Most Cited and Other Publications

Most Cited and Other Publications

Kuhar’s Nine Most Cited Publications:

 (see https://research.com/u/michael-j-kuhar  for lists) October, 2025

Cocaine receptors on dopamine transporters are related to self-administration of cocaine. Mary C. Ritz;R. J.. Lamb;Steven R. Goldberg;Michael J. Kuhar. Science (1987) 3384 Citations

Neurotransmitter Transporters: Recent Progress. Susan G. Amara;Michael J. Kuhar.
Annual Review of Neuroscience (1993) 1453 Citations

The dopamine hypothesis of the reinforcing properties of cocaine M.J. Kuhar;M.C. Ritz;J.W. Boja. Trends in Neurosciences (1991) 1427 Citations

Autoradiographic localization of opiate receptors in rat brain. I. Spinal cord and lower medulla. Samir F. Atweh;Michael J. Kuhar. Brain Research (1977) 1247 Citations

Positron emission tomography reveals elevated D2 dopamine receptors in drug-naive schizophrenics. Dean F. Wong;Henry N. Wagner;Larry E. Tune;Robert F. Dannals. Science (1986) 1189 Citations

Regional Distribution of Opiate Receptor Binding in Monkey and Human Brain Michael J. Kuhar;Candace B. Pert;Solomon H. Snyder. Nature (1973) 1119 Citations

Distribution of α2 agonist binding sites in the rat and human central nervous system: Analysis of some functional, anatomic correlates of the pharmacologic effects of clonidine and related adrenergic agents. James R. Unnerstall;Theresa A. Kopajtic;Michael J. Kuhar. Brain Research Reviews (1984) 1060 Citations

A new method for receptor autoradiography: [3H]opioid receptors in rat brain. W. Scott Young;Michael J. Kuhar. Brain Research (1979) 956 Citations

Imaging dopamine receptors in the human brain by positron tomography. Henry N. Wagner;H. Donald Burns;Robert F. Dannals;Dean F. Wong, … MJ Kuhar Science (1983) 911 Citations

Selected Books and Volumes:

13 books written and edited. Seven of these are:

  1.     Yamamura, H.I., Enna, S.J., and Kuhar, M.J. (Eds.). Neurotransmitter Receptor Binding. Raven Press, New York, 1978.

2       Schuster, C.R. and Kuhar, M.J. (Eds.).  Pharmacological Aspects of Drug Dependence, Vol. 118, Handbook of Experimental Pharmacology. Springer-Verlag, New York, 1996.

3      Kranzler, HR and Korsmeyer, P (Eds).  Kuhar MJ et al., (Assoc Eds.). Encyclopedia of Drugs, Alcohol, and Addictive Behavior, 3rd Edition.  MacMillan Reference USA, New York, 2009.

4      Kuhar, MJ. The Addicted Brain: why we abuse drugs, alcohol, and nicotine. FT Press, Upper Saddle River, NJ, 2012. ISBN-10: 0-13-254250-1. Four printings of the hardback, many sales of softcover, and Translations into Korean, Japanese, Spanish, Chinese, Arabic and parts of book into Polish and Russian. Second Edition, 2023, Amazon, ISBN: 9798374305302

5      Kuhar, MJ. Research Ethics in The Life Sciences. Amazon.com. Second Edition. Oct 9, 2019, ISBN-13: 9781080760237. Third Edition. April 2022, ISBN 9798413967607.

6  Kuhar, MJ. The Art and Ethics of Being a Good Colleague. Amazon. First edition, 2016. Second Edition, April 1, 2020. ISBN-13: 978-1656762917.

7       Kuhar, MJ. Essays for Living, Amazon 2025. ISBN: 979831

Thirteen Patents Issued: (not shown).

