity and migration in live zebrafish. J Cell Sci. 2012 Dec 1;125(Pt 23):5702-10. doi: 10.1242/jcs.108324. Epub 2012 Sep 19. PubMed PMID: 22992461; PubMed Central PMCID: PMC3575705.

Lam PY, Yoo SK, Green JM, Huttenlocher A. The SH2-domain-containing inositol 5-phosphatase (SHIP) limits the motility of neutrophils and their recruitment to wounds in zebrafish. J Cell Sci. 2012 Nov 1;125(Pt 21):4973-8. doi: 10.1242/jcs.106625. Epub 2012 Sep 3. PubMed PMID: 22946052; PubMed Central PMCID: PMC3533387.

Mangos S, Lam PY, Zhao A, Liu Y, Mudumana S, Vasilyev A, Liu A, Drummond IA. The ADPKD genes pkd1a/b and pkd2 regulate extracellular matrix formation. Dis Model Mech. 2010 May-Jun;3(5-6):354-65. doi: 10.1242/dmm.003194. Epub 2010 Mar 24. PubMed PMID: 20335443; PubMed Central PMCID: PMC2860853.

Lam PY, Webb SE, Leclerc C, Moreau M, Miller AL. Inhibition of stored Ca2+ release disrupts convergence-related cell movements in the lateral intermediate mesoderm resulting in abnormal positioning and morphology of the pronephric anlagen in intact zebrafish embryos. Dev Growth Differ. 2009 May;51(4):429-42. doi: 10.1111/j.1440-169X.2009.01106.x. PubMed PMID: 19382938.

Vasilyev A, Liu Y, Mudumana S, Mangos S, Lam PY, Majumdar A, Zhao J, Poon KL, Kondrychyn I, Korzh V, Drummond IA. Collective cell migration drives morphogenesis of the kidney nephron. PLoS Biol. 2009 Jan 6;7(1):e9. doi: 10.1371/journal.pbio.1000009. PubMed PMID: 19127979; PubMed Central PMCID: PMC2613420.

Qi J, Gong J, Zhao T, Zhao J, Lam P, Ye J, Li JZ, Wu J, Zhou HM, Li P. Downregulation of AMP-activated protein kinase by Cidea-mediated ubiquitination and degradation in brown adipose tissue. EMBO J. 2008 Jun 4;27(11):1537-48. doi: 10.1038/emboj.2008.92. Epub 2008 May 15. PubMed PMID: 18480843; PubMed Central PMCID: PMC2426729.