Selected Refereed Journal Articles:      

         Dr Kuhar has published about 500 articles in refereed journals that have generated more than 74,000 lifetime citations. A more complete list of research publications can be found at: PubMed using the search term “Kuhar MJ.” Or at the site: https://research.com/university/biology-and-biochemistry/yerkes-national-primate-research-center

         As noted in the previous paragraph, a measure of the usefulness of these articles is the lifetime citation number. This is the number of times various researchers have cited his work. Dr Kuhar has about 75,000 lifetime citations which is outstanding.  https://research.com/university/biology-and-biochemistry/yerkes-national-primate-research-center 

         A helpful overview of Kuhar’s work can be found in the “Reminiscences” section, where various topics rather than individual publications are presented.

An Additional List of Interesting Publications:

1.   Kuhar, M.J. and Snyder, S.H.  The Subcellular Distribution of Free 3H‑Glutamic Acid in Rat Cerebral Cortical Slices. J. Pharmacol. Exp. Ther. 171: 141‑152, 1970. (publication from PhD thesis)

3.              Murrin, L.C. and Kuhar, M.J.  Activation of High Affinity Choline Uptake in vitro by Depolarizing Agents.  Mol. Pharmacol. 12: 1082‑1090, 1976..

4.              Simantov, R., Kuhar, M.J., Uhl, G.R., and Snyder, S.H.  Opioid Peptide Enkephalin: Immuno­histo­chemical Mapping in Rat Central Nervous System.  Proc. Natl. Acad. Sci. (USA) 74: 2167‑2171, 1977.

5.              Atweh, S.F., Murrin, L.C., and Kuhar, M.J.  Presynaptic Localization of Opiate Receptors in the Vagal and Accessory Optic System: An Autoradiographic Study.  Neuropharmacol. 17: 65‑71, 1978.

6.              Zarbin, M.A., Palacios, J.M., Wamsley J.K., and Kuhar, M.J.  Axonal Transport of Beta‑Adrenergic Receptors: Antero‑ and Retrogradely Transported Receptors Differ in Agonist Affinity and Nucleotide Sensitivity.  Molec. Pharmacol. 24: 341‑348, 1983.

7.              Shimada, S., Kitiyama, S., Lin, C.-L., Patel, A., Nanthakumar, E., Gregor, P., Kuhar, M.J., and Uhl, G. Cloning and Expression of a Cocaine‑Sensitive Dopamine Transporter Complementary DNA.  Science, 254: 576‑578, 1991.

8.              Kuhar, M.J., Lloyd, D.G., Appel N and Loats, H.L.  Imaging Receptors by Autoradiography: Computer‑Assisted Approaches.  J. Chem. Neuroanat. 4: 319‑327, 1991.

9.              Carroll, F.I., Rahman, M.A., Abraham, P., Parham, K., Lewin, A.H., Dannals, R.F., Shaya, E., Scheffel, U., Pögün, S., Dawson, V., and Kuhar, M.J.  Nitric Oxide Inhibits 3H-Glutamate Transport in Synapto­somes. Synapse 18: 21-26, 1994.

10.          Nirenberg, M.J., Vaughan, R.A., Uhl, G.R., Kuhar, M.J., and Pickel, V.M.  The Dopamine Transporter is Localized to Dendritic and Axonal Plasma Membranes of Nigrostriatal Dopaminergic Neurons.  J. Neurosci. 16(2): 436-447, 1996.

11.          Vaughan, R.A. and Kuhar, M.J.  Dopamine Transporter Ligand Binding Domains.  J. Biol. Chem. 271: 21672-21680, 1996.

12.          Nirenberg, M.J., Chan, J., Vaughan, R.A., Uhl, G.R., Kuhar, M.J., and Pickel, V.M.  Immunogold Localization of the Dopamine Transporter: An Ultrastructural Study of the Rat Ventral Tegmental Area.  J. Neurosci. 17(14): 5255-5262, 1997.

13.          Smith, Y., Koylu, E.O., Couceyro, P., and Kuhar, M.J.  Ultrastructural Localization of CART (Cocaine- and Amphetamine-Regulated Transcript) Peptides in the Nucleus Accumbens of Monkeys.  Synapse 27: 90-94, 1997.

14.          Koylu, E.O., Couceyro, P.R., Lambert, P.D., Ling, N.C., DeSouza, E.B., and Kuhar, M.J.  Immuno­histochemical Localization of Novel CART Peptides in Rat Hypothalamus, Pituitary and Adrenal Gland.  J. Neuroendocrinol. 9: 823-833, 1997.

15.          Kuhar, M.J. and Joyce, A.R.  Slow Onset of CNS Drugs: Can Changes in Protein Concentration Account for the Delay?  Trends Pharmacol. Sci. 22: 450-456, 2001.

21. Yanik, T., Dominguez, G., Kuhar, M.J., del Giudice, E.M., and Loh Y.P. The Leu34Phe ProCART Mutation Leads to Cocaine- and Amphetamine-Regulated Transcript (CART) Deficiency: A Possible Cause for Obesity in Humans. Endocrinology 147: 39-43, 2006.

22. del Giudice, EM, E., Santoro, N., Fiumani, P., Dominguez, G., Kuhar, M.J., and Perrone, L. Adolescents Carrying a Missense Mutation in the CART Gene Exhibit Increased Anxiety and Depression. Depress. Anxiety 23: 90-92, 2006.

23.   Jaworski JN, Hansen ST, Kuhar MJ, Mark GP.  Injection of CART peptide into the nucleus accumbens reduces     cocaine self-administration in the rat.  Behav Brain Res 191:266-271, 2008.  PMID: 18485497.

24.   Francis DD and Kuhar MJ. Frequency of maternal licking and grooming correlates negatively with vulnerability to cocaine and alcohol use in rats.  Pharmacol Biochem Behav 90:497-500, 2008. 

25.   Kuhar MJ, Job MO. CART Peptide Regulates Psychostimulant-Induced Activity and Exhibits a Rate Dependency. J Drug Alcohol Res. 2017;6:236032. doi: 10.4303/jdar/236032. Epub 2017 May 26.PMID: 29225992

Abstracts:

      While not listed here, the number of abstracts are about equal to the number of journal articles found on Pub Med. They contain the same information as the journal articles but in abbreviated format.

Selected Book Chapters, Reviews, and Other:

                There are about 195 items in this category, but only selected ones are shown.

1.    Kuhar, M.J.  Characteristics and Significance of Sodium‑Dependent, High Affinity Choline Uptake.  In: Cholinergic Mechanisms and Psychopharmacology, D. Jenden (Ed.).  Plenum Publ. Corp., New York,  pp. 447‑456, 1978.

2.    Kuhar, M.J. and Uhl, G.R.  Histochemical Localization of Opiate Receptors and the Enkephalins. In: Neuro­chemical Mechanisms of Opiate Action, D.H. Ross and H.H. Loh (Eds.).  Raven Press, New York, pp. 53‑68, 1978.

3.    Young, W.S., III, and Kuhar, M.J.  The Light Microscopic Radiohistochemistry of Drug and Neurotrans­mitter Receptors Using Diffusible Ligands.   In: Current Trends in Morphological Techniques, Vol. III, J.E. Johnson, Jr. (Ed.).  CRC Press, Boca Raton, FL, pp. 119‑135, 1981.

4.    Kuhar, M.J.  Localization of Drug and Neurotransmitter Receptors in Brain by Light Microscopic Auto­radiography.  In: The Handbook of Psychopharmacology, Vol. 15, S.D. Iversen, L.L. Iversen and S.H. Snyder (Eds.).  Plenum Publ. Co., New York, pp. 299‑320, 1982..

5.    Pögün, S., Duelfer, T., Corley, E.G., Dannals, R.F., Dranbauer, B.J., Scheffel, U., Waud, J.M., O'Brien, H.A., Kuhar, M.J., Burns, H.D., and Wagner, H.N., Jr.  Radiolabeled Spiperone Analogues for Imaging Dopamine Receptors.  In: Nuclear Medicine and Biology Advances. Proceedings of the Third World Congress of Nuclear Medicine and Biology, Vol. IV, C. Raynaud (Ed.).  Pergamon Press, Paris, pp. 3606‑3609, 1982.

6.    Wagner, H.M., Jr., Burns, H.D., Dannals, R.F., Wong, D.F., Langstrom, B., Duelfer, T., Frost, J.J., Ravert, H.T., Links, J.M., Rosenbloom, S., Lukas, S.E., Kramer, A.V., and Kuhar, M.J.  Assessment of Dopamine Receptor Activity in the Human Brain with Carbon‑11 N‑Methylspiperone.  In: Proceed­ings from the Third Symposium on the Medical Application of Cyclotrons, Turku, Finland, June 13‑16, 1983.  Ann. Univ. Turkvensis D 17: 263‑268, 1984.

7.    Whitehouse, P.J., Loats, H.L., Price, D.L., Lloyd, D.G., Kuhar, M.J., and Altschuler, R.J.  New Approaches in Quantitative Neuropathology.  In: Biological Psychiatry, C. Shagass et al. (Eds.). Elsevier Science Publishing Co., New York, pp. 1385‑1387, 1986.

8.    Kuhar, M.J.  Human Brain Mapping.  In: Molecular Biology of the Human Brain, E.G. Jones (Ed.). Alan R. Liss, New York, pp. 185-190, 1988.

9.    Kuhar, M.J., Ritz, M.C., and Sharkey, J.  Cocaine Receptors on Dopamine Transporters Mediate Cocaine-Reinforced Behavior.  In: Mechanisms of Cocaine Abuse and Toxicity (NIDA Research Monograph Series 88), D. Clouet, K. Asglan and R. Brown (Eds.).  U.S. Government Printing Office, Washington, DC, pp. 14‑22, 1988.

10.  Carroll, F.I., Rahman, M.A., Philip, A., Lewin, A.H., Boja, J.W., and Kuhar, M.J.  Synthesis and Receptor Binding of Cocaine Analogs.  In: Problems of Drug Dependence 1990: Proceeding of the 52nd Annual Scientific Meeting, The College on Problems of Drug Dependence, Inc. (NIDA Research Monograph Series 105), L.S. Harris (Ed.).  U.S. Government Printing Office, Washington, DC, pp. 147‑153, 1991.

11.  Vaughan, R.A., Huff, R.A., Uhl, G.R., and Kuhar, M.J.  Phosphorylation of Dopamine Transporters and Rapid Adaptation to Cocaine.  In: Catecholamines: Bridging Basic Science with Clinical Medicine, D.S. Goldstein, G. Eisenhofer, and R. McCarty (Eds.).  Academic Press, San Diego, pp. 1042-, 1998.

12.  Kuhar, M.J.  Addiction.  In: The Dana Brain Science Guide: Resources of Secondary and Post-Secondary Teachers and Students.  The Dana Press, New York, pp. 47-48, 1999.

13.  Kuhar, M.J., Minneman, K., and Muly, E.C. Catecholamines.  In: Basic Neurochemistry: Molecular, Cellular, and Medical Aspects, 7th Edition, G.J. Siegel, R.W. Albers, S.T. Brady and D.L. Price (Eds.). Elsevier Academic Press: Burlington, MA, pp. 211-225, 2006.

14.  Kuhar, M.J.  Why Just Saying No Is Not Enough.  In: 2007 Advances in Brain Research, B. Rich (Ed.). Dana Foundation Press, pp. 11-12, 2007.

15.    Kuhar, M.J.  Introduction of the Nathan B. Eddy Recipient.  NIDA Research Monograph Series No. 187.  Problems of Drug Dependence, 2006: Proceedings of the 68th Annual Scientific Meeting, The College on Problems of Drug Dependence, Inc., pp 69-70, 2007.

16.     Carroll FI, Howard, JL, Howell LL, Fox BS, Kuhar MJ.  Development of the Dopamine Transporter selective RTI-336 as a Pharmacotherapy for cocaine abuse.  In: Drug Addiction: from basic research to therapy, Rapaka RS and Sadee W (Eds).  Springer, pp 1179-192, 2008